Jacques Simard holds a Canadian Research Chair in Oncogenetics since 2001. He is Professor in the Department of Molecular Medicine at Laval University’s School of Medicine, and is a scientist at the CHUL since 1990.

He is the author of more than 430 publications, review articles and book chapters. His research focuses on the genetic susceptibility of hormone-dependent cancers, including breast, ovarian and prostate cancer. Specifically, he participated in the characterization of the impact of mutations in the breast and ovarian cancer susceptibility genes BRCA1 and BRCA2. He has been Director of the Interdisciplinary Health Research International Team on Breast Cancer Susceptibility (INHERIT BRCAs), an international interdisciplinary health research team on genetic susceptibility to breast cancer funded by the Canadian Institutes of Health Research (CIHR) 2001 -2007, which was renewed in 2008 for five years as the CIHR Team in Familial Risks of Breast Cancer. The establishment of this international team has allowed Dr. Simard to pursue numerous collaborations allowing him to accelerate the development of his oncogenetics research activities. Indeed, his close collaboration with several international consortia, notably the Breast Cancer Consortium Consortium (BCAC) and the Consortium of Investigators of Modifiers of BRCA1 and BRCA2 (CIMBA), has led to a significant increase in the validity and the impact of scientific breakthroughs to improve the identification of women at increased risk of developing breast cancer which should benefit most from a better adapted clinical follow-up.

He is currently the principal investigator of a large-scale interdisciplinary project funded by Génome Québec/Genome Canada/CIHR/Quebec Breast Cancer Foundation (2013-2018) entitled Personalized Risk Stratification for Prevention and Early Detection of Breast Cancer (PERSPECTIVE), bringing together 27 co-researchers including fundamentalists, biostatisticians and clinicians from Quebec, Ontario, the United States, the United Kingdom, the Netherlands and Germany. This project is designed to develop the tools needed to implement a risk stratification approach that will target breast cancer screening in women most likely to develop the disease. In this context, recommendations on the starting age and frequency of mammography screening could be adapted for women’s individual risk of breast cancer. Indeed, risk stratification will better serve the subpopulation of younger women, who are at high risk of developing breast cancer, and who are currently missed by the standard age-based screening program as a criterion for eligibility. Since breast cancer in these young women often has a poorer prognosis, earlier detection and follow-up would improve survival rates, provide less aggressive treatment, reduce side effects, and increase their quality of life.

Pr. Simard is also a partner on two large European Commission Horizon 2020 (2015-2020) projects entitled BRIDGES (Breast Cancer Risk after Diagnostic Gene Sequencing) and B-CAST (Breast Cancer Stratification: Understanding the Determinants of Risk and Prognosis of Molecular Subtypes). Briefly, the BRIDGES project aims to develop a targeted prevention program for breast cancer, specifically to promote the health of women with a family history of the disease. In achieving its objectives, the BRIDGES program will improve targeted prevention of breast cancer, primarily in the context of oncogenetic clinics for breast cancer. To that end, Pr. Simard is the Principal Investigator of a grant from the Ministry of the Economy, Science and Innovation ($ 1.5 million) entitled PRÉVENTION (Predisposition, Prediction and Prevention of Breast Cancer), to substantially increase the collaboration of his interdisciplinary team with the BRIDGES project in order to validate and increase the impact of the discoveries made under the PERSPECTIVE project.

CHUL
2705, boulevard Laurier
R-4720
Québec, Québec
Canada G1V 4G2
CHUL
2705, boulevard Laurier
R-4787
Québec, Québec
Canada G1V 4G2
484 entries « 3 of 49 »

Li H, Terry MB, Antoniou AC, Phillips KA, Kast K, Mooij TM, Engel C, Nogues C, Stoppa-Lyonnet D, Lasset C, Berthet P, Mari V, Caron O, Barrowdale D, Frost D, Brewer C, Evans DG, Izatt L, Side L, Walker L, Tischkowitz M, Rogers MT, Porteous ME, Meijers-Heijboer HEJ, Gille JJ, Blok MJ, Hoogerbrugge N, Daly MB, Andrulis IL, Buys SS, John EM, McLachlan SA, Friedlander M, Tan YY, Osorio A, Caldes T, Jakubowska A, Simard J, Singer CF, Olah E, Navratilova M, Foretova L, Gerdes AM, Roos-Blom MJ, Arver B, Olsson H, Schmutzler RK, Hopper JL, Milne RL, Easton DF, Van Leeuwen FE, Rookus MA, Andrieu N, Goldgar DE

Alcohol Consumption, Cigarette Smoking, and Risk of Breast Cancer for BRCA1 and BRCA2 Mutation Carriers: Results from The BRCA1 and BRCA2 Cohort Consortium.

