Dr. François Marceau has been studying bradykinin receptors for over 30 years, their regulation, ligands and functions. Notably, as early as in the 1980s, the regulation of B1 receptor expression by cytokines and immunopathology was highlighted, with work replicated and expanded around the world. He has been part of an international committee on the nomenclature of bradykinin receptors, leading to a review article cited over 800 times, of which he is a co-author (Pharmacol Rev. 2005; 57: 27). More recently, two subjects have caught the attention of the laboratory, i.e. the creation of bifunctional biotechnological ligands for peptide hormone receptors, including those of bradykinin, and the angioedema states, presently the main clinical application of bradykinin. Dr. Marceau has been, and is, regularly invited as a speaker at specialized conferences.

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2705, boulevard Laurier
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189 entries « 1 of 19 »

Marceau F, Bachelard H, Charest-Morin X, Hebert J, Rivard GE

In Vitro Modeling of Bradykinin-Mediated Angioedema States.

Journal Article

Pharmaceuticals (Basel), 13 (9), 2020, ISSN: 1424-8247.

Abstract | Links:

Pare G, Vitry J, Marceau F, Vaillancourt M, Winter P, Bachelard H, Naccache PH, Tuszynski JA, Fernandes MJ

The development of a targeted and more potent, anti-Inflammatory derivative of colchicine: Implications for gout.

Journal Article

Biochem Pharmacol, 180 , pp. 114125, 2020, ISSN: 0006-2952.

Abstract | Links:

Marceau F, Bachelard H, Bouthillier J, Fortin JP, Morissette G, Bawolak MT, Charest-Morin X, Gera L

Bradykinin receptors: Agonists, antagonists, expression, signaling, and adaptation to sustained stimulation.

Journal Article

Int Immunopharmacol, 82 , pp. 106305, 2020, ISSN: 1567-5769.

Abstract | Links:

Marceau F, Rivard GE, Gauthier JM, Binkley KE, Bonnefoy A, Boccon-Gibod I, Bouillet L, Picard M, Levesque G, Elfassy HL, Bachelard H, Hebert J, Bork K

Measurement of Bradykinin Formation and Degradation in Blood Plasma: Relevance for Acquired Angioedema Associated With Angiotensin Converting Enzyme Inhibition and for Hereditary Angioedema Due to Factor XII or Plasminogen Gene Variants.

Journal Article

Front Med (Lausanne), 7 , pp. 358, 2020, ISSN: 2296-858X.

Abstract | Links:

Marceau F, Bachelard H, Rivard GE, Hebert J

Increased fibrinolysis-induced bradykinin formation in hereditary angioedema confirmed using stored plasma and biotechnological inhibitors.

Journal Article

BMC Res Notes, 12 (1), pp. 291, 2019.

Abstract | Links:

Charest-Morin X, Lodge R, Marceau F

Bifunctional fusion proteins containing the sequence of the bradykinin homologue maximakinin: activities at the rat bradykinin B2 receptor.

Journal Article

Can J Physiol Pharmacol, 96 (5), pp. 459-470, 2018, ISSN: 0008-4212.

Abstract | Links:

Marceau F

Editorial: Correspondence from Chirumbolo and Bjorklund.

Journal Article

Int Immunopharmacol, 55 , pp. A1, 2018, ISSN: 1567-5769.

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Bachelard H, Charest-Morin X, Marceau F

D-Arg0-Bradykinin-Arg-Arg, a Latent Vasoactive Bradykinin B2 Receptor Agonist Metabolically Activated by Carboxypeptidases.

Journal Article

Front Pharmacol, 9 , pp. 273, 2018.

Abstract | Links:

Marceau F, Bawolak MT, Fortin JP, Morissette G, Roy C, Bachelard H, Gera L, Charest-Morin X

Bifunctional ligands of the bradykinin B2 and B1 receptors: An exercise in peptide hormone plasticity.

Journal Article

Peptides, 105 , pp. 37-50, 2018, ISSN: 0196-9781.

Abstract | Links:

Marceau F

Reprint of: Editorial: Correspondence from Chirumbolo and Bjorklund.

Journal Article

Int Immunopharmacol, 62 , pp. 334, 2018, ISSN: 1567-5769.

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189 entries « 1 of 19 »
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Active projects

  • Centre de recherche du CHU de Québec - Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31

Recently finished projects

  • Caractérisation du système kallikréine-kinines chez les familles de patients atteints d'angio-œdème héréditaire avec niveau normal de " C1-esterase inhibitor", Subvention, Fondation du CHU de Québec, from 2019-05-31 to 2020-03-31
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