Dr. Frédéric Calon is a Professor at the Faculty of Pharmacy and principal investigator at the Centre de recherche du CHU de Québec-Laval University since 2003. He is a biochemist-pharmacist focusing his research program on the development of treatments for neurodegenerative diseases.

Author of more than 120 peer-reviewed articles, he and his team at Laval University, Quebec City, mainly carry on preclinical assays in animal models of brain diseases or neuropathology studies on human brain samples. His fields of expertise are focused on neurodegenerative diseases (Alzheimer’s and Parkinson’s), essential tremor, as well as general neuropharmacology. Dr. Calon is mostly known for his contribution to the discovery of a neuroprotective effect of omega-3 fatty acids in animal models of Alzheimer’s disease, Parkinson’s disease, and ischemic stroke. He cofounded with Sophie Layé (Bordeaux) in 2014 the Laboratoire International Associé (LIA) OptiNutriBrain, a unique collaborative laboratory now one of the world references in research on nutrition and brain diseases.

Dr. Calon’s group has also contributed to the discoveries of neuropathological clues in the cerebellum of patients that had suffered from essential tremor.

Finally, Dr. Calon’s team has developed a unique research platform to quantitatively and qualitatively the capacity of drugs to cross the blood-brain barrier, which is now the limiting step in CNS drug development.

His discoveries have been the subject of hundreds of public reports (radio, TV, and written press) and were highlighted by major national and international media. These discoveries have attracted considerable public interest and media coverage, including prime time interviews for Radio-Canada (TV, radio, internet) and the front page of the Globe and Mail. Dr. Calon’s work on GABA receptors in ET was selected among the top 10 scientific discoveries made in Quebec in 2012 and featured on “Le code Chastenay” on Télé-Québec, and he was also chosen as one of the “Lauréats de Québec LeSoleil/Radio-Canada” (personalities of the week) in 2013. In addition, one of his latest discoveries was published in Paris Match in 2015.

The goal of Dr. Calon’s work is to accelerate the transfer of knowledge from basic neuroscience to clinical applications for CNS diseases.

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AlOtaibi M, Chouinard-Watkins R, Plourde M, Calon F, Graham RK, Lessard-Beaudoin M, M Gonzalez L

Diet enriched in omega-3 fatty acids alleviates olfactory system deficits in APOE4 transgenic mice.

Journal Article

Eur J Neurosci, 54 (9), 2021.

Abstract | Links:

Fanet H, Capuron L, Castanon N, Calon F, Vancassel S

Tetrahydrobioterin (BH4) Pathway: From Metabolism to Neuropsychiatry.

Journal Article

Curr Neuropharmacol, 19 (5), 2021.

Abstract | Links:

Tournissac M, Vu TM, Vrabic N, Hozer C, Tremblay C, Mélançon K, Planel E, Pifferi F, Calon F

Repurposing beta-3 adrenergic receptor agonists for Alzheimer's disease: beneficial effects in a mouse model.

Journal Article

Alzheimers Res Ther, 13 (1), 2021.

Abstract | Links:

Tournissac M, Leclerc M, Valentin-Escalera J, Vandal M, Bosoi CR, Planel E, Calon F

Metabolic determinants of Alzheimer's disease: A focus on thermoregulation.

Journal Article

Ageing Res Rev, 72 , 2021.

Abstract | Links:

Rao PPN, Shakeri A, Zhao Y, Calon F

Strategies in the design and development of (TAR) DNA-binding protein 43 (TDP-43) binding ligands.

Journal Article

Eur J Med Chem, 225 , 2021.

Abstract | Links:

Vandal M, Tournissac M, Leclerc M, Fanet H, Mitchell PL, Verreault M, Trottier J, Virgili J, Tremblay C, Lippman HR, Barbier O, Marette A, Bosoi CR, Bajaj JS, Calon F

High-Fat Diet Modulates Hepatic Amyloid β and Cerebrosterol Metabolism in the Triple Transgenic Mouse Model of Alzheimer's Disease.

Journal Article

Hepatol Commun, 5 (3), 2021.

Abstract | Links:

Leclerc M, Dudonne S, Calon F

Can Natural Products Exert Neuroprotection without Crossing the Blood-Brain Barrier?

Journal Article

Int J Mol Sci, 22 (7), 2021.

Abstract | Links:

Thammisetty SS, Renaud L, Picher-Martel V, Weng YC, Calon F, Saikali S, Julien JP, Kriz J

Targeting TDP-43 Pathology Alleviates Cognitive and Motor Deficits Caused by Chronic Cerebral Hypoperfusion.