Journal Article

Cancer Epidemiol Biomarkers Prev, 29 (2), pp. 368-378, 2020, ISSN: 1055-9965.

Abstract | Links:

Fachal L, Aschard H, Beesley J, Barnes DR, Allen J, Kar S, Pooley KA, Dennis J, Michailidou K, Turman C, Soucy P, Lemacon A, Lush M, Tyrer JP, Ghoussaini M, Marjaneh MM, Jiang X, Agata S, Aittomaki K, Alonso MR, Andrulis IL, Anton-Culver H, Antonenkova NN, Arason A, Arndt V, Aronson KJ, Arun BK, Auber B, Auer PL, Azzollini J, Balmana J, Barkardottir RB, Barrowdale D, Beeghly-Fadiel A, Benitez J, Bermisheva M, Bialkowska K, Blanco AM, Blomqvist C, Blot W, Bogdanova NV, Bojesen SE, Bolla MK, Bonanni B, Borg A, Bosse K, Brauch H, Brenner H, Briceno I, Brock IW, Brooks-Wilson A, Bruning T, Burwinkel B, Buys SS, Cai Q, Caldes T, Caligo MA, Camp NJ, Campbell I, Canzian F, Carroll JS, Carter BD, Castelao JE, Chiquette J, Christiansen H, Chung WK, Claes KBM, Clarke CL, GEMO Study Collaborators, EMBRACE Collaborators, Collee JM, Cornelissen S, Couch FJ, Cox A, Cross SS, Cybulski C, Czene K, Daly MB, de la Hoya M, Devilee P, Diez O, Ding YC, Dite GS, Domchek SM, Dork T, Dos-Santos-Silva I, Droit A, Dubois S, Dumont M, Duran M, Durcan L, Dwek M, Eccles DM, Engel C, Eriksson M, Evans DG, Fasching PA, Fletcher O, Floris G, Flyger H, Foretova L, Foulkes WD, Friedman E, Fritschi L, Frost D, Gabrielson M, Gago-Dominguez M, Gambino G, Ganz PA, Gapstur SM, Garber J, Garcia-Saenz JA, Gaudet MM, Georgoulias V, Giles GG, Glendon G, Godwin AK, Goldberg MS, Goldgar DE, Gonzalez-Neira A, Tibiletti MG, Greene MH, Grip M, Gronwald J, Grundy A, Guenel P, Hahnen E, Haiman CA, Hakansson N, Hall P, Hamann U, Harrington PA, Hartikainen JM, Hartman M, He W, Healey CS, Heemskerk-Gerritsen BAM, Heyworth J, Hillemanns P, Hogervorst FBL, Hollestelle A, Hooning MJ, Hopper JL, Howell A, Huang G, Hulick PJ, Imyanitov EN, KConFab Investigators, HEBON Investigators, ABCTB Investigators, Isaacs C, Iwasaki M, Jager A, Jakimovska M, Jakubowska A, James PA, Janavicius R, Jankowitz RC, John EM, Johnson N, Jones ME, Jukkola-Vuorinen A, Jung A, Kaaks R, Kang D, Kapoor PM, Karlan BY, Keeman R, Kerin MJ, Khusnutdinova E, Kiiski JI, Kirk J, Kitahara CM, Ko YD, Konstantopoulou I, Kosma VM, Koutros S, Kubelka-Sabit K, Kwong A, Kyriacou K, Laitman Y, Lambrechts D, Lee E, Leslie G, Lester J, Lesueur F, Lindblom A, Lo WY, Long J, Lophatananon A, Loud JT, Lubinski J, MacInnis RJ, Maishman T, Makalic E, Mannermaa A, Manoochehri M

Fine-mapping of 150 breast cancer risk regions identifies 191 likely target genes.

