Dr. François Gros-Louis is a regular researcher at the CHU Research Center of Québec-Laval University and Professor in the Department of Surgery of the School of Medicine at Laval University. Dr. Gros-Louis’ research activities are grouped together at the Multidisciplinary Center for Tissue Engineering (LOEX), a research center dedicated to organogenesis, stem cells, regenerative medicine and to the reconstruction of living human tissues and organs through tissue engineering. He holds the Canada Research Chair in Biomodeling and Treatment of Brain Diseases, and is the co-director of the induced pluripotent stem cell platform (iPSC).

Several neurological conditions such as neurodegenerative diseases and other brain diseases occupy a prominent place because of their severity and increasing frequency related to the aging of the population. One of the major obstacles to understanding the development of these diseases is the accessibility of neuronal tissues. Dr. Gros-Louis’ research, at the crossroads between basic research and clinical research, is positioned in a fast-growing research field that aims to reconstruct human tissue through tissue engineering, using patient-derived tissue, to model and better understand the pathophysiological mechanisms underlying these diseases. The main objective of his research program is to reconstruct by tissue engineering, from the patient’s own cells, organs / organoids (skins and blood vessels) whose histological, physiological and functional properties make it possible to reproduce the pathological signatures of various brain diseases (Amyotrophic Lateral Sclerosis (ALS), intracranial aneurysm and neurofibromatosis). The specific objectives are: 1) to identify new strategies for early diagnosis, 2) to study and monitor the progression of targeted diseases, 3) to evaluate the response to existing and future treatments, 4) to identify and understand pathogenic mechanisms, and 5) to identify specific biomarkers and to develop new therapeutic pathways. Dr. Gros-Louis has played a major role in the discovery and application of a novel method for the in vitro reconstruction of tissue, through tissue engineering, for the study of ALS, neurofibromatosis, and intracranial aneurysms.

1401, 18e Rue
Local R-211 LOEX / CMDGT
Québec, Québec
Canada G1J 1Z4
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Gros-Louis F, Meijer IA, Hand CK, Dube MP, MacGregor DL, Seni MH, Devon RS, Hayden MR, Andermann F, Andermann E, Rouleau GA

An ALS2 gene mutation causes hereditary spastic paraplegia in a Pakistani kindred.

Journal Article

Ann Neurol, 53 (1), pp. 144-5, 2003, ISSN: 0364-5134.

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Hand CK, Khoris J, Salachas F, Gros-Louis F, Lopes AA, Mayeux-Portas V, Brewer CG, Brown RH Jr, Meininger V, Camu W, Rouleau GA

A novel locus for familial amyotrophic lateral sclerosis, on chromosome 18q.

Journal Article

Am J Hum Genet, 70 (1), pp. 251-6, 2002, ISSN: 0002-9297.

Abstract | Links:

Krabchi K, Gros-Louis F, Yan J, Bronsard M, Masse J, Forest JC, Drouin R

Quantification of all fetal nucleated cells in maternal blood between the 18th and 22nd weeks of pregnancy using molecular cytogenetic techniques.

Journal Article

Clin Genet, 60 (2), pp. 145-50, 2001, ISSN: 0009-9163.

Abstract | Links:

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Active projects

  • Centre de recherche du CHU de Québec - Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
  • Centre de recherche en organogenèse expérimentale, Subvention, Institutionnel - BDR, BDR - Centres de recherche reconnus, from 2011-05-01 to 2020-09-22
  • Centre thématique de recherche en neurosciences, Subvention, Institutionnel - BDR, BDR - Centres de recherche reconnus, from 1999-06-01 to 2023-05-01
  • Chaire de recherche du Canada en biomodélisation et traitement des maladies du cerveau, Subvention, Secrétariat des programmes interorganismes à l’intention des établissements, Chaires de recherche du Canada - Fonctionnement, from 2017-11-01 to 2022-10-31
  • Chaire de recherche sur les organes reconstruits en laboratoire et leurs applications cliniques, Subvention, Fondation de l'Université Laval, Chaires de recherche sans organismes subventionnaires, from 2013-05-01 to 2023-08-12
  • Design and testing of a next-generation tissue-engineered living human heart valve, Subvention, Secrétariat des programmes interorganismes à l’intention des établissements, Nouvelles frontières en recherche, from 2020-03-31 to 2022-03-30
  • Pathogenic Pathways and in-vitro modelization of Intracranial Aneurysms in populations of Inuit and French Canadian descent, Subvention, Instituts de recherche en santé du Canada, Subvention Projet, from 2017-04-01 to 2022-03-31
  • Renforcement de la plateforme de production de cellules souches induites à la pluripotence (IPSC) du CRCHU de Québec, Subvention, Ministère de l'Économie et de l'Innovation, Appel de projets en appui aux plateformes technologiques stratégiques, from 2019-12-05 to 2022-03-31
Data provided by the Université Laval research projects registery