In addition to being the director of the Centre de recherche en Organogenèse Expérimentale/LOEX de l’Université Laval intégré au CHU de Québec, Dr. Auger is also a member of the Laval University Research Commission, and full professor in the department of surgery. In 1985, he founded the Burn Lab, which rapidly became the Experimental Organogenesis Laboratory (Laboratoire d’Organogénèse Expérimentale or LOEX), working on various technologies to develop skin substitutes. In response to the needs of treating surgeons, the LOEX continued to produce autologous skin substitutes via tissue engineering for burn victims from Montreal, Quebec and outside the province. The lab has thus generated over 200 scientific publications.

Dr. Auger’s remarkable achievements have led him receive the distinction of Chevalier de l’Ordre National du Québec in 2003 for the development of exceptional expertise in tissue engineering. He was received as a member of the Canadian Academy of Health Sciences as well as for l’Académie des Grands Québécois of the Quebec Chamber of Commerce. He received the Gloire de l’Escolle Medal, a distinction given to an honorable graduate of Laval University having distinguished himself in his profession. Dr. Auger also received the medal of excellence from the Collège des médecins du Québec.

Area of research

  • Tissue engineering and regenerative medicine.

 

Research thematic

  • In vitro biological applications of reconstructed tissue-engineering substitutes: physiology, pathophysiology, pharmacology, toxicology.
  • In vivo preclinical and clinical applications of tissue substitutes in the form of tissue constructions and cell therapy.
  • Reconstructed substitutes produced by tissue engineering for skin, small blood vessels, the cornea and bone tissue.

 

Research interests

  • Reconstruction of human tissue, wound healing, stem cells, cellular and molecular biology.
  • Skin, bone, vascular and corneal substitutes produced through tissue engineering.
  • Transplantation.

Translational research

Although interested by the work done by LOEX, Dr. Auger’s scientific projects are specifically linked to tissue engineering for skin, corneal, vascular (small blood vessels), bone and heart valves. Dr. Auger works in a 55,000 sq. ft. infrastructure with tissue engineering and regenerative medicine cleanrooms, to continue to improve on the technology of reconstructed skin tissue. He is involved in a clinical trial using bilamellar skin substitutes to treat burn victims.

Micro blood vessel, lymphatics, and melanoma modelling

Dr. Auger’s discoveries on the formation of capillary blood networks allow us to now reconstruct tissues in the lab that are biologically more representative of native tissue. A discovery was recently the subject of two publications in Biomaterials and Nature Protocols, i.e. achieving lymphatic capillary networks in reconstructed tissue. Whether to improve our understanding of fundamental physiological mechanisms, or to work as a study model for complex pathologies such as melanoma, this discovery opens some new and original research options and puts the team in a positive position where they can use research tools that are more representative than the well-known in vitro models, while also being more simple, affordable, and ethically accepted than animal study models.

1401, 18e Rue
Bureau: R-105, LOEX / CMDGT
Québec, Québec
Canada G1J 1Z4
180 entries « 2 of 18 »

Bourget JM, Laterreur V, Gauvin R, Guillemette MD, Miville-Godin C, Mounier M, Tondreau MY, Tremblay C, Labbe R, Ruel J, Auger FA, Veres T, Germain L

Microstructured human fibroblast-derived extracellular matrix scaffold for vascular media fabrication.

Journal Article

J Tissue Eng Regen Med, 11 (9), pp. 2479-2489, 2017, ISSN: 1932-6254.

Abstract | Links:

Beaudoin Cloutier C, Goyer B, Perron C, Guignard R, Larouche D, Moulin VJ, Germain L, Gauvin R, Auger FA

In Vivo Evaluation and Imaging of a Bilayered Self-Assembled Skin Substitute Using a Decellularized Dermal Matrix Grafted on Mice.

Journal Article

Tissue Eng Part A, 23 (7-8), pp. 313-322, 2017, ISSN: 1937-3341.

Abstract | Links:

Gibot L, Galbraith T, Bourland J, Rogic A, Skobe M, Auger FA

Tissue-engineered 3D human lymphatic microvascular network for in vitro studies of lymphangiogenesis.

Journal Article

Nat Protoc, 12 (5), pp. 1077-1088, 2017.

Abstract | Links:

Gibot L, Galbraith T, Kloos B, Das S, Lacroix DA, Auger FA, Skobe M

Cell-based approach for 3D reconstruction of lymphatic capillaries in vitro reveals distinct functions of HGF and VEGF-C in lymphangiogenesis.

Journal Article

Biomaterials, 78 , pp. 129-39, 2016, ISSN: 0142-9612.

Abstract | Links:

Larouche D, Cantin-Warren L, Desgagne M, Guignard R, Martel I, Ayoub A, Lavoie A, Gauvin R, Auger FA, Moulin VJ, Germain L

Improved Methods to Produce Tissue-Engineered Skin Substitutes Suitable for the Permanent Closure of Full-Thickness Skin Injuries.

Journal Article

Biores Open Access, 5 (1), pp. 320-329, 2016, ISSN: 2164-7844.

Abstract | Links:

Tondreau MY, Laterreur V, Vallieres K, Gauvin R, Bourget JM, Tremblay C, Lacroix D, Germain L, Ruel J, Auger FA

In Vivo Remodeling of Fibroblast-Derived Vascular Scaffolds Implanted for 6 Months in Rats.

Journal Article

Biomed Res Int, 2016 , pp. 3762484, 2016.

Abstract | Links:

Beaudoin Cloutier C, Guignard R, Bernard G, Gauvin R, Larouche D, Lavoie A, Lacroix D, Moulin VJ, Germain L, Auger FA

Production of a Bilayered Self-Assembled Skin Substitute Using a Tissue-Engineered Acellular Dermal Matrix.

Journal Article

Tissue Eng Part C Methods, 21 (12), pp. 1297-305, 2015, ISSN: 1937-3384.

Abstract | Links:

Vallieres K, Laterreur V, Tondreau MY, Ruel J, Germain L, Fradette J, Auger FA

Human adipose-derived stromal cells for the production of completely autologous self-assembled tissue-engineered vascular substitutes.

Journal Article

Acta Biomater, 24 , pp. 209-19, 2015, ISSN: 1742-7061.

Abstract | Links:

Tondreau MY, Laterreur V, Gauvin R, Vallieres K, Bourget JM, Lacroix D, Tremblay C, Germain L, Ruel J, Auger FA

Mechanical properties of endothelialized fibroblast-derived vascular scaffolds stimulated in a bioreactor.

Journal Article

Acta Biomater, 18 , pp. 176-85, 2015, ISSN: 1742-7061.

Abstract | Links:

Bisson F, Paquet C, Bourget JM, Zaniolo K, Rochette PJ, Landreville S, Damour O, Boudreau F, Auger FA, Guerin SL, Germain L

Contribution of Sp1 to Telomerase Expression and Activity in Skin Keratinocytes Cultured With a Feeder Layer.

Journal Article

J Cell Physiol, 230 (2), pp. 308-17, 2015, ISSN: 0021-9541.

Abstract | Links:

180 entries « 2 of 18 »
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Active projects

  • Centre de recherche du CHU de Québec - Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
  • Centre de recherche en organogenèse expérimentale, Subvention, Institutionnel - BDR, BDR - Centres de recherche reconnus, from 2011-05-01 to 2020-09-22

Recently finished projects

  • Soutien aux projets de recherche en génie tissulaire, Subvention, Fondation du CHU de Québec, from 2014-04-01 to 2019-03-31
Data provided by the Université Laval research projects registery