Dr. François Gros-Louis is a regular researcher at the CHU Research Center of Québec-Laval University and Professor in the Department of Surgery of the School of Medicine at Laval University. Dr. Gros-Louis’ research activities are grouped together at the Multidisciplinary Center for Tissue Engineering (LOEX), a research center dedicated to organogenesis, stem cells, regenerative medicine and to the reconstruction of living human tissues and organs through tissue engineering. He holds the Canada Research Chair in Biomodeling and Treatment of Brain Diseases, and is the co-director of the induced pluripotent stem cell platform (iPSC).

Several neurological conditions such as neurodegenerative diseases and other brain diseases occupy a prominent place because of their severity and increasing frequency related to the aging of the population. One of the major obstacles to understanding the development of these diseases is the accessibility of neuronal tissues. Dr. Gros-Louis’ research, at the crossroads between basic research and clinical research, is positioned in a fast-growing research field that aims to reconstruct human tissue through tissue engineering, using patient-derived tissue, to model and better understand the pathophysiological mechanisms underlying these diseases. The main objective of his research program is to reconstruct by tissue engineering, from the patient’s own cells, organs / organoids (skins and blood vessels) whose histological, physiological and functional properties make it possible to reproduce the pathological signatures of various brain diseases (Amyotrophic Lateral Sclerosis (ALS), intracranial aneurysm and neurofibromatosis). The specific objectives are: 1) to identify new strategies for early diagnosis, 2) to study and monitor the progression of targeted diseases, 3) to evaluate the response to existing and future treatments, 4) to identify and understand pathogenic mechanisms, and 5) to identify specific biomarkers and to develop new therapeutic pathways. Dr. Gros-Louis has played a major role in the discovery and application of a novel method for the in vitro reconstruction of tissue, through tissue engineering, for the study of ALS, neurofibromatosis, and intracranial aneurysms.

1401, 18e Rue
Local R-211 LOEX / CMDGT
Québec, Québec
Canada G1J 1Z4
29 entries « 1 of 6 »

Pare B, Lehmann M, Beaudin M, Nordstrom U, Saikali S, Julien JP, Gilthorpe JD, Marklund SL, Cashman NR, Andersen PM, Forsberg K, Dupre N, Gould P, Brannstrom T, Gros-Louis F

Misfolded SOD1 pathology in sporadic Amyotrophic Lateral Sclerosis.

Journal Article

Sci Rep, 8 (1), pp. 14223, 2018, ISSN: 2045-2322.

Abstract | Links:

Pare B, Gros-Louis F

Potential skin involvement in ALS: revisiting Charcot's observation - a review of skin abnormalities in ALS.

Journal Article

Rev Neurosci, 28 (5), pp. 551-572, 2017, ISSN: 0334-1763.

Abstract | Links:

Ohta Y, Soucy G, Phaneuf D, Audet JN, Gros-Louis F, Rouleau GA, Blasco H, Corcia P, Andersen PM, Nordin F, Yamashita T, Abe K, Julien JP

Sex-dependent effects of chromogranin B P413L allelic variant as disease modifier in amyotrophic lateral sclerosis.

Journal Article

Hum Mol Genet, 25 (21), pp. 4771-4786, 2016, ISSN: 0964-6906.

Abstract | Links:

Pare B, Deschenes LT, Pouliot R, Dupre N, Gros-Louis F

An Optimized Approach to Recover Secreted Proteins from Fibroblast Conditioned-Media for Secretomic Analysis.

Journal Article

Front Cell Neurosci, 10 , pp. 70, 2016.

Abstract | Links:

Beaudet MJ, Yang Q, Cadau S, Blais M, Bellenfant S, Gros-Louis F, Berthod F

High yield extraction of pure spinal motor neurons, astrocytes and microglia from single embryo and adult mouse spinal cord.

Journal Article

Sci Rep, 5 , pp. 16763, 2015, ISSN: 2045-2322.

Abstract | Links:

29 entries « 1 of 6 »

Active projects

  • Centre de recherche en organogenèse expérimentale, Subvention, Institutionnel - BDR, BDR - Centres de recherche reconnus, from 2011-05-01 to 2020-09-22
  • Centre hospitalier universitaire de Québec - CHU de Québec-Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
  • Centre thématique de recherche en neurosciences, Subvention, Institutionnel - BDR, BDR - Centres de recherche reconnus, from 1999-06-01 to 2020-10-18
  • Chaire de recherche du Canada en biomodélisation et traitement des maladies du cerveau, Subvention, Secrétariat des programmes interorganismes à l’intention des établissements, Chaires de recherche du Canada - Fonctionnement, from 2017-11-01 to 2022-10-31
  • Chaire de recherche sur les organes reconstruits en laboratoire et leurs applications cliniques, Subvention, Fondation de l'Université Laval, Chaires de recherche sans organismes subventionnaires, from 2013-05-01 to 2023-04-30
  • Pathogenic Pathways and in-vitro modelization of Intracranial Aneurysms in populations of Inuit and French Canadian descent, Subvention, Instituts de recherche en santé du Canada, Subvention Projet, from 2017-04-01 to 2022-03-31
  • Tissue-engineered skin model of ALS to accelerate biomarkers and drug discoveries., Subvention, Weston Brain institute, Transformational Research, from 2016-01-15 to 2019-02-15

Recently finished projects

  • Chaire de recherche du Canada en biomodélisation et traitement des maladies neurodégénératives, Subvention, Secrétariat des Chaires de recherche du Canada, Chaires de recherche du Canada - Fonctionnement, from 2012-11-01 to 2017-10-31
  • Development of a tissue-engineered skin model derived from NF1 patients to study tumor genesis and to predict response to therapy, Subvention, Hospital for Sick Children Research Institute (The), from 2016-02-01 to 2017-03-31
  • Human inducible pluripotent stem cells (IPSC) plateform, Subvention, La Fondation Neuro Canada / Brain Canada, Soutien aux plateformes technologiques (SSPT), from 2015-04-01 to 2018-03-31
  • Infrastructure Gros-Louis, Partenariat, Secrétariat des Chaires de recherche du Canada, Fonds des leaders John-R.-Evans - CRC (anciennement : Chaires de recherche du Canada - infrastructure et Fonds des leaders - Volet 2), from 2012-12-01 to 2016-12-31
  • Recherche en neurochirurgie, Subvention, Fondation du CHU de Québec, from 2017-07-10 to 2018-03-31
  • Tissue-engineered in-vitro skin model to facilitate the identification of disease biomarkers for Amyotrophic Lateral Sclerosis., Subvention, Instituts de recherche en santé du Canada, Subvention de fonctionnement, from 2015-07-01 to 2016-06-30
Data provided by the Université Laval research projects registery