Jacques Simard holds a Canadian Research Chair in Oncogenetics since 2001. He is Professor in the Department of Molecular Medicine at Laval University’s School of Medicine, and is a scientist at the CHUL since 1990.

He is the author of more than 430 publications, review articles and book chapters. His research focuses on the genetic susceptibility of hormone-dependent cancers, including breast, ovarian and prostate cancer. Specifically, he participated in the characterization of the impact of mutations in the breast and ovarian cancer susceptibility genes BRCA1 and BRCA2. He has been Director of the Interdisciplinary Health Research International Team on Breast Cancer Susceptibility (INHERIT BRCAs), an international interdisciplinary health research team on genetic susceptibility to breast cancer funded by the Canadian Institutes of Health Research (CIHR) 2001 -2007, which was renewed in 2008 for five years as the CIHR Team in Familial Risks of Breast Cancer. The establishment of this international team has allowed Dr. Simard to pursue numerous collaborations allowing him to accelerate the development of his oncogenetics research activities. Indeed, his close collaboration with several international consortia, notably the Breast Cancer Consortium Consortium (BCAC) and the Consortium of Investigators of Modifiers of BRCA1 and BRCA2 (CIMBA), has led to a significant increase in the validity and the impact of scientific breakthroughs to improve the identification of women at increased risk of developing breast cancer which should benefit most from a better adapted clinical follow-up.

He is currently the principal investigator of a large-scale interdisciplinary project funded by Génome Québec/Genome Canada/CIHR/Quebec Breast Cancer Foundation (2013-2018) entitled Personalized Risk Stratification for Prevention and Early Detection of Breast Cancer (PERSPECTIVE), bringing together 27 co-researchers including fundamentalists, biostatisticians and clinicians from Quebec, Ontario, the United States, the United Kingdom, the Netherlands and Germany. This project is designed to develop the tools needed to implement a risk stratification approach that will target breast cancer screening in women most likely to develop the disease. In this context, recommendations on the starting age and frequency of mammography screening could be adapted for women’s individual risk of breast cancer. Indeed, risk stratification will better serve the subpopulation of younger women, who are at high risk of developing breast cancer, and who are currently missed by the standard age-based screening program as a criterion for eligibility. Since breast cancer in these young women often has a poorer prognosis, earlier detection and follow-up would improve survival rates, provide less aggressive treatment, reduce side effects, and increase their quality of life.

Pr. Simard is also a partner on two large European Commission Horizon 2020 (2015-2020) projects entitled BRIDGES (Breast Cancer Risk after Diagnostic Gene Sequencing) and B-CAST (Breast Cancer Stratification: Understanding the Determinants of Risk and Prognosis of Molecular Subtypes). Briefly, the BRIDGES project aims to develop a targeted prevention program for breast cancer, specifically to promote the health of women with a family history of the disease. In achieving its objectives, the BRIDGES program will improve targeted prevention of breast cancer, primarily in the context of oncogenetic clinics for breast cancer. To that end, Pr. Simard is the Principal Investigator of a grant from the Ministry of the Economy, Science and Innovation ($ 1.5 million) entitled PRÉVENTION (Predisposition, Prediction and Prevention of Breast Cancer), to substantially increase the collaboration of his interdisciplinary team with the BRIDGES project in order to validate and increase the impact of the discoveries made under the PERSPECTIVE project.

CHUL
2705, boulevard Laurier
R-4720
Québec, Québec
Canada G1V 4G2
CHUL
2705, boulevard Laurier
R-4787
Québec, Québec
Canada G1V 4G2
457 entries « 1 of 46 »

Rodrigue A, Margaillan G, Torres Gomes T, Coulombe Y, Montalban G, da Costa E Silva Carvalho S, Milano L, Ducy M, De-Gregoriis G, Dellaire G, Araujo da Silva W Jr, Monteiro AN, Carvalho MA, Simard J, Masson JY

A global functional analysis of missense mutations reveals two major hotspots in the PALB2 tumor suppressor.

Journal Article

Nucleic Acids Res, 2019, ISSN: 0305-1048.

