Dr. Eric Boilard, PhD, is a recipient of a CIHR award, Associate Professor in the Department of Microbiology and Immunology at the Laval University School of Medicine, and a researcher at the CHU de Québec Research Center. He is also a researcher with the Canadian National Transplant Research Program (CNTRP), where he is co-leader and consulting member of the international group Systemic Lupus Collaborating Clinics (SLICC).

He obtained his PhD in Microbiology and Immunology from Laval University (2003) and pursued postdoctoral trainings at the Université de Nice-Sophia-Antipolis (2003-2006) and at Harvard University at Brigham and Women’s Hospital (2006-2010). It was during his studies at Harvard that Dr. Boilard highlighted the role of platelets in rheumatoid arthritis (Boilard et al., Science 2010).

His research aims to better understand the pathogenesis of rheumatic diseases, and to improve the success of blood transplants and transfusions to develop new therapeutics and biomarkers. He investigates how platelets and the small extracellular vesicles they produce, called microparticles, contribute to the inflammatory responses in place in rheumatoid arthritis, lupus, and the cases of immune responses involved in transplant rejection and adverse reactions related to transfusions. He conducts clinical research with patients and mouse models of disease.

He is an internationally renowned scientist and lecturer recognized by his peers. He won the Radio-Canada Award for the greatest medical discovery of the year (2011 and 2013), the Radio-Canada and Le Soleil Award of the Scientist of the Year (2011), and is the recipient of the André Dupont Award for Quebec’s most prolific young researcher (2017). His work is in part funded by the CIHR Foundation Program (Platelets and their microparticles: versatile players of inflammation) and NSERC.

CHUL
2705, boulevard Laurier
T-1-49
Québec, Québec
Canada G1V 4G2
85 entries « 8 of 9 »

Boilard E, Lai Y, Larabee K, Balestrieri B, Ghomashchi F, Fujioka D, Gobezie R, Coblyn JS, Weinblatt ME, Massarotti EM, Thornhill TS, Divangahi M, Remold H, Lambeau G, Gelb MH, Arm JP, Lee DM

A novel anti-inflammatory role for secretory phospholipase A2 in immune complex-mediated arthritis.

Journal Article

EMBO Mol Med, 2 (5), pp. 172-87, 2010, ISSN: 1757-4676.

Abstract | Links:

Boilard E, Nigrovic PA, Larabee K, Watts GF, Coblyn JS, Weinblatt ME, Massarotti EM, Remold-O'Donnell E, Farndale RW, Ware J, Lee DM

Platelets amplify inflammation in arthritis via collagen-dependent microparticle production.

Journal Article

Science, 327 (5965), pp. 580-3, 2010, ISSN: 0036-8075.

Abstract | Links:

Surrel F, Jemel I, Boilard E, Bollinger JG, Payre C, Mounier CM, Talvinen KA, Laine VJ, Nevalainen TJ, Gelb MH, Lambeau G

Group X phospholipase A2 stimulates the proliferation of colon cancer cells by producing various lipid mediators.

Journal Article

Mol Pharmacol, 76 (4), pp. 778-90, 2009, ISSN: 0026-895X.

Abstract | Links:

Guichard G, Lena G, Boeglin J, Muller P, Boilard E, Lambeau G, Rognan D, Didierjean C

1,3,5-Triazepan-2,6-diones as conformationally constrained dipeptide mimetics. In silico guided identification of sPLA2 inhibitors.

Journal Article

Adv Exp Med Biol, 611 , pp. 201-2, 2009, ISSN: 0065-2598.

| Links:

Shin K, Nigrovic PA, Crish J, Boilard E, McNeil HP, Larabee KS, Adachi R, Gurish MF, Gobezie R, Stevens RL, Lee DM

Mast cells contribute to autoimmune inflammatory arthritis via their tryptase/heparin complexes.

Journal Article

J Immunol, 182 (1), pp. 647-56, 2009, ISSN: 0022-1767.

Abstract | Links:

Chen M, Boilard E, Nigrovic PA, Clark P, Xu D, Fitzgerald GA, Audoly LP, Lee DM

Predominance of cyclooxygenase 1 over cyclooxygenase 2 in the generation of proinflammatory prostaglandins in autoantibody-driven K/BxN serum-transfer arthritis.

Journal Article

Arthritis Rheum, 58 (5), pp. 1354-65, 2008, ISSN: 0004-3591.

