Dr. Jessica Deslauriers is a researcher within the Neurosciences Axis of the CRCHU de Québec-Université Laval, and an Assistant Professor at the Faculty of Pharmacy, Université Laval.
Dr. Deslauriers completed her graduate studies in physiology at Université de Sherbrookeunder the supervision of Drs. Sylvain Grignon and Philippe Sarret. She investigated the role of prenatal inflammation in the development of psychotic-like and depressive-like behaviors in mice. She then pursued a postdoctoral fellowship at the University of California San Diego and Veterans Affairs San Diego Medical Center under the supervision of Dr. Victoria Risbrough. The preclinical and clinical studies conducted by Dr. Deslauriers helped to gain a better understanding of the role of the inflammatory response following a psychological trauma in the development of posttraumatic stress disorder (PTSD). She acquired a strong expertise in pharmacology, molecular biology, neurodevelopmental models of psychiatric disorders, behavioral neuroscience and study of the immune signaling pathways.
Susceptibility to post-traumatic disorders: towards a personalized medicine in psychiatry
90% of the population has endorsed or will experience a traumatic event during their life, and more than half of these individuals develop psychiatric symptoms, such as PTSD, schizophrenia, or depression. The current available treatments have a limited efficacy. Thus, there is an urgent need to develop novel pharmacological therapies.
Dr. Deslauriers’ laboratory at the CRCHU de Québec-Université Laval uses translational and multidisciplinary approaches (1) to understand the mechanisms of susceptibility to psychological trauma, with a primary focus on immune signaling pathways; (2) to identify inflammatory and imaging biomarkers of increased susceptibility to trauma; and (3) to use a personalized medicine by targeting pharmacological approaches based on molecular and pathophysiological characteristics specific to the patient or the “at-risk” individual. Dr. Deslauriers uses a methodology translatable from rodents to humans, including behavioral paradigms, magnetic resonance imaging, as well as genetic and chemogenetic approaches. Her projects are currently funded by the National Institute of Mental Health (NIMH) and the Fondation du CHU de Québec.
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Heritable Differences in Catecholamine Signaling Modulate Susceptibility to Trauma and Response to Methylphenidate Treatment: Relevance for PTSD.Journal Article
Front Behav Neurosci, 13 , pp. 111, 2019, ISSN: 1662-5153.
The 5α-reductase inhibitor finasteride increases suicide-related aggressive behaviors and blocks clozapine-induced beneficial effects in an animal model of schizophrenia.Journal Article
Physiol Behav, 191 , pp. 65-72, 2018, ISSN: 0031-9384.
Current Status of Animal Models of Posttraumatic Stress Disorder: Behavioral and Biological Phenotypes, and Future Challenges in Improving Translation.Journal Article
Biol Psychiatry, 83 (10), pp. 895-907, 2018, ISSN: 0006-3223.
COMT val158met polymorphism links to altered fear conditioning and extinction are modulated by PTSD and childhood trauma.Journal Article
Depress Anxiety, 35 (1), pp. 32-42, 2018, ISSN: 1091-4269.
Effects of LPS-induced immune activation prior to trauma exposure on PTSD-like symptoms in mice.Journal Article
Behav Brain Res, 323 , pp. 117-123, 2017, ISSN: 0166-4328.
Immune signaling mechanisms of PTSD risk and symptom development: insights from animal models.Journal Article
Curr Opin Behav Sci, 14 , pp. 123-132, 2017, ISSN: 2352-1546.
Neuroprotective effects of hypothermia in inflammatory-sensitized hypoxic-ischemic encephalopathy.Journal Article
Int J Dev Neurosci, 55 , pp. 1-8, 2016, ISSN: 0736-5748.
Mitochondrial Dysfunction in Schizophrenia: Determination of Mitochondrial Respiratory Activity in a Two-Hit Mouse Model.Journal Article
J Mol Neurosci, 59 (4), pp. 440-51, 2016, ISSN: 0895-8696.
Overexpression of Forebrain CRH During Early Life Increases Trauma Susceptibility in Adulthood.Journal Article
Neuropsychopharmacology, 41 (6), pp. 1681-90, 2016, ISSN: 0893-133X.
A two-hit model of suicide-trait-related behaviors in the context of a schizophrenia-like phenotype: Distinct effects of lithium chloride and clozapine.Journal Article
Physiol Behav, 156 , pp. 48-58, 2016, ISSN: 0031-9384.