Abstract | Links:

Jiang X, Finucane HK, Schumacher FR, Schmit SL, Tyrer JP, Han Y, Michailidou K, Lesseur C, Kuchenbaecker KB, Dennis J, Conti DV, Casey G, Gaudet MM, Huyghe JR, Albanes D, Aldrich MC, Andrew AS, Andrulis IL, Anton-Culver H, Antoniou AC, Antonenkova NN, Arnold SM, Aronson KJ, Arun BK, Bandera EV, Barkardottir RB, Barnes DR, Batra J, Beckmann MW, Benitez J, Benlloch S, Berchuck A, Berndt SI, Bickeboller H, Bien SA, Blomqvist C, Boccia S, Bogdanova NV, Bojesen SE, Bolla MK, Brauch H, Brenner H, Brenton JD, Brook MN, Brunet J, Brunnstrom H, Buchanan DD, Burwinkel B, Butzow R, Cadoni G, Caldes T, Caligo MA, Campbell I, Campbell PT, Cancel-Tassin G, Cannon-Albright L, Campa D, Caporaso N, Carvalho AL, Chan AT, Chang-Claude J, Chanock SJ, Chen C, Christiani DC, Claes KBM, Claessens F, Clements J, Collee JM, Correa MC, Couch FJ, Cox A, Cunningham JM, Cybulski C, Czene K, Daly MB, deFazio A, Devilee P, Diez O, Gago-Dominguez M, Donovan JL, Dork T, Duell EJ, Dunning AM, Dwek M, Eccles DM, Edlund CK, Edwards DRV, Ellberg C, Evans DG, Fasching PA, Ferris RL, Liloglou T, Figueiredo JC, Fletcher O, Fortner RT, Fostira F, Franceschi S, Friedman E, Gallinger SJ, Ganz PA, Garber J, Garcia-Saenz JA, Gayther SA, Giles GG, Godwin AK, Goldberg MS, Goldgar DE, Goode EL, Goodman MT, Goodman G, Grankvist K, Greene MH, Gronberg H, Gronwald J, Guenel P, Hakansson N, Hall P, Hamann U, Hamdy FC, Hamilton RJ, Hampe J, Haugen A, Heitz F, Herrero R, Hillemanns P, Hoffmeister M, Hogdall E, Hong YC, Hopper JL, Houlston R, Hulick PJ, Hunter DJ, Huntsman DG, Idos G, Imyanitov EN, Ingles SA, Isaacs C, Jakubowska A, James P, Jenkins MA, Johansson M, John EM, Joshi AD, Kaneva R, Karlan BY, Kelemen LE, Kuhl T, Khaw KT, Khusnutdinova E, Kibel AS, Kiemeney LA, Kim J, Kjaer SK, Knight JA, Kogevinas M, Kote-Jarai Z, Koutros S, Kristensen VN, Kupryjanczyk J, Lacko M, Lam S, Lambrechts D, Landi MT, Lazarus P, Le ND, Lee E, Lejbkowicz F, Lenz HJ, Leslie G, Lessel D, Lester J, Levine DA, Li L, Li CI, Lindblom A, Lindor NM, Liu G, Loupakis F, Lubinski J, Maehle L, Maier C, Mannermaa A, Marchand LL, Margolin S, May T, McGuffog L, Meindl A, Middha P, Miller A, Milne RL, MacInnis RJ, Modugno F, Montagna M, Moreno V, Moysich KB, Mucci L, Muir K, Mulligan AM, Nathanson KL, Neal DE, Ness AR, Neuhausen SL, Nevanlinna H

Publisher Correction: Shared heritability and functional enrichment across six solid cancers.

Journal Article

Nat Commun, 10 (1), pp. 4386, 2019, ISSN: 2041-1723.

Abstract | Links:

