Dr. St-Amand completed his doctoral studies at Laval University, and his postdoctoral studies at the University of British Columbia. In 1998, he optimized the SAGE method in his laboratory located in Japan, at the pharmaceutical company Otsuka. He is currently a full professor in the Department of Molecular Medicine at Laval University, and director of the Functional Genomics Laboratory and SAGE platform at the CHU Research Centre of Quebec. He is an expert in genetic engineering and functional genomics.

Dr. St-Amand’s research program aims to characterize the transcriptomes of several tissues and their regulation through physical exercise, a lipid-rich diet, and steroid hormones, in order to identify, clone and characterize functionally the genes of interest that can be used as therapeutic targets for coronary heart disease, obesity, and cancer. Dr. St-Amand’s laboratory is developing genetic engineering methods and bioinformatics programs, particularly for the analysis of functional genomics results. Dr. St-Amand developed the first SAGE platform in Canada. This powerful strategy makes it possible to compare all transcripts, including new genes, to identify the molecular mechanisms responsible for diseases.

Dr. St-Amand and his team are also studying in vitro cells and knockout mice to characterize the functions of candidate genes. These research projects will identify therapeutic targets to, in turn, develop therapeutic treatments for obesity and cardiovascular disease.

CHUL
2705, boulevard Laurier
R-4720
Québec, Québec
Canada G1V 4G2
CHUL
2705, boulevard Laurier
R-4775
Québec, Québec
Canada G1V 4G2
+1 418-525-4444, extension 46448
+1 418-654-2298
jonny.st-amand@crchudeque...

Latest news

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50 entries « ‹ 1 of 5 › »

Ghanemi A, Melouane A, Yoshioka M, St-Amand J

Secreted protein acidic and rich in cysteine and bioenergetics: Extracellular matrix, adipocytes remodeling and skeletal muscle metabolism.

Journal Article

Int J Biochem Cell Biol, 117 , pp. 105627, 2019, ISSN: 1357-2725.

Abstract | Links:

Melouane A, Yoshioka M, Kanzaki M, St-Amand J

Sparc, an EPS-induced gene, modulates the extracellular matrix and mitochondrial function via ILK/AMPK pathways in C2C12 cells.

Journal Article

Life Sci, 229 , pp. 277-287, 2019, ISSN: 0024-3205.

Abstract | Links:

Melouane A, Ghanemi A, Yoshioka M, St-Amand J

Functional genomics applications and therapeutic implications in sarcopenia.

Journal Article

Mutat Res, 781 , pp. 175-185, 2019, ISSN: 0027-5107.

Abstract | Links:

Ghanemi A, Melouane A, Mucunguzi O, Yoshioka M, St-Amand J

Energy and metabolic pathways in trefoil factor family member 2 (Tff2) KO mice beyond the protection from high-fat diet-induced obesity.

Journal Article

Life Sci, 215 , pp. 190-197, 2018, ISSN: 0024-3205.

Abstract | Links:

Ghanemi A, Yoshioka M, St-Amand J

Broken Energy Homeostasis and Obesity Pathogenesis: The Surrounding Concepts.

Journal Article

J Clin Med, 7 (11), 2018, ISSN: 2077-0383.

Abstract | Links:

Melouane A, Ghanemi A, Aube S, Yoshioka M, St-Amand J

Differential gene expression analysis in ageing muscle and drug discovery perspectives.

Journal Article

Ageing Res Rev, 41 , pp. 53-63, 2018, ISSN: 1568-1637.

Abstract | Links:

Melouane A, Carbonell A, Yoshioka M, Puymirat J, St-Amand J

Implication of SPARC in the modulation of the extracellular matrix and mitochondrial function in muscle cells.

Journal Article

PLoS ONE, 13 (2), pp. e0192714, 2018.

Abstract | Links:

Ghanemi A, St-Amand J

Redefining obesity toward classifying as a disease.

Journal Article

Eur J Intern Med, 55 , pp. 20-22, 2018, ISSN: 0953-6205.

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Ghanemi A, St-Amand J

Interleukin-6 as a "metabolic hormone".

Journal Article

Cytokine, 112 , pp. 132-136, 2018, ISSN: 1043-4666.

Abstract | Links:

Mucunguzi O, Melouane A, Ghanemi A, Yoshioka M, Boivin A, Calvo EL, St-Amand J

Identification of the principal transcriptional regulators for low-fat and high-fat meal responsive genes in small intestine.

Journal Article

Nutr Metab (Lond), 14 , pp. 66, 2017.

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50 entries « ‹ 1 of 5 › »
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Active projects

  • Centre de recherche du CHU de Québec - Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31

Recently finished projects

  • Centre de recherche en endocrinologie, métabolisme et inflammation, Subvention, Institutionnel - BDR, BDR - Centres de recherche reconnus, from 1996-06-01 to 2018-04-30
  • Roles of exercise-induced gene, SPARC, against sarcopenia: Link between extracellular matrix and mitochondria., Subvention, Instituts de recherche en santé du Canada, Subvention de fonctionnement, from 2014-04-01 to 2019-03-31
Data provided by the Université Laval research projects registery