Journal Article

Nat Genet, 52 (1), pp. 56-73, 2020, ISSN: 1061-4036.

Abstract | Links:

Feng H, Gusev A, Pasaniuc B, Wu L, Long J, Abu-Full Z, Aittomaki K, Andrulis IL, Anton-Culver H, Antoniou AC, Arason A, Arndt V, Aronson KJ, Arun BK, Asseryanis E, Auer PL, Azzollini J, Balmana J, Barkardottir RB, Barnes DR, Barrowdale D, Beckmann MW, Behrens S, Benitez J, Bermisheva M, Bialkowska K, Blanco A, Blomqvist C, Boeckx B, Bogdanova NV, Bojesen SE, Bolla MK, Bonanni B, Borg A, Brauch H, Brenner H, Briceno I, Broeks A, Bruning T, Burwinkel B, Cai Q, Caldes T, Caligo MA, Campbell I, Canisius S, Campa D, Carter BD, Carter J, Castelao JE, Chang-Claude J, Chanock SJ, Christiansen H, Chung WK, Claes KBM, Clarke CL, GEMO Study Collaborators, EMBRACE Collaborators, GC-HBOC study Collaborators, Couch FJ, Cox A, Cross SS, Cybulski C, Czene K, Daly MB, de la Hoya M, De Leeneer K, Dennis J, Devilee P, Diez O, Domchek SM, Dork T, Dos-Santos-Silva I, Dunning AM, Dwek M, Eccles DM, Ejlertsen B, Ellberg C, Engel C, Eriksson M, Fasching PA, Fletcher O, Flyger H, Fostira F, Friedman E, Fritschi L, Frost D, Gabrielson M, Ganz PA, Gapstur SM, Garber J, Garcia-Closas M, Garcia-Saenz JA, Gaudet MM, Giles GG, Glendon G, Godwin AK, Goldberg MS, Goldgar DE, Gonzalez-Neira A, Greene MH, Gronwald J, Guenel P, Haiman CA, Hall P, Hamann U, Hake C, He W, Heyworth J, Hogervorst FBL, Hollestelle A, Hooning MJ, Hoover RN, Hopper JL, Huang G, Hulick PJ, Humphreys K, Imyanitov EN, ABCTB Investigators, HEBON Investigators, BCFR Investigators, OCGN Investigators, Isaacs C, Jakimovska M, Jakubowska A, James P, Janavicius R, Jankowitz RC, John EM, Johnson N, Joseph V, Jung A, Karlan BY, Khusnutdinova E, Kiiski JI, Konstantopoulou I, Kristensen VN, Laitman Y, Lambrechts D, Lazaro C, Leroux D, Leslie G, Lester J, Lesueur F, Lindor N, Lindstrom S, Lo WY, Loud JT, Lubinski J, Makalic E, Mannermaa A, Manoochehri M, Manoukian S, Margolin S, Martens JWM, Martinez ME, Matricardi L, Maurer T, Mavroudis D, McGuffog L, Meindl A, Menon U, Michailidou K, Kapoor PM, Miller A, Montagna M, Moreno F, Moserle L, Mulligan AM, Muranen TA, Nathanson KL, Neuhausen SL, Nevanlinna H, Nevelsteen I, Nielsen FC, Nikitina-Zake L, Offit K, Olah E, Olopade OI, Olsson H, Osorio A, Papp J, Park-Simon TW, Parsons MT, Pedersen IS, Peixoto A, Peterlongo P, Peto J, Pharoah PDP, Phillips KA, Plaseska-Karanfilska D, Poppe B, Pradhan N, Prajzendanc K

Transcriptome-wide association study of breast cancer risk by estrogen-receptor status.

Journal Article

Genet Epidemiol, 44 (5), pp. 442-468, 2020, ISSN: 0741-0395.

