Dr. François Gros-Louis is a regular researcher at the CHU Research Center of Québec-Laval University and Professor in the Department of Surgery of the School of Medicine at Laval University. Dr. Gros-Louis’ research activities are grouped together at the Multidisciplinary Center for Tissue Engineering (LOEX), a research center dedicated to organogenesis, stem cells, regenerative medicine and to the reconstruction of living human tissues and organs through tissue engineering. He holds the Canada Research Chair in Biomodeling and Treatment of Brain Diseases, and is the co-director of the induced pluripotent stem cell platform (iPSC).

Several neurological conditions such as neurodegenerative diseases and other brain diseases occupy a prominent place because of their severity and increasing frequency related to the aging of the population. One of the major obstacles to understanding the development of these diseases is the accessibility of neuronal tissues. Dr. Gros-Louis’ research, at the crossroads between basic research and clinical research, is positioned in a fast-growing research field that aims to reconstruct human tissue through tissue engineering, using patient-derived tissue, to model and better understand the pathophysiological mechanisms underlying these diseases. The main objective of his research program is to reconstruct by tissue engineering, from the patient’s own cells, organs / organoids (skins and blood vessels) whose histological, physiological and functional properties make it possible to reproduce the pathological signatures of various brain diseases (Amyotrophic Lateral Sclerosis (ALS), intracranial aneurysm and neurofibromatosis). The specific objectives are: 1) to identify new strategies for early diagnosis, 2) to study and monitor the progression of targeted diseases, 3) to evaluate the response to existing and future treatments, 4) to identify and understand pathogenic mechanisms, and 5) to identify specific biomarkers and to develop new therapeutic pathways. Dr. Gros-Louis has played a major role in the discovery and application of a novel method for the in vitro reconstruction of tissue, through tissue engineering, for the study of ALS, neurofibromatosis, and intracranial aneurysms.

1401, 18e Rue
Local R-211 LOEX / CMDGT
Québec, Québec
Canada G1J 1Z4
33 entries « 2 of 4 »

Paré B, Berthod F, Gros-Louis F

The relation between ALS and the skin: a novel human in vitro model to identify new biomarkers

Journal Article

J Mol Biomark Diagn, 6 (5), pp. 1000e121, 2015, ISSN: 2155-9929.

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Saxena S, Roselli F, Singh K, Leptien K, Julien JP, Gros-Louis F, Caroni P

Neuroprotection through excitability and mTOR required in ALS motoneurons to delay disease and extend survival.

Journal Article

Neuron, 80 (1), pp. 80-96, 2013, ISSN: 0896-6273.

Abstract | Links:

Kabashi E, El Oussini H, Bercier V, Gros-Louis F, Valdmanis PN, McDearmid J, Mejier IA, Dion PA, Dupre N, Hollinger D, Sinniger J, Dirrig-Grosch S, Camu W, Meininger V, Loeffler JP, Rene F, Drapeau P, Rouleau GA, Dupuis L

Investigating the contribution of VAPB/ALS8 loss of function in amyotrophic lateral sclerosis.

Journal Article

Hum Mol Genet, 22 (12), pp. 2350-60, 2013, ISSN: 0964-6906.

Abstract | Links:

Berthod F, Gros-Louis F

In vivo and in vitro models to study amyotrophic lateral sclerosis (Chapter 4)

Book Chapter

M, Maurer (Ed.): Amyotrophic Lateral Sclerosis, pp. 81-124, InTech, 2012, ISBN: 978-953-307-806-9.

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Daoud H, Valdmanis PN, Gros-Louis F, Belzil V, Spiegelman D, Henrion E, Diallo O, Desjarlais A, Gauthier J, Camu W, Dion PA, Rouleau GA

Resequencing of 29 candidate genes in familial and sporadic ALS patients

Journal Article

Arch Neurol, 68 (5), 2011, ISSN: 0003-9942.

