Dr. François Marceau has been studying bradykinin receptors for over 30 years, their regulation, ligands and functions. Notably, as early as in the 1980s, the regulation of B1 receptor expression by cytokines and immunopathology was highlighted, with work replicated and expanded around the world. He has been part of an international committee on the nomenclature of bradykinin receptors, leading to a review article cited over 800 times, of which he is a co-author (Pharmacol Rev. 2005; 57: 27). More recently, two subjects have caught the attention of the laboratory, i.e. the creation of bifunctional biotechnological ligands for peptide hormone receptors, including those of bradykinin, and the angioedema states, presently the main clinical application of bradykinin. Dr. Marceau has been, and is, regularly invited as a speaker at specialized conferences.
2705, boulevard Laurier
Canada G1V 4G2
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Bifunctional ligands of the bradykinin B2 and B1 receptors: An exercise in peptide hormone plasticity.Journal Article
Peptides, 105 , pp. 37-50, 2018, ISSN: 0196-9781.
Bifunctional fusion proteins containing the sequence of the bradykinin homologue maximakinin: activities at the rat bradykinin B2 receptor.Journal Article
Can J Physiol Pharmacol, 96 (5), pp. 459-470, 2018, ISSN: 0008-4212.
Editorial: Correspondence from Chirumbolo and Bjorklund.Journal Article
Int Immunopharmacol, 55 , pp. A1, 2018, ISSN: 1567-5769.
D-Arg0-Bradykinin-Arg-Arg, a Latent Vasoactive Bradykinin B2 Receptor Agonist Metabolically Activated by Carboxypeptidases.Journal Article
Front Pharmacol, 9 , pp. 273, 2018.
Production and evaluation of parathyroid hormone receptor1 ligands with intrinsic or assembled peroxidase domains.Journal Article
Sci Rep, 7 (1), pp. 13099, 2017, ISSN: 2045-2322.
- Centre hospitalier universitaire de Québec - CHU de Québec-Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
Recently finished projects
- Capture, retention and cellular effects of organic amines, Subvention, Conseil de recherches en sciences naturelles et génie Canada, Subventions à la découverte SD (individuelles et d'équipe), from 2012-04-01 to 2017-03-31
- Endothelial bradykinin receptors as therapeutic targets., Subvention, Instituts de recherche en santé du Canada, Subvention de fonctionnement, from 2014-04-01 to 2017-03-31