Abstract | Links:

Zhang H, Ahearn TU, Lecarpentier J, Barnes D, Beesley J, Qi G, Jiang X, O'Mara TA, Zhao N, Bolla MK, Dunning AM, Dennis J, Wang Q, Ful ZA, Aittomaki K, Andrulis IL, Anton-Culver H, Arndt V, Aronson KJ, Arun BK, Auer PL, Azzollini J, Barrowdale D, Becher H, Beckmann MW, Behrens S, Benitez J, Bermisheva M, Bialkowska K, Blanco A, Blomqvist C, Bogdanova NV, Bojesen SE, Bonanni B, Bondavalli D, Borg A, Brauch H, Brenner H, Briceno I, Broeks A, Brucker SY, Bruning T, Burwinkel B, Buys SS, Byers H, Caldes T, Caligo MA, Calvello M, Campa D, Castelao JE, Chang-Claude J, Chanock SJ, Christiaens M, Christiansen H, Chung WK, Claes KBM, Clarke CL, Cornelissen S, Couch FJ, Cox A, Cross SS, Czene K, Daly MB, Devilee P, Diez O, Domchek SM, Dork T, Dwek M, Eccles DM, Ekici AB, Evans DG, Fasching PA, Figueroa J, Foretova L, Fostira F, Friedman E, Frost D, Gago-Dominguez M, Gapstur SM, Garber J, Garcia-Saenz JA, Gaudet MM, Gayther SA, Giles GG, Godwin AK, Goldberg MS, Goldgar DE, Gonzalez-Neira A, Greene MH, Gronwald J, Guenel P, Haberle L, Hahnen E, Haiman CA, Hake CR, Hall P, Hamann U, Harkness EF, Heemskerk-Gerritsen BAM, Hillemanns P, Hogervorst FBL, Holleczek B, Hollestelle A, Hooning MJ, Hoover RN, Hopper JL, Howell A, Huebner H, Hulick PJ, Imyanitov EN, kConFab Investigators, ABCTB Investigators, Isaacs C, Izatt L, Jager A, Jakimovska M, Jakubowska A, James P, Janavicius R, Janni W, John EM, Jones ME, Jung A, Kaaks R, Kapoor PM, Karlan BY, Keeman R, Khan S, Khusnutdinova E, Kitahara CM, Ko YD, Konstantopoulou I, Koppert LB, Koutros S, Kristensen VN, Laenkholm AV, Lambrechts D, Larsson SC, Laurent-Puig P, Lazaro C, Lazarova E, Lejbkowicz F, Leslie G, Lesueur F, Lindblom A, Lissowska J, Lo WY, Loud JT, Lubinski J, Lukomska A, MacInnis RJ, Mannermaa A, Manoochehri M, Manoukian S, Margolin S, Martinez ME, Matricardi L, McGuffog L, McLean C, Mebirouk N, Meindl A, Menon U, Miller A, Mingazheva E, Montagna M, Mulligan AM, Mulot C, Muranen TA, Nathanson KL, Neuhausen SL, Nevanlinna H, Neven P, Newman WG, Nielsen FC, Nikitina-Zake L, Nodora J, Offit K, Olah E, Olopade OI, Olsson H, Orr N, Papi L, Papp J, Park-Simon TW, Parsons MT, Peissel B, Peixoto A, Peshkin B, Peterlongo P, Peto J, Phillips KA, Piedmonte M, Plaseska-Karanfilska D, Prajzendanc K, Prentice R, Prokofyeva D, Rack B, Radice P

Genome-wide association study identifies 32 novel breast cancer susceptibility loci from overall and subtype-specific analyses.

Journal Article

Nat Genet, 52 (6), pp. 572-581, 2020, ISSN: 1061-4036.

Abstract | Links:

Muranen TA, Khan S, Fagerholm R, Aittomaki K, Cunningham JM, Dennis J, Leslie G, McGuffog L, Parsons MT, Simard J, Slager S, Soucy P, Easton DF, Tischkowitz M, Spurdle AB, kConFab Investigators, Schmutzler RK, Wappenschmidt B, Hahnen E, Hooning MJ, HEBON Investigators, Singer CF, Wagner G, Thomassen M, Pedersen IS, Domchek SM, Nathanson KL, Lazaro C, Rossing CM, Andrulis IL, Teixeira MR, James P, Garber J, Weitzel JN, SWE-BRCA Investigators, Jakubowska A, Yannoukakos D, John EM, Southey MC, Schmidt MK, Antoniou AC, Chenevix-Trench G, Blomqvist C, Nevanlinna H

Association of germline variation with the survival of women with BRCA1/2 pathogenic variants and breast cancer.

Journal Article

NPJ Breast Cancer, 6 , pp. 44, 2020, ISSN: 2374-4677.

