Dr. Guy Boivin is a professor in the Department of Microbiology-Immunology and Infectious Diseases of the Faculty of Medicine at Laval University. He holds the Canada Research Chair in Emerging Viruses and Antiviral Resistance, as well as a “Foundation” grant from the Canadian Institutes of Health Research (CIHR). He is also co-principal investigator of major grants, such as the FPQIS ($ 12M), for the development of new generation influenza vaccine in the elderly.

Dr. Boivin is the author or co-author of 300 scientific publications and 350 presentations at various international conferences and symposia. He has also contributed to the creation of 9 patents and is co-founder of the company Signia Therapeutics, specializing in the repositioning of drugs to counter viral respiratory infections. He is also the director of an NC3 laboratory that will be operational in 2018, which will expand the various research projects to highly pathogenic respiratory viruses, such as avian influenza viruses (H5N1, H7N9) and other emerging respiratory viruses. (MERS-CoV).

His research program focuses on the diagnosis, pathogenesis, and treatment of viral infections. He studies herpetic and respiratory viruses, including those causing the flu (including avian flu). More recently, he has also been interested in the Zika virus. He uses cell and molecular biology technologies, as well as different animal models to develop rapid diagnostic tests, evaluate new antiviral molecules, elucidate mechanisms of resistance to antiviral agents, and generate new vaccines. He has developed several multicenter studies to assess the clinical and epidemiological impact of emerging respiratory viruses. He collaborates with several fundamental and clinical research groups as well as various pharmaceutical companies. His work will have a significant impact on the diagnosis, treatment, and prevention of frequent and potentially life-threatening viral infections in certain groups of individuals.

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Dubois J, Traversier A, Julien T, Padey B, Lina B, Bourdon JC, Marcel V, Boivin G, Rosa-Calatrava M, Terrier O

The Nonstructural NS1 Protein of Influenza Viruses Modulates TP53 Splicing through Host Factor CPSF4.

Journal Article

J Virol, 93 (7), 2019, ISSN: 0022-538X.

Abstract | Links:

Piret J, Boivin G

Clinical development of letermovir and maribavir: Overview of human cytomegalovirus drug resistance.

Journal Article

Antiviral Res, 163 , pp. 91-105, 2019, ISSN: 0166-3542.

Abstract | Links:

Turgeon N, Hamelin ME, Verreault D, Levesque A, Rheaume C, Carbonneau J, Checkmahomed L, Girard M, Boivin G, Duchaine C

Design and Validation with Influenza A Virus of an Aerosol Transmission Chamber for Ferrets.

Journal Article

Int J Environ Res Public Health, 16 (4), 2019, ISSN: 1661-7827.

Abstract | Links:

Canivet C, Uyar O, Rheaume C, Piret J, Boivin G

The recruitment of peripheral blood leukocytes to the brain is delayed in susceptible BALB/c compared to resistant C57BL/6 mice during herpes simplex virus encephalitis.

Journal Article

J Neurovirol, 2019, ISSN: 1355-0284.

Abstract | Links:

El Idrissi KR, Isabel S, Carbonneau J, Lafond M, Quach C, Caya C, Fontela PS, Beltempo M, Boivin G, Lefebvre MA, Papenburg J

Molecular and epidemiologic investigation of a rhinovirus outbreak in a neonatal intensive care unit.

Journal Article

Infect Control Hosp Epidemiol, 40 (2), pp. 245-247, 2019, ISSN: 0899-823X.

Abstract | Links:

de La Vega MA, Piret J, Griffin BD, Rheaume C, Venable MC, Carbonneau J, Couture C, das Neves Almeida R, Tremblay RR, Magalhaes KG, Park YK, Roberts CC, Maslow JN, Sardesai NY, Kim JJ, Muthumani K, Weiner DB, Kobinger GP, Boivin G

Zika-Induced Male Infertility in Mice Is Potentially Reversible and Preventable by Deoxyribonucleic Acid Immunization.

Journal Article

J Infect Dis, 219 (3), pp. 365-374, 2019, ISSN: 0022-1899.

Abstract | Links:

Mulpuru S, Li L, Ye L, Hatchette T, Andrew MK, Ambrose A, Boivin G, Bowie W, Chit A, Dos Santos G, ElSherif M, Green K, Haguinet F, Halperin SA, Ibarguchi B, Johnstone J, Katz K, Langley JM, LeBlanc J, Loeb M, MacKinnon-Cameron D, McCarthy A, McElhaney JE, McGeer A, Powis J, Richardson D, Semret M, Shinde V, Smyth D, Trottier S, Valiquette L, Webster D, McNeil SA, Serious Outcomes Surveillance (SOS) Network of the Canadian Immunization Research

Effectiveness of Influenza Vaccination on Hospitalizations and Risk Factors for Severe Outcomes in Hospitalized Patients With COPD.

