Jacques Côté obtained his PhD from Laval University after he characterized the structure and function of Endo G, an endonuclease involved in the replication of mitochondrial DNA and cell apoptosis. He did post-doctoral training with Dr. Jerry Workman at Penn State University where he identified and characterized chromatin remodeling complexes (SWI/SNF) involved in gene activation. In 1997, he joined Laval University where he is Full Professor in the department of Molecular Biology, Medical Biochemistry and Pathology. He currently holds the Canada Research Chair in Chromatin Biology and Molecular Epigenetics. His research projects characterize the dynamic role of chromatin in the regulation of nuclear functions and cell proliferation. His work uses the yeast model system as well as human cells to define the structure, function and regulation of histone modifying complexes implicated in genome expression and maintenance. Research in his laboratory led to important discoveries on the regulatory mechanisms involved in gene transcription and the cellular response to DNA damage, using expertise in molecular biology and genetics, biochemistry, epigenetics, genomics, proteomics and genome editing.

The Côté lab research aim is to understand chromatin dynamics associated with gene regulation, DNA repair and replication. They study protein complexes that control acetylation and methylation of histones, and the composition of chromatin. They dissect the molecular mechanisms of epigenetics, in which signals to chromatin mark different genomic loci and are read by effectors to translate a biological response. Their work has characterized the structure and function of several protein complexes, identifying their intrinsic recognition modules for the epigenetic histone signature. Discoveries in the laboratory identified and extensively characterized the highly conserved NuA4/Tip60 acetyltransferase complex and demonstrated for the first time the essential role of chromatin modifying activities in the process of DNA repair and replication in eukaryotes. Accurate writing and reading of these epigenetic marks lead to changes in chromatin dynamics, in a targeted manner within the genome, and this process is subverted in cancer. In fact, the clear majority of the activities studied in the Côté lab are tumor suppressors and Tip60 itself is down-regulated in a very large spectrum of cancers.

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126 entries « 12 of 13 »

Utley RT, Ikeda K, Grant PA, Cote J, Steger DJ, Eberharter A, John S, Workman JL

Transcriptional activators direct histone acetyltransferase complexes to nucleosomes.

Journal Article

Nature, 394 (6692), pp. 498-502, 1998, ISSN: 0028-0836.

Abstract | Links:

Cote J, Peterson CL, Workman JL

Perturbation of nucleosome core structure by the SWI/SNF complex persists after its detachment, enhancing subsequent transcription factor binding.

Journal Article

Proc Natl Acad Sci U S A, 95 (9), pp. 4947-52, 1998, ISSN: 0027-8424.

Abstract | Links:

Steger DJ, Utley RT, Grant PA, John S, Eberharter A, Cote J, Owen-Hughes T, Ikeda K, Workman JL

Regulation of transcription by multisubunit complexes that alter nucleosome structure.

Journal Article

Cold Spring Harb Symp Quant Biol, 63 , pp. 483-91, 1998, ISSN: 0091-7451.

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Grant PA, Duggan L, Cote J, Roberts SM, Brownell JE, Candau R, Ohba R, Owen-Hughes T, Allis CD, Winston F, Berger SL, Workman JL

Yeast Gcn5 functions in two multisubunit complexes to acetylate nucleosomal histones: characterization of an Ada complex and the SAGA (Spt/Ada) complex.

Journal Article

Genes Dev, 11 (13), pp. 1640-50, 1997, ISSN: 0890-9369.

Abstract | Links:

Utley RT, Cote J, Owen-Hughes T, Workman JL

SWI/SNF stimulates the formation of disparate activator-nucleosome complexes but is partially redundant with cooperative binding.

Journal Article

J Biol Chem, 272 (19), pp. 12642-9, 1997, ISSN: 0021-9258.

Abstract | Links:

Wang W, Cote J, Xue Y, Zhou S, Khavari PA, Biggar SR, Muchardt C, Kalpana GV, Goff SP, Yaniv M, Workman JL, Crabtree GR

Purification and biochemical heterogeneity of the mammalian SWI-SNF complex.

Journal Article

EMBO J, 15 (19), pp. 5370-82, 1996, ISSN: 0261-4189.

Abstract | Links:

Owen-Hughes T, Utley RT, Cote J, Peterson CL, Workman JL

Persistent site-specific remodeling of a nucleosome array by transient action of the SWI/SNF complex.

Journal Article

Science, 273 (5274), pp. 513-6, 1996, ISSN: 0036-8075.

Abstract | Links:

Utley RT, Owen-Hughes TA, Juan LJ, Cote J, Adams CC, Workman JL

In vitro analysis of transcription factor binding to nucleosomes and nucleosome disruption/displacement.

Journal Article

Methods Enzymol, 274 , pp. 276-91, 1996, ISSN: 0076-6879.

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Walter PP, Owen-Hughes TA, Cote J, Workman JL

Stimulation of transcription factor binding and histone displacement by nucleosome assembly protein 1 and nucleoplasmin requires disruption of the histone octamer.

Journal Article

Mol Cell Biol, 15 (11), pp. 6178-87, 1995, ISSN: 0270-7306.

Abstract | Links:

Walter PP, Vettese-Dadey M, Cote J, Adams CC, Utley R, Workman JL, Juan LJ

Mechanisms and Consequences of Transcription Factor Binding to Nucleosomes (Chapter 4)

Book Chapter

AP, Wolffe (Ed.): The Nucleosome. A Multi-Volume Treatise, pp. 79-100, Amsterdam, Elsevier, 1995, ISBN: 978-1-55938-940-2.

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126 entries « 12 of 13 »
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Active projects

  • Centre de recherche du CHU de Québec - Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
  • Centre de recherche sur le cancer, Subvention, Institutionnel - BDR, BDR - Centres de recherche reconnus, from 1996-05-01 to 2022-06-13
  • Chaire de recherche du Canada en biologie de la chromatine et épigénétique moléculaire, Subvention, Secrétariat des Chaires de recherche du Canada, Chaires de recherche du Canada - Fonctionnement, from 2015-01-01 to 2021-12-31
  • Control of Genome Expression and Maintenance by MYST-ING Tumor Suppressor Complexes., Subvention, Instituts de recherche en santé du Canada, Subventions Fondation, from 2015-07-01 to 2022-06-30

Recently finished projects

  • Bourses-Desjardins et Axe oncologie, Subvention, Fondation du CHU de Québec, from 2019-01-19 to 2020-01-18
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