Dr. Lambert is a regular researcher at the CHU de Québec-Université Laval Research Center and an assistant professor at the Faculty of Medicine of l’Université Laval in the department of Molecular Medicine. Dr. Lambert’s work aims to decipher how epigenetic regulators are assembled into functional units at the level of chromatin and how they impact transcription in healthy and cancerous cells. To address these fundamental questions, Dr. Lambert employs a multidisciplinary approach that includes mass spectrometry-based proteomics, protein biochemistry and cancer biology. He was recently awarded a prestigious Scholarship for the Next Generation of Scientists from the Cancer Research Society to support him as he establishes his research program.

Characterization of bromodomain-containing proteins in hormone-responsive cancers

Bromodomain-containing proteins are epigenetic regulators involved in many facets of the transcription process. Recently, numerous bromodomain inhibitors have been developed enabling the modulation of their activity for therapeutic benefit. Dr. Lambert’s group is currently investigating the functions of bromodomain-containing proteins in the context of hormone-responsive breast cancers to define their physical interplay with hormone receptors. In addition, Dr. Lambert is defining how specific cancer contexts impinged on bromodomain-containing proteins function and whether they generate actionable vulnerabilities that can targeted with bromodomain inhibitors.

Development of innovative functional proteomics technologies

To enable functional studies of epigenetic regulators, Dr. Lambert’s group is developing and implementing novel proteomics technologies to enable the study of proteomes, protein-protein interactions and post-translational modifications from clinically relevant samples. A particular focus of Dr. Lambert’s efforts remains the study of protein complexes associated with chromatin allowing the elucidation of the mechanisms enabling the ordered recruitment of epigenetic regulators to particular genomic loci.

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2705, boulevard Laurier
R-4779 et R-4720
Québec, QC
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62 entries « 1 of 7 »

Tao H, Lambert JP, Yung TM, Zhu M, Hahn NA, Li D, Lau K, Sturgeon K, Puviindran V, Zhang X, Gong W, Chen XX, Anderson G, Garry DJ, Henkelman RM, Sun Y, Iulianella A, Kawakami Y, Gingras AC, Hui CC, Hopyan S

IRX3/5 regulate mitotic chromatid segregation and limb bud shape.

Journal Article

Development, 2020, ISSN: 0950-1991.

Abstract | Links:

Louphrasitthiphol P, Siddaway R, Loffreda A, Pogenberg V, Friedrichsen H, Schepsky A, Zeng Z, Lu M, Strub T, Freter R, Lisle R, Suer E, Thomas B, Schuster-Bockler B, Filippakopoulos P, Middleton M, Lu X, Patton EE, Davidson I, Lambert JP, Wilmanns M, Steingrimsson E, Mazza D, Goding CR

Tuning Transcription Factor Availability through Acetylation-Mediated Genomic Redistribution.

Journal Article

Mol Cell, 79 (3), pp. 472-487.e10, 2020, ISSN: 1097-2765.

Abstract | Links:

Kothari C, Osseni MA, Agbo L, Ouellette G, Deraspe M, Laviolette F, Corbeil J, Lambert JP, Diorio C, Durocher F

Machine learning analysis identifies genes differentiating triple negative breast cancers.

Journal Article

Sci Rep, 10 (1), pp. 10464, 2020, ISSN: 2045-2322.

Abstract | Links:

Maltais R, Ngueta Djiemeny A, Roy J, Barbeau X, Lambert JP, Poirier D

Design and synthesis of dansyl-labeled inhibitors of steroid sulfatase for optical imaging.

Journal Article

Bioorg Med Chem, 28 (7), pp. 115368, 2020, ISSN: 0968-0896.

Abstract | Links:

Nabeel-Shah S, Ashraf K, Saettone A, Garg J, Derynck J, Lambert JP, Pearlman RE, Fillingham J

Nucleus-specific linker histones Hho1 and Mlh1 form distinct protein interactions during growth, starvation and development in Tetrahymena thermophila.

Journal Article

Sci Rep, 10 (1), pp. 168, 2020, ISSN: 2045-2322.

Abstract | Links:

Fages J, Chailleux C, Humbert J, Jang SM, Loehr J, Lambert JP, Cote J, Trouche D, Canitrot Y

JMJD6 participates in the maintenance of ribosomal DNA integrity in response to DNA damage.

