Dr. Isabelle Marc is a clinician researcher at the Research Centre of the CHU de Québec, and an associate professor at the Department of Pediatrics at Laval University. She has built her research environment around her clinical practice as a pediatrician. Dr. Marc works on the effects of maternal life habits (exercise, sleep, breastfeeding) on child growth and development. Several of her studies have been realised with her students in cohorts in which she is involved. She developed an exercise laboratory for pregnant women and children at the Research Centre, which allows her to collect objective measurements of this population’s physical condition.

Dr. Marc is interested in the effects of omega-3 on the neonatal morbidity of extremely premature infants (less than 28 weeks of gestation). A supplementation with omega-3 administered to the lactating mother is an effective way to provide a daily dose of omega-3 to the preterm child through breast milk. She now wants to demonstrate the positive effects of this intervention on the infant’s health, growth, and development.

Maternal omega-3 supplementation to reduce bronchopulmonary dysplasia in very preterm infants: A randomized controlled trial (MOBYDIck Trial)
This multicenter clinical trial, funded by the CIHR, is performed in collaboration with researchers from 18 Canadian neonatal level III intensive care units. Bronchopulmonary dysplasia (BPD) is defined as the need for ventilatory support/oxygen at 36 weeks of postmenstrual age. It is the most common and severe neonatal complication of extremely premature infants, but current approaches for the treatment and prevention are limited. After birth, breast milk becomes a source of omega-3 for preterm infants. The MOBYDIck Trial will evaluate the efficiency of maternal supplementation with omega-3 during lactation 1) to reduce the prevalence of BPD or it’s severity for the preterm infants and 2) to improve the neuro-development of the child at 2 years of age.

Sino-Canada HeLTI: A multifaceted community-family-mother-child intervention study for the prevention of childhood obesity
Obesity and its related metabolic syndrome disorders are a major public health concern. Increasing evidence points to the role of early life adverse factors in the developmental origins of the vulnerability to such metabolic disorders. Reducing the risk of overweight and obesity (OWO) from early life stages will produce substantial benefits to decrease population burdens of metabolic diseases. Dr. Marc is part of a research team in Canada and China that collaborates to identify the mechanisms that may underline the development of OWO, and the impacts of a community-family-mother-child intervention on OWO in children aged 5 years old in China.

3D cohort (Découvrir, Développer, Devenir) and the transition project of the Integrated Research Network in Perinatology of Quebec and Eastern Ontario (IRNPQEO)
The 3D cohort is following more than 2 300 families in the province of Quebec from pregnancy to childhood. The Integrated Research Network in Perinatology of Quebec and Eastern Ontario is a research team interested in the effects of various adverse prenatal risk factors (life habits, social, behavioral, environmental, and genetic) on the pregnancy, on the health of the mother and the father, and on infant development. The IRNPQEO will transfer much needed new knowledge to legislators, policy makers, clinicians, and consumers.

CHUL
2705, boulevard Laurier
T-3-08
Québec, Québec
Canada G1V 4G2
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Reutrakul S, Anothaisintawee T, Herring SJ, Balserak BI, Marc I, Thakkinstian A

Short sleep duration and hyperglycemia in pregnancy: Aggregate and individual patient data meta-analysis.

Journal Article

Sleep Med Rev, 40 , pp. 31-42, 2018, ISSN: 1087-0792.

Abstract | Links:

Babar A, Bujold E, Leblanc V, Lavoie-Lebel E, Paquette J, Bazinet L, Lemieux S, Marc I, Abdous B, Dodin S

Changes in endothelial function, arterial stiffness and blood pressure in pregnant women after consumption of high-flavanol and high-theobromine chocolate: a double blind randomized clinical trial.

Journal Article

Hypertens Pregnancy, 37 (2), pp. 68-80, 2018, ISSN: 1064-1955.

Abstract | Links:

Kearney M, Perron J, Marc I, Weisnagel SJ, Tchernof A, Robitaille J

Association of prenatal exposure to gestational diabetes with offspring body composition and regional body fat distribution.

Journal Article

Clin Obes, 8 (2), pp. 81-87, 2018, ISSN: 1758-8103.

Abstract | Links:

Dugas C, Kearney M, Mercier R, Perron J, Tchernof A, Marc I, Weisnagel SJ, Robitaille J

Early life nutrition, glycemic and anthropometric profiles of children exposed to gestational diabetes mellitus in utero.

Journal Article

Early Hum Dev, 118 , pp. 37-41, 2018, ISSN: 0378-3782.

| Links:

He H, Nuyt AM, Luo ZC, Audibert F, Dubois L, Wei SQ, Abenhaim HA, Bujold E, Marc I, Julien P, Fraser WD, 3D Study Group

Maternal Circulating Placental Growth Factor and Neonatal Metabolic Health Biomarkers in Small for Gestational Age Infants.

Journal Article

Front Endocrinol (Lausanne), 9 , pp. 198, 2018.

Abstract | Links:

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Active projects

  • Centre de recherche en endocrinologie, métabolisme et inflammation, Subvention, Institutionnel - BDR, BDR - Centres de recherche reconnus, from 1996-06-01 to 2023-04-30
  • Centre hospitalier universitaire de Québec - CHU de Québec-Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
  • Challenges to the vulnerable child in the transitions from preschool in a pregnacy cohort, Subvention, Instituts de recherche en santé du Canada, Volet Projet: Concours pilotes, from 2016-07-01 to 2021-06-30
  • Isoprostanes and phospholipases A2: Roles in the pathophysiology of preeclampsia, Subvention, Instituts de recherche en santé du Canada, Subvention Projet, from 2017-04-01 to 2022-03-31
  • Maternal Omega-3 supplementation to reduce Bronchopulmonary Dysplasia in very Preterm Infants : A Randomized controlled trial (MOBYDIck trial)., Subvention, Instituts de recherche en santé du Canada, Subvention de fonctionnement, from 2014-07-01 to 2019-06-30
  • Sino-Canada Hel Tl: A Multifaceted. Community-Family-Mother-Child Intervention Study for the Prevention ofthildhood Obesity, Subvention, Instituts de recherche en santé du Canada, Programme de subvention d'équipe, from 2016-07-01 to 2021-06-30
  • Une approche nutritionnelle pour améliorer la croissance et le développement des grands prématurés., Subvention, Fonds de recherche du Québec - Santé, Chercheurs-boursiers cliniciens - Juniors 1 et 2, Seniors, from 2016-07-01 to 2020-06-30

Recently finished projects

  • Impact of gestational diabetes mellitus on offspring health: role of the prenatal and postnatal environment., Subvention, Association canadienne du diabète, Subvention de fonctionnement, from 2014-09-01 to 2018-03-01
  • Maternal Omega-3 supplementation to reduce Bronchopulmonary Dysplasia in very Preterm Infants., Subvention, Fondation du CHU de Québec, from 2016-04-01 to 2017-03-31
  • Soutien financier pour la mesure de la compliance à l’intervention du projet MOBYDIck, Subvention, Fondation de l'Université Laval, from 2016-09-01 to 2017-12-31
Data provided by the Université Laval research projects registery