Dr. Tremblay is a scientist in the Reproduction, Mother and Child Health axis of the Centre de recherche du CHU de Québec—Laval University, and Full Professor in Laval University’s School of Medicine Department of Obstetrics, Gynecology and Reproduction. His research focuses on the study of various facets of Leydig cells, cells that belong to the endocrine system, with applications for disorders of sexual development, hormone-dependent diseases, cell differentiation, as well as the regulation of gene expression.

In 2013, Dr. Tremblay was awarded the prestigious Young Andrologist Award from the American Society of Andrology for his contribution to the field of andrology.

Dr. Tremblay’s research program is at the interface of endocrinology and cellular and molecular biology. His team studies the molecular mechanisms of Leydig cell differentiation and function. Leydig cells are testicular cells involved in the production of the steroid hormone, testosterone. Inadequate levels of steroid hormones are a cause, or at least an aggravating factor, of many human pathologies such as cancers, PCOS, endometriosis, and autoimmune and inflammatory diseases. In addition to male reproductive health, sufficient testosterone levels are essential for male general health. Understanding how this system works in normal conditions by studying Leydig cells, will provide essential information that will ultimately lead to better diagnoses and treatments for these problems.

Although different hormones and signalling molecules are involved in the differentiation and function of Leydig cells, the transcription factors downstream of these pathways remain unknown. His team has identified various transcription factors, some never reported in Leydig cells, which are essential regulators of cell differentiation in other tissues. Some are found exclusively in the male gonad, while others are present specifically in the adult population of Leydig cells, or are unique markers of Leydig stem cells. In addition, they have demonstrated the presence of the CAMKI kinase in Leydig cells, and its involvement in gene expression following hormonal stimulation. Finally, they have identified the AMPK kinase as the first molecular brake of steroidogenesis, which has many clinical implications. The targets of these two kinases are yet to be identified. Their work on the characterization of the role of these transcription factors and kinases involves classical molecular and cellular biology approaches, as well as gene editing, animal models and proteomic, genomic and bioinformatics.

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Di-Luoffo M, Daems C, Bergeron F, Tremblay JJ

Novel Targets for the Transcription Factors MEF2 in MA-10 Leydig Cells.

Journal Article

Biol Reprod, 93 (1), pp. 9, 2015, ISSN: 0006-3363.

Abstract | Links:

Abdou HS, Bergeron F, Tremblay JJ

A cell-autonomous molecular cascade initiated by AMP-activated protein kinase represses steroidogenesis.

Journal Article

Mol Cell Biol, 34 (23), pp. 4257-71, 2014, ISSN: 0270-7306.

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Mendoza-Villarroel RE, Di-Luoffo M, Camire E, Giner XC, Brousseau C, Tremblay JJ

The INSL3 gene is a direct target for the orphan nuclear receptor, COUP-TFII, in Leydig cells.

Journal Article

J Mol Endocrinol, 53 (1), pp. 43-55, 2014, ISSN: 0952-5041.

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Mendoza-Villarroel RE, Robert NM, Martin LJ, Brousseau C, Tremblay JJ

The nuclear receptor NR2F2 activates star expression and steroidogenesis in mouse MA-10 and MLTC-1 Leydig cells.

Journal Article

Biol Reprod, 91 (1), pp. 26, 2014, ISSN: 0006-3363.

Abstract | Links:

Daems C, Martin LJ, Brousseau C, Tremblay JJ

MEF2 is restricted to the male gonad and regulates expression of the orphan nuclear receptor NR4A1.

Journal Article

Mol Endocrinol, 28 (6), pp. 886-98, 2014, ISSN: 0888-8809.

Abstract | Links:

Enangue Njembele AN, Bailey JL, Tremblay JJ

In vitro exposure of Leydig cells to an environmentally relevant mixture of organochlorines represses early steps of steroidogenesis.

Journal Article

Biol Reprod, 90 (6), pp. 118, 2014, ISSN: 0006-3363.

Abstract | Links:

Abdou HS, Villeneuve G, Tremblay JJ

The calcium signaling pathway regulates leydig cell steroidogenesis through a transcriptional cascade involving the nuclear receptor NR4A1 and the steroidogenic acute regulatory protein.

Journal Article

Endocrinology, 154 (1), pp. 511-20, 2013, ISSN: 0013-7227.

Abstract | Links:

Martin LJ, Bergeron F, Viger RS, Tremblay JJ

Functional cooperation between GATA factors and cJUN on the star promoter in MA-10 Leydig cells.

Journal Article

J Androl, 33 (1), pp. 81-7, 2012, ISSN: 0196-3635.

Abstract | Links:

Lambert RD, Tremblay JJ

Leçons de la médecine de la reproduction

Book Chapter

JJ, Tremblay (Ed.): La conduite responsable de la recherche : cadres normatifs, pp. 24 pages, Québec, QC, Université Laval, Faculté de médecine, 2012.

Lambert RD, Tremblay JJ

Les cellules souches embryonnaires humaines

Book Chapter

JJ, Tremblay (Ed.): La conduite responsable de la recherche : cadres normatifs, pp. 28 pages, Québec, QC, Université Laval, Faculté de médecine, 2012.

56 entries « 2 of 6 »
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Active projects

  • Centre de recherche du CHU de Québec - Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
  • Centre de recherche en reproduction, développement et santé intergénérationnelle, Subvention, Institutionnel - BDR, BDR - Centres de recherche reconnus, from 1996-06-01 to 2021-02-02
  • Mechanisms of CAMKI and AMPK antagonistic action in steroidogenesis, Subvention, Instituts de recherche en santé du Canada, Volet Projet: Concours pilotes, from 2016-07-01 to 2021-06-30
  • Réseau Québécois en Reproduction (RQR), Subvention, Fonds de recherche du Québec - Nature et technologies, Regroupements stratégiques NT, from 2017-04-01 to 2023-03-31
  • Transcriptional regulators of Leydig cell differentiation and function., Subvention, Instituts de recherche en santé du Canada, Subvention de fonctionnement, from 2015-07-01 to 2021-06-30
Data provided by the Université Laval research projects registery