Abstract | Links:

Touaibia M, Djimde A, Cao F, Boilard E, Bezzine S, Lambeau G, Redeuilh C, Lamouri A, Massicot F, Chau F, Dong CZ, Heymans F

Inhibition of secreted phospholipase A2. 4-glycerol derivatives of 4,5-dihydro-3-(4-tetradecyloxybenzyl)-1,2,4-4H-oxadiazol-5-one with broad activities.

Journal Article

J Med Chem, 50 (7), pp. 1618-26, 2007, ISSN: 0022-2623.

Abstract | Links:

Rouault M, Le Calvez C, Boilard E, Surrel F, Singer A, Ghomashchi F, Bezzine S, Scarzello S, Bollinger J, Gelb MH, Lambeau G

Recombinant production and properties of binding of the full set of mouse secreted phospholipases A2 to the mouse M-type receptor.

Journal Article

Biochemistry, 46 (6), pp. 1647-62, 2007, ISSN: 0006-2960.

Abstract | Links:

Muller P, Lena G, Boilard E, Bezzine S, Lambeau G, Guichard G, Rognan D

In silico-guided target identification of a scaffold-focused library: 1,3,5-triazepan-2,6-diones as novel phospholipase A2 inhibitors.

Journal Article

J Med Chem, 49 (23), pp. 6768-78, 2006, ISSN: 0022-2623.

Abstract | Links:

Boilard E, Rouault M, Surrel F, Le Calvez C, Bezzine S, Singer A, Gelb MH, Lambeau G

Secreted phospholipase A2 inhibitors are also potent blockers of binding to the M-type receptor.

Journal Article

Biochemistry, 45 (44), pp. 13203-18, 2006, ISSN: 0006-2960.

Abstract | Links:

85 entries « 8 of 9 »
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Active projects

  • Centre de recherche en arthrite de l'Université Laval, Subvention, Institutionnel - BDR, BDR - Entités de recherche en émergence, from 2019-01-01 to 2020-01-31
  • Centres hospitaliers universitaires de Québec - Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
  • Contribution of phospholipase A2 enzymes in the homeostasis of the immune system., Subvention, Conseil de recherches en sciences naturelles et génie Canada, Subventions à la découverte SD (individuelles et d'équipe), from 2016-04-01 to 2023-03-31
  • Mapping anti-mitochondrial antibodies in systemic lupus erythematosus, Subvention, Instituts de recherche en santé du Canada, Subvention Projet, from 2019-04-01 to 2022-03-31
  • Pathogenic roles of platelets in sepsis, Subvention, Instituts de recherche en santé du Canada, Subvention Projet, from 2019-04-01 to 2020-03-31
  • Platelets and their microparticles: versatile players of inflammation., Subvention, Instituts de recherche en santé du Canada, Subventions Fondation, from 2015-07-01 to 2020-06-30
  • Role of autotaxin bound to platelet-derived microparticles to development of vascular damage in arthritis., Subvention, Instituts de recherche en santé du Canada, Subvention de fonctionnement, from 2015-07-01 to 2020-06-30
  • The Canadian National Transplant Research Program : Increasing Donation and Improving Transplantation Outcomes, Subvention, Instituts de recherche en santé du Canada, Autre : Recherche sur la transplantation, from 2013-04-01 to 2022-03-31
  • The role of platelets in rheumatoid arthritis- an animated journey in the arthritic joint, Subvention, Instituts de recherche en santé du Canada, Subventions de planification et dissémination – Programme d’appui communautaire des instituts, from 2019-05-01 to 2020-04-30

Recently finished projects

  • Erythrocyte-derived extracellular vesicles: A biomarker of Parkinson's disease progression, Subvention, Weston Brain institute, Rapid Response, from 2017-03-01 to 2018-11-28
  • Études des vésicules extracellulaires de plaquettes contenant des organelles dans un contexte de transfusion, Partenariat, MITACS Inc., Bourse de recherche Mitacs Globalink, from 2019-03-18 to 2019-08-15
  • Functions of platelets and microparticles in inflammation., Subvention, Instituts de recherche en santé du Canada, Bourse salariale pour nouveau chercheur, from 2014-08-01 to 2019-07-31
  • Propriétés immunomodulatrices de l'activité bactéricide de la phospholipase A2-IIA sécrétée sur le microbiote, Subvention, MITACS Inc., Bourse de recherche Mitacs Globalink, from 2019-03-18 to 2019-08-14
Data provided by the Université Laval research projects registery