Abstract | Links:

Boonen RACM, Rodrigue A, Stoepker C, Wiegant WW, Vroling B, Sharma M, Rother MB, Celosse N, Vreeswijk MPG, Couch F, Simard J, Devilee P, Masson JY, van Attikum H

Functional analysis of genetic variants in the high-risk breast cancer susceptibility gene PALB2.

Journal Article

Nat Commun, 10 (1), pp. 5296, 2019, ISSN: 2041-1723.

Abstract | Links:

Rodrigue A, Margaillan G, Torres Gomes T, Coulombe Y, Montalban G, da Costa E Silva Carvalho S, Milano L, Ducy M, De-Gregoriis G, Dellaire G, Araujo da Silva W Jr, Monteiro AN, Carvalho MA, Simard J, Masson JY

A global functional analysis of missense mutations reveals two major hotspots in the PALB2 tumor suppressor.

Journal Article

Nucleic Acids Res, 47 (20), pp. 10662-10677, 2019, ISSN: 0305-1048.

Abstract | Links:

Kar SP, Brenner H, Giles GG, Huo D, Milne RL, Rennert G, Simard J, Zheng W, Burgess S, Pharoah PDP

Body mass index and the association between low-density lipoprotein cholesterol as predicted by HMGCR genetic variants and breast cancer risk.

Journal Article

Int J Epidemiol, 48 (5), pp. 1727-1730, 2019, ISSN: 0300-5771.

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Yang Y, Shu X, Shu XO, Bolla MK, Kweon SS, Cai Q, Michailidou K, Wang Q, Dennis J, Park B, Matsuo K, Kwong A, Park SK, Wu AH, Teo SH, Iwasaki M, Choi JY, Li J, Hartman M, Shen CY, Muir K, Lophatananon A, Li B, Wen W, Gao YT, Xiang YB, Aronson KJ, Spinell JJ, Gago-Dominguez M, John EM, Kurian AW, Chang-Claude J, Chen ST, Dork T, Evans DGR, Schmidt MK, Shin MH, Giles GG, Milne RL, Simard J, Kubo M, Kraft P, Kang D, Easton DF, Zheng W, Long J

Re-evaluating genetic variants identified in candidate gene studies of breast cancer risk using data from nearly 280,000 women of Asian and European ancestry.

Journal Article

EBioMedicine, 48 , pp. 203-211, 2019, ISSN: 2352-3964.

Abstract | Links:

Jiang X, Finucane HK, Schumacher FR, Schmit SL, Tyrer JP, Han Y, Michailidou K, Lesseur C, Kuchenbaecker KB, Dennis J, Conti DV, Casey G, Gaudet MM, Huyghe JR, Albanes D, Aldrich MC, Andrew AS, Andrulis IL, Anton-Culver H, Antoniou AC, Antonenkova NN, Arnold SM, Aronson KJ, Arun BK, Bandera EV, Barkardottir RB, Barnes DR, Batra J, Beckmann MW, Benitez J, Benlloch S, Berchuck A, Berndt SI, Bickeboller H, Bien SA, Blomqvist C, Boccia S, Bogdanova NV, Bojesen SE, Bolla MK, Brauch H, Brenner H, Brenton JD, Brook MN, Brunet J, Brunnstrom H, Buchanan DD, Burwinkel B, Butzow R, Cadoni G, Caldes T, Caligo MA, Campbell I, Campbell PT, Cancel-Tassin G, Cannon-Albright L, Campa D, Caporaso N, Carvalho AL, Chan AT, Chang-Claude J, Chanock SJ, Chen C, Christiani DC, Claes KBM, Claessens F, Clements J, Collee JM, Correa MC, Couch FJ, Cox A, Cunningham JM, Cybulski C, Czene K, Daly MB, deFazio A, Devilee P, Diez O, Gago-Dominguez M, Donovan JL, Dork T, Duell EJ, Dunning AM, Dwek M, Eccles DM, Edlund CK, Edwards DRV, Ellberg C, Evans DG, Fasching PA, Ferris RL, Liloglou T, Figueiredo JC, Fletcher O, Fortner RT, Fostira F, Franceschi S, Friedman E, Gallinger SJ, Ganz PA, Garber J, Garcia-Saenz JA, Gayther SA, Giles GG, Godwin AK, Goldberg MS, Goldgar DE, Goode EL, Goodman MT, Goodman G, Grankvist K, Greene MH, Gronberg H, Gronwald J, Guenel P, Hakansson N, Hall P, Hamann U, Hamdy FC, Hamilton RJ, Hampe J, Haugen A, Heitz F, Herrero R, Hillemanns P, Hoffmeister M, Hogdall E, Hong YC, Hopper JL, Houlston R, Hulick PJ, Hunter DJ, Huntsman DG, Idos G, Imyanitov EN, Ingles SA, Isaacs C, Jakubowska A, James P, Jenkins MA, Johansson M, John EM, Joshi AD, Kaneva R, Karlan BY, Kelemen LE, Kuhl T, Khaw KT, Khusnutdinova E, Kibel AS, Kiemeney LA, Kim J, Kjaer SK, Knight JA, Kogevinas M, Kote-Jarai Z, Koutros S, Kristensen VN, Kupryjanczyk J, Lacko M, Lam S, Lambrechts D, Landi MT, Lazarus P, Le ND, Lee E, Lejbkowicz F, Lenz HJ, Leslie G, Lessel D, Lester J, Levine DA, Li L, Li CI, Lindblom A, Lindor NM, Liu G, Loupakis F, Lubinski J, Maehle L, Maier C, Mannermaa A, Marchand LL, Margolin S, May T, McGuffog L, Meindl A, Middha P, Miller A, Milne RL, MacInnis RJ, Modugno F, Montagna M, Moreno V, Moysich KB, Mucci L, Muir K, Mulligan AM, Nathanson KL, Neal DE, Ness AR, Neuhausen SL, Nevanlinna H

