Dr. Jean-François Bilodeau, PhD, is a professor in the Laval University School of Medicine’s Department of Medicine and a regular researcher at the CHU of Quebec-Laval University Research Center. His research focuses on the physiological and pathological roles of oxidative stress, at the cellular and tissue levels.

Early detection of hypertension in pregnancy

Hypertensive disorders complicate 5-8% of all pregnancies. Hypertension with proteinuria (preeclampsia) is a complex pathology of the second half of pregnancy, with an estimated prevalence of 3%. Preeclampsia is a major health concern for the newborn and the mother, as it can lead to premature births associated with high perinatal mortality. Currently, there is no effective treatment against it, except for induced childbirth. Our recent work showed that the imbalance between antioxidants and reactive oxygen species (oxidative stress) plays a major role. In addition, this oxidative stress can alter the biosynthesis of bioactive lipids affecting vascular tone (hypertension) and inflammatory response. Our research objectives are to understand the physiopathology in relation to oxidative stress, and to develop a method of early detection of this syndrome.

Targeted lipidomics of oxidized derivatives of polyunsaturated fatty acids

Our laboratory has developed a unique expertise in the determination of hundreds of isomers of oxidized polyunsaturated fatty acids, by mass spectrometry. Omega-3 and omega-6 fatty acids are susceptible to oxidation, and are also the substrate for the eicosanoids involved in inflammation and vascular tone control. Specifically, we use LC-MS /MS and GC /MS methodology, in addition to other complementary methodologies derived from transcriptomics and proteomics.

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Lapointe J, Bilodeau JF

Antioxidant defenses are modulated in the cow oviduct during the estrous cycle.

Journal Article

Biol Reprod, 68 (4), pp. 1157-64, 2003, ISSN: 0006-3363.

Abstract | Links:

Ali AA, Bilodeau JF, Sirard MA

Antioxidant requirements for bovine oocytes varies during in vitro maturation, fertilization and development.

Journal Article

Theriogenology, 59 (3-4), pp. 939-49, 2003, ISSN: 0093-691X.

Abstract | Links:

Bilodeau JF, Patenaude A, Piedboeuf B, Carrier C, Petrov P, Faure R, Mirault ME

Glutathione peroxidase-1 expression enhances recovery of human breast carcinoma cells from hyperoxic cell cycle arrest.

Journal Article

Free Radic Biol Med, 33 (9), pp. 1279-89, 2002, ISSN: 0891-5849.

Abstract | Links:

Bilodeau JF, Blanchette S, Cormier N, Sirard MA

Reactive oxygen species-mediated loss of bovine sperm motility in egg yolk Tris extender: protection by pyruvate, metal chelators and bovine liver or oviductal fluid catalase.

Journal Article

Theriogenology, 57 (3), pp. 1105-22, 2002, ISSN: 0093-691X.

Abstract | Links:

Bilodeau JF, Blanchette S, Gagnon C, Sirard MA

Thiols prevent H2O2-mediated loss of sperm motility in cryopreserved bull semen.

Journal Article

Theriogenology, 56 (2), pp. 275-86, 2001, ISSN: 0093-691X.

Abstract | Links:

Lapointe S, Bilodeau JF, Lemieux D, Asselin E, Fortier MA, Sirard MA

Epithelial and stromal uterine cells cultured in vitro protect bovine sperm from hydrogen peroxide

Journal Article

Theriogenology, 54 (3), pp. 355-69, 2000, ISSN: 0093-691X.

Abstract | Links:

Bilodeau JF, Faure R, Piedboeuf B, Mirault ME

Hyperoxia induces S-phase cell-cycle arrest and p21(Cip1/Waf1)-independent Cdk2 inhibition in human carcinoma T47D-H3 cells.

Journal Article

Exp Cell Res, 256 (2), pp. 347-57, 2000, ISSN: 0014-4827.

Abstract | Links:

Bilodeau JF, Chatterjee S, Sirard MA, Gagnon C

Levels of antioxidant defenses are decreased in bovine spermatozoa after a cycle of freezing and thawing.

Journal Article

Mol Reprod Dev, 55 (3), pp. 282-8, 2000, ISSN: 1040-452X.

Abstract | Links:

Bailey JL, Bilodeau JF, Cormier N

Semen cryopreservation in domestic animals: a damaging and capacitating phenomenon.

Journal Article

J Androl, 21 (1), pp. 1-7, 2000, ISSN: 0196-3635.

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Bilodeau JF, Mirault ME

Increased resistance of GPx-1 transgenic mice to tumor promoter-induced loss of glutathione peroxidase activity in skin.

Journal Article

Int J Cancer, 80 (6), pp. 863-7, 1999, ISSN: 0020-7136.

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Active projects

  • Centre de recherche du CHU de Québec - Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
  • Isoprostanes and phospholipases A2: Roles in the pathophysiology of preeclampsia, Subvention, Instituts de recherche en santé du Canada, Subvention Projet, from 2017-04-01 to 2022-03-31
Data provided by the Université Laval research projects registery