In addition to being the director of the Centre de recherche en Organogenèse Expérimentale/LOEX de l’Université Laval intégré au CHU de Québec, Dr. Auger is also a member of the Laval University Research Commission, and full professor in the department of surgery. In 1985, he founded the Burn Lab, which rapidly became the Experimental Organogenesis Laboratory (Laboratoire d’Organogénèse Expérimentale or LOEX), working on various technologies to develop skin substitutes. In response to the needs of treating surgeons, the LOEX continued to produce autologous skin substitutes via tissue engineering for burn victims from Montreal, Quebec and outside the province. The lab has thus generated over 200 scientific publications.

Dr. Auger’s remarkable achievements have led him receive the distinction of Chevalier de l’Ordre National du Québec in 2003 for the development of exceptional expertise in tissue engineering. He was received as a member of the Canadian Academy of Health Sciences as well as for l’Académie des Grands Québécois of the Quebec Chamber of Commerce. He received the Gloire de l’Escolle Medal, a distinction given to an honorable graduate of Laval University having distinguished himself in his profession. Dr. Auger also received the medal of excellence from the Collège des médecins du Québec.

Area of research

  • Tissue engineering and regenerative medicine.

 

Research thematic

  • In vitro biological applications of reconstructed tissue-engineering substitutes: physiology, pathophysiology, pharmacology, toxicology.
  • In vivo preclinical and clinical applications of tissue substitutes in the form of tissue constructions and cell therapy.
  • Reconstructed substitutes produced by tissue engineering for skin, small blood vessels, the cornea and bone tissue.

 

Research interests

  • Reconstruction of human tissue, wound healing, stem cells, cellular and molecular biology.
  • Skin, bone, vascular and corneal substitutes produced through tissue engineering.
  • Transplantation.

Translational research

Although interested by the work done by LOEX, Dr. Auger’s scientific projects are specifically linked to tissue engineering for skin, corneal, vascular (small blood vessels), bone and heart valves. Dr. Auger works in a 55,000 sq. ft. infrastructure with tissue engineering and regenerative medicine cleanrooms, to continue to improve on the technology of reconstructed skin tissue. He is involved in a clinical trial using bilamellar skin substitutes to treat burn victims.

Micro blood vessel, lymphatics, and melanoma modelling

Dr. Auger’s discoveries on the formation of capillary blood networks allow us to now reconstruct tissues in the lab that are biologically more representative of native tissue. A discovery was recently the subject of two publications in Biomaterials and Nature Protocols, i.e. achieving lymphatic capillary networks in reconstructed tissue. Whether to improve our understanding of fundamental physiological mechanisms, or to work as a study model for complex pathologies such as melanoma, this discovery opens some new and original research options and puts the team in a positive position where they can use research tools that are more representative than the well-known in vitro models, while also being more simple, affordable, and ethically accepted than animal study models.

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Kawecki F, Galbraith T, Clafshenkel WP, Fortin M, Auger FA, Fradette J

In Vitro Prevascularization of Self-Assembled Human Bone-Like Tissues and Preclinical Assessment Using a Rat Calvarial Bone Defect Model.

Journal Article

Materials (Basel), 14 (8), 2021.

Abstract | Links:

Kawecki F, Mayrand D, Ayoub A, Attiogbe E, Germain L, Auger FA, Moulin VJ

Biofabrication and preclinical evaluation of a large-sized human self-assembled skin substitute.

Journal Article

Biomed Mater, 16 (2), 2021.

Abstract | Links:

Ghadhab S, Bilem I, Guay-Bégin AA, Chevallier P, Auger FA, Ruel J, Pauthe E, Laroche G

Fibronectin grafting to enhance skin sealing around transcutaneous titanium implant.

Journal Article

J Biomed Mater Res A, 109 (11), 2021.

Abstract | Links:

Dorr MM, Guignard R, Auger FA, Rochette PJ

The use of tissue-engineered skin to demonstrate the negative effect of CXCL5 on epidermal ultraviolet radiation-induced cyclobutane pyrimidine dimer repair efficiency.

Journal Article

Br J Dermatol, 184 (1), 2021.

Abstract | Links:

Roy V, Magne B, Vaillancourt-Audet M, Blais M, Chabaud S, Grammond E, Piquet L, Fradette J, Laverdiere I, Moulin VJ, Landreville S, Germain L, Auger FA, Gros-Louis F, Bolduc S

Human Organ-Specific 3D Cancer Models Produced by the Stromal Self-Assembly Method of Tissue Engineering for the Study of Solid Tumors.

Journal Article

Biomed Res Int, 2020 , 2020.

Abstract | Links:

Goyer B, Larouche D, Kim DH, Veillette N, Pruneau V, Bernier V, Auger FA, Germain L

Immune tolerance of tissue-engineered skin produced with allogeneic or xenogeneic fibroblasts and syngeneic keratinocytes grafted on mice.

Journal Article

Acta Biomater, 90 , 2019.

Abstract | Links:

Galbraith T, Roy V, Bourget JM, Tsutsumi T, Picard-Deland M, Morin JF, Gauvin R, Ismail AA, Auger FA, Gros-Louis F

Cell Seeding on UV-C-Treated 3D Polymeric Templates Allows for Cost-Effective Production of Small-Caliber Tissue-Engineered Blood Vessels.

Journal Article

Biotechnol J, 14 (1), 2019.

Abstract | Links:

Bourland J, Mayrand D, Tremblay N, Moulin VJ, Fradette J, Auger FA

Isolation and Culture of Human Dermal Microvascular Endothelial Cells.

Journal Article

Methods Mol Biol, 1993 , 2019.

Abstract | Links:

Sener A, Anderson CC, Auger FA, Barralet J, Brindle M, Cayabyab FS, Fehlings MG, Lacombe L, Perrault LP, Sabbagh R, Seely AJ, Wallace C, Ellsmere J, Keijzer R

Best practices for enhancing surgical research: a perspective from the Canadian Association of Chairs of Surgical Research

Journal Article

Can J Surg, 62 (6), 2019.

Abstract | Links:

Cantin-Warren L, Guignard R, Cortez Ghio S, Larouche D, Auger FA, Germain L

Specialized Living Wound Dressing Based on the Self-Assembly Approach of Tissue Engineering.

Journal Article

J Funct Biomater, 9 (3), 2018.

Abstract | Links:

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Active projects

  • Cultured epithelial corneal autografts for the treatment of canadians with limbal stem cell deficiency, from 2020-01-01 to 2023-01-31
  • Self-Assembly Skin Substitutes (SASS) for the treatment of acute wounds of Canadian burn patients, from 2020-01-01 to 2022-01-31

Recently finished projects

  • Centre du génie tissulaire (CHU de Québec - Université Laval), from 2019-04-01 to 2021-03-31
Data provided by the Université Laval research projects registery