Dr. Isabelle Marc is a clinician researcher at the Research Centre of the CHU de Québec, and an associate professor at the Department of Pediatrics at Laval University. She has built her research environment around her clinical practice as a pediatrician. Dr. Marc works on the effects of maternal life habits (exercise, sleep, breastfeeding) on child growth and development. Several of her studies have been realised with her students in cohorts in which she is involved. She developed an exercise laboratory for pregnant women and children at the Research Centre, which allows her to collect objective measurements of this population’s physical condition.

Dr. Marc is interested in the effects of omega-3 on the neonatal morbidity of extremely premature infants (less than 28 weeks of gestation). A supplementation with omega-3 administered to the lactating mother is an effective way to provide a daily dose of omega-3 to the preterm child through breast milk. She now wants to demonstrate the positive effects of this intervention on the infant’s health, growth, and development.

Maternal omega-3 supplementation to reduce bronchopulmonary dysplasia in very preterm infants: A randomized controlled trial (MOBYDIck Trial)
This multicenter clinical trial, funded by the CIHR, is performed in collaboration with researchers from 18 Canadian neonatal level III intensive care units. Bronchopulmonary dysplasia (BPD) is defined as the need for ventilatory support/oxygen at 36 weeks of postmenstrual age. It is the most common and severe neonatal complication of extremely premature infants, but current approaches for the treatment and prevention are limited. After birth, breast milk becomes a source of omega-3 for preterm infants. The MOBYDIck Trial will evaluate the efficiency of maternal supplementation with omega-3 during lactation 1) to reduce the prevalence of BPD or it’s severity for the preterm infants and 2) to improve the neuro-development of the child at 2 years of age.

Sino-Canada HeLTI: A multifaceted community-family-mother-child intervention study for the prevention of childhood obesity
Obesity and its related metabolic syndrome disorders are a major public health concern. Increasing evidence points to the role of early life adverse factors in the developmental origins of the vulnerability to such metabolic disorders. Reducing the risk of overweight and obesity (OWO) from early life stages will produce substantial benefits to decrease population burdens of metabolic diseases. Dr. Marc is part of a research team in Canada and China that collaborates to identify the mechanisms that may underline the development of OWO, and the impacts of a community-family-mother-child intervention on OWO in children aged 5 years old in China.

3D cohort (Découvrir, Développer, Devenir) and the transition project of the Integrated Research Network in Perinatology of Quebec and Eastern Ontario (IRNPQEO)
The 3D cohort is following more than 2 300 families in the province of Quebec from pregnancy to childhood. The Integrated Research Network in Perinatology of Quebec and Eastern Ontario is a research team interested in the effects of various adverse prenatal risk factors (life habits, social, behavioral, environmental, and genetic) on the pregnancy, on the health of the mother and the father, and on infant development. The IRNPQEO will transfer much needed new knowledge to legislators, policy makers, clinicians, and consumers.

CHUL
2705, boulevard Laurier
T3-08
Québec, Québec
Canada G1V 4G2
95 entries « 1 of 10 »

Fougère H, Bilodeau JF, Lavoie PM, Mohamed I, Rudkowska I, Pronovost E, Simonyan D, Berthiaume L, Guillot M, Piedboeuf B, Julien P, Marc I

Docosahexaenoic acid-rich algae oil supplementation on breast milk fatty acid profile of mothers who delivered prematurely: a randomized clinical trial.

Journal Article

Sci Rep, 11 (1), 2021.

