Dr. Beauregard is an assistant professor in the Department of Radiology and Nuclear Medicine at Laval University, a clinician scientist in the Oncology axis of the CHU Research Centre of Quebec – Laval University, and a specialist in nuclear medicine in the Department of Medical Imaging of the CHU of Quebec. Dr. Jean-Mathieu Beauregard completed his residency in nuclear medicine and his master’s degree in radiobiology at the Université de Sherbrooke. He completed additional training at the Peter MacCallum Cancer Centre in Melbourne, Australia from 2007 to 2010, during which he developed a strong interest in molecular imaging and radionuclide therapy for neuroendocrine tumors. Since his return to the CHU of Quebec, he has set up a new radiopeptide therapy program for neuroendocrine tumors. His research program is multidisciplinary and integrates translational research projects in medical and clinical physics.

Dr. Beauregard’s main clinical research project is the radiopeptide therapy (or PRRT for peptide receptor radionuclide therapy) of patients with neuroendocrine tumors (NETs), where a radioligand (ex. 177Lu-octreotate), binding to the somatostatin receptor expressed by NETs, is administered in several cycles to deliver radiotherapy said internal. We have developed an innovative approach, the personalization of the administered activity, to achieve safe target doses of radiation absorbed by healthy tissue, in order to maximize the irradiation of tumors, without increasing the treatment’s toxicity. Our preliminary results show that we are substantially increasing the radiation dose to tumors compared to the standard regimen where all patients receive the same activity at each cycle.

At the same time, we are working to improve and simplify dosimetry based on SPECT / CT quantitative imaging. To this end, we are fine-tuning the calibration of the SPECT / CT cameras and optimizing the sequence of serial imaging of patient performed after each PRRT treatment cycle in order to achieve the highest precision possible with a minimum of imaging sessions. These serial studies allow us to evaluate the biodistribution of the radiopharmaceutical and its kinetics in different tissues and tumors to derive absorbed radiation doses.

In collaboration with Dr. Girish M. Shah, we are also conducting in vitro and in vivo translational research projects, evaluating novel approaches to PRRT potentiation. One of these is the coadministration of radiosensitizing molecules, such as poly (ADP-ribose) and polymerase (PARP) inhibitors. These inhibit the repair of damages caused to the tumors’ DNA by the PRRT, and thus amplify the therapeutic effects. Another strategy we are studying is to pre-treat NET cells with molecules that can increase their somatostatin receptor expression, thereby promoting increased PRRT radiopharmaceutical accumulation within these cells.

Finally, Dr. Beauregard is also a co-investigator and collaborator on several other clinical research projects using, among other things, positron emission tomography (PET / CT) molecular imaging of prostate cancer and neurodegenerative disorders. Dr. Beauregard supervises graduate students and clinical fellows as part of a complementary training program in nuclear oncology.

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Purohit NK, Shah RG, Adant S, Hoepfner M, Shah GM, Beauregard JM

Potentiation of 177Lu-octreotate peptide receptor radionuclide therapy of human neuroendocrine tumor cells by PARP inhibitor.

Journal Article

Oncotarget, 9 (37), pp. 24693-24706, 2018, ISSN: 1949-2553.

Abstract | Links:

Zhao W, Esquinas PL, Hou X, Uribe CF, Gonzalez M, Beauregard JM, Dewaraja YK, Celler A

Determination of gamma camera calibration factors for quantitation of therapeutic radioisotopes.

Journal Article

EJNMMI Phys, 5 (1), pp. 8, 2018, ISSN: 2197-7364.

Abstract | Links:

Arsenault F, Beauregard JM, Pouliot F

Prostate-specific membrane antigen for prostate cancer theranostics: from imaging to targeted therapy.

Journal Article

Curr Opin Support Palliat Care, 12 (3), pp. 359-365, 2018, ISSN: 1751-4258.

Abstract | Links:

Uribe CF, Esquinas PL, Tanguay J, Gonzalez M, Gaudin E, Beauregard JM, Celler A

Accuracy of 177Lu activity quantification in SPECT imaging: a phantom study.

Journal Article

EJNMMI Phys, 4 (1), pp. 2, 2017, ISSN: 2197-7364.

