Dr. Eric Biron, PhD, is a Regular Researcher at the CHU de Québec Research Center and Full Professor at the Faculty of Pharmacy of Laval University. Recognized for his contributions in peptide chemistry, combinatorial chemistry and antimicrobial peptides, Dr. Biron is particularly interested in the use of peptidomimetic macrocycles and heterocycles in medicinal chemistry. His research focuses on the discovery and development of novel therapeutic agents for the treatment of infectious diseases and cancers.

Discovery and development of new antibacterial agents

The alarming spread of antibiotic resistance has become a major problem in the treatment of bacterial infections. In this context, Dr. Biron is particularly interested in bacteriocins, a family of low molecular weight proteins produced by several bacteria, with strong antimicrobial activity. As they exhibit inhibitory activities against a large number of clinically important pathogenic bacteria, bacteriocins are increasingly considered as a promising substitute to antibiotics.

Based on their enormous potential in the pharmaceutical and medical areas, Dr. Biron’s laboratory is developing novel synthetic approaches to produce bacteriocins, and uses peptidomimetic strategies to optimize their pharmacological properties, improve their pharmacokinetic profile, and modify their spectrum of activity.

Development of new anti-cancer agents

Despite the progress made in various therapeutic approaches, the effectiveness of main anti-cancer therapies has reached a critical plateau in the treatment of several cancers. As a result, the demand for innovative and effective compounds with new modes of action is growing rapidly. In this context, Dr. Biron’s laboratory uses combinatorial chemistry to prepare libraries with high molecular diversity and perform target-based or phenotypic screenings to discover promising anti-cancer molecules.

In another approach, Dr. Biron is interested in the addiction of cancer cells to some multifunctional proteins that also play an important role in the resistance to treatment. In this case, Dr. Biron’s laboratory aims to develop functional inhibitors of these proteins through rational design, and peptidomimetic approaches.

CHUL
2705, boulevard Laurier
T-4-50
Québec, Québec
Canada G1V 4G2
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Biron E, Chatterjee J, Kessler H

Optimized selective N-methylation of peptides on solid support.

Journal Article

J Pept Sci, 12 (3), pp. 213-9, 2006, ISSN: 1075-2617.

Abstract | Links:

Biron E, Voyer N

Synthesis of cationic porphyrin modified amino acids.

Journal Article

Chem Commun (Camb), (37), pp. 4652-4, 2005, ISSN: 1359-7345.

Abstract | Links:

Biron E, Kessler H

Convenient synthesis of N-methylamino acids compatible with Fmoc solid-phase peptide synthesis.

Journal Article

J Org Chem, 70 (13), pp. 5183-9, 2005, ISSN: 0022-3263.

Abstract | Links:

Sukopp M, Schwab R, Marinelli L, Biron E, Heller M, Varkondi E, Pap A, Novellino E, Keri G, Kessler H

Structure-activity relationship studies optimizing the antiproliferative activity of novel cyclic somatostatin analogues containing a restrained cyclic beta-amino acid.

Journal Article

J Med Chem, 48 (8), pp. 2916-26, 2005, ISSN: 0022-2623.

Abstract | Links:

Biron E, Otis F, Meillon JC, Robitaille M, Lamothe J, Van Hove P, Cormier ME, Voyer N

Design, synthesis, and characterization of peptide nanostructures having ion channel activity.

Journal Article

Bioorg Med Chem, 12 (6), pp. 1279-90, 2004, ISSN: 0968-0896.

Abstract | Links:

Vandenburg YR, Smith BD, Biron E, Voyer N

Membrane disruption ability of facially amphiphilic helical peptides.

Journal Article

Chem Commun (Camb), (16), pp. 1694-5, 2002, ISSN: 1359-7345.

Abstract | Links:

Voyer N, Côté S, Biron E, Beaumont M, Chaput M, Levac S

Chiral Recognition of Carboxylic Acids by Bis-Crown Ether Peptides

Journal Article

J Supramol Chem, 1 (1), pp. 1-5, 2001, ISSN: 1472-7862.

Biron E, Voyer N, Meillon JC, Cormier ME, Auger M

Conformational and orientation studies of artificial ion channels incorporated into lipid bilayers.

Journal Article

Biopolymers, 55 (5), pp. 364-72, 2000, ISSN: 0006-3525.

Abstract | Links:

Meillon JC, Voyer N, Biron E, Sanschagrin F, Stoddart JF

Thermoregulated Optical Properties of Peptidic Pseudorotaxanes.

Journal Article

Angew Chem Int Ed Engl, 39 (1), pp. 143-145, 2000, ISSN: 0570-0833.

Abstract | Links:

Boulanger Y, Biron E, Khiat A, Fournier A

Conformational analysis of biologically active truncated linear analogs of endothelin-1 using NMR and molecular modeling.

Journal Article

J Pept Res, 53 (2), pp. 214-22, 1999, ISSN: 1397-002X.

Abstract | Links:

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Active projects

  • Centre de recherche du CHU de Québec - Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
  • Design and development of inhibitory peptides as tools to resolve the daratumumab interference in blood compatibility testing, Partenariat, MITACS Inc., Accélération Québec (MITACS et gouvernement provincial), from 2019-05-01 to 2021-06-30
  • Design et synthèse d'acides aminés biosourcés pour la préparation de nouveaux triterpènes fonctionnalisés et de peptides conjugés, Partenariat, MITACS Inc., Accélération Québec (MITACS/MEIE), from 2020-01-13 to 2022-03-12
  • Institut sur la nutrition et les aliments fonctionnels (INAF), Subvention, Fonds de recherche du Québec - Nature et technologies, Regroupements stratégiques NT, from 2017-04-01 to 2024-03-31
  • New approaches for the design and synthesis of heterocyclic and macrocyclic bioactive peptidomimetics, Subvention, Conseil de recherches en sciences naturelles et génie Canada, Subventions à la découverte SD (individuelles et d'équipe), from 2020-04-01 to 2025-03-31

Recently finished projects

  • Development and synthesis of molecular scaffolds for the manipulation of protein interactions and function, Subvention, Conseil de recherches en sciences naturelles et génie Canada, Subventions à la découverte SD (individuelles et d'équipe), from 2015-04-01 to 2020-03-31
  • Essais d’activité et de stabilité des bactériocines de synthèses pour prévenir les infections alimentaires et vétérinaires, Partenariat, Ministère de l'Économie et de l'Innovation, Programme de soutien aux organismes de recherche et d’innovation (PSO) - Volet 1 : Soutien au fonctionnement d'organisme (Ancien PSVT), from 2018-04-01 to 2020-06-30
  • Utilisation de bactériocines de synthèse pour prévenir les infections alimentaires et vétérinaires, Subvention, Conseil de recherches en sciences naturelles et génie Canada, De l'idée à l'innovation (INNOV), from 2019-05-31 to 2020-05-30
Data provided by the Université Laval research projects registery