Abstract | Links:

Dharel D, Singhal N, Wood C, Cieslak Z, Bacchini F, Shah PS, Ye XY, Alshaikh B, Abenhaim H, Afifi J, Alvaro R, Andrews J, Armson A, Audibert F, Aziz K, Ballantyne M, Barrett J, Beltempo M, Berard A, Bertelle V, Blais L, Bocking A, Bodani J, Burrows J, Butt K, Canning R, Carson G, Chaillet N, Chandra S, Church P, Coughlin K, Crane J, Creighton D, Da Silva O, Daboval T, Dahlgren L, Daspal S, de Cabo C, Deshpandey A, Dow K, Drolet C, Dunn M, El Helou S, El-Chaar D, El-Naggar W, Fajardo C, Foster J, Gagnon R, Gratton R, Han V, Harrison A, Hasan S, Helewa M, Hicks M, Joseph KS, Kajetanowicz A, Kalapesi Z, Khairy M, Lacaze-Masmonteil T, Lee KS, Lemyre B, Lodha A, Louis D, Mai Luu T, Ly L, Majnemer A, Makary H, Marc I, Masse E, McDonald SD, McMillan D, Melamed N, Metcalfe A, Moddemann D, Monterrosa L, Morais M, Mukerji A, Mundle W, Murphy L, Murphy K, Nuyt AM, Nwaesei C, O'Brien K, Offringa M, Ojah C, Ouellet A, Pasquier JC, Pechlivanoglou P, Pelausa E, Piedboeuf B, Portales-Casamar E, Premji S, Puligandla P, Pullenayegum E, Reichert A, Schneider C, Seshia M, Shah V, Sherlock R, Shivananda S, Skarsgard E, Skoll A, Smith G, Synnes A, Thériault K, Ting J, Tough S, Toye J, Ubhi J, Vincer M, Whittle W, Whyte H, Wilson D, Wood S, Ye P, Yee W, Zwicker J

Rates and Determinants of Mother's Own Milk Feeding in Infants Born Very Preterm.

Journal Article

J Pediatr, 236 , 2021.

Abstract | Links:

Hiersch L, Shah PS, Khurshid F, Masse E, Murphy K, McDonald SD, Carson G, Barrett J, Melamed N, Ting J, Cieslak Z, Sherlock R, Abou Mehrem A, Toye J, Fajardo C, Kalapesi Z, Bodani J, Sankaran K, Daspal S, Seshia M, Louis D, Alvaro R, Mukerji A, Da Silva O, Adie M, Lee KS, Dunn M, Lemyre B, Pelausa E, Barrington K, Lapoint A, Ethier G, Drolet C, Piedboeuf B, Claveau M, Beltempo M, Bertelle V, Canning R, Makary H, Ojah C, Monterrosa L, Emberley J, Afifi J, Kajetanowicz A, Lee SK, Abenhaim H, Andrews J, Armson A, Audibert F, Aziz K, Ballantyne M, Berard A, Blais L, Bocking A, Burrows J, Butt K, Chaillet N, Chandra S, Church P, Coughlin K, Crane J, Creighton D, Daboval T, Dahlgren L, de Cabo C, Deshpandey A, Dow K, El Helou S, El-Chaar D, El-Naggar W, Foster J, Gagnon R, Gratton R, Han V, Harrison A, Hasan S, Helewa M, Hicks M, Joseph KS, Lacaze-Masmonteil T, Lodha A, Luu TM, Ly L, Majnemer A, Marc I, McMillan D, Metcalfe A, Moddemann D, Morais M, Mundle W, Murphy L, Nuyt AM, Nwaesei C, O'Brien K, Offringa M, Ouellet A, Pasquier JC, Pechlivanoglou P, Portales-Casamar E, Premji S, Puligandla P, Pullenayegum E, Reichert A, Robson K, Schneider C, Shah V, Shivananda S, Singhal N, Skarsgard E, Skoll A, Smith G, Synnes A, Thériault K, Tough S, Ubhi J, Vincer M, Whittle W, Whyte H, Wilson D, Wood S, Ye P, Yee W, Zwicker J

Mode of delivery and neonatal outcomes in extremely preterm Vertex/nonVertex twins.

Journal Article

Am J Obstet Gynecol, 224 (6), 2021.

