Jacques Côté obtained his PhD from Laval University after he characterized the structure and function of Endo G, an endonuclease involved in the replication of mitochondrial DNA and cell apoptosis. He did post-doctoral training with Dr. Jerry Workman at Penn State University where he identified and characterized chromatin remodeling complexes (SWI/SNF) involved in gene activation. In 1997, he joined Laval University where he is Full Professor in the department of Molecular Biology, Medical Biochemistry and Pathology. He currently holds the Canada Research Chair in Chromatin Biology and Molecular Epigenetics. His research projects characterize the dynamic role of chromatin in the regulation of nuclear functions and cell proliferation. His work uses the yeast model system as well as human cells to define the structure, function and regulation of histone modifying complexes implicated in genome expression and maintenance. Research in his laboratory led to important discoveries on the regulatory mechanisms involved in gene transcription and the cellular response to DNA damage, using expertise in molecular biology and genetics, biochemistry, epigenetics, genomics, proteomics and genome editing.

The Côté lab research aim is to understand chromatin dynamics associated with gene regulation, DNA repair and replication. They study protein complexes that control acetylation and methylation of histones, and the composition of chromatin. They dissect the molecular mechanisms of epigenetics, in which signals to chromatin mark different genomic loci and are read by effectors to translate a biological response. Their work has characterized the structure and function of several protein complexes, identifying their intrinsic recognition modules for the epigenetic histone signature. Discoveries in the laboratory identified and extensively characterized the highly conserved NuA4/Tip60 acetyltransferase complex and demonstrated for the first time the essential role of chromatin modifying activities in the process of DNA repair and replication in eukaryotes. Accurate writing and reading of these epigenetic marks lead to changes in chromatin dynamics, in a targeted manner within the genome, and this process is subverted in cancer. In fact, the clear majority of the activities studied in the Côté lab are tumor suppressors and Tip60 itself is down-regulated in a very large spectrum of cancers.

L'Hôtel-Dieu de Québec
9, rue McMahon
2784-2
Québec, Québec
Canada G1R 2J6
117 entries « 1 of 12 »

Ducy M, Sesma-Sanz L, Guitton-Sert L, Lashgari A, Gao Y, Brahiti N, Rodrigue A, Margaillan G, Caron MC, Cote J, Simard J, Masson JY

The Tumor Suppressor PALB2: Inside Out.

Journal Article

Trends Biochem Sci, 44 (3), pp. 226-240, 2019, ISSN: 0968-0004.

Abstract | Links:

Lashgari A, Lambert JP, Cote J

Measurement and Analysis of Lysine Acetylation by KAT Complexes In Vitro and In Vivo.

Journal Article

Methods Mol Biol, 1983 , pp. 57-77, 2019, ISSN: 1064-3745.

Abstract | Links:

Horikoshi N, Sharma D, Leonard F, Pandita RK, Charaka VK, Hambarde S, Horikoshi NT, Gaur Khaitan P, Chakraborty S, Cote J, Godin B, Hunt CR, Pandita TK

Pre-existing H4K16ac levels in euchromatin drive DNA repair by homologous recombination in S-phase.

Journal Article

Commun Biol, 2 , pp. 253, 2019, ISSN: 2399-3642.

Abstract | Links:

Clouaire T, Rocher V, Lashgari A, Arnould C, Aguirrebengoa M, Biernacka A, Skrzypczak M, Aymard F, Fongang B, Dojer N, Iacovoni JS, Rowicka M, Ginalski K, Cote J, Legube G

Comprehensive Mapping of Histone Modifications at DNA Double-Strand Breaks Deciphers Repair Pathway Chromatin Signatures.

Journal Article

Mol Cell, 72 (2), pp. 250-262.e6, 2018, ISSN: 1097-2765.

Abstract | Links:

Cheng X, Jobin-Robitaille O, Billon P, Buisson R, Niu H, Lacoste N, Abshiru N, Cote V, Thibault P, Kron SJ, Sung P, Brandl CJ, Masson JY, Cote J

Phospho-dependent recruitment of the yeast NuA4 acetyltransferase complex by MRX at DNA breaks regulates RPA dynamics during resection.

Journal Article

Proc Natl Acad Sci U S A, 115 (40), pp. 10028-10033, 2018, ISSN: 0027-8424.

Abstract | Links:

Setiaputra D, Ahmad S, Dalwadi U, Steunou AL, Lu S, Ross JD, Dong MQ, Cote J, Yip CK

Molecular Architecture of the Essential Yeast Histone Acetyltransferase Complex NuA4 Redefines Its Multimodularity.

Journal Article

Mol Cell Biol, 38 (9), 2018, ISSN: 0270-7306.

Abstract | Links:

Han J, Lachance C, Ricketts MD, McCullough CE, Gerace M, Black BE, Cote J, Marmorstein R

The scaffolding protein JADE1 physically links the acetyltransferase subunit HBO1 with its histone H3-H4 substrate.

Journal Article

J Biol Chem, 293 (12), pp. 4498-4509, 2018, ISSN: 0021-9258.

Abstract | Links:

Wang X, Ahmad S, Zhang Z, Cote J, Cai G

Architecture of the Saccharomyces cerevisiae NuA4/TIP60 complex.

Journal Article

Nat Commun, 9 (1), pp. 1147, 2018, ISSN: 2041-1723.

Abstract | Links:

Klein BJ, Ahmad S, Vann KR, Andrews FH, Mayo ZA, Bourriquen G, Bridgers JB, Zhang J, Strahl BD, Cote J, Kutateladze TG

Yaf9 subunit of the NuA4 and SWR1 complexes targets histone H3K27ac through its YEATS domain.

Journal Article

Nucleic Acids Res, 46 (1), pp. 421-430, 2018, ISSN: 0305-1048.

Abstract | Links:

Klein BJ, Simithy J, Wang X, Ahn J, Andrews FH, Zhang Y, Cote J, Shi X, Garcia BA, Kutateladze TG

Recognition of Histone H3K14 Acylation by MORF.

Journal Article

Structure, 25 (4), pp. 650-654.e2, 2017, ISSN: 0969-2126.

Abstract | Links:

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Active projects

  • Bourses-Desjardins et Axe oncologie, Subvention, Fondation du CHU de Québec, from 2019-01-19 to 2020-01-18
  • Centre de recherche du CHU de Québec - Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
  • Centre de recherche sur le cancer, Subvention, Institutionnel - BDR, BDR - Centres de recherche reconnus, from 1996-05-01 to 2023-04-30
  • Chaire de recherche du Canada en biologie de la chromatine et épigénétique moléculaire, Subvention, Secrétariat des Chaires de recherche du Canada, Chaires de recherche du Canada - Fonctionnement, from 2015-01-01 to 2021-12-31
  • Control of Genome Expression and Maintenance by MYST-ING Tumor Suppressor Complexes., Subvention, Instituts de recherche en santé du Canada, Subventions Fondation, from 2015-07-01 to 2022-06-30

Recently finished projects

  • Acetylation of the breast cancer suppressors BRCA1, BRCA2 and PALB2: from functional insights to an anti-cancer approach., Subvention, Société de recherche sur le cancer, Subvention stratégique de recherche sur le cancer du sein (FCSQ/SRC), from 2015-01-23 to 2018-12-31
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