Dr. Jean-François Bilodeau, PhD, is a professor in the Laval University School of Medicine’s Department of Medicine and a regular researcher at the CHU of Quebec-Laval University Research Center. His research focuses on the physiological and pathological roles of oxidative stress, at the cellular and tissue levels.

Early detection of hypertension in pregnancy

Hypertensive disorders complicate 5-8% of all pregnancies. Hypertension with proteinuria (preeclampsia) is a complex pathology of the second half of pregnancy, with an estimated prevalence of 3%. Preeclampsia is a major health concern for the newborn and the mother, as it can lead to premature births associated with high perinatal mortality. Currently, there is no effective treatment against it, except for induced childbirth. Our recent work showed that the imbalance between antioxidants and reactive oxygen species (oxidative stress) plays a major role. In addition, this oxidative stress can alter the biosynthesis of bioactive lipids affecting vascular tone (hypertension) and inflammatory response. Our research objectives are to understand the physiopathology in relation to oxidative stress, and to develop a method of early detection of this syndrome.

Targeted lipidomics of oxidized derivatives of polyunsaturated fatty acids

Our laboratory has developed a unique expertise in the determination of hundreds of isomers of oxidized polyunsaturated fatty acids, by mass spectrometry. Omega-3 and omega-6 fatty acids are susceptible to oxidation, and are also the substrate for the eicosanoids involved in inflammation and vascular tone control. Specifically, we use LC-MS /MS and GC /MS methodology, in addition to other complementary methodologies derived from transcriptomics and proteomics.

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Roland L, Gagne A, Belanger MC, Boutet M, Julien P, Bilodeau JF

Plasma interleukin-18 (IL-18) levels are correlated with antioxidant vitamin coenzyme Q(10) in preeclampsia.

Journal Article

Acta Obstet Gynecol Scand, 89 (3), pp. 360-6, 2010, ISSN: 0001-6349.

Abstract | Links:

Gauvreau D, Moisan V, Roy M, Fortier MA, Bilodeau JF

Expression of prostaglandin E synthases in the bovine oviduct.

Journal Article

Theriogenology, 73 (1), pp. 103-11, 2010, ISSN: 0093-691X.

Abstract | Links:

Roland L, Gagne A, Belanger MC, Boutet M, Berthiaume L, Fraser WD, Julien P, Bilodeau JF

Existence of compensatory defense mechanisms against oxidative stress and hypertension in preeclampsia.

Journal Article

Hypertens Pregnancy, 29 (1), pp. 21-37, 2010, ISSN: 1064-1955.

Abstract | Links:

Boutet M, Roland L, Thomas N, Bilodeau JF

Specific systemic antioxidant response to preeclampsia in late pregnancy: the study of intracellular glutathione peroxidases in maternal and fetal blood.

Journal Article

Am J Obstet Gynecol, 200 (5), pp. 530.e1-7, 2009, ISSN: 0002-9378.

Abstract | Links:

Roy M, Gauvreau D, Bilodeau JF

Expression of superoxide dismutases in the bovine oviduct during the estrous cycle.

Journal Article

Theriogenology, 70 (5), pp. 836-42, 2008, ISSN: 0093-691X.

Abstract | Links:

Peris SI, Bilodeau JF, Dufour M, Bailey JL

Impact of cryopreservation and reactive oxygen species on DNA integrity, lipid peroxidation, and functional parameters in ram sperm.

Journal Article

Mol Reprod Dev, 74 (7), pp. 878-92, 2007, ISSN: 1040-452X.

Abstract | Links:

Lapointe J, Roy M, St-Pierre I, Kimmins S, Gauvreau D, MacLaren LA, Bilodeau JF

Hormonal and spatial regulation of nitric oxide synthases (NOS) (neuronal NOS, inducible NOS, and endothelial NOS) in the oviducts.

Journal Article

Endocrinology, 147 (12), pp. 5600-10, 2006, ISSN: 0013-7227.

Abstract | Links:

Lapointe J, Kimmins S, Maclaren LA, Bilodeau JF

Estrogen selectively up-regulates the phospholipid hydroperoxide glutathione peroxidase in the oviducts.

Journal Article

Endocrinology, 146 (6), pp. 2583-92, 2005, ISSN: 0013-7227.

Abstract | Links:

Bilodeau JF, Hubel CA

Current concepts in the use of antioxidants for the treatment of preeclampsia.

Journal Article

J Obstet Gynaecol Can, 25 (9), pp. 742-50, 2003, ISSN: 1701-2163.

Abstract | Links:

Lessard C, Masseau I, Bilodeau JF, Kroetsch T, Twagiramungu H, Bailey JL, Leclerc P, Sullivan R

Semen characteristics of genetically identical quadruplet bulls.

Journal Article

Theriogenology, 59 (8), pp. 1865-77, 2003, ISSN: 0093-691X.

Abstract | Links:

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Active projects

  • Centre de recherche du CHU de Québec - Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
  • Isoprostanes and phospholipases A2: Roles in the pathophysiology of preeclampsia, Subvention, Instituts de recherche en santé du Canada, Subvention Projet, from 2017-04-01 to 2022-03-31
Data provided by the Université Laval research projects registery