Dr. Jean-François Bilodeau, PhD, is a professor in the Laval University School of Medicine’s Department of Medicine and a regular researcher at the CHU of Quebec-Laval University Research Center. His research focuses on the physiological and pathological roles of oxidative stress, at the cellular and tissue levels.

Early detection of hypertension in pregnancy

Hypertensive disorders complicate 5-8% of all pregnancies. Hypertension with proteinuria (preeclampsia) is a complex pathology of the second half of pregnancy, with an estimated prevalence of 3%. Preeclampsia is a major health concern for the newborn and the mother, as it can lead to premature births associated with high perinatal mortality. Currently, there is no effective treatment against it, except for induced childbirth. Our recent work showed that the imbalance between antioxidants and reactive oxygen species (oxidative stress) plays a major role. In addition, this oxidative stress can alter the biosynthesis of bioactive lipids affecting vascular tone (hypertension) and inflammatory response. Our research objectives are to understand the physiopathology in relation to oxidative stress, and to develop a method of early detection of this syndrome.

Targeted lipidomics of oxidized derivatives of polyunsaturated fatty acids

Our laboratory has developed a unique expertise in the determination of hundreds of isomers of oxidized polyunsaturated fatty acids, by mass spectrometry. Omega-3 and omega-6 fatty acids are susceptible to oxidation, and are also the substrate for the eicosanoids involved in inflammation and vascular tone control. Specifically, we use LC-MS /MS and GC /MS methodology, in addition to other complementary methodologies derived from transcriptomics and proteomics.

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O'Connor S, Greffard K, Leclercq M, Julien P, Weisnagel SJ, Gagnon C, Droit A, Bilodeau JF, Rudkowska I

Increased Dairy Products Intake Alters Serum Metabolite Profiles in Subjects at Risk of Developing Type 2 Diabetes.

Journal Article

Mol Nutr Food Res, pp. e1900126, 2019, ISSN: 1613-4125.

Abstract | Links:

Bilodeau JF, Bisson M, Larose J, Pronovost E, Brien M, Greffard K, Marc I

Physical fitness is associated with prostaglandin F2α isomers during pregnancy.

Journal Article

Prostaglandins Leukot Essent Fatty Acids, 145 , pp. 7-14, 2019, ISSN: 0952-3278.

Abstract | Links:

Taschereau-Charron A, Bilodeau JF, Larose J, Greffard K, Berthiaume L, Audibert F, Fraser WD, Julien P, Rudkowska I

F2-isoprostanes and fatty acids profile in early pregnancy complicated by pre-existing diabetes.

Journal Article

Prostaglandins Leukot Essent Fatty Acids, 135 , pp. 115-120, 2018, ISSN: 0952-3278.

Abstract | Links:

Da Silva MS, Bilodeau JF, Julien P, Rudkowska I

Dietary fats and F2-isoprostanes: A review of the clinical evidence.

Journal Article

Crit Rev Food Sci Nutr, 57 (18), pp. 3929-3941, 2017, ISSN: 1040-8398.

Abstract | Links:

Da Silva MS, Bilodeau JF, Larose J, Greffard K, Julien P, Barbier O, Rudkowska I

Modulation of the biomarkers of inflammation and oxidative stress by ruminant trans fatty acids and dairy proteins in vascular endothelial cells (HUVEC).

Journal Article

Prostaglandins Leukot Essent Fatty Acids, 126 , pp. 64-71, 2017, ISSN: 0952-3278.

Abstract | Links:

Brien M, Larose J, Greffard K, Julien P, Bilodeau JF

Increased placental phospholipase A2 gene expression and free F2-isoprostane levels in response to oxidative stress in preeclampsia.

Journal Article

Placenta, 55 , pp. 54-62, 2017, ISSN: 0143-4004.

Abstract | Links:

Taschereau-Charron A, Da Silva MS, Bilodeau JF, Morisset AS, Julien P, Rudkowska I

Alterations of fatty acid profiles in gestational diabetes and influence of the diet.

Journal Article

Maturitas, 99 , pp. 98-104, 2017, ISSN: 0378-5122.

Abstract | Links:

Brien M, Berthiaume L, Rudkowska I, Julien P, Bilodeau JF

Placental dimethyl acetal fatty acid derivatives are elevated in preeclampsia.

Journal Article

Placenta, 51 , pp. 82-88, 2017, ISSN: 0143-4004.

Abstract | Links:

Da Silva MS, Julien P, Bilodeau JF, Barbier O, Rudkowska I

Trans Fatty Acids Suppress TNF-α-Induced Inflammatory Gene Expression in Endothelial (HUVEC) and Hepatocellular Carcinoma (HepG2) Cells.

Journal Article

Lipids, 52 (4), pp. 315-325, 2017, ISSN: 0024-4201.

Abstract | Links:

Luo ZC, Bilodeau JF, Monique Nuyt A, Fraser WD, Julien P, Audibert F, Xiao L, Garofalo C, Levy E

Perinatal Oxidative Stress May Affect Fetal Ghrelin Levels in Humans.

Journal Article

Sci Rep, 5 , pp. 17881, 2015, ISSN: 2045-2322.

Abstract | Links:

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Active projects

  • Centres hospitaliers universitaires de Québec - Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
  • Isoprostanes and phospholipases A2: Roles in the pathophysiology of preeclampsia, Subvention, Instituts de recherche en santé du Canada, Subvention Projet, from 2017-04-01 to 2022-03-31

Recently finished projects

  • Centre de recherche en endocrinologie, métabolisme et inflammation, Subvention, Institutionnel - BDR, BDR - Centres de recherche reconnus, from 1996-06-01 to 2018-04-30
Data provided by the Université Laval research projects registery