Professor Jérôme Frenette is a researcher with a background in physical therapy and post-graduate training in muscle physiology and immunology at the University of California in Los-Angeles. He is a full-time researcher at the Centre de recherche du CHU de Québec-Laval University, and full professor in the department of rehabilitation at Laval University’s School of Medicine. He has been the principal investigator on several CIHR and NSERC grants. Many of his publications, and one CIHR grant were recognized and rewarded as being among the best in the field of muscle physiology. He started his career as a researcher by investigating the roles played by blood cells and mechanical loading in models of tendon injury and muscle atrophy/regrowth. In 2005, he expanded his research program to include the Buruli Ulcer, which is caused by mycobacterium ulcerans, a neglected disease of wet tropical zones, that is closely related to tuberculosis and leprosy. His research group was the first to show that mycobacterium ulcerans and its toxin, mycolactone, extend well beyond the skin, and severely affect underlying skeletal muscles. Today, the focus of his research program is to understand the link between osteoporosis and muscle atrophy/disease through one common pathway i.e. the RANK/RANKL/OPG pathway. In collaboration with Duchenne muscular dystrophy foundations in Canada, the United States and Australia, as well as sustainable financial support from public and private sources, his team is developing new drugs that would potentially alleviate, in tandem, osteoporosis and muscle degeneration in Duchenne muscular dystrophy patients or other forms of bone and muscle diseases.

CHUL
2705, boulevard Laurier
P-09823
Québec, Québec
Canada G1V 4G2
+1 418-525-4444, extension 47779
+1 418-654-2145
jerome.frenette@crchudequ...

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64 entries « ‹ 1 of 7 › »

Hamoudi D, Bouredji Z, Marcadet L, Yagita H, Landry LB, Argaw A, Frenette J

Muscle weakness and selective muscle atrophy in osteoprotegerin-deficient mice.

Journal Article

Hum Mol Genet, 29 (3), pp. 483-494, 2020, ISSN: 0964-6906.

Abstract | Links:

Hamoudi D, Marcadet L, Piette AB, Yagita H, Bouredji Z, Argaw A, Frenette J

An anti-RANKL treatment reduces muscle inflammation and dysfunction and strengthens bone in dystrophic mice.

Journal Article

Hum Mol Genet, 28 (18), pp. 3101-3112, 2019, ISSN: 0964-6906.

Abstract | Links:

Le Sage N, Tardif PA, Frenette J, Emond M, Chauny JM, Moore L, Archambault P, Perry J, Boulanger-Piette A

Detection of S-100β Protein in Plasma and Urine After a Mild Traumatic Brain Injury.

Journal Article

Can J Neurol Sci, 46 (5), pp. 599-602, 2019, ISSN: 0317-1671.

Abstract | Links:

Dionne CE, Laurin D, Desrosiers T, Abdous B, Le Sage N, Frenette J, Mondor M, Pelletier S

Vitamin C is not the Missing Link Between Cigarette Smoking and Spinal Pain.

Journal Article

Spine, 43 (12), pp. E712-E721, 2018, ISSN: 0362-2436.

Abstract | Links:

Rancourt A, Dufresne SS, St-Pierre G, Levesque JC, Nakamura H, Kikuchi Y, Satoh MS, Frenette J, Sato S

Galectin-3 and N-acetylglucosamine promote myogenesis and improve skeletal muscle function in the mdx model of Duchenne muscular dystrophy.

Journal Article

FASEB J, pp. fj201701151RRR, 2018, ISSN: 0892-6638.

Abstract | Links:

Dufresne SS, Boulanger-Piette A, Bosse S, Argaw A, Hamoudi D, Marcadet L, Gamu D, Fajardo VA, Yagita H, Penninger JM, Russell Tupling A, Frenette J

Genetic deletion of muscle RANK or selective inhibition of RANKL is not as effective as full-length OPG-fc in mitigating muscular dystrophy.

Journal Article

Acta Neuropathol Commun, 6 (1), pp. 31, 2018, ISSN: 2051-5960.

