The research of Dr. Sévigny’s team focusses on the functions of extracellular nucleotides, exerted through the activation of P2 receptors, with an emphasis on the enzymes that regulate their concentrations at the cell surface.  Dr. Sévigny and his team have also identified, cloned and characterized six new genes, including the first member of a new family encoding enzymes called NTPDases.  His team is interested in several biological functions including the regulation of inflammation in response to pathogenic determinants, the migration of immune cells, the functions of leukocytes, the contraction of smooth muscles, and in particular the regulation of inflammation of the intestine with an emphasis on epithelial cells and on a potential treatment for inflammatory bowel disease.

Dr Sévigny’s team uses animal models with KO mice as well as methods of cell biology (murine and human primary cells), pharmacology, biochemistry and immunology.

CHUL
2705, boulevard Laurier
T-1-49
Québec, Québec
Canada G1V 4G2
+1 418-525-4444, extension 46319
+1 418-654-2765
jean.sevigny@crchudequebe...

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244 entries « ‹ 2 of 25 › »

Aziz H, Mahmood A, Zaib S, Saeed A, El-Seedi HR, Pelletier J, Sevigny J, Iqbal J

Synthesis, characterization, alkaline phosphatase inhibition assay and molecular modeling studies of 1-benzylidene-2-(4-tert- butylthiazol-2-yl) hydrazines.

Journal Article

J Biomol Struct Dyn, pp. 1-14, 2020, ISSN: 0739-1102.

Abstract | Links:

Varano F, Catarzi D, Vincenzi F, Pasquini S, Pelletier J, Lopes Rangel Fietto J, Espindola Gelsleichter N, Sarlandie M, Guilbaud A, Sevigny J, Varani K, Colotta V

Structural investigation on thiazolo[5,4-d]pyrimidines to obtain dual-acting blockers of CD73 and adenosine A2A receptor as potential antitumor agents.

Journal Article

Bioorg Med Chem Lett, 30 (9), pp. 127067, 2020, ISSN: 0960-894X.

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Teixeira FC, Bruxel F, Azambuja JH, Berenguer AM, Stefani MA, Sevigny J, Spanevello RM, Battastini AMO, Teixeira HF, Braganhol E

Development and characterization of CD73-siRNA-loaded nanoemulsion: effect on C6 glioma cells and primary astrocytes.

Journal Article

Pharm Dev Technol, 25 (4), pp. 408-415, 2020, ISSN: 1083-7450.

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Herman-de-Sousa C, Pinheiro AR, Paramos-de-Carvalho D, Costa MA, Ferreirinha F, Magalhaes-Cardoso T, Ribeiro S, Pelletier J, Sevigny J, Correia-de-Sa P

Opposing Effects of Adenosine and Inosine in Human Subcutaneous Fibroblasts May Be Regulated by Third Party ADA Cell Providers.

Journal Article

Cells, 9 (3), 2020, ISSN: 2073-4409.

Abstract | Links:

Azambuja JH, Schuh RS, Michels LR, Gelsleichter NE, Beckenkamp LR, Iser IC, Lenz GS, de Oliveira FH, Venturin G, Greggio S, daCosta JC, Wink MR, Sevigny J, Stefani MA, Battastini AMO, Teixeira HF, Braganhol E

Nasal Administration of Cationic Nanoemulsions as CD73-siRNA Delivery System for Glioblastoma Treatment: a New Therapeutical Approach.

Journal Article

Mol Neurobiol, 57 (2), pp. 635-649, 2020, ISSN: 0893-7648.

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Afzal S, Zaib S, Jafari B, Langer P, Lecka J, Sevigny J, Iqbal J

Highly Potent and Selective Ectonucleoside Triphosphate Diphosphohydrolase (ENTPDase1, 2, 3 and 8) Inhibitors Having 2-substituted-7- trifluoromethyl-thiadiazolopyrimidones Scaffold.

Journal Article

Med Chem, 16 (5), pp. 689-702, 2020, ISSN: 1573-4064.

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Willig JB, Vianna DRB, Beckenkamp A, Beckenkamp LR, Sevigny J, Wink MR, Buffon A, Pilger DA

Imatinib mesylate affects extracellular ATP catabolism and expression of NTPDases in a chronic myeloid leukemia cell line.

Journal Article

Purinergic Signal, 16 (1), pp. 29-40, 2020, ISSN: 1573-9538.

Abstract | Links:

Ullah S, El-Gamal MI, Zaib S, Anbar HS, Zaraei SO, Sbenati RM, Pelletier J, Sevigny J, Oh CH, Iqbal J

Synthesis, biological evaluation, and docking studies of new pyrazole-based thiourea and sulfonamide derivatives as inhibitors of nucleotide pyrophosphatase/phosphodiesterase.

Journal Article

Bioorg Chem, 99 , pp. 103783, 2020, ISSN: 0045-2068.

Abstract | Links:

Scholl JN, de Fraga Dias A, Pizzato PR, Lopes DV, Moritz CEJ, Jandrey EHF, Souto GD, Colombo M, Rohden F, Sevigny J, Pohlmann AR, Guterres SS, Oliveira Battastini AM, Figueiro F

Characterization and antiproliferative activity of glioma-derived extracellular vesicles.

Journal Article

Nanomed, 15 (10), pp. 1001-1018, 2020, ISSN: 1743-5889.

Abstract | Links:

Younus HA, Hameed A, Mahmood A, Khan MS, Saeed M, Batool F, Asari A, Mohamad H, Pelletier J, Sevigny J, Iqbal J, Al-Rashida M

Sulfonylhydrazones: Design, synthesis and investigation of ectonucleotidase (ALP & e5'NT) inhibition activities.

Journal Article

Bioorg Chem, 100 , pp. 103827, 2020, ISSN: 0045-2068.

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244 entries « ‹ 2 of 25 › »
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Active projects

  • A novel approach to treating inflammatory bowel diseases through the blocking of P2Y6 receptors, Subvention, Instituts de recherche en santé du Canada, Subvention Projet, from 2018-04-01 to 2023-03-31
  • Centre de recherche du CHU de Québec - Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
  • Role of NTPDase1 and Extracellular Nucleotides in Smooth Muscle Cell Contraction., Subvention, Conseil de recherches en sciences naturelles et génie Canada, Subventions à la découverte SD (individuelles et d'équipe), from 2016-04-01 to 2021-03-31

Recently finished projects

  • Centre de recherche en arthrite de l'Université Laval, Subvention, Institutionnel - BDR, BDR - Entités de recherche en émergence, from 2019-01-01 to 2020-01-31
  • Soluble NTPDase8 as a novel biological therapy for inflammatory bowel disease, Subvention, Crohn et Colite Canada, from 2019-07-01 to 2020-06-30
  • Treating inflammatory Bowel diseases through blocking P2Y6 Receptor, Partenariat, MITACS Inc., Accélération Québec (MITACS et gouvernement provincial), from 2018-02-12 to 2019-04-11
Data provided by the Université Laval research projects registery