Publisher Correction: Shared heritability and functional enrichment across six solid cancers.

Journal Article

Nat Commun, 10 (1), pp. 4386, 2019, ISSN: 2041-1723.

Abstract | Links:

484 entries « 3 of 49 »
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Active projects

  • Centre de recherche du CHU de Québec - Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
  • Centre de recherche sur le cancer, Subvention, Institutionnel - BDR, BDR - Centres de recherche reconnus, from 1996-05-01 to 2022-06-13
  • Chaire de recherche du Canada en oncogénétique, Subvention, Secrétariat des Chaires de recherche du Canada, Chaires de recherche du Canada - Fonctionnement, from 2015-03-01 to 2022-06-30
  • From correlation to causation in genomics: identifying mechanisms underlying disease, Subvention, Instituts de recherche en santé du Canada, Subventions Fondation, from 2015-07-01 to 2022-06-30
  • Observatoire international sur les impacts sociétaux de l'intelligence artificielle et du numérique, Subvention, Fonds de recherche du Québec - Société et culture, Appel à propositions : création d’un Observatoire international sur les impacts sociétaux de l’intelligence artificielle et du numérique, from 2018-04-01 to 2024-03-31
  • Personalized Risk Assesment for Prevention and Early Detection of Breast Cancer : Integration and Implementation (PERSPECTIVE II), Subvention, Génome Canada, Projets de recherche appliquée à grande échelle - Large-Scale Applied Research Project, from 2017-11-01 to 2022-03-31

Recently finished projects

  • Breast Cancer Risk after Diagnostic Gene Sequencing (BRIDGES), Subvention, Commission européenne, Programme-cadre pour le recherche et l'innovation: Horizon 2020, from 2015-01-09 to 2020-01-08
  • Breast CAncer STratification: understanding the determinants of risk and prognosis of molecular subtypes (B-CAST), Subvention, Commission européenne, Programme-cadre pour le recherche et l'innovation: Horizon 2020, from 2015-01-09 to 2020-01-08
  • GE3LS Network in genomics and personalized health, Subvention, Génome Canada, from 2016-01-01 to 2019-12-31
  • Journée de la recherche de la Faculté de médecine, Subvention, Institutionnel - BDR, Fonds général de recherche du CRSNG, from 2010-11-24 to 2020-03-31
  • Next generation integrative genomics (RS3).NGS data analysis or consultation., Subvention, Fonds de recherche du Québec - Santé, Réseaux thématiques de recherche, from 2010-04-01 to 2019-06-30
Data provided by the Université Laval research projects registery