Dr. Éric Vigneault is a radiation oncologist-clinician in the Department of Radiation Oncology at CHUQ, and a researcher in the oncology axis of the CHU Research Centre of Laval University-Quebec, affiliated with the Centre for Cancer Research at Laval University.

He is also Associate Clinical Professor in the Department of Medicine of the Faculty of Medicine at Laval University. Dr. Vigneault has been actively involved in the development of the first Iodine-125 prostate brachytherapy program in Canada, and is the pioneer of high dose-rate, non-permanent brachytherapy in Canada. He is the principal investigator of randomized phase II CCTG studies, comparing HDR brachytherapy with conventional radiotherapy in the treatment of intermediate-risk prostatic cancers (PR15), and comparing HDR brachytherapy with LDR monotherapy (PR19).

Dr. Vigneault is deeply involved at the national level, including as the former President of the Canadian Association of Radiation Oncologists, as a member of the Steering Committee of the Canadian Urologic Oncology Group (CUOG), as well as internationally as the Associate Editor of the Brachytherapy journal.

Since 2015, he holds the Research Chair in Image-guided Brachytherapy, whose mission is to integrate technological advances in the field of imaging, computer science, dosimetry optimization, radioactive source implantation systems, as well as clinical expertise to improve brachytherapy treatments for solid tumors, thereby promoting a better therapeutic ratio – i.e., an increase in tumor control and a decrease in toxicity. This research Chair is part of Laval University’s Program for the Advancement of Innovation, Research and Teaching, which aims to create a research environment that stimulates innovation, inventiveness and creativity among research professors.

The objectives of the Chair are:

  1. Improve the integration of real-time imaging, implantation and dosimetry systems to improve the quality and accuracy of radioactive material implantation in cancers.
  2. Develop protocols for treating tumor sites by brachytherapy.
  3. Promote clinical research to evaluate and compare tumor controls, toxicities, and quality of life assessment with conventional treatment, including dissemination of results and knowledge transfer;
  4. Promote the education and training of graduate students and fellows in the field of brachytherapy;
  5. Develop clinical databases of tissue banks collected to support translational research.
L'Hôtel-Dieu de Québec
Hôtel-Dieu de Québec
11, Côte du Palais, Bureau 3336
Québec, Québec
Canada G1R 2J6
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Michalski JM, Moughan J, Purdy J, Bosch W, Bruner DW, Bahary JP, Lau H, Duclos M, Parliament M, Morton G, Hamstra D, Seider M, Lock MI, Patel M, Gay H, Vigneault E, Winter K, Sandler H

Effect of Standard vs Dose-Escalated Radiation Therapy for Patients With Intermediate-Risk Prostate Cancer: The NRG Oncology RTOG 0126 Randomized Clinical Trial.

Journal Article

JAMA Oncol, 4 (6), pp. e180039, 2018.

Abstract | Links:

Vigneault E, Morton G, Parulekar WR, Niazi TM, Springer CW, Barkati M, Chung P, Koll W, Kamran A, Monreal M, Ding K, Loblaw A

Randomised Phase II Feasibility Trial of Image-guided External Beam Radiotherapy With or Without High Dose Rate Brachytherapy Boost in Men with Intermediate-risk Prostate Cancer (CCTG PR15/ NCT01982786).

Journal Article

Clin Oncol (R Coll Radiol), 2018, ISSN: 0936-6555.

Abstract | Links:

Vigneault E, Martell K, Taussky D, Husain S, Delouya G, Mbodji K, Piotte J, Magnan S, Despres P, Lavallee MC, Aubin S, Beaulieu L, Foster W, Martin AG

Does Seed Migration Increase the Risk of Second Malignancies in Prostate Cancer Patients Treated With Iodine-125 Loose Seeds Brachytherapy?

Journal Article

Int J Radiat Oncol Biol Phys, 100 (5), pp. 1190-1194, 2018, ISSN: 0360-3016.

Abstract | Links:

Beaulieu L, Racine E, Han DY, Vigneault E, Hsu IC, Cunha JAM

Real-time electromagnetic tracking-based treatment platform for high-dose-rate prostate brachytherapy: Clinical workflows and end-to-end validation.

Journal Article

Brachytherapy, 17 (1), pp. 103-110, 2018, ISSN: 1538-4721.

Abstract | Links:

Fakhry C, Zhang Q, Nguyen-Tan PF, Rosenthal DI, Weber RS, Lambert L, Trotti AM 3rd, Barrett WL, Thorstad WL, Jones CU, Yom SS, Wong SJ, Ridge JA, Rao SSD, Bonner JA, Vigneault E, Raben D, Kudrimoti MR, Harris J, Le QT, Gillison ML

Development and Validation of Nomograms Predictive of Overall and Progression-Free Survival in Patients With Oropharyngeal Cancer.

Journal Article

J Clin Oncol, 35 (36), pp. 4057-4065, 2017, ISSN: 0732-183X.

Abstract | Links:

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Active projects

  • (FRSQ 78415)Evaluation of sphingolipid cermide and intracellular signaling markers of prostate ... prostate cancer receiving a hypofractionation regimen treatment combined with a high dose rate brachytherapy boost., Subvention, Canadian Urologic Oncology Group, from 2017-08-22 to 2018-08-21
  • Centre de recherche sur le cancer, Subvention, Institutionnel - BDR, BDR - Centres de recherche reconnus, from 1996-05-01 to 2023-04-30
  • Centre hospitalier universitaire de Québec - CHU de Québec-Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
  • Chaire de recherche sur la curiethérapie guidée par imagerie (Fondation UL-0610), Subvention, Fondation de l'Université Laval, Chaires de recherche sans organismes subventionnaires, from 2015-05-01 to 2022-03-31

Recently finished projects

  • (FRSQ 73029)A Pilot phase II randomized trial evaluating acute and late toxicity of High-Dose Rate brachytherapy and Low-Dose Rate brachytherapy as monotherapy in localized prostate cancer. , Subvention, Association canadienne de radio-oncologie, from 2015-04-27 to 2016-04-26
  • (FRSQ 76109) Acquisition de systèmes robotisés guidés par imagerie ultrason (traitement de curiethérapie), Subvention, Fondation du CHU de Québec, from 2016-04-01 to 2017-03-31
  • Détresse et satisfactions face au processus informationnel et décisionnel lors d'un cancer de la prostate localisé, Subvention, Fondation de l'Université Laval, from 2017-02-01 to 2018-03-31
  • Radiotherapy and Androgen Deprovation in Combination After Local Surgery. A randomized controlled trial in prostate cancer, Subvention, L'Institut de recherche de la Société canadienne du cancer, from 2007-09-27 to 2017-09-27
Data provided by the Université Laval research projects registery