Dr. Jacques Brown graduated from medical school and completed his residency in Internal Medicine at Laval University. He finished his residency in rheumatology at Université de Sherbrooke before undertaking post-doctoral training in metabolic bone diseases at the INSERM unit in Lyon, France.
He is a clinical researcher at the Centre de recherche du CHU de Québec-Laval University and a clinical professor at the Department of Medicine at Laval University. His major research interest is metabolic bone disorders such as Paget’s disease of bone, and osteoporosis.
Through the characterization of three French-Canadian families with Paget’s disease of bone, he first contributed to the discovery (2001) of the SQSTM1 gene mutations linked to this disease. In collaboration with Dr. Laëtitia Michou, this cohort now contains 43 families, 263 unrelated individuals with Paget’s disease and 298 controls, totalling 1,426 DNA samples with detailed phenotypes. The recruitment of new families and unrelated patients continues to help better identify new genetic factors of Paget’s disease of bone.
Since 1994, he has been a co-principal investigator and Quebec Centre Director on the Canadian Multicentre Osteoporosis Study (CaMOS), an epidemiologic study looking at the prevalence of osteoporosis, as well as the incidence of osteoporotic fractures in a large cohort (9,400 subjects) of the Canadian population. He is the principal investigator of the Recognizing Osteoporosis and its Consequences Programme, a patient health-management programme aimed at evaluating the diagnostic and treatment care gaps for osteoporosis following a fragility fracture in women 50 years of age and over.
He has published over 240 scientific articles in several high-impact journals. He has received several distinctions, including two John G. Haddad Jr. Research Awards from the Paget’s Foundation (2003 and 2005) and the Lindy-Fraser Memorial Award from Osteoporosis Canada (2004) for his work on the clinical practice guidelines of osteoporosis. In 2009, he was knighted to the Ordre National du Québec. More recently, Dr. Brown received the 2017 Distinguished Investigator Award from the Canadian Rheumatology Association for his exceptional contribution to rheumatology in Canada, and the Council of Physicians, Pharmacists, and Dentists of the CHU de Québec has awarded him the Diamant Hommage Héritage for the development and accomplishment of his career which will leave a solid legacy for the future of the institution.
2705, boulevard Laurier
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Comparative Analysis of the Radiology of Osteoporotic Vertebral Fractures in Women and Men: Cross-Sectional and Longitudinal Observations from the Canadian Multicentre Osteoporosis Study (CaMos).Journal Article
J Bone Miner Res, 33 (4), pp. 569-579, 2018, ISSN: 0884-0431.
Ly6Chigh monocytes facilitate transport of Murid herpesvirus 68 into inflamed joints of arthritic mice.Journal Article
Eur J Immunol, 48 (2), pp. 250-257, 2018, ISSN: 0014-2980.
Effect of genetic variants of OPTN in the pathophysiology of Paget's disease of bone.Journal Article
Biochim Biophys Acta, 1864 (1), pp. 143-151, 2018, ISSN: 0006-3002.
Remodeling- and Modeling-Based Bone Formation With Teriparatide Versus Denosumab: A Longitudinal Analysis From Baseline to 3 Months in the AVA Study.Journal Article
J Bone Miner Res, 33 (2), pp. 298-306, 2018, ISSN: 0884-0431.
Vertebral Fractures After Discontinuation of Denosumab: A Post Hoc Analysis of the Randomized Placebo-Controlled FREEDOM Trial and Its Extension.Journal Article
J Bone Miner Res, 33 (2), pp. 190-198, 2018, ISSN: 0884-0431.
Response to Dr Lamy and Dr Gonzalez-Rodriguez.Journal Article
J Bone Miner Res, 33 (3), pp. 548, 2018, ISSN: 0884-0431.
Effects of 24 Months of Treatment With Romosozumab Followed by 12 Months of Denosumab or Placebo in Postmenopausal Women With Low Bone Mineral Density: A Randomized, Double-Blind, Phase 2, Parallel Group Study.Journal Article
J Bone Miner Res, 33 (8), pp. 1397-1406, 2018, ISSN: 0884-0431.
Molecular effect of an OPTN common variant associated to Paget's disease of bone.Journal Article
PLoS ONE, 13 (5), pp. e0197543, 2018.
Number, Location, and Time Since Prior Fracture as Predictors of Future Fracture in the Elderly From the General Population.Journal Article
J Bone Miner Res, 33 (11), pp. 1956-1966, 2018, ISSN: 0884-0431.
Environmental factors associated with familial or non-familial forms of Paget's disease of bone.Journal Article
Joint Bone Spine, 84 (6), pp. 719-723, 2017, ISSN: 1297-319X.
- Centre de recherche du CHU de Québec - Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
- Clinical validity and clinical utility of a screening test for Paget's disease of bone, Subvention, Instituts de recherche en santé du Canada, Subvention Projet, from 2019-03-01 to 2020-03-31
Recently finished projects
- Clinical and molecular heterogeneity of Paget's disease of bone., Subvention, Instituts de recherche en santé du Canada, Subvention de fonctionnement, from 2013-10-01 to 2018-09-30
- Explorations clinique et moléculaire des fractures de stress d'origine génétique, incluant les fractures atypiques des fémurs, Subvention, Fonds de recherche du Québec - Santé, Réseaux thématiques de recherche, from 2018-08-01 to 2019-03-31