Professor and Director of the Department of Molecular Medicine, Laval University School of Medicine, Dr. Jean Gosselin’s laboratory is located at the Centre de recherche du CHU de Québec-Laval University. He founded the laboratory of flow cytometry which is among the best equipped in Canada. He also sits on several faculty and hospital committees, and is chairman of the animal facility committee of the Centre de recherche du CHU de Québec-Laval University. His research program aims to clarify the mechanisms of the innate immunity involved in the control of pulmonary infections and in the regulation of the inflammatory response.
Immunological mechanisms to regulate pulmonary inflammation and respiratory infections
Inflammation is an immune mechanism activated in response to injuries and to viruses such as the influenza virus. The influenza virus is an important pathogen that causes severe airway diseases in thousands of people yearly in Canada and the United States, mostly in the elderly, children, and in individuals with chronic pulmonary diseases. An appealing strategy to control excessive lung inflammation is the use of drugs that act on the immune system to fight viral infections, and to appropriately balance the inflammatory response to avoid severe lung tissue damage. Such an approach has the advantage to be effective on a broad range of viral strains, and to act on the immune cells involved in the control of lung homeostasis. (Supported by the Canadian Institutes of Health Research)
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Both IRF3 and especially IRF7 play a key role to orchestrate an effective cerebral inflammatory response in a mouse model of herpes simplex virus encephalitis.Journal Article
J Neurovirol, 24 (6), pp. 761-768, 2018, ISSN: 1355-0284.
Ly6Chigh monocytes facilitate transport of Murid herpesvirus 68 into inflamed joints of arthritic mice.Journal Article
Eur J Immunol, 48 (2), pp. 250-257, 2018, ISSN: 0014-2980.
Contribution of Regulatory T Cells in Nucleotide-Binding Oligomerization Domain 2 Response to Influenza Virus Infection.Journal Article
Front Immunol, 9 , pp. 132, 2018, ISSN: 1664-3224.
Triggering of NOD2 Receptor Converts Inflammatory Ly6Chigh into Ly6Clow Monocytes with Patrolling Properties.Journal Article
Cell Rep, 20 (8), pp. 1830-1843, 2017.
Protective role of CX3CR1 signalling in resident cells of the central nervous system during experimental herpes simplex virus encephalitis.Journal Article
J Gen Virol, 98 (3), pp. 447-460, 2017, ISSN: 0022-1317.
Treatment with the NR4A1 agonist cytosporone B controls influenza virus infection and improves pulmonary function in infected mice.Journal Article
PLoS ONE, 12 (10), pp. e0186639, 2017.
Overexpression of TLR2 and TLR9 on monocyte subsets of active rheumatoid arthritis patients contributes to enhance responsiveness to TLR agonists.Journal Article
Arthritis Res Ther, 18 , pp. 10, 2016, ISSN: 1478-6354.
NR4A1-dependent Ly6Clow monocytes contribute to reducing joint inflammation in arthritic mice through Treg cells.Journal Article
Eur J Immunol, 46 (12), pp. 2789-2800, 2016, ISSN: 0014-2980.
Both Cerebral and Hematopoietic Deficiencies in CCR2 Result in Uncontrolled Herpes Simplex Virus Infection of the Central Nervous System in Mice.Journal Article
PLoS ONE, 11 (12), pp. e0168034, 2016.
Does Epstein-Barr Virus Contribute to Disease Flares in Rheumatoid Arthritis?Journal Article
J Arthritis, 5 (4), pp. 208, 2016, ISSN: 2167-7921.
- Aménagement des animaleries du CRCHU de Québec, Subvention, Ministère de l'Économie, de la Science et de l'Innovation, Programme de soutien à la recherche (PSR-V2) : Soutien au financement d'infrastructures de recherche, from 2015-05-26 to 2020-05-25
- Centre hospitalier universitaire de Québec - Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
- Contribution of the orphan receptor NR4A1 in the control of influenza virus infection and lung inflammation., Subvention, Instituts de recherche en santé du Canada, Subvention de fonctionnement, from 2015-07-01 to 2020-06-30
Recently finished projects
- Centre de recherche en endocrinologie, métabolisme et inflammation, Subvention, Institutionnel - BDR, BDR - Centres de recherche reconnus, from 1996-06-01 to 2018-04-30
- Role of NOD-like receptors in lung immune response against respiratory virus infection, Subvention, Instituts de recherche en santé du Canada, Subvention de fonctionnement, from 2012-10-01 to 2018-03-31
- Role of the innate immune system and evaluation of immunomodulatory strategies in herpes simplex virus encephalitis., Subvention, Instituts de recherche en santé du Canada, Subvention de fonctionnement, from 2014-04-01 to 2018-03-31