Dr. François Marceau has been studying bradykinin receptors for over 30 years, their regulation, ligands and functions. Notably, as early as in the 1980s, the regulation of B1 receptor expression by cytokines and immunopathology was highlighted, with work replicated and expanded around the world. He has been part of an international committee on the nomenclature of bradykinin receptors, leading to a review article cited over 800 times, of which he is a co-author (Pharmacol Rev. 2005; 57: 27). More recently, two subjects have caught the attention of the laboratory, i.e. the creation of bifunctional biotechnological ligands for peptide hormone receptors, including those of bradykinin, and the angioedema states, presently the main clinical application of bradykinin. Dr. Marceau has been, and is, regularly invited as a speaker at specialized conferences.
2705, boulevard Laurier
Canada G1V 4G2
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Effects of complement fragments on pulmonary and vascular smooth muscle.Journal Article
Am Rev Respir Dis, 135 (6 Pt 2), pp. S9-13, 1987, ISSN: 0003-0805.
Mitogenic effect of bradykinin and of des-Arg9-bradykinin on cultured fibroblasts.Journal Article
Life Sci, 39 (24), pp. 2351-8, 1986, ISSN: 0024-3205.
Anaphylatoxin C5a fails to promote prostacyclin release in cultured endothelial cells from human umbilical veins.Journal Article
Immunopharmacology, 12 (2), pp. 135-43, 1986, ISSN: 0162-3109.
Effects of the C5a anaphylatoxin and its relationship to cyclo-oxygenase metabolites in rabbit vascular strips.Journal Article
Br J Pharmacol, 84 (3), pp. 725-33, 1985, ISSN: 0007-1188.
Effect of C3a and C5a anaphylatoxins on guinea-pig isolated blood vessels.Journal Article
J Pharmacol Exp Ther, 230 (3), pp. 749-54, 1984, ISSN: 0022-3565.
Selective induction of cardiovascular responses to des-Arg9-bradykinin by bacterial endotoxin.Journal Article
Pharmacology, 29 (2), pp. 70-4, 1984, ISSN: 0031-7012.
Rapid assay of human plasma carboxypeptidase N by high-performance liquid chromatographic separation of hippuryl-lysine and its product.Journal Article
J Chromatogr, 266 , pp. 173-7, 1983, ISSN: 0021-9673.
Pharmacology of kinins: their relevance to tissue injury and inflammation.Journal Article
Gen Pharmacol, 14 (2), pp. 209-29, 1983, ISSN: 0306-3623.
Kininases and vascular responses to kinins.Journal Article
Eur J Pharmacol, 78 (2), pp. 167-74, 1982, ISSN: 0014-2999.
Pharmacological characterization of the vascular permeability enhancing effects of kinins in the rabbit skin.Journal Article
Can J Physiol Pharmacol, 59 (9), pp. 921-6, 1981, ISSN: 0008-4212.
- Centre de recherche du CHU de Québec - Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
Recently finished projects
- Caractérisation du système kallikréine-kinines chez les familles de patients atteints d'angio-œdème héréditaire avec niveau normal de " C1-esterase inhibitor", Subvention, Fondation du CHU de Québec, from 2019-05-31 to 2020-03-31