Abstract | Links:

Mercier E, Tardif PA, Cameron P, Batomen Kuimi BL, Emond M, Moore L, Mitra B, Frenette J, de Guise E, Ouellet MC, Bordeleau M, Le Sage N

Prognostic Value of S-100β Protein for Prediction of Post-Concussion Symptoms after a Mild Traumatic Brain Injury: Systematic Review and Meta-Analysis.

Journal Article

J Neurotrauma, 35 (4), pp. 609-622, 2018, ISSN: 0897-7151.

Abstract | Links:

Mercier E, Tardif PA, Cameron PA, Emond M, Moore L, Mitra B, Ouellet MC, Frenette J, de Guise E, Le Sage N

Prognostic value of neuron-specific enolase (NSE) for prediction of post-concussion symptoms following a mild traumatic brain injury: a systematic review.

Journal Article

Brain Inj, 32 (1), pp. 29-40, 2018, ISSN: 0269-9052.

Abstract | Links:

Boulanger Piette A, Hamoudi D, Marcadet L, Kyomi Labelle F, Ovidiu David R, Bosse S, Argaw A, Frenette J

Utrophin haploinsufficiency does not worsen the functional performance, resistance to eccentric contractions and force production of dystrophic mice.

Journal Article

PLoS ONE, 13 (6), pp. e0198408, 2018.

Abstract | Links:

Mazon M, Julien J, Ung RV, Picard S, Hamoudi D, Tam R, Filiatrault J, Frenette J, Mac-Way F, Carreau M

Deletion of the Fanconi Anemia C Gene in Mice Leads to Skeletal Anomalies and Defective Bone Mineralization and Microarchitecture.

Journal Article

J Bone Miner Res, 33 (11), pp. 2007-2020, 2018, ISSN: 0884-0431.

Abstract | Links:

64 entries « ‹ 1 of 7 › »
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Active projects

  • Centre de recherche du CHU de Québec - Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
  • Deciphering the role of RANK/RANKL/OPG in skeletal muscle., Subvention, Conseil de recherches en sciences naturelles et génie Canada, Subventions à la découverte SD (individuelles et d'équipe), from 2016-04-01 to 2021-03-31
  • Investigation of the role of galectin-3 and its ligands in skeletal muscle strength, regeneration, and pathology, Subvention, Instituts de recherche en santé du Canada, Subvention Projet, from 2018-10-01 to 2023-03-31
  • La protéine S100B est-elle un outil de dépistage valide pour réduire le nombre de tomodensitométries inutiles suite à un traumatisme cranio-cérébral léger?, Subvention, Fonds de recherche du Québec - Santé, Consortium pour le développement de la recherche en traumatologie, from 2017-04-01 to 2021-03-31
  • Multifunctional properties of osteoprotegerin in muscular dystrophy and muscle repair, Subvention, Instituts de recherche en santé du Canada, Subvention Projet, from 2020-04-01 to 2025-03-31
  • Therapeutic impact of OPG on muscle structure and function in a preclinical mouse model of Duchenne Muscular Distrophy, Subvention, Ryan's Quest, from 2016-02-17 to 2021-02-16

Recently finished projects

  • Development of a therapy for Duchenne muscular dystrophy using N-acetylglucosamine, Subvention, Secrétariat Inter-Conseils (Canada) (CRSH, CRSNG, IRSC), Réseau de centres d'excellence (RCE), from 2019-06-15 to 2020-06-30
  • To understand mechanistically how RANK/RANKL/OPG and b-adrenergic pathways mitigate Duchenne muscular dystrophy, Subvention, The Foundation for gene and cell therapy Jesse's Journey, from 2016-07-01 to 2020-06-30
  • Validation of a clinical decision rule integrating the use of biomarkers for early detection of persistent symptoms after a MTBI, Subvention, Instituts de recherche en santé du Canada, Volet Projet: Concours pilotes, from 2016-07-01 to 2019-06-30
Data provided by the Université Laval research projects registery