Journal Article

Chest, 155 (1), pp. 69-78, 2019, ISSN: 0012-3692.

Abstract | Links:

Del Campo J, Pizzorno A, Djebali S, Bouley J, Haller M, Perez-Vargas J, Lina B, Boivin G, Hamelin ME, Nicolas F, Le Vert A, Leverrier Y, Rosa-Calatrava M, Marvel J, Hill F

OVX836 a recombinant nucleoprotein vaccine inducing cellular responses and protective efficacy against multiple influenza A subtypes.

Journal Article

NPJ Vaccines, 4 , pp. 4, 2019, ISSN: 2059-0105.

Abstract | Links:

Pizzorno A, Terrier O, Nicolas de Lamballerie C, Julien T, Padey B, Traversier A, Roche M, Hamelin ME, Rheaume C, Croze S, Escuret V, Poissy J, Lina B, Legras-Lachuer C, Textoris J, Boivin G, Rosa-Calatrava M

Repurposing of Drugs as Novel Influenza Inhibitors From Clinical Gene Expression Infection Signatures.

Journal Article

Front Immunol, 10 , pp. 60, 2019, ISSN: 1664-3224.

Abstract | Links:

Fage C, Abed Y, Checkmahomed L, Venable MC, Boivin G

In Vitro Properties and Virulence of Contemporary Recombinant Influenza B Viruses Harboring Mutations of Cross-Resistance to Neuraminidase Inhibitors.

Journal Article

Viruses, 11 (1), 2018, ISSN: 1999-4915.

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Active projects

  • A research program on the pathogenesis, treatment and prevention of respiratory and herpes viruses, Subvention, Instituts de recherche en santé du Canada, Subventions Fondation, from 2016-07-01 to 2023-06-30
  • Centre de recherche en infectiologie, Subvention, Institutionnel - BDR, BDR - Centres de recherche reconnus, from 1996-06-01 to 2019-04-30
  • Centre hospitalier universitaire de Québec - Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
  • Chaire de recherche du Canada sur les virus en émergence et la résistance aux antiviraux, Subvention, Secrétariat des Chaires de recherche du Canada, Chaires de recherche du Canada - Fonctionnement, from 2013-07-01 to 2020-06-30
  • PHAC / CIHR Influenza Research Network, Subvention, Instituts de recherche en santé du Canada, from 2012-06-01 to 2019-03-31

Recently finished projects

  • (SO04) Severe outcomes of laboratory-confirmed influenza in adults for the 2015-2016 influenza season, Subvention, Instituts de recherche en santé du Canada, Réseau canadien de recherche sur l’immunisation, from 2015-11-01 to 2018-04-30
  • Canadian Immunization Research Network, Subvention, Instituts de recherche en santé du Canada, Réseau canadien de recherche sur l’immunisation, from 2014-06-01 to 2017-05-31
  • Caractérisation des signatures cellulaires des infections virales pour identifier des antiviraux contre les paramyxivirus., Subvention, Fondation de l'Université Laval, from 2015-10-01 to 2017-09-30
  • Discovery and validation of biomarkers to predict the outcome of influenza, Subvention, Génome Canada, Projets de recherche appliquée à grande échelle, from 2017-08-09 to 2018-03-31
  • Exploring plant-made vaccines to protect the elderly against respiratory viruses., Subvention, Génome Québec, from 2014-04-01 to 2017-09-30
  • Mechanisms of antiviral drug resistance for Herpesviruses., Subvention, Instituts de recherche en santé du Canada, Subvention de fonctionnement, from 2015-07-01 to 2018-03-31
  • Role of the innate immune system and evaluation of immunomodulatory strategies in herpes simplex virus encephalitis., Subvention, Instituts de recherche en santé du Canada, Subvention de fonctionnement, from 2014-04-01 to 2018-03-31
  • The critical role of human metapneumovirus fusion protein in the pathogenesis, treatment and prevention of childhood viral infections., Subvention, Instituts de recherche en santé du Canada, Subvention de fonctionnement, from 2012-10-01 to 2018-03-31
Data provided by the Université Laval research projects registery