Jacques Côté obtained his PhD from Laval University after he characterized the structure and function of Endo G, an endonuclease involved in the replication of mitochondrial DNA and cell apoptosis. He did post-doctoral training with Dr. Jerry Workman at Penn State University where he identified and characterized chromatin remodeling complexes (SWI/SNF) involved in gene activation. In 1997, he joined Laval University where he is Full Professor in the department of Molecular Biology, Medical Biochemistry and Pathology. He currently holds the Canada Research Chair in Chromatin Biology and Molecular Epigenetics. His research projects characterize the dynamic role of chromatin in the regulation of nuclear functions and cell proliferation. His work uses the yeast model system as well as human cells to define the structure, function and regulation of histone modifying complexes implicated in genome expression and maintenance. Research in his laboratory led to important discoveries on the regulatory mechanisms involved in gene transcription and the cellular response to DNA damage, using expertise in molecular biology and genetics, biochemistry, epigenetics, genomics, proteomics and genome editing.

The Côté lab research aim is to understand chromatin dynamics associated with gene regulation, DNA repair and replication. They study protein complexes that control acetylation and methylation of histones, and the composition of chromatin. They dissect the molecular mechanisms of epigenetics, in which signals to chromatin mark different genomic loci and are read by effectors to translate a biological response. Their work has characterized the structure and function of several protein complexes, identifying their intrinsic recognition modules for the epigenetic histone signature. Discoveries in the laboratory identified and extensively characterized the highly conserved NuA4/Tip60 acetyltransferase complex and demonstrated for the first time the essential role of chromatin modifying activities in the process of DNA repair and replication in eukaryotes. Accurate writing and reading of these epigenetic marks lead to changes in chromatin dynamics, in a targeted manner within the genome, and this process is subverted in cancer. In fact, the clear majority of the activities studied in the Côté lab are tumor suppressors and Tip60 itself is down-regulated in a very large spectrum of cancers.

L'Hôtel-Dieu de Québec
9, rue McMahon
2784-2
Québec, Québec
Canada G1R 2J6
130 entries « 1 of 13 »

Galloy M, Lachance C, Cheng X, Distéfano-Gagné F, Côté J, Fradet-Turcotte A

Approaches to Study Native Chromatin-Modifying Complex Activities and Functions.

Journal Article

Front Cell Dev Biol, 9 , 2021.

Abstract | Links:

Ahmad S, Côté V, Côté J

DNA damage-induced phosphorylation of histone H2A at serine 15 is linked to DNA end resection.

Journal Article

Mol Cell Biol, 2021.

Abstract | Links:

Ahmad S, Côté V, Cheng X, Bourriquen G, Sapountzi V, Altaf M, Côté J

Antagonistic relationship of NuA4 with the non-homologous end-joining machinery at DNA damage sites.

Journal Article

PLoS Genet, 17 (9), 2021.

Abstract | Links:

Cheng X, Côté V, Côté J

NuA4 and SAGA acetyltransferase complexes cooperate for repair of DNA breaks by homologous recombination.

Journal Article

PLoS Genet, 17 (7), 2021.

Abstract | Links:

Klein BJ, Cox KL, Jang SM, Singh RK, Côté J, Poirier MG, Kutateladze TG

Structural and biophysical characterization of the nucleosome-binding PZP domain.

Journal Article

STAR Protoc, 2 (2), 2021.

Abstract | Links:

Klein BJ, Cox KL, Jang SM, Cote J, Poirier MG, Kutateladze TG

Molecular Basis for the PZP Domain of BRPF1 Association with Chromatin.

Journal Article

Structure, 28 (1), 2020.

Abstract | Links:

Eyboulet F, Jeronimo C, Cote J, Robert F

The deubiquitylase Ubp15 couples transcription to mRNA export.

Journal Article

Elife, 9 , 2020.

Abstract | Links:

Lamaa A, Humbert J, Aguirrebengoa M, Cheng X, Nicolas E, Cote J, Trouche D

Integrated analysis of H2A.Z isoforms function reveals a complex interplay in gene regulation.

Journal Article

Elife, 9 , 2020.

Abstract | Links:

Zhang H, Devoucoux M, Song X, Li L, Ayaz G, Cheng H, Tempel W, Dong C, Loppnau P, Cote J, Min J

Structural Basis for EPC1-Mediated Recruitment of MBTD1 into the NuA4/TIP60 Acetyltransferase Complex.

Journal Article

Cell Rep, 30 (12), 2020.

Abstract | Links:

Fages J, Chailleux C, Humbert J, Jang SM, Loehr J, Lambert JP, Cote J, Trouche D, Canitrot Y

JMJD6 participates in the maintenance of ribosomal DNA integrity in response to DNA damage.

Journal Article

PLoS Genet, 16 (6), 2020.

Abstract | Links:

130 entries « 1 of 13 »
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Active projects

  • Chaire de recherche du Canada en biologie de la chromatine et épigénétique moléculaire, from 2015-01-01 to 2021-12-31
  • Control of Genome Expression and Maintenance by MYST-ING Tumor Suppressor Complexes., from 2015-07-01 to 2022-06-30

Recently finished projects

  • Bourses-Desjardins et Axe oncologie, from 2019-01-19 to 2020-01-18
Data provided by the Université Laval research projects registery