Abstract | Links:

Rios JD, Shah PS, Beltempo M, Louis D, Mukerji A, Premji S, Shah V, Lee SK, Pechlivanoglou P, Abenhaim H, Afifi J, Alvaro R, Andrews J, Armson A, Audibert F, Aziz K, Ballantyne M, Barrett J, Berard A, Bertelle V, Blais L, Bocking A, Bodani J, Burrows J, Butt K, Canning R, Carson G, Chaillet N, Chandra S, Church P, Cieslak Z, Crane J, Creighton D, Da Silva O, Daboval T, Dahlgren L, Daspal S, de Cabo C, Deshpandey A, Dow K, Drolet C, Dunn M, Salhab El Helou , El-Chaar D, El-Naggar W, Fajardo C, Gagnon R, Gratton R, Han V, Harrison A, Hasan S, Helewa M, Hicks M, Joseph KS, Kajetanowicz A, Kalapesi Z, Khairy M, Lacaze-Masmonteil T, Lee KS, Lemyre B, Lodha A, Mai Luu T, Ly L, Majnemer A, Makary H, Marc I, Masse E, McDonald SD, McMillan D, Melamed N, Metcalfe A, Moddemann D, Monterrosa L, Morais M, Mundle W, Murphy L, Murphy K, Nuyt AM, Nwaesei C, O'Brien K, Offringa M, Ojah C, Ouellet A, Pasquier JC, Pelausa E, Piedboeuf B, Portales-Casamar E, Puligandla P, Pullenayegum E, Reichert A, Robson K, Schneider C, Seshia M, Sherlock R, Shivananda S, Singhal N, Skarsgard E, Skoll A, Smith G, Synnes A, Thériault K, Ting J, Tough S, Toye J, Ubhi J, Vincer M, Whittle W, Whyte H, Wilson D, Wood S, Ye P, Yee W, Zwicker J, Jaideep Kanungo , Mehrem AA, Sankaran K, Adie M, Khurshid F, Barrington K, Lapoint A, Ethier G, Claveau M, Emberley J

Costs of Neonatal Intensive Care for Canadian Infants with Preterm Birth.

Journal Article

J Pediatr, 229 , 2021.

Abstract | Links:

Melamed N, Murphy K, Barrett J, Asztalos E, McDonald SD, Yoon EW, Shah PS, Kanungo J, Ting J, Cieslak Z, Sherlock R, Mehrem AA, Toye J, Fajardo C, Kalapesi Z, Bodani J, Sankaran K, Daspal S, Seshia M, Louis D, Alvaro R, Mukerji A, Da Silva O, Adie M, Lee KS, Dunn M, Lemyre B, Khurshid F, Pelausa E, Barrington K, Lapoint A, Ethier G, Drolet C, Piedboeuf B, Claveau M, Beltempo M, Bertelle V, Masse E, Canning R, Makary H, Ojah C, Monterrosa L, Emberley J, Afifi J, Kajetanowicz A, Lee SK, Abenhaim H, Andrews J, Armson A, Audibert F, Aziz K, Ballantyne M, Berard A, Blais L, Bocking A, Burrows J, Butt K, Carson G, Chaillet N, Chandra S, Church P, Coughlin K, Crane J, Creighton D, Daboval T, Dahlgren L, de Cabo C, Deshpandey A, Dow K, El Helou S, El-Chaar D, El-Naggar W, Foster J, Gagnon R, Gratton R, Han V, Harrison A, Hasan S, Helewa M, Hicks M, Joseph KS, Khairy M, Lacaze-Masmonteil T, Lodha A, Luu M, Ly L, Majnemer A, Marc I, McMillan D, Metcalfe A, Moddemann D, Morais M, Mundle W, Murphy L, Nuyt AM, Nwaesei C, O'Brien K, Offringa M, Ouellet A, Pasquier JC, Pechlivanoglou P, Portales-Casamar E, Premji S, Puligandla P, Pullenayegum E, Reichert A, Robson K, Schneider C, Shah V, Shivananda S, Singhal N, Skarsgard E, Skoll A, Smith G, Synnes A, Thériault K, Tough S, Ubhi J, Vincer M, Whittle W, Whyte H, Wilson D, Wood S, Ye P, Yee W, Zwicker J

Benefit of antenatal corticosteroids by year of birth among preterm infants in Canada during 2003-2017: a population-based cohort study.

