Jacques Côté obtained his PhD from Laval University after he characterized the structure and function of Endo G, an endonuclease involved in the replication of mitochondrial DNA and cell apoptosis. He did post-doctoral training with Dr. Jerry Workman at Penn State University where he identified and characterized chromatin remodeling complexes (SWI/SNF) involved in gene activation. In 1997, he joined Laval University where he is Full Professor in the department of Molecular Biology, Medical Biochemistry and Pathology. He currently holds the Canada Research Chair in Chromatin Biology and Molecular Epigenetics. His research projects characterize the dynamic role of chromatin in the regulation of nuclear functions and cell proliferation. His work uses the yeast model system as well as human cells to define the structure, function and regulation of histone modifying complexes implicated in genome expression and maintenance. Research in his laboratory led to important discoveries on the regulatory mechanisms involved in gene transcription and the cellular response to DNA damage, using expertise in molecular biology and genetics, biochemistry, epigenetics, genomics, proteomics and genome editing.

The Côté lab research aim is to understand chromatin dynamics associated with gene regulation, DNA repair and replication. They study protein complexes that control acetylation and methylation of histones, and the composition of chromatin. They dissect the molecular mechanisms of epigenetics, in which signals to chromatin mark different genomic loci and are read by effectors to translate a biological response. Their work has characterized the structure and function of several protein complexes, identifying their intrinsic recognition modules for the epigenetic histone signature. Discoveries in the laboratory identified and extensively characterized the highly conserved NuA4/Tip60 acetyltransferase complex and demonstrated for the first time the essential role of chromatin modifying activities in the process of DNA repair and replication in eukaryotes. Accurate writing and reading of these epigenetic marks lead to changes in chromatin dynamics, in a targeted manner within the genome, and this process is subverted in cancer. In fact, the clear majority of the activities studied in the Côté lab are tumor suppressors and Tip60 itself is down-regulated in a very large spectrum of cancers.

L'Hôtel-Dieu de Québec
9, rue McMahon
2784-2
Québec, Québec
Canada G1R 2J6
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Clouaire T, Rocher V, Lashgari A, Arnould C, Aguirrebengoa M, Biernacka A, Skrzypczak M, Aymard F, Fongang B, Dojer N, Iacovoni JS, Rowicka M, Ginalski K, Cote J, Legube G

Comprehensive Mapping of Histone Modifications at DNA Double-Strand Breaks Deciphers Repair Pathway Chromatin Signatures.

Journal Article

Mol Cell, 2018, ISSN: 1097-2765.

Abstract | Links:

Cheng X, Jobin-Robitaille O, Billon P, Buisson R, Niu H, Lacoste N, Abshiru N, Cote V, Thibault P, Kron SJ, Sung P, Brandl CJ, Masson JY, Cote J

Phospho-dependent recruitment of the yeast NuA4 acetyltransferase complex by MRX at DNA breaks regulates RPA dynamics during resection.

Journal Article

Proc Natl Acad Sci U S A, 2018, ISSN: 0027-8424.

Abstract | Links:

Setiaputra D, Ahmad S, Dalwadi U, Steunou AL, Lu S, Ross JD, Dong MQ, Cote J, Yip CK

Molecular Architecture of the Essential Yeast Histone Acetyltransferase Complex NuA4 Redefines Its Multimodularity.

Journal Article

Mol Cell Biol, 38 (9), 2018, ISSN: 0270-7306.

Abstract | Links:

Han J, Lachance C, Ricketts MD, McCullough CE, Gerace M, Black BE, Cote J, Marmorstein R

The scaffolding protein JADE1 physically links the acetyltransferase subunit HBO1 with its histone H3-H4 substrate.

Journal Article

J Biol Chem, 293 (12), pp. 4498-4509, 2018, ISSN: 0021-9258.

Abstract | Links:

Wang X, Ahmad S, Zhang Z, Cote J, Cai G

Architecture of the Saccharomyces cerevisiae NuA4/TIP60 complex.

Journal Article

Nat Commun, 9 (1), pp. 1147, 2018, ISSN: 2041-1723.

Abstract | Links:

76 entries « 1 of 16 »

Active projects

  • Acetylation of the breast cancer suppressors BRCA1, BRCA2 and PALB2: from functional insights to an anti-cancer approach., Subvention, Société de recherche sur le cancer, Subvention stratégique de recherche sur le cancer du sein (FCSQ/SRC), from 2015-01-23 to 2018-12-31
  • Centre de recherche sur le cancer, Subvention, Institutionnel - BDR, BDR - Centres de recherche reconnus, from 1996-05-01 to 2023-04-30
  • Centre hospitalier universitaire de Québec - CHU de Québec-Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
  • Chaire de recherche du Canada en biologie de la chromatine et épigénétique moléculaire, Subvention, Secrétariat des Chaires de recherche du Canada, Chaires de recherche du Canada - Fonctionnement, from 2015-01-01 to 2021-12-31
  • Control of Genome Expression and Maintenance by MYST-ING Tumor Suppressor Complexes., Subvention, Instituts de recherche en santé du Canada, Subventions Fondation, from 2015-07-01 to 2022-06-30

Recently finished projects

  • Dissection of the NuA4 acetyltransferase complex in nuclear functions, Subvention, Instituts de recherche en santé du Canada, Subvention de fonctionnement, from 2010-10-01 to 2017-03-31
  • FGR - 21ème Journée Scientifique des Étudiants du Centre de Recherche sur le Cancer, Subvention, Institutionnel - BDR, Fonds général de recherche du CRSH, from 2017-05-05 to 2018-03-31
  • Regulation of nuclear processes and cell fate by MYST-ING tumor suppressor complexes., Subvention, Instituts de recherche en santé du Canada, Subvention de fonctionnement, from 2012-04-01 to 2017-03-31
Data provided by the Université Laval research projects registery