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Bosco DA, Morfini G, Karabacak NM, Song Y, Gros-Louis F, Pasinelli P, Goolsby H, Fontaine BA, Lemay N, McKenna-Yasek D, Frosch MP, Agar JN, Julien JP, Brady ST, Brown RH Jr

Wild-type and mutant SOD1 share an aberrant conformation and a common pathogenic pathway in ALS.

Journal Article

Nat Neurosci, 13 (11), pp. 1396-403, 2010, ISSN: 1097-6256.

Abstract | Links:

Gros-Louis F, Soucy G, Lariviere R, Julien JP

Intracerebroventricular infusion of monoclonal antibody or its derived Fab fragment against misfolded forms of SOD1 mutant delays mortality in a mouse model of ALS.

Journal Article

J Neurochem, 113 (5), pp. 1188-99, 2010, ISSN: 0022-3042.

Abstract | Links:

Gros-Louis F, Andersen PM, Dupre N, Urushitani M, Dion P, Souchon F, D'Amour M, Camu W, Meininger V, Bouchard JP, Rouleau GA, Julien JP

Chromogranin B P413L variant as risk factor and modifier of disease onset for amyotrophic lateral sclerosis.

Journal Article

Proc Natl Acad Sci U S A, 106 (51), pp. 21777-82, 2009, ISSN: 0027-8424.

Abstract | Links:

Gros-Louis F, Kriz J, Kabashi E, McDearmid J, Millecamps S, Urushitani M, Lin L, Dion P, Zhu Q, Drapeau P, Julien JP, Rouleau GA

Als2 mRNA splicing variants detected in KO mice rescue severe motor dysfunction phenotype in Als2 knock-down zebrafish.

Journal Article

Hum Mol Genet, 17 (17), pp. 2691-702, 2008, ISSN: 0964-6906.

Abstract | Links:

Dupre N, Gros-Louis F, Chrestian N, Verreault S, Brunet D, de Verteuil D, Brais B, Bouchard JP, Rouleau GA

Clinical and genetic study of autosomal recessive cerebellar ataxia type 1.

Journal Article

Ann Neurol, 62 (1), pp. 93-8, 2007, ISSN: 0364-5134.

Abstract | Links:

33 entries « 2 of 4 »
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Active projects

  • Centre de recherche du CHU de Québec - Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
  • Centre de recherche en organogenèse expérimentale, Subvention, Institutionnel - BDR, BDR - Centres de recherche reconnus, from 2011-05-01 to 2020-09-22
  • Centre thématique de recherche en neurosciences, Subvention, Institutionnel - BDR, BDR - Centres de recherche reconnus, from 1999-06-01 to 2023-05-01
  • Chaire de recherche du Canada en biomodélisation et traitement des maladies du cerveau, Subvention, Secrétariat des programmes interorganismes à l’intention des établissements, Chaires de recherche du Canada - Fonctionnement, from 2017-11-01 to 2022-10-31
  • Chaire de recherche sur les organes reconstruits en laboratoire et leurs applications cliniques, Subvention, Fondation de l'Université Laval, Chaires de recherche sans organismes subventionnaires, from 2013-05-01 to 2023-08-12
  • Design and testing of a next-generation tissue-engineered living human heart valve, Subvention, Secrétariat des programmes interorganismes à l’intention des établissements, Nouvelles frontières en recherche, from 2020-03-31 to 2022-03-30
  • Pathogenic Pathways and in-vitro modelization of Intracranial Aneurysms in populations of Inuit and French Canadian descent, Subvention, Instituts de recherche en santé du Canada, Subvention Projet, from 2017-04-01 to 2022-03-31
  • Renforcement de la plateforme de production de cellules souches induites à la pluripotence (IPSC) du CRCHU de Québec, Subvention, Ministère de l'Économie et de l'Innovation, Appel de projets en appui aux plateformes technologiques stratégiques, from 2019-12-05 to 2022-03-31
Data provided by the Université Laval research projects registery