Dr. Jean-François Bilodeau, PhD, is a professor in the Laval University School of Medicine’s Department of Medicine and a regular researcher at the CHU of Quebec-Laval University Research Center. His research focuses on the physiological and pathological roles of oxidative stress, at the cellular and tissue levels.

Early detection of hypertension in pregnancy

Hypertensive disorders complicate 5-8% of all pregnancies. Hypertension with proteinuria (preeclampsia) is a complex pathology of the second half of pregnancy, with an estimated prevalence of 3%. Preeclampsia is a major health concern for the newborn and the mother, as it can lead to premature births associated with high perinatal mortality. Currently, there is no effective treatment against it, except for induced childbirth. Our recent work showed that the imbalance between antioxidants and reactive oxygen species (oxidative stress) plays a major role. In addition, this oxidative stress can alter the biosynthesis of bioactive lipids affecting vascular tone (hypertension) and inflammatory response. Our research objectives are to understand the physiopathology in relation to oxidative stress, and to develop a method of early detection of this syndrome.

Targeted lipidomics of oxidized derivatives of polyunsaturated fatty acids

Our laboratory has developed a unique expertise in the determination of hundreds of isomers of oxidized polyunsaturated fatty acids, by mass spectrometry. Omega-3 and omega-6 fatty acids are susceptible to oxidation, and are also the substrate for the eicosanoids involved in inflammation and vascular tone control. Specifically, we use LC-MS /MS and GC /MS methodology, in addition to other complementary methodologies derived from transcriptomics and proteomics.

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Bilodeau JF, Qin Wei S, Larose J, Greffard K, Moisan V, Audibert F, Fraser WD, Julien P

Plasma F2-isoprostane class VI isomers at 12-18 weeks of pregnancy are associated with later occurrence of preeclampsia.

Journal Article

Free Radic Biol Med, 85 , pp. 282-7, 2015, ISSN: 0891-5849.

Abstract | Links:

Larose J, Julien P, Greffard K, Fraser WD, Audibert F, Wei SQ, Bilodeau JF

F2-isoprostanes are correlated with trans fatty acids in the plasma of pregnant women.

Journal Article

Prostaglandins Leukot Essent Fatty Acids, 91 (6), pp. 243-9, 2014, ISSN: 0952-3278.

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Bilodeau JF

Review: maternal and placental antioxidant response to preeclampsia - impact on vasoactive eicosanoids.

Journal Article

Placenta, 35 Suppl , pp. S32-8, 2014, ISSN: 0143-4004.

Abstract | Links:

Larose J, Julien P, Bilodeau JF

Analysis of F2-isoprostanes in plasma of pregnant women by HPLC-MS/MS using a column packed with core-shell particles.

Journal Article

J Lipid Res, 54 (5), pp. 1505-11, 2013, ISSN: 0022-2275.

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Bilodeau JF

The Use of Antioxidants in Pre-eclampsia Studies on Women's Health

Book Chapter

A, Agarwal; N, Aziz; B, Rizk (Ed.): Studies on Women's Health, pp. 115-129, New York, NY, Springer/Humana Press, 2013, ISBN: 978-1-62703-041-0.

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Larose J, Laflamme J, Cote I, Lapointe J, Frenette G, Sullivan R, Bilodeau JF

The polyol pathway in the bovine oviduct.

Journal Article

Mol Reprod Dev, 79 (9), pp. 603-12, 2012, ISSN: 1040-452X.

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Tondreau MY, Boucher E, Simard M, Tremblay Y, Bilodeau JF

Sex-specific perinatal expression of glutathione peroxidases during mouse lung development.

Journal Article

Mol Cell Endocrinol, 355 (1), pp. 87-95, 2012, ISSN: 0303-7207.

Abstract | Links:

Fortier ME, Audet I, Giguere A, Laforest JP, Bilodeau JF, Quesnel H, Matte JJ

Effect of dietary organic and inorganic selenium on antioxidant status, embryo development, and reproductive performance in hyperovulatory first-parity gilts.

Journal Article

J Anim Sci, 90 (1), pp. 231-40, 2012, ISSN: 0021-8812.

Abstract | Links:

Roland-Zejly L, Moisan V, St-Pierre I, Bilodeau JF

Altered placental glutathione peroxidase mRNA expression in preeclampsia according to the presence or absence of labor.

Journal Article

Placenta, 32 (2), pp. 161-7, 2011, ISSN: 0143-4004.

Abstract | Links:

Roland L, Beauchemin D, Acteau G, Fradette C, St-Pierre I, Bilodeau JF

Effects of labor on placental expression of superoxide dismutases in preeclampsia.

Journal Article

Placenta, 31 (5), pp. 392-400, 2010, ISSN: 0143-4004.

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Active projects

  • Centre de recherche du CHU de Québec - Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
  • Isoprostanes and phospholipases A2: Roles in the pathophysiology of preeclampsia, Subvention, Instituts de recherche en santé du Canada, Subvention Projet, from 2017-04-01 to 2022-03-31
Data provided by the Université Laval research projects registery