The research of Dr. Sévigny’s team focusses on the functions of extracellular nucleotides, exerted through the activation of P2 receptors, with an emphasis on the enzymes that regulate their concentrations at the cell surface.  Dr. Sévigny and his team have also identified, cloned and characterized six new genes, including the first member of a new family encoding enzymes called NTPDases.  His team is interested in several biological functions including the regulation of inflammation in response to pathogenic determinants, the migration of immune cells, the functions of leukocytes, the contraction of smooth muscles, and in particular the regulation of inflammation of the intestine with an emphasis on epithelial cells and on a potential treatment for inflammatory bowel disease.

Dr Sévigny’s team uses animal models with KO mice as well as methods of cell biology (murine and human primary cells), pharmacology, biochemistry and immunology.

CHUL
2705, boulevard Laurier
T-1-49
Québec, Québec
Canada G1V 4G2
244 entries « 24 of 25 »

Imai M, Takigami K, Guckelberger O, Enjyoji K, Smith RN, Lin Y, Csizmadia E, Sévigny J, Rosenberg RD, Bach FH, Robson SC

Modulation of nucleoside [correction of nucleotide] triphosphate diphosphohydrolase-1 (NTPDase-1)cd39 in xenograft rejection.

Journal Article

Mol Med, 5 (11), pp. 743-52, 1999, ISSN: 1076-1551.

Abstract | Links:

Benrezzak O, Grondin G, Sévigny J, Gendron FP, Rousseau E, D'Orléans-Juste P, Beaudoin AR

Identification and immunolocalization of two isoforms of ATP-diphosphohydrolase (ATPDase) in the pig immune system.

Journal Article

Arch Biochem Biophys, 370 (2), pp. 314-22, 1999, ISSN: 0003-9861.

Abstract | Links:

Imai M, Kaczmarek E, Koziak K, Sévigny J, Goepfert C, Guckelberger O, Csizmadia E, Schulte am Esch J, Robson SC

Suppression of ATP diphosphohydrolase/CD39 in human vascular endothelial cells.

Journal Article

Biochemistry, 38 (41), pp. 13473-9, 1999, ISSN: 0006-2960.

Abstract | Links:

Kittel A, Kaczmarek E, Sevigny J, Lengyel K, Csizmadia E, Robson SC

CD39 as a caveolar-associated ectonucleotidase.

Journal Article

Biochem Biophys Res Commun, 262 (3), pp. 596-9, 1999, ISSN: 0006-291X.

Abstract | Links:

Enjyoji K, Sévigny J, Lin Y, Frenette PS, Christie PD, Esch JS, Imai M, Edelberg JM, Rayburn H, Lech M, Beeler DL, Csizmadia E, Wagner DD, Robson SC, Rosenberg RD

Targeted disruption of cd39/ATP diphosphohydrolase results in disordered hemostasis and thromboregulation.

Journal Article

Nat Med, 5 (9), pp. 1010-7, 1999, ISSN: 1078-8956.

Abstract | Links:

Schulte am Esch J, Sévigny J, Kaczmarek E, Siegel JB, Imai M, Koziak K, Beaudoin AR, Robson SC

Structural elements and limited proteolysis of CD39 influence ATP diphosphohydrolase activity.

Journal Article

Biochemistry, 38 (8), pp. 2248-58, 1999, ISSN: 0006-2960.

Abstract | Links:

Sévigny J, Grondin G, Gendron FP, Roy J, Beaudoin AR

Demonstration and immunolocalization of ATP diphosphohydrolase in the pig digestive system.

Journal Article

Am J Physiol, 275 (3 Pt 1), pp. G473-82, 1998, ISSN: 0002-9513.

Abstract | Links:

Beaudoin AR, Sévigny J, Grondin G, Daoud S, Levesque FP

Purification, characterization, and localization of two ATP diphosphohydrolase isoforms in bovine heart.

Journal Article

Am J Physiol, 273 (2 Pt 2), pp. H673-81, 1997, ISSN: 0002-9513.

Abstract | Links:

Sévigny J, Picher M, Grondin G, Beaudoin AR

Purification and immunohistochemical localization of the ATP diphosphohydrolase in bovine lungs.

Journal Article

Am J Physiol, 272 (5 Pt 1), pp. L939-50, 1997, ISSN: 0002-9513.

Abstract | Links:

Sévigny J, Levesque FP, Grondin G, Beaudoin AR

Purification of the blood vessel ATP diphosphohydrolase, identification and localisation by immunological techniques.

Journal Article

Biochim Biophys Acta, 1334 (1), pp. 73-88, 1997, ISSN: 0006-3002.

Abstract | Links:

244 entries « 24 of 25 »
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Active projects

  • A novel approach to treating inflammatory bowel diseases through the blocking of P2Y6 receptors, Subvention, Instituts de recherche en santé du Canada, Subvention Projet, from 2018-04-01 to 2023-03-31
  • Centre de recherche du CHU de Québec - Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
  • Role of NTPDase1 and Extracellular Nucleotides in Smooth Muscle Cell Contraction., Subvention, Conseil de recherches en sciences naturelles et génie Canada, Subventions à la découverte SD (individuelles et d'équipe), from 2016-04-01 to 2021-03-31

Recently finished projects

  • Centre de recherche en arthrite de l'Université Laval, Subvention, Institutionnel - BDR, BDR - Entités de recherche en émergence, from 2019-01-01 to 2020-01-31
  • Soluble NTPDase8 as a novel biological therapy for inflammatory bowel disease, Subvention, Crohn et Colite Canada, from 2019-07-01 to 2020-06-30
  • Treating inflammatory Bowel diseases through blocking P2Y6 Receptor, Partenariat, MITACS Inc., Accélération Québec (MITACS et gouvernement provincial), from 2018-02-12 to 2019-04-11
Data provided by the Université Laval research projects registery