Dork T, Peterlongo P, Mannermaa A, Bolla MK, Wang Q, Dennis J, Ahearn T, Andrulis IL, Anton-Culver H, Arndt V, Aronson KJ, Augustinsson A, Freeman LEB, Beckmann MW, Beeghly-Fadiel A, Behrens S, Bermisheva M, Blomqvist C, Bogdanova NV, Bojesen SE, Brauch H, Brenner H, Burwinkel B, Canzian F, Chan TL, Chang-Claude J, Chanock SJ, Choi JY, Christiansen H, Clarke CL, Couch FJ, Czene K, Daly MB, Dos-Santos-Silva I, Dwek M, Eccles DM, Ekici AB, Eriksson M, Evans DG, Fasching PA, Figueroa J, Flyger H, Fritschi L, Gabrielson M, Gago-Dominguez M, Gao C, Gapstur SM, Garcia-Closas M, Garcia-Saenz JA, Gaudet MM, Giles GG, Goldberg MS, Goldgar DE, Guenel P, Haeberle L, Haiman CA, Hakansson N, Hall P, Hamann U, Hartman M, Hauke J, Hein A, Hillemanns P, Hogervorst FBL, Hooning MJ, Hopper JL, Howell T, Huo D, Ito H, Iwasaki M, Jakubowska A, Janni W, John EM, Jung A, Kaaks R, Kang D, Kapoor PM, Khusnutdinova E, Kim SW, Kitahara CM, Koutros S, Kraft P, Kristensen VN, Kwong A, Lambrechts D, Marchand LL, Li J, Lindstrom S, Linet M, Lo WY, Long J, Lophatananon A, Lubinski J, Manoochehri M, Manoukian S, Margolin S, Martinez E, Matsuo K, Mavroudis D, Meindl A, Menon U, Milne RL, Mohd Taib NA, Muir K, Mulligan AM, Neuhausen SL, Nevanlinna H, Neven P, Newman WG, Offit K, Olopade OI, Olshan AF, Olson JE, Olsson H, Park SK, Park-Simon TW, Peto J, Plaseska-Karanfilska D, Pohl-Rescigno E, Presneau N, Rack B, Radice P, Rashid MU, Rennert G, Rennert HS, Romero A, Ruebner M, Saloustros E, Schmidt MK, Schmutzler RK, Schneider MO, Schoemaker MJ, Scott C, Shen CY, Shu XO, Simard J, Slager S, Smichkoska S, Southey MC, Spinelli JJ, Stone J, Surowy H, Swerdlow AJ, Tamimi RM, Tapper WJ, Teo SH, Terry MB, Toland AE, Tollenaar RAEM, Torres D, Torres-Mejia G, Troester MA, Truong T, Tsugane S, Untch M, Vachon CM, Ouweland AMWVD, Veen EMV, Vijai J, Wendt C, Wolk A, Yu JC, Zheng W, Ziogas A, Ziv E, ABCTB Investigators, NBCS Collaborators, Dunning AM, Pharoah PDP, Schindler D, Devilee P, Easton DF

Two truncating variants in FANCC and breast cancer risk.

Journal Article

Sci Rep, 9 (1), pp. 12524, 2019, ISSN: 2045-2322.

Abstract | Links:

Shu X, Bao J, Wu L, Long J, Shu XO, Guo X, Yang Y, Michailidou K, Bolla MK, Wang Q, Dennis J, Andrulis IL, Castelao JE, Dork T, Gago-Dominguez M, Garcia-Closas M, Giles GG, Lophatananon A, Muir K, Olsson H, Rennert G, Saloustros E, Scott RJ, Southey MC, Pharoah PDP, Milne RL, Kraft P, Simard J, Easton DF, Zheng W

Evaluation of associations between genetically predicted circulating protein biomarkers and breast cancer risk.

Journal Article

Int J Cancer, 2019, ISSN: 0020-7136.

Abstract | Links:

Qian F, Rookus MA, Leslie G, Risch HA, Greene MH, Aalfs CM, Adank MA, Adlard J, Agnarsson BA, Ahmed M, Aittomaki K, Andrulis IL, Arnold N, Arun BK, Ausems MGEM, Azzollini J, Barrowdale D, Barwell J, Benitez J, Bialkowska K, Bonadona V, Borde J, Borg A, Bradbury AR, Brunet J, Buys SS, Caldes T, Caligo MA, Campbell I, Carter J, Chiquette J, Chung WK, Claes KBM, Collee JM, Collonge-Rame MA, Couch FJ, Daly MB, Delnatte C, Diez O, Domchek SM, Dorfling CM, Eason J, Easton DF, Eeles R, Engel C, Evans DG, Faivre L, Feliubadalo L, Foretova L, Friedman E, Frost D, Ganz PA, Garber J, Garcia-Barberan V, Gehrig A, Glendon G, Godwin AK, Gomez Garcia EB, Hamann U, Hauke J, Hopper JL, Hulick PJ, Imyanitov EN, Isaacs C, Izatt L, Jakubowska A, Janavicius R, John EM, Karlan BY, Kets CM, Laitman Y, Lazaro C, Leroux D, Lester J, Lesueur F, Loud JT, Lubinski J, Lukomska A, McGuffog L, Mebirouk N, Meijers-Heijboer HEJ, Meindl A, Miller A, Montagna M, Mooij TM, Mouret-Fourme E, Nathanson KL, Nehoray B, Neuhausen SL, Nevanlinna H, Nielsen FC, Offit K, Olah E, Ong KR, Oosterwijk JC, Ottini L, Parsons MT, Peterlongo P, Pfeiler G, Pradhan N, Radice P, Ramus SJ, Rantala J, Rennert G, Robson M, Rodriguez GC, Salani R, Scheuner MT, Schmutzler RK, Shah PD, Side LE, Simard J, Singer CF, Steinemann D, Stoppa-Lyonnet D, Tan YY, Teixeira MR, Terry MB, Thomassen M, Tischkowitz M, Tognazzo S, Toland AE, Tung N, van Asperen CJ, van Engelen K, van Rensburg EJ, Venat-Bouvet L, Vierstraete J, Wagner G, Walker L, Weitzel JN, Yannoukakos D, KConFab Investigators, HEBON Investigators, GEMO Study Collaborators, EMBRACE Collaborators, Antoniou AC, Goldgar DE, Olopade OI, Chenevix-Trench G, Rebbeck TR, Huo D, CIMBA

