Dr. Eric Biron, PhD, is a Regular Researcher at the CHU de Québec Research Center and Full Professor at the Faculty of Pharmacy of Laval University. Recognized for his contributions in peptide chemistry, combinatorial chemistry and antimicrobial peptides, Dr. Biron is particularly interested in the use of peptidomimetic macrocycles and heterocycles in medicinal chemistry. His research focuses on the discovery and development of novel therapeutic agents for the treatment of infectious diseases and cancers.

Discovery and development of new antibacterial agents

The alarming spread of antibiotic resistance has become a major problem in the treatment of bacterial infections. In this context, Dr. Biron is particularly interested in bacteriocins, a family of low molecular weight proteins produced by several bacteria, with strong antimicrobial activity. As they exhibit inhibitory activities against a large number of clinically important pathogenic bacteria, bacteriocins are increasingly considered as a promising substitute to antibiotics.

Based on their enormous potential in the pharmaceutical and medical areas, Dr. Biron’s laboratory is developing novel synthetic approaches to produce bacteriocins, and uses peptidomimetic strