Dr. Lambert is a regular researcher at the CHU de Québec-Université Laval Research Center and an assistant professor at the Faculty of Medicine of l’Université Laval in the department of Molecular Medicine. Dr. Lambert’s work aims to decipher how epigenetic regulators are assembled into functional units at the level of chromatin and how they impact transcription in healthy and cancerous cells. To address these fundamental questions, Dr. Lambert employs a multidisciplinary approach that includes mass spectrometry-based proteomics, protein biochemistry and cancer biology. He was recently awarded a prestigious Scholarship for the Next Generation of Scientists from the Cancer Research Society to support him as he establishes his research program.

Characterization of bromodomain-containing proteins in hormone-responsive cancers

Bromodomain-containing proteins are epigenetic regulators involved in many facets of the transcription process. Recently, numerous bromodomain inhibitors have been developed enabling the modulation of their activity for therapeutic benefit. Dr. Lambert’s group is currently investigating the functions of bromodomain-containing proteins in the context of hormone-responsive breast cancers to define their physical interplay with hormone receptors. In addition, Dr. Lambert is defining how specific cancer contexts impinged on bromodomain-containing proteins function and whether they generate actionable vulnerabilities that can targeted with bromodomain inhibitors.

Development of innovative functional proteomics technologies

To enable functional studies of epigenetic regulators, Dr. Lambert’s group is developing and implementing novel proteomics technologies to enable the study of proteomes, protein-protein interactions and post-translational modifications from clinically relevant samples. A particular focus of Dr. Lambert’s efforts remains the study of protein complexes associated with chromatin allowing the elucidation of the mechanisms enabling the ordered recruitment of epigenetic regulators to particular genomic loci.

CHUL
2705, boulevard Laurier
R-4779 et R-4720
Québec, QC
Canada G1V 4G2
+1 418-525-4444, extension 49399
Jean-Philippe.Lambert@crc...

Latest news

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Lambert JP, Picaud S, Fujisawa T, Hou H, Savitsky P, Uuskula-Reimand L, Gupta GD, Abdouni H, Lin ZY, Tucholska M, Knight JDR, Gonzalez-Badillo B, St-Denis N, Newman JA, Stucki M, Pelletier L, Bandeira N, Wilson MD, Filippakopoulos P, Gingras AC

Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.

Journal Article

Mol Cell, 73 (3), pp. 621-638.e17, 2019, ISSN: 1097-2765.

Abstract | Links:

Lashgari A, Lambert JP, Cote J

Measurement and Analysis of Lysine Acetylation by KAT Complexes In Vitro and In Vivo.

Journal Article

Methods Mol Biol, 1983 , pp. 57-77, 2019, ISSN: 1064-3745.

Abstract | Links:

Agbo L, Lambert JP

Proteomics contribution to the elucidation of the steroid hormone receptors functions.

Journal Article

J Steroid Biochem Mol Biol, 192 , pp. 105387, 2019, ISSN: 0960-0760.

Abstract | Links:

Banerjee SL, Dionne U, Lambert JP, Bisson N

Targeted proteomics analyses of phosphorylation-dependent signalling networks.

Journal Article

J Proteomics, 189 , pp. 39-47, 2018, ISSN: 1874-3919.

Abstract | Links:

Saettone A, Garg J, Lambert JP, Nabeel-Shah S, Ponce M, Burtch A, Thuppu Mudalige C, Gingras AC, Pearlman RE, Fillingham J

The bromodomain-containing protein Ibd1 links multiple chromatin-related protein complexes to highly expressed genes in Tetrahymena thermophila.

Journal Article

Epigenetics Chromatin, 11 (1), pp. 10, 2018.

Abstract | Links:

Meier JC, Tallant C, Fedorov O, Witwicka H, Hwang SY, van Stiphout RG, Lambert JP, Rogers C, Yapp C, Gerstenberger BS, Fedele V, Savitsky P, Heidenreich D, Daniels DL, Owen DR, Fish PV, Igoe NM, Bayle ED, Haendler B, Oppermann UCT, Buffa F, Brennan PE, Muller S, Gingras AC, Odgren PR, Birnbaum MJ, Knapp S

Selective Targeting of Bromodomains of the Bromodomain-PHD Fingers Family Impairs Osteoclast Differentiation.

Journal Article

ACS Chem Biol, 12 (10), pp. 2619-2630, 2017, ISSN: 1554-8929.

Abstract | Links:

Xie JL, Bohovych I, Wong EOY, Lambert JP, Gingras AC, Khalimonchuk O, Cowen LE, Leach MD

Ydj1 governs fungal morphogenesis and stress response, and facilitates mitochondrial protein import via Mas1 and Mas2.

Journal Article

Microb Cell, 4 (10), pp. 342-361, 2017, ISSN: 2311-2638.

Abstract | Links:

Gu B, Lambert JP, Cockburn K, Gingras AC, Rossant J

AIRE is a critical spindle-associated protein in embryonic stem cells.

Journal Article

Elife, 6 , 2017, ISSN: 2050-084X.

Abstract | Links:

Wan LC, Maisonneuve P, Szilard RK, Lambert JP, Ng TF, Manczyk N, Huang H, Laister R, Caudy AA, Gingras AC, Durocher D, Sicheri F

Proteomic analysis of the human KEOPS complex identifies C14ORF142 as a core subunit homologous to yeast Gon7.

Journal Article

Nucleic Acids Res, 45 (2), pp. 805-817, 2017, ISSN: 0305-1048.

Abstract | Links:

Billon P, Li J, Lambert JP, Chen Y, Tremblay V, Brunzelle JS, Gingras AC, Verreault A, Sugiyama T, Couture JF, Cote J

Acetylation of PCNA Sliding Surface by Eco1 Promotes Genome Stability through Homologous Recombination.

Journal Article

Mol Cell, 65 (1), pp. 78-90, 2017, ISSN: 1097-2765.

Abstract | Links:

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Active projects

  • Caractérisation fonctionnelle des régulateurs épigénétiques et de leurs rôles dans des modèles de cancer, Subvention, Fonds de recherche du Québec - Santé, Chercheur-boursier Juniors 1 et 2, Seniors, from 2018-07-01 to 2022-06-30
  • Caractérisation fonctionnelle des régulateurs épigénétiques et de leurs rôles dans des modèles de cancer, Subvention, Fonds de recherche du Québec - Santé, Établissement de jeunes chercheurs - Juniors 1, from 2018-07-01 to 2022-06-30
  • Centre de recherche sur le cancer, Subvention, Institutionnel - BDR, BDR - Centres de recherche reconnus, from 1996-05-01 to 2022-06-13
  • Characterization of the scaffolding roles of bromodomain containing proteins at the level of chromatin, Subvention, Conseil de recherches en sciences naturelles et génie Canada, Subventions à la découverte SD (individuelles et d'équipe), from 2017-04-01 to 2022-03-31
  • Elucidation of bromodomain functions within SWI/SNF complexes (Prix), Subvention, Instituts de recherche en santé du Canada, Subvention Projet - Annonce de priorités : Prix : Chercheur en début de carrière dans le domaine du cancer, from 2020-03-01 to 2021-02-28
  • Elucidation of bromodomain functions within SWI/SNF complexes, Subvention, Instituts de recherche en santé du Canada, Subvention Projet, from 2020-04-01 to 2025-03-31
  • Establishment of an infrastructure for functional proteomics studies of cancer, Partenariat, Fondation Canadienne pour l'innovation (La), Fonds des leaders John-R.-Evans (FLJR), from 2018-09-01 to 2020-12-31

Recently finished projects

  • Bromodomain and extra-terminal (BET) proteins, novel therapeutic targets in melanoma, Subvention, Société de recherche sur le cancer, Bourse pour la relève scientifique, from 2017-07-01 to 2019-06-30
  • High throughput analysis of protein interactions and modifications using peptide arrays, Subvention, Conseil de recherches en sciences naturelles et génie Canada, Subventions d'outils et d'instruments de recherche (OIR), from 2019-03-28 to 2020-03-31
  • Programme de soutien aux nouveaux professeurs de la Faculté de médecine, Subvention, Université Laval - démarrage nouveau chercheur, Soutien facultaire aux jeunes chercheurs de la Faculté de médecine, from 2017-07-01 to 2019-06-30
Data provided by the Université Laval research projects registery