Journal Article

PLoS Genet, 16 (6), pp. e1008511, 2020, ISSN: 1553-7390.

Abstract | Links:

Kougnassoukou Tchara PE, Filippakopoulos P, Lambert JP

Emerging tools to investigate bromodomain functions.

Journal Article

Methods, 2019, ISSN: 1046-2023.

Abstract | Links:

Garg J, Saettone A, Nabeel-Shah S, Cadorin M, Ponce M, Marquez S, Pu S, Greenblatt J, Lambert JP, Pearlman RE, Fillingham J

The Med31 Conserved Component of the Divergent Mediator Complex in Tetrahymena thermophila Participates in Developmental Regulation.

Journal Article

Curr Biol, 29 (14), pp. 2371-2379.e6, 2019, ISSN: 0960-9822.

Abstract | Links:

Ashraf K, Nabeel-Shah S, Garg J, Saettone A, Derynck J, Gingras AC, Lambert JP, Pearlman RE, Fillingham J

Proteomic Analysis of Histones H2A/H2B and Variant Hv1 in Tetrahymena thermophila Reveals an Ancient Network of Chaperones.

Journal Article

Mol Biol Evol, 36 (5), pp. 1037-1055, 2019, ISSN: 0737-4038.

Abstract | Links:

Saettone A, Nabeel-Shah S, Garg J, Lambert JP, Pearlman RE, Fillingham J

Functional Proteomics of Nuclear Proteins in Tetrahymena thermophila: A Review.

Journal Article

Genes (Basel), 10 (5), 2019.

Abstract | Links:

62 entries « 1 of 7 »
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Active projects

  • Caractérisation fonctionnelle des régulateurs épigénétiques et de leurs rôles dans des modèles de cancer, Subvention, Fonds de recherche du Québec - Santé, Chercheur-boursier Juniors 1 et 2, Seniors, from 2018-07-01 to 2022-06-30
  • Caractérisation fonctionnelle des régulateurs épigénétiques et de leurs rôles dans des modèles de cancer, Subvention, Fonds de recherche du Québec - Santé, Établissement de jeunes chercheurs - Juniors 1, from 2018-07-01 to 2022-06-30
  • Centre de recherche sur le cancer, Subvention, Institutionnel - BDR, BDR - Centres de recherche reconnus, from 1996-05-01 to 2022-06-13
  • Characterization of the scaffolding roles of bromodomain containing proteins at the level of chromatin, Subvention, Conseil de recherches en sciences naturelles et génie Canada, Subventions à la découverte SD (individuelles et d'équipe), from 2017-04-01 to 2022-03-31
  • Elucidation of bromodomain functions within SWI/SNF complexes (Prix), Subvention, Instituts de recherche en santé du Canada, Subvention Projet - Annonce de priorités : Prix : Chercheur en début de carrière dans le domaine du cancer, from 2020-03-01 to 2021-02-28
  • Elucidation of bromodomain functions within SWI/SNF complexes, Subvention, Instituts de recherche en santé du Canada, Subvention Projet, from 2020-04-01 to 2025-03-31
  • Establishment of an infrastructure for functional proteomics studies of cancer, Partenariat, Fondation Canadienne pour l'innovation (La), Fonds des leaders John-R.-Evans (FLJR), from 2018-09-01 to 2021-06-30
  • Using BET bromodomain inhibitors to create phenotypic lethality in melanoma, Subvention, Société de recherche sur le cancer, Subvention de fonctionnement, from 2020-09-01 to 2022-08-31

Recently finished projects

  • Bromodomain and extra-terminal (BET) proteins, novel therapeutic targets in melanoma, Subvention, Société de recherche sur le cancer, Bourse pour la relève scientifique, from 2017-07-01 to 2019-06-30
  • High throughput analysis of protein interactions and modifications using peptide arrays, Subvention, Conseil de recherches en sciences naturelles et génie Canada, Subventions d'outils et d'instruments de recherche (OIR), from 2019-03-28 to 2020-03-31
  • Programme de soutien aux nouveaux professeurs de la Faculté de médecine, Subvention, Université Laval - démarrage nouveau chercheur, Soutien facultaire aux jeunes chercheurs de la Faculté de médecine, from 2017-07-01 to 2019-06-30
Data provided by the Université Laval research projects registery