Dr. Eric Boilard, PhD, is a recipient of a CIHR award, Associate Professor in the Department of Microbiology and Immunology at the Laval University School of Medicine, and a researcher at the CHU de Québec Research Center. He is also a researcher with the Canadian National Transplant Research Program (CNTRP), where he is co-leader and consulting member of the international group Systemic Lupus Collaborating Clinics (SLICC).

He obtained his PhD in Microbiology and Immunology from Laval University (2003) and pursued postdoctoral trainings at the Université de Nice-Sophia-Antipolis (2003-2006) and at Harvard University at Brigham and Women’s Hospital (2006-2010). It was during his studies at Harvard that Dr. Boilard highlighted the role of platelets in rheumatoid arthritis (Boilard et al., Science 2010).

His research aims to better understand the pathogenesis of rheumatic diseases, and to improve the success of blood transplants and transfusions to develop new therapeutics and biomarkers. He investigates how platelets and the small extracellular vesicles they produce, called microparticles, contribute to the inflammatory responses in place in rheumatoid arthritis, lupus, and the cases of immune responses involved in transplant rejection and adverse reactions related to transfusions. He conducts clinical research with patients and mouse models of disease.

He is an internationally renowned scientist and lecturer recognized by his peers. He won the Radio-Canada Award for the greatest medical discovery of the year (2011 and 2013), the Radio-Canada and Le Soleil Award of the Scientist of the Year (2011), and is the recipient of the André Dupont Award for Quebec’s most prolific young researcher (2017). His work is in part funded by the CIHR Foundation Program (Platelets and their microparticles: versatile players of inflammation) and NSERC.

CHUL
2705, boulevard Laurier
T-1-49
Québec, Québec
Canada G1V 4G2
85 entries « 1 of 9 »

Boilard E

Osteopontin makes the bridge in TRALI.

Journal Article

Blood, 134 (1), pp. 4-6, 2019, ISSN: 0006-4971.

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Marcoux G, Magron A, Sut C, Laroche A, Laradi S, Hamzeh-Cognasse H, Allaeys I, Cabon O, Julien AS, Garraud O, Cognasse F, Boilard E

Platelet-derived extracellular vesicles convey mitochondrial DAMPs in platelet concentrates and their levels are associated with adverse reactions.

Journal Article

Transfusion, 59 (7), pp. 2403-2414, 2019, ISSN: 0041-1132.

Abstract | Links:

Puhm F, Afonyushkin T, Resch U, Obermayer G, Rohde M, Penz T, Schuster M, Wagner G, Rendeiro AF, Melki I, Kaun C, Wojta J, Bock C, Jilma B, Mackman N, Boilard E, Binder CJ

Mitochondria Are a Subset of Extracellular Vesicles Released by Activated Monocytes and Induce Type I IFN and TNF Responses in Endothelial Cells.

Journal Article

Circ Res, 125 (1), pp. 43-52, 2019, ISSN: 0009-7330.

Abstract | Links:

Dore E, Boilard E

Roles of secreted phospholipase A2 group IIA in inflammation and host defense.

Journal Article

Biochim Biophys Acta Mol Cell Biol Lipids, 1864 (6), pp. 789-802, 2019, ISSN: 1388-1981.

Abstract | Links:

Duchez AC, Boudreau LH, Naika GS, Rousseau M, Cloutier N, Levesque T, Gelb MH, Boilard E

Respective contribution of cytosolic phospholipase A2alpha and secreted phospholipase A2 IIA to inflammation and eicosanoid production in arthritis.

Journal Article

Prostaglandins Other Lipid Mediat, 143 , pp. 106340, 2019, ISSN: 1098-8823.

Abstract | Links:

Hardy MP, Audemard E, Migneault F, Feghaly A, Brochu S, Gendron P, Boilard E, Major F, Dieude M, Hebert MJ, Perreault C

Apoptotic endothelial cells release small extracellular vesicles loaded with immunostimulatory viral-like RNAs.

Journal Article

Sci Rep, 9 (1), pp. 7203, 2019, ISSN: 2045-2322.

