Dr. St-Amand completed his doctoral studies at Laval University, and his postdoctoral studies at the University of British Columbia. In 1998, he optimized the SAGE method in his laboratory located in Japan, at the pharmaceutical company Otsuka. He is currently a full professor in the Department of Molecular Medicine at Laval University, and director of the Functional Genomics Laboratory and SAGE platform at the CHU Research Centre of Quebec. He is an expert in genetic engineering and functional genomics.

Dr. St-Amand’s research program aims to characterize the transcriptomes of several tissues and their regulation through physical exercise, a lipid-rich diet, and steroid hormones, in order to identify, clone and characterize functionally the genes of interest that can be used as therapeutic targets for coronary heart disease, obesity, and cancer. Dr. St-Amand’s laboratory is developing genetic engineering methods and bioinformatics programs, particularly for the analysis of functional genomics results. Dr. St-Amand developed the first SAGE platform in Canada. This powerful strategy makes it possible to compare all transcripts, including new genes, to identify the molecular mechanisms responsible for diseases.

Dr. St-Amand and his team are also studying in vitro cells and knockout mice to characterize the functions of candidate genes. These research projects will identify therapeutic targets to, in turn, develop therapeutic treatments for obesity and cardiovascular disease.

CHUL
2705, boulevard Laurier
R-4720
Québec, Québec
Canada G1V 4G2
CHUL
2705, boulevard Laurier
R-4775
Québec, Québec
Canada G1V 4G2

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57 entries « 1 of 6 »

Ghanemi A, Yoshioka M, St-Amand J

Trefoil Factor Family Member 2 (TFF2) as an Inflammatory-Induced and Anti-Inflammatory Tissue Repair Factor.

Journal Article

Animals (Basel), 10 (9), 2020, ISSN: 2076-2615.

Abstract | Links:

Ghanemi A, Yoshioka M, St-Amand J

Secreted protein acidic and rich in cysteine and inflammation: Another homeostatic property?

Journal Article

Cytokine, 133 , pp. 155179, 2020, ISSN: 1043-4666.

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Ghanemi A, Melouane A, Yoshioka M, St-Amand J

Exercise and High-Fat Diet in Obesity: Functional Genomics Perspectives of Two Energy Homeostasis Pillars.

Journal Article

Genes (Basel), 11 (8), 2020.

Abstract | Links:

Ghanemi A, Yoshioka M, St-Amand J

Will an obesity pandemic replace the coronavirus disease-2019 (COVID-19) pandemic?

Journal Article

Med Hypotheses, 144 , pp. 110042, 2020, ISSN: 0306-9877.

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Ghanemi A, Yoshioka M, St-Amand J

Secreted protein acidic and rich in cysteine and cancer: A homeostatic hormone?

Journal Article

Cytokine, 127 , pp. 154996, 2020, ISSN: 1043-4666.

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Melouane A, Yoshioka M, St-Amand J

Extracellular matrix/mitochondria pathway: A novel potential target for sarcopenia.

Journal Article

Mitochondrion, 50 , pp. 63-70, 2020, ISSN: 1567-7249.

Abstract | Links:

Ghanemi A, Yoshioka M, St-Amand J

Secreted Protein Acidic and Rich in Cysteine: Metabolic and Homeostatic Properties beyond the Extracellular Matrix Structure

Journal Article

Appl Sci (Basel), 10 , pp. 2388 (9 pages), 2020, ISSN: 2076-3417.

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Melouane A, Yoshioka M, Kanzaki M, St-Amand J

Sparc, an EPS-induced gene, modulates the extracellular matrix and mitochondrial function via ILK/AMPK pathways in C2C12 cells.

Journal Article

Life Sci, 229 , pp. 277-287, 2019, ISSN: 0024-3205.

Abstract | Links:

Melouane A, Ghanemi A, Yoshioka M, St-Amand J

Functional genomics applications and therapeutic implications in sarcopenia.

Journal Article

Mutat Res, 781 , pp. 175-185, 2019, ISSN: 0027-5107.

Abstract | Links:

Ghanemi A, Melouane A, Yoshioka M, St-Amand J

Secreted protein acidic and rich in cysteine and bioenergetics: Extracellular matrix, adipocytes remodeling and skeletal muscle metabolism.

Journal Article

Int J Biochem Cell Biol, 117 , pp. 105627, 2019, ISSN: 1357-2725.

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57 entries « 1 of 6 »
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Active projects

  • Centre de recherche du CHU de Québec - Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
  • Roles of exercise-induced gene, SPARC, against sarcopenia: Link between extracellular matrix and mitochondria., Subvention, Instituts de recherche en santé du Canada, Subvention de fonctionnement, from 2014-04-01 to 2021-03-31
Data provided by the Université Laval research projects registery