Abstract | Links:

Espagnet R, Frezza A, Martin JP, Hamel LA, Lechippey L, Beauregard JM, Despres P

A CZT-based blood counter for quantitative molecular imaging.

Journal Article

EJNMMI Phys, 4 (1), pp. 18, 2017, ISSN: 2197-7364.

Abstract | Links:

Del Prete M, Buteau FA, Beauregard JM

Personalized 177Lu-octreotate peptide receptor radionuclide therapy of neuroendocrine tumours: a simulation study.

Journal Article

Eur J Nucl Med Mol Imaging, 44 (9), pp. 1490-1500, 2017, ISSN: 1619-7070.

Abstract | Links:

Morin F, Beauregard JM, Bergeron M, Nguile Makao M, Lacombe L, Fradet V, Fradet Y, Pouliot F

Metabolic Imaging of Prostate Cancer Reveals Intrapatient Intermetastasis Response Heterogeneity to Systemic Therapy.

Journal Article

Eur Urol Focus, 3 (6), pp. 639-642, 2017.

Abstract | Links:

Beauregard JM, Beaulieu A

How we read FCH-PET/CT for prostate cancer.

Journal Article

Cancer Imaging, 16 (1), pp. 41, 2016, ISSN: 1740-5025.

Abstract | Links:

Bensaidane MR, Beauregard JM, Poulin S, Buteau FA, Guimond J, Bergeron D, Verret L, Fortin MP, Houde M, Bouchard RW, Soucy JP, Laforce R

Clinical Utility of Amyloid PET Imaging in the Differential Diagnosis of Atypical Dementias and Its Impact on Caregivers.

Journal Article

J Alzheimers Dis, 52 (4), pp. 1251-62, 2016, ISSN: 1387-2877.

Abstract | Links:

Bergeron D, Beauregard JM, Guimond J, Fortin MP, Houde M, Poulin S, Verret L, Bouchard RW, Laforce R

Clinical Impact of a Second FDG-PET in Atypical/Unclear Dementia Syndromes.

Journal Article

J Alzheimers Dis, 49 (3), pp. 695-705, 2016, ISSN: 1387-2877.

Abstract | Links:

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Active projects

  • Centre de recherche du CHU de Québec - Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
  • Centre de recherche sur le cancer, Subvention, Institutionnel - BDR, BDR - Centres de recherche reconnus, from 1996-05-01 to 2022-06-13
  • National Program on Radioligand Therapy for Prostate Cancer, Subvention, Cancer de la prostate Canada, from 2018-01-01 to 2022-12-31
  • Optimiser les soins des patients atteints du cancer de la prostate résistant à la castration en utilisant une stratégie de triple traceur en imagerie moléculaire et en radiothérapie ciblée, Subvention, Fonds de recherche du Québec - Santé, ONCOPOLE EMC2: Équipes multi-institutionnelles contre le cancer, from 2018-04-01 to 2021-03-31

Recently finished projects

  • Bourses d'aide au démarrage d'études cliniques en oncologie effectuées à l'initiative des chercheurs , Subvention, Consortium de recherche en oncologie clinique du Québec, from 2019-06-06 to 2020-03-31
  • Implantation de la TEP/TDM au Ga68-octreotate dans le cadre de la mise en image des récepteurs à la somatostatine , Subvention, Ministère de l'Économie et de l'Innovation, from 2018-04-01 to 2020-03-31
  • Personalizing Radionuclide Therapy of Neuroendocrine Tumours., Subvention, Instituts de recherche en santé du Canada, Subvention de fonctionnement : Concours transitoire de subvention de fonctionnement : 2014-2015, from 2015-07-01 to 2019-06-30
  • Therapie radiopeptidique personnalisee des patients atteints de tumeurs neuroendocrines, Subvention, Fonds de recherche du Québec - Santé, Chercheurs-boursiers cliniciens - Juniors 1 et 2, Seniors, from 2018-07-01 to 2020-06-30
  • Upregulating expression of SSTR to enhance PRRT of neuroendocrine tumors, Subvention, L'Institut de recherche de la Société canadienne du cancer, Subventions pour l'innovation, from 2017-02-01 to 2020-01-31
Data provided by the Université Laval research projects registery