Dr. Tremblay is a scientist in the Reproduction, Mother and Child Health axis of the Centre de recherche du CHU de Québec—Laval University, and Full Professor in Laval University’s School of Medicine Department of Obstetrics, Gynecology and Reproduction. His research focuses on the study of various facets of Leydig cells, cells that belong to the endocrine system, with applications for disorders of sexual development, hormone-dependent diseases, cell differentiation, as well as the regulation of gene expression.

In 2013, Dr. Tremblay was awarded the prestigious Young Andrologist Award from the American Society of Andrology for his contribution to the field of andrology.

Dr. Tremblay’s research program is at the interface of endocrinology and cellular and molecular biology. His team studies the molecular mechanisms of Leydig cell differentiation and function. Leydig cells are testicular cells involved in the production of the steroid hormone, testosterone. Inadequate levels of steroid hormones are a cause, or at least an aggravating factor, of many human pathologies such as cancers, PCOS, endometriosis, and autoimmune and inflammatory diseases. In addition to male reproductive health, sufficient testosterone levels are essential for male general health. Understanding how this system works in normal conditions by studying Leydig cells, will provide essential information that will ultimately lead to better diagnoses and treatments for these problems.

Although different hormones and signalling molecules are involved in the differentiation and function of Leydig cells, the transcription factors downstream of these pathways remain unknown. His team has identified various transcription factors, some never reported in Leydig cells, which are essential regulators of cell differentiation in other tissues. Some are found exclusively in the male gonad, while others are present specifically in the adult population of Leydig cells, or are unique markers of Leydig stem cells. In addition, they have demonstrated the presence of the CAMKI kinase in Leydig cells, and its involvement in gene expression following hormonal stimulation. Finally, they have identified the AMPK kinase as the first molecular brake of steroidogenesis, which has many clinical implications. The targets of these two kinases are yet to be identified. Their work on the characterization of the role of these transcription factors and kinases involves classical molecular and cellular biology approaches, as well as gene editing, animal models and proteomic, genomic and bioinformatics.

CHUL
2705, boulevard Laurier
T-3-67
Québec, Québec
Canada G1V 4G2

Latest news

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Garon G, Bergeron F, Brousseau C, Robert NM, Tremblay JJ

FOXA3 Is Expressed in Multiple Cell Lineages in the Mouse Testis and Regulates Pdgfra Expression in Leydig Cells.

Journal Article

Endocrinology, 158 (6), pp. 1886-1897, 2017, ISSN: 0013-7227.

Abstract | Links:

Di-Luoffo M, Brousseau C, Tremblay JJ

MEF2 and NR2F2 cooperate to regulate Akr1c14 gene expression in mouse MA-10 Leydig cells.

Journal Article

Andrology, 4 (2), pp. 335-44, 2016, ISSN: 2047-2919.

Abstract | Links:

Abdou HS, Robert NM, Tremblay JJ

Calcium-dependent Nr4a1 expression in mouse Leydig cells requires distinct AP1/CRE and MEF2 elements.

Journal Article

J Mol Endocrinol, 56 (3), pp. 151-61, 2016, ISSN: 0952-5041.

Abstract | Links:

Tremblay MA, Mendoza-Villarroel RE, Robert NM, Bergeron F, Tremblay JJ

KLF6 cooperates with NUR77 and SF1 to activate the human INSL3 promoter in mouse MA-10 leydig cells.

Journal Article

J Mol Endocrinol, 56 (3), pp. 163-73, 2016, ISSN: 0952-5041.

Abstract | Links:

Di-Luoffo M, Brousseau C, Bergeron F, Tremblay JJ

The Transcription Factor MEF2 Is a Novel Regulator of Gsta Gene Class in Mouse MA-10 Leydig Cells.

Journal Article

Endocrinology, 156 (12), pp. 4695-706, 2015, ISSN: 0013-7227.

Abstract | Links:

54 entries « 1 of 11 »

Active projects

  • Centre de recherche en reproduction, développement et santé intergénérationnelle, Subvention, Institutionnel - BDR, BDR - Centres de recherche reconnus, from 1996-06-01 to 2021-04-30
  • Centre hospitalier universitaire de Québec - CHU de Québec-Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
  • Mechanisms of CAMKI and AMPK antagonistic action in steroidogenesis, Subvention, Instituts de recherche en santé du Canada, Volet Projet: Concours pilotes, from 2016-07-01 to 2021-06-30
  • Réseau Québécois en Reproduction (RQR), Subvention, Fonds de recherche du Québec - Nature et technologies, Regroupements stratégiques, from 2017-04-01 to 2023-03-31
  • Transcriptional regulators of Leydig cell differentiation and function., Subvention, Instituts de recherche en santé du Canada, Subvention de fonctionnement, from 2015-07-01 to 2020-06-30

Recently finished projects

  • Réseau Québécois en reproduction (RQR), Subvention, Fonds de recherche du Québec - Nature et technologies, Regroupements stratégiques, from 2011-04-01 to 2017-03-31
Data provided by the Université Laval research projects registery