Dr. St-Amand completed his doctoral studies at Laval University, and his postdoctoral studies at the University of British Columbia. In 1998, he optimized the SAGE method in his laboratory located in Japan, at the pharmaceutical company Otsuka. He is currently a full professor in the Department of Molecular Medicine at Laval University, and director of the Functional Genomics Laboratory and SAGE platform at the CHU Research Centre of Quebec. He is an expert in genetic engineering and functional genomics.

Dr. St-Amand’s research program aims to characterize the transcriptomes of several tissues and their regulation through physical exercise, a lipid-rich diet, and steroid hormones, in order to identify, clone and characterize functionally the genes of interest that can be used as therapeutic targets for coronary heart disease, obesity, and cancer. Dr. St-Amand’s laboratory is developing genetic engineering methods and bioinformatics programs, particularly for the analysis of functional genomics results. Dr. St-Amand developed the first SAGE platform in Canada. This powerful strategy makes it possible to compare all transcripts, including new genes, to identify the molecular mechanisms responsible for diseases.

Dr. St-Amand and his team are also studying in vitro cells and knockout mice to characterize the functions of candidate genes. These research projects will identify therapeutic targets to, in turn, develop therapeutic treatments for obesity and cardiovascular disease.

CHUL
2705, boulevard Laurier
R-4720
Québec, Québec
Canada G1V 4G2
CHUL
2705, boulevard Laurier
R-4775
Québec, Québec
Canada G1V 4G2

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57 entries « 3 of 6 »

Riedl I, Yoshioka M, Nishida Y, Tobina T, Paradis R, Shono N, Tanaka H, St-Amand J

Regulation of skeletal muscle transcriptome in elderly men after 6 weeks of endurance training at lactate threshold intensity.

Journal Article

Exp Gerontol, 45 (11), pp. 896-903, 2010, ISSN: 0531-5565.

Abstract | Links:

Riedl I, Yoshioka M, St-Amand J

Concomitant modulation of transcripts related to fiber type determination and energy metabolism in skeletal muscle of female ovariectomized mice by estradiol injection.

Journal Article

J Steroid Biochem Mol Biol, 122 (1-3), pp. 91-9, 2010, ISSN: 0960-0760.

Abstract | Links:

Giorgio MR, Yoshioka M, St-Amand J

A single dose of dihydrotestosterone induced a myogenic transcriptional program in female intra-abdominal adipose tissue.

Journal Article

J Steroid Biochem Mol Biol, 122 (1-3), pp. 53-64, 2010, ISSN: 0960-0760.

Abstract | Links:

Nishida Y, Tanaka H, Tobina T, Murakami K, Shono N, Shindo M, Ogawa W, Yoshioka M, St-Amand J

Regulation of muscle genes by moderate exercise.

Journal Article

Int J Sports Med, 31 (9), pp. 656-70, 2010, ISSN: 0172-4622.

Abstract | Links:

Bolduc C, Yoshioka M, St-Amand J

Acute molecular mechanisms responsive to feeding and meal constitution in mesenteric adipose tissue.

Journal Article

Obesity (Silver Spring), 18 (2), pp. 410-3, 2010, ISSN: 1930-7381.

Abstract | Links:

De Giorgio MR, Yoshioka M, St-Amand J

Feeding regulates the expression of pancreatic genes in gastric mucosa.

Journal Article

J Obes, 2010 , pp. 371950, 2010, ISSN: 2090-0708.

Abstract | Links:

De Giorgio MR, Yoshioka M, St-Amand J

Feeding induced changes in the hypothalamic transcriptome.

Journal Article

Clin Chim Acta, 406 (1-2), pp. 103-7, 2009, ISSN: 0009-8981.

Abstract | Links:

Ma C, Yoshioka M, Boivin A, Gan L, Takase Y, Labrie F, St-Amand J

Atlas of dihydrotestosterone actions on the transcriptome of prostate in vivo.

Journal Article

Prostate, 69 (3), pp. 293-316, 2009, ISSN: 0270-4137.

Abstract | Links:

Nishida Y, Yoshioka M, Ray CA, Bolduc C, Tanaka H, St-Amand J

Regulation of pituitary gene expression by adrenalectomy.

Journal Article

Obesity (Silver Spring), 17 (1), pp. 114-20, 2009, ISSN: 1930-7381.

Abstract | Links:

Aboghe DH, Yoshioka M, Phaneuf D, St-Amand J

Regulation of gene expression by estrogen in mammary gland of wild type and estrogen receptor alpha knockout mice.

Journal Article

J Steroid Biochem Mol Biol, 113 (1-2), pp. 116-26, 2009, ISSN: 0960-0760.

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57 entries « 3 of 6 »
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Active projects

  • Centre de recherche du CHU de Québec - Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
  • Roles of exercise-induced gene, SPARC, against sarcopenia: Link between extracellular matrix and mitochondria., Subvention, Instituts de recherche en santé du Canada, Subvention de fonctionnement, from 2014-04-01 to 2021-03-31
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