Dr. François Marceau has been studying bradykinin receptors for over 30 years, their regulation, ligands and functions. Notably, as early as in the 1980s, the regulation of B1 receptor expression by cytokines and immunopathology was highlighted, with work replicated and expanded around the world. He has been part of an international committee on the nomenclature of bradykinin receptors, leading to a review article cited over 800 times, of which he is a co-author (Pharmacol Rev. 2005; 57: 27). More recently, two subjects have caught the attention of the laboratory, i.e. the creation of bifunctional biotechnological ligands for peptide hormone receptors, including those of bradykinin, and the angioedema states, presently the main clinical application of bradykinin. Dr. Marceau has been, and is, regularly invited as a speaker at specialized conferences.
2705, boulevard Laurier
Canada G1V 4G2
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Induction of beta 1-receptors for kinins in the rabbit by a bacterial lipopolysaccharide.Journal Article
Eur J Pharmacol, 71 (1), pp. 105-15, 1981, ISSN: 0014-2999.
The degradation of bradykinin (BK) and of des-Arg9-BK in plasma.Journal Article
Can J Physiol Pharmacol, 59 (2), pp. 131-8, 1981, ISSN: 0008-4212.
[Vasoactive polypeptide receptors]Journal Article
Union Med Can, 109 (9), pp. 1315-22, 1980, ISSN: 0041-6959.
Kinin receptors in experimental inflammation.Journal Article
Can J Physiol Pharmacol, 58 (5), pp. 536-42, 1980, ISSN: 0008-4212.
Cardiovascular actions of kinins in the rabbit.Journal Article
Can J Physiol Pharmacol, 57 (1), pp. 78-91, 1979, ISSN: 0008-4212.
De novo formation of vascular receptors for bradykinin.Journal Article
Can J Physiol Pharmacol, 56 (4), pp. 674-7, 1978, ISSN: 0008-4212.
The rabbit mesenteric vein: a specific bioassay for substance P.Journal Article
Can J Physiol Pharmacol, 56 (4), pp. 603-9, 1978, ISSN: 0008-4212.
[Erythropoiesis during antiepileptic treatments in childhood]Journal Article
Nouv Presse Med, 1 (20), pp. 1362, 1972, ISSN: 0301-1518.
[Statistical analysis of Price Jones curves for 100 children undergoing antiepileptic treatment]Journal Article
C R Seances Soc Biol Fil, 165 (9), pp. 1936-41, 1971, ISSN: 0037-9026.
- Caractérisation du système kallikréine-kinines chez les familles de patients atteints d'angio-œdème héréditaire avec niveau normal de " C1-esterase inhibitor", Subvention, Fondation du CHU de Québec, from 2019-05-31 to 2021-03-31
- Centre de recherche du CHU de Québec - Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31