Abstract | Links:

Boilard E, Flamand L

The role of the megakaryocyte in immunity has gone viral.

Journal Article

Blood, 133 (19), pp. 2001-2002, 2019, ISSN: 0006-4971.

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Cunin P, Bouslama R, Machlus KR, Martinez-Bonet M, Lee PY, Wactor A, Nelson-Maney N, Morris A, Guo L, Weyrich A, Sola-Visner M, Boilard E, Italiano JE, Nigrovic PA

Megakaryocyte emperipolesis mediates membrane transfer from intracytoplasmic neutrophils to platelets.

Journal Article

Elife, 8 , 2019, ISSN: 2050-084X.

Abstract | Links:

Becker Y, Loignon RC, Julien AS, Marcoux G, Allaeys I, Levesque T, Rollet-Labelle E, Benk-Fortin H, Cloutier N, Melki I, Eder L, Wagner E, Pelletier M, Hajj HE, Tremblay ME, Belleannee C, Hebert MJ, Dieude M, Rauch J, Fortin PR, Boilard E

Anti-mitochondrial autoantibodies in systemic lupus erythematosus and their association with disease manifestations.

Journal Article

Sci Rep, 9 (1), pp. 4530, 2019, ISSN: 2045-2322.

Abstract | Links:

Denis HL, Lamontagne-Proulx J, St-Amour I, Mason SL, Rowley JW, Cloutier N, Tremblay ME, Vincent AT, Gould PV, Chouinard S, Weyrich AS, Rondina MT, Barker RA, Boilard E, Cicchetti F

Platelet abnormalities in Huntington's disease.

Journal Article

J Neurol Neurosurg Psychiatry, 90 (3), pp. 272-283, 2019, ISSN: 0022-3050.

Abstract | Links:

85 entries « 1 of 9 »
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Active projects

  • Centre de recherche en arthrite de l'Université Laval, Subvention, Institutionnel - BDR, BDR - Entités de recherche en émergence, from 2019-01-01 to 2020-01-31
  • Centre hospitalier universitaire de Québec - Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
  • Contribution of phospholipase A2 enzymes in the homeostasis of the immune system., Subvention, Conseil de recherches en sciences naturelles et génie Canada, Subventions à la découverte SD (individuelles et d'équipe), from 2016-04-01 to 2021-03-31
  • Functions of platelets and microparticles in inflammation., Subvention, Instituts de recherche en santé du Canada, Bourse salariale pour nouveau chercheur, from 2014-08-01 to 2019-07-31
  • Platelets and their microparticles: versatile players of inflammation., Subvention, Instituts de recherche en santé du Canada, Subventions Fondation, from 2015-07-01 to 2020-06-30
  • Role of autotaxin bound to platelet-derived microparticles to development of vascular damage in arthritis., Subvention, Instituts de recherche en santé du Canada, Subvention de fonctionnement, from 2015-07-01 to 2020-06-30

Recently finished projects

  • Erythrocyte-derived extracellular vesicles: A biomarker of Parkinson's disease progression, Subvention, Weston Brain institute, Rapid Response, from 2017-03-01 to 2018-11-28
  • Release, delivery and cell programming effects of platelet microparticles and microRNAs., Subvention, Instituts de recherche en santé du Canada, Subvention de fonctionnement, from 2014-10-01 to 2018-03-31
  • Role of extracellular mitochondria in adverse transfusion reaction, Partenariat, MITACS Inc., Accélération Québec (MITACS/FQRNT), from 2015-05-21 to 2017-11-30
  • Role of extracellular mitochondria in adverse transfusion reactions- A prospective study. (FONDS 0493), Subvention, Fondation de l'Université Laval, from 2014-11-05 to 2017-10-31
  • The Canadian National Transplant Research Program : Increasing Donation and Improving Transplantation Outcomes, Subvention, Instituts de recherche en santé du Canada, Autre : Recherche sur la transplantation, from 2013-04-01 to 2018-03-31
Data provided by the Université Laval research projects registery