Dr. Lambert is a regular researcher at the CHU de Québec-Université Laval Research Center and an assistant professor at the Faculty of Medicine of l’Université Laval in the department of Molecular Medicine. Dr. Lambert’s work aims to decipher how epigenetic regulators are assembled into functional units at the level of chromatin and how they impact transcription in healthy and cancerous cells. To address these fundamental questions, Dr. Lambert employs a multidisciplinary approach that includes mass spectrometry-based proteomics, protein biochemistry and cancer biology. He was recently awarded a prestigious Scholarship for the Next Generation of Scientists from the Cancer Research Society to support him as he establishes his research program.
Characterization of bromodomain-containing proteins in hormone-responsive cancers
Bromodomain-containing proteins are epigenetic regulators involved in many facets of the transcription process. Recently, numerous bromodomain inhibitors have been developed enabling the modulation of their activity for therapeutic benefit. Dr. Lambert’s group is currently investigating the functions of bromodomain-containing proteins in the context of hormone-responsive breast cancers to define their physical interplay with hormone receptors. In addition, Dr. Lambert is defining how specific cancer contexts impinged on bromodomain-containing proteins function and whether they generate actionable vulnerabilities that can targeted with bromodomain inhibitors.
Development of innovative functional proteomics technologies
To enable functional studies of epigenetic regulators, Dr. Lambert’s group is developing and implementing novel proteomics technologies to enable the study of proteomes, protein-protein interactions and post-translational modifications from clinically relevant samples. A particular focus of Dr. Lambert’s efforts remains the study of protein complexes associated with chromatin allowing the elucidation of the mechanisms enabling the ordered recruitment of epigenetic regulators to particular genomic loci.
2705, boulevard Laurier
R-4779 et R-4720
Québec, QC
Canada G1V 4G2
Latest news
- Quatorze chercheurs du CRCHU reçoivent près de 9 millions de dollars de subvention des IRSC 2020-02-28
- Équiper les scientifiques canadiens avec les meilleurs outils de recherche : 4 projets financés par le Fonds des leaders John-R.-Evans 2018-04-11
- 13 chercheurs se partagent plus de 800,000$ en subventions du CRSNG 2017-09-08
- Agbo, LyndaDoctoral studentCHULlynda.agbo.1@ulaval.calynda.agbo@crchudequebec.ulaval.ca
2705 boulevard Laurier
R-4720
Québec, QC
Canada G1V 4G2 - Kougnassoukou Tchara, Pata-EtingDoctoral studentpata-eting.kougnassoukou-tchara.1@ulaval.capata-eting.kougnassoukou-tchara@crchudequebec.ulaval.ca
- Loehr, JérémyEmployeeCHUL+1 418-525-4444, extension 42296jeremy.loehr.1@ulaval.ca
2705, boulevard Laurier
R-4
Québec, Québec
Canada G1V 4G2
BRN2 suppresses apoptosis, reprograms DNA damage repair, and is associated with a high somatic mutation burden in melanoma.
Journal ArticleGenes Dev, 33 (5-6), pp. 310-332, 2019, ISSN: 0890-9369.
Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.
Journal ArticleMol Cell, 73 (3), pp. 621-638.e17, 2019, ISSN: 1097-2765.
Measurement and Analysis of Lysine Acetylation by KAT Complexes In Vitro and In Vivo.
Journal ArticleMethods Mol Biol, 1983 , pp. 57-77, 2019, ISSN: 1064-3745.
Proteomics contribution to the elucidation of the steroid hormone receptors functions.
Journal ArticleJ Steroid Biochem Mol Biol, 192 , pp. 105387, 2019, ISSN: 0960-0760.
Targeted proteomics analyses of phosphorylation-dependent signalling networks.
Journal ArticleJ Proteomics, 189 , pp. 39-47, 2018, ISSN: 1874-3919.
The bromodomain-containing protein Ibd1 links multiple chromatin-related protein complexes to highly expressed genes in Tetrahymena thermophila.
Journal ArticleEpigenetics Chromatin, 11 (1), pp. 10, 2018.
Selective Targeting of Bromodomains of the Bromodomain-PHD Fingers Family Impairs Osteoclast Differentiation.
Journal ArticleACS Chem Biol, 12 (10), pp. 2619-2630, 2017, ISSN: 1554-8929.
Ydj1 governs fungal morphogenesis and stress response, and facilitates mitochondrial protein import via Mas1 and Mas2.
Journal ArticleMicrob Cell, 4 (10), pp. 342-361, 2017, ISSN: 2311-2638.
AIRE is a critical spindle-associated protein in embryonic stem cells.
Journal ArticleElife, 6 , 2017, ISSN: 2050-084X.
Proteomic analysis of the human KEOPS complex identifies C14ORF142 as a core subunit homologous to yeast Gon7.
Journal ArticleNucleic Acids Res, 45 (2), pp. 805-817, 2017, ISSN: 0305-1048.
Active projects
- Caractérisation fonctionnelle des régulateurs épigénétiques et de leurs rôles dans des modèles de cancer, Subvention, Fonds de recherche du Québec - Santé, Chercheur-boursier Juniors 1 et 2, Seniors, from 2018-07-01 to 2022-06-30
- Caractérisation fonctionnelle des régulateurs épigénétiques et de leurs rôles dans des modèles de cancer, Subvention, Fonds de recherche du Québec - Santé, Établissement de jeunes chercheurs - Juniors 1, from 2018-07-01 to 2022-06-30
- Centre de recherche sur le cancer, Subvention, Institutionnel - BDR, BDR - Centres de recherche reconnus, from 1996-05-01 to 2022-06-13
- Characterization of the scaffolding roles of bromodomain containing proteins at the level of chromatin, Subvention, Conseil de recherches en sciences naturelles et génie Canada, Subventions à la découverte SD (individuelles et d'équipe), from 2017-04-01 to 2022-03-31
- Elucidation of bromodomain functions within SWI/SNF complexes (Prix), Subvention, Instituts de recherche en santé du Canada, Subvention Projet - Annonce de priorités : Prix : Chercheur en début de carrière dans le domaine du cancer, from 2020-03-01 to 2021-02-28
- Elucidation of bromodomain functions within SWI/SNF complexes, Subvention, Instituts de recherche en santé du Canada, Subvention Projet, from 2020-04-01 to 2025-03-31
- Establishment of an infrastructure for functional proteomics studies of cancer, Partenariat, Fondation Canadienne pour l'innovation (La), Fonds des leaders John-R.-Evans (FLJR), from 2018-09-01 to 2021-06-30
- Using BET bromodomain inhibitors to create phenotypic lethality in melanoma, Subvention, Société de recherche sur le cancer, Subvention de fonctionnement, from 2020-09-01 to 2022-08-31
Recently finished projects
- Bromodomain and extra-terminal (BET) proteins, novel therapeutic targets in melanoma, Subvention, Société de recherche sur le cancer, Bourse pour la relève scientifique, from 2017-07-01 to 2019-06-30
- High throughput analysis of protein interactions and modifications using peptide arrays, Subvention, Conseil de recherches en sciences naturelles et génie Canada, Subventions d'outils et d'instruments de recherche (OIR), from 2019-03-28 to 2020-03-31
- Programme de soutien aux nouveaux professeurs de la Faculté de médecine, Subvention, Université Laval - démarrage nouveau chercheur, Soutien facultaire aux jeunes chercheurs de la Faculté de médecine, from 2017-07-01 to 2019-06-30