Dr. François Marceau has been studying bradykinin receptors for over 30 years, their regulation, ligands and functions. Notably, as early as in the 1980s, the regulation of B1 receptor expression by cytokines and immunopathology was highlighted, with work replicated and expanded around the world. He has been part of an international committee on the nomenclature of bradykinin receptors, leading to a review article cited over 800 times, of which he is a co-author (Pharmacol Rev. 2005; 57: 27). More recently, two subjects have caught the attention of the laboratory, i.e. the creation of bifunctional biotechnological ligands for peptide hormone receptors, including those of bradykinin, and the angioedema states, presently the main clinical application of bradykinin. Dr. Marceau has been, and is, regularly invited as a speaker at specialized conferences.
2705, boulevard Laurier
T-1-49
Québec, Québec
Canada G1V 4G2
Latest news
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The development of a targeted and more potent, anti-Inflammatory derivative of colchicine: Implications for gout.
Journal ArticleBiochem Pharmacol, 180 , pp. 114125, 2020, ISSN: 0006-2952.
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Bradykinin receptors: Agonists, antagonists, expression, signaling, and adaptation to sustained stimulation.
Journal ArticleInt Immunopharmacol, 82 , pp. 106305, 2020, ISSN: 1567-5769.
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Increased fibrinolysis-induced bradykinin formation in hereditary angioedema confirmed using stored plasma and biotechnological inhibitors.
Journal ArticleBMC Res Notes, 12 (1), pp. 291, 2019.
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Bifunctional fusion proteins containing the sequence of the bradykinin homologue maximakinin: activities at the rat bradykinin B2 receptor.
Journal ArticleCan J Physiol Pharmacol, 96 (5), pp. 459-470, 2018, ISSN: 0008-4212.
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Editorial: Correspondence from Chirumbolo and Bjorklund.
Journal ArticleInt Immunopharmacol, 55 , pp. A1, 2018, ISSN: 1567-5769.
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D-Arg0-Bradykinin-Arg-Arg, a Latent Vasoactive Bradykinin B2 Receptor Agonist Metabolically Activated by Carboxypeptidases.
Journal ArticleFront Pharmacol, 9 , pp. 273, 2018.
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Bifunctional ligands of the bradykinin B2 and B1 receptors: An exercise in peptide hormone plasticity.
Journal ArticlePeptides, 105 , pp. 37-50, 2018, ISSN: 0196-9781.
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Reprint of: Editorial: Correspondence from Chirumbolo and Bjorklund.
Journal ArticleInt Immunopharmacol, 62 , pp. 334, 2018, ISSN: 1567-5769.
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Comparing Pathways of Bradykinin Formation in Whole Blood From Healthy Volunteers and Patients With Hereditary Angioedema Due to C1 Inhibitor Deficiency.
Journal ArticleFront Immunol, 9 , pp. 2183, 2018, ISSN: 1664-3224.
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Production and evaluation of parathyroid hormone receptor1 ligands with intrinsic or assembled peroxidase domains.
Journal ArticleSci Rep, 7 (1), pp. 13099, 2017, ISSN: 2045-2322.
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Active projects
- Centre de recherche du CHU de Québec - Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
Recently finished projects
- Caractérisation du système kallikréine-kinines chez les familles de patients atteints d'angio-œdème héréditaire avec niveau normal de " C1-esterase inhibitor", Subvention, Fondation du CHU de Québec, from 2019-05-31 to 2020-03-31