Journal Article

Neurotherapeutics, 18 (2), 2021.

Abstract | Links:

Fanet H, Tournissac M, Leclerc M, Caron V, Tremblay C, Vancassel S, Calon F

Tetrahydrobiopterin Improves Recognition Memory in the Triple-Transgenic Mouse Model of Alzheimer's Disease, Without Altering Amyloid-β and Tau Pathologies.

Journal Article

J Alzheimers Dis, 79 (2), 2021.

Abstract | Links:

Menet R, Bourassa P, Calon F, ElAli A

Dickkopf-related protein-1 inhibition attenuates amyloid-beta pathology associated to Alzheimer's disease.

Journal Article

Neurochem Int, 141 , 2020.

Abstract | Links:

162 entries « 1 of 17 »
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Active projects

  • Approches clinicopathologiques et précliniques au développement de traitements pour les maladies neurodégénératives, from 2018-07-01 to 2022-06-30
  • Elimination of senescent endothelial cells to prevent vascular dementia in aging atheroscierotic mice, from 2019-10-01 to 2024-09-30
  • Elucidating the role of the Alzheimer risk factor CD2AP in brain capillary endothelial cells and vascular functions, from 2018-10-01 to 2023-03-31
  • Fatty acid metabolism in carriers of apolipoprotein E. epsilon 4 allele: determining the blood-to-brain link, from 2020-04-01 to 2025-03-31
  • How does insulin interact with the blood-brain barrier? Therapeutic implications for diabetes and Alzheimer’s disease, from 2020-04-01 to 2025-03-31
  • Institut sur la nutrition et les aliments fonctionnels (INAF), from 2017-04-01 to 2024-03-31
  • Investigating the contribution of Shank3 in Alzheimer's disease, from 2018-04-01 to 2023-03-31
  • Laboratoire international associé (LIA) OptiNutriBrain, from 2015-03-01 to 2025-03-01
  • Mechanisms of endocytosis and transcytosis into endothelial cells of the blood-brain barrier, from 2020-04-01 to 2025-03-31
  • Neuronalg - Les effets bénéfiques des macroalgues du Saint-Laurent sur la santé cognitive, from 2020-04-01 to 2022-10-31
  • Nutrition and brain health, from predictive biology to disease prevention and treatment - Food4BrainHealth, from 2019-03-18 to 2024-03-17
  • Phase Two of the Canadian Consortium on Neurodegeneration in Aging, from 2019-04-01 to 2024-03-31
  • Team 7.1.1: Investigation of cerebrovascular pathology using cerebral microvessel extracts and in animal models, from 2019-04-01 to 2024-03-31
  • Valorisation d'algues marines et étude de la bioactivité des acides aminés de type mycosporine (NeuronAlg), from 2020-04-01 to 2023-03-31

Recently finished projects

  • 3.8 Deciphering host-microbial interactions for cardiometabolic and mental health disorders with novel multimodal light-based sensing tools, from 2016-04-01 to 2020-03-31
  • Delivering intrabodies Intracellular antibody delivery using Feldan's proven peptide-based intracellular delivery technology, from 2018-12-01 to 2021-03-31
  • Development of the Feldan Shuttle platform, from 2018-09-01 to 2021-04-30
  • Développement de méthodes de détection des acides aminés de type mycosporine dans des extraits d'algues marines et dans des tissus biologiques, from 2018-12-01 to 2019-12-31
  • Étude de la neuroligine-1 comme biomarqueur sanguin des stades précliniques et prodromiques de la maladie d'Alzheimer, from 2019-04-01 to 2021-03-31
  • Manipulating thermogenesis to treat Alzheimer’s disease, from 2019-09-01 to 2021-08-31
  • Manipuler la thermorégulation pour traiter la maladie d'Alzheimer, from 2020-08-31 to 2021-03-31
  • Multi-pathway cholesterol depletion on top of FOLFIRINOX in newly diagnosed metastatic pancreatic adenocarcinoma: a feasibility and proof-of-concept study, from 2019-10-01 to 2021-09-30
  • Plateforme Biomarqueurs et cibles thérapeutiques – Cohorte clinique CIMA-Q, from 2019-04-01 to 2021-03-31
  • Rôle de la protéine Shank3 dans la maladie d’Alzheimer, from 2020-08-28 to 2020-12-31
  • Understanding the role of thermoregulatory deficits in Alzheimer's disease pathogenesis, from 2018-04-01 to 2019-11-30
Data provided by the Université Laval research projects registery