Mendelian randomisation study of height and body mass index as modifiers of ovarian cancer risk in 22,588 BRCA1 and BRCA2 mutation carriers.

Journal Article

Br J Cancer, 121 (2), pp. 180-192, 2019, ISSN: 0007-0920.

Abstract | Links:

Shu X, Wu L, Khankari NK, Shu XO, Wang TJ, Michailidou K, Bolla MK, Wang Q, Dennis J, Milne RL, Schmidt MK, Pharoah PDP, Andrulis IL, Hunter DJ, Simard J, Easton DF, Zheng W, Breast Cancer Association Consortium

Associations of obesity and circulating insulin and glucose with breast cancer risk: a Mendelian randomization analysis.

Journal Article

Int J Epidemiol, 48 (3), pp. 795-806, 2019, ISSN: 0300-5771.

Abstract | Links:

Kar SP, Andrulis IL, Brenner H, Burgess S, Chang-Claude J, Considine D, Dork T, Evans DGR, Gago-Dominguez M, Giles GG, Hartman M, Huo D, Kaaks R, Li J, Lophatananon A, Margolin S, Milne RL, Muir KR, Olsson H, Punie K, Radice P, Simard J, Tamimi RM, Van Nieuwenhuysen E, Wendt C, Zheng W, Pharoah PDP

The association between weight at birth and breast cancer risk revisited using Mendelian randomisation.

Journal Article

Eur J Epidemiol, 34 (6), pp. 591-600, 2019, ISSN: 0393-2990.

Abstract | Links:

Lee A, Mavaddat N, Wilcox AN, Cunningham AP, Carver T, Hartley S, de Villiers CB, Izquierdo A, Simard J, Schmidt MK, Walter FM, Chatterjee N, Garcia-Closas M, Tischkowitz M, Pharoah P, Easton DF, Antoniou AC

Correction: BOADICEA: a comprehensive breast cancer risk prediction model incorporating genetic and nongenetic risk factors.

Journal Article

Genet Med, 21 (6), pp. 1462, 2019, ISSN: 1098-3600.

Abstract | Links:

Shu X, Wu L, Khankari NK, Shu XO, Wang TJ, Michailidou K, Bolla MK, Wang Q, Dennis J, Milne RL, Schmidt MK, Pharoah P, Andrulis IL, Hunter DJ, Simard J, Easton DF, Zheng W

Authors' response: Associations of obesity and circulating insulin and glucose with breast cancer risk.

Journal Article

Int J Epidemiol, 48 (3), pp. 1016-1017, 2019, ISSN: 0300-5771.

| Links:

Yang Y, Wu L, Shu XO, Cai Q, Shu X, Li B, Guo X, Ye F, Michailidou K, Bolla MK, Wang Q, Dennis J, Andrulis IL, Brenner H, Chenevix-Trench G, Campa D, Castelao JE, Gago-Dominguez M, Dork T, Hollestelle A, Lophatananon A, Muir K, Neuhausen SL, Olsson H, Sandler DP, Simard J, Kraft P, Pharoah PDP, Easton DF, Zheng W, Long J

Genetically predicted levels of DNA methylation biomarkers and breast cancer risk: data from 228,951 women of European descent.

Journal Article

J Natl Cancer Inst, 2019, ISSN: 0027-8874.