Journal Article

BJOG, 128 (3), 2021.

Abstract | Links:

Huang R, Dong Y, Levy E, Julien P, Marc I, He H, Xu YJ, Wei SQ, Fraser WD, Luo ZC

Large-for-gestational-age, leptin and adiponectin in infancy.

Journal Article

J Clin Endocrinol Metab, 2021.

Abstract | Links:

Wu Y, Marc I, Bouchard L, Ouyang F, Luo ZC, Fan J, Dubois L, Masse B, Zhang J, Leung PCK, Liao XP, Herba CM, Booij L, Shen J, Lewin A, Jiang H, Wang L, Xu J, Wu W, Sun W, Wu J, Li H, Lei C, Kozyrskyj A, Semenic S, Chaillet N, Fortier I, Masse L, Zhan J, Allard C, Knoppers B, Zawati M, Baillargeon JP, Velez MP, Zhang H, Yu Y, Yu W, Ding Y, Vaillancourt C, Liu H, Tetu A, Fang W, Zhang R, Zhao X, Jin Y, Liu XM, Chen Z, Yang X, Hao YH, Abdelouahab N, Fraser W, Huang HF

Study protocol for the Sino-Canadian Healthy Life Trajectories Initiative (SCHeLTI): a multicentre, cluster-randomised, parallel-group, superiority trial of a multifaceted community-family-mother-child intervention to prevent childhood overweight and obesity.

Journal Article

BMJ Open, 11 (4), 2021.

Abstract | Links:

Wu Y, Ma X, Fraser WD, Li M, Wang W, Huang H, Landry M, Hao Y, Liu H, Semenic S, Zhang Y, Wang H, Zhang J, Yu J, La X, Zhang C, Marc I, Jiang H

Caregivers' perceptions, challenges and service needs related to tackling childhood overweight and obesity: a qualitative study in three districts of Shanghai, China.

Journal Article

BMC Public Health, 21 (1), 2021.

Abstract | Links:

Dugas C, Kearney M, Perron J, Weisnagel SJ, Marc I, Robitaille J

Breastfeeding and growth trajectory from birth to 5 years among children exposed and unexposed to gestational diabetes mellitus in utero.

Journal Article

J Perinatol, 41 (5), 2021.

Abstract | Links:

He H, Zhu WT, Nuyt AM, Marc I, Julien P, Huang R, Dubois L, Wei SQ, Zhang J, Levy E, Fraser WD, Luo ZC

Cord Blood IGF-I, Proinsulin, Leptin, HMW Adiponectin, and Ghrelin in Short or Skinny Small-for-Gestational-Age Infants.

Journal Article

J Clin Endocrinol Metab, 106 (8), 2021.

Abstract | Links:

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Active projects

  • Isoprostanes and phospholipases A2: Roles in the pathophysiology of preeclampsia, from 2017-04-01 to 2022-03-31
  • Maternal Omega-3 supplementation to reduce Bronchopulmonary Dysplasia in very Preterm Infants : A Randomized controlled trial (MOBYDIck trial)., from 2014-07-01 to 2023-03-31
  • Maternal sleep-disordered breathing during pregnancy and long-term health outcomes in children: the 3D pregnancy and birth cohort, from 2019-04-01 to 2024-09-30
  • Perinatal research unit for a sustainable health of mother and child, from 2018-03-01 to 2021-12-31

Recently finished projects

  • Challenges to the vulnerable child in the transitions from preschool in a pregnacy cohort, from 2016-07-01 to 2021-06-30
  • Sino-Canada Hel Tl: A Multifaceted. Community-Family-Mother-Child Intervention Study for the Prevention ofthildhood Obesity, from 2016-07-01 to 2021-06-30
  • Une approche nutritionnelle pour améliorer la croissance et le développement des grands prématurés., from 2016-07-01 to 2020-06-30
Data provided by the Université Laval research projects registery