Abstract | Links:

457 entries « 1 of 46 »
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Active projects

  • Breast CAncer STratification: understanding the determinants of risk and prognosis of molecular subtypes (B-CAST), Subvention, Commission européenne, Programme-cadre pour le recherche et l'innovation: Horizon 2020, from 2015-01-09 to 2020-01-08
  • Centre de recherche du CHU de Québec - Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
  • Centre de recherche sur le cancer, Subvention, Institutionnel - BDR, BDR - Centres de recherche reconnus, from 1996-05-01 to 2023-04-30
  • Chaire de recherche du Canada en oncogénétique, Subvention, Secrétariat des Chaires de recherche du Canada, Chaires de recherche du Canada - Fonctionnement, from 2015-03-01 to 2022-02-28
  • From correlation to causation in genomics: identifying mechanisms underlying disease, Subvention, Instituts de recherche en santé du Canada, Subventions Fondation, from 2015-07-01 to 2022-06-30
  • GE3LS Network in genomics and personalized health, Subvention, Génome Canada, from 2016-01-01 to 2019-12-31
  • Journée de la recherche de la Faculté de médecine, Subvention, Institutionnel - BDR, Fonds général de recherche du CRSNG, from 2010-11-24 to 2020-03-31
  • Observatoire international sur les impacts sociétaux de l'intelligence artificielle et du numérique, Subvention, Fonds de recherche du Québec - Société et culture, Appel à propositions : création d’un Observatoire international sur les impacts sociétaux de l’intelligence artificielle et du numérique, from 2018-04-01 to 2024-03-31
  • Personalized Risk Assesment for Prevention and Early Detection of Breast Cancer : Integration and Implementation (PERSPECTIVE II) : Activité 1.1, Subvention, Génome Canada, Projets de recherche appliquée à grande échelle, from 2017-11-01 to 2022-03-31
  • Personalized Risk Assesment for Prevention and Early Detection of Breast Cancer : Integration and Implementation (PERSPECTIVE II) : Activité 1.2, Subvention, Génome Canada, Projets de recherche appliquée à grande échelle, from 2017-11-01 to 2022-03-31
  • Personalized Risk Assesment for Prevention and Early Detection of Breast Cancer : Integration and Implementation (PERSPECTIVE II) : Activité 2.3, Subvention, Génome Canada, Projets de recherche appliquée à grande échelle, from 2017-11-01 to 2022-03-31
  • Personalized Risk Assesment for Prevention and Early Detection of Breast Cancer : Integration and Implementation (PERSPECTIVE II) : Activité 3.3, Subvention, Génome Canada, Projets de recherche appliquée à grande échelle, from 2017-11-01 to 2022-03-31
  • Personalized Risk Assesment for Prevention and Early Detection of Breast Cancer : Integration and Implementation (PERSPECTIVE II) : Activité 5, Subvention, Génome Canada, Projets de recherche appliquée à grande échelle, from 2017-11-01 to 2022-03-31
  • Personalized Risk Assesment for Prevention and Early Detection of Breast Cancer : Integration and Implementation (PERSPECTIVE II) : Activités 3.1/3.2, Subvention, Génome Canada, Projets de recherche appliquée à grande échelle, from 2017-11-01 to 2022-03-31
  • Personalized Risk Assesment for Prevention and Early Detection of Breast Cancer : Integration and Implementation (PERSPECTIVE II) : R92 - Transferts de fonds interinstitutions, Subvention, Génome Canada, Projets de recherche appliquée à grande échelle, from 2017-11-01 to 2022-03-31
  • Personalized Risk Assesment for Prevention and Early Detection of Breast Cancer : Integration and Implementation (PERSPECTIVE II), Subvention, Génome Canada, Projets de recherche appliquée à grande échelle, from 2017-11-01 to 2022-03-31

Recently finished projects

  • Centre de recherche en endocrinologie, métabolisme et inflammation, Subvention, Institutionnel - BDR, BDR - Centres de recherche reconnus, from 1996-06-01 to 2018-04-30
  • Next generation integrative genomics (RS3).NGS data analysis or consultation., Subvention, Fonds de recherche du Québec - Santé, Réseaux thématiques de recherche, from 2010-04-01 to 2019-03-31
  • Prédisposition, prédiction et prévention du cancer du sein, Subvention, Ministère de l'Économie, de l'Innovation et des Exportations, Programme de soutien à la recherche (PSR-V4) : Programme de soutien à des initiatives internationales de recherche et d'innovation (SIIRI), from 2016-04-01 to 2019-03-31
  • Projet de recherche pour dépistage précoce du cancer du sein, Subvention, Fondation du CHU de Québec, from 2019-03-20 to 2019-03-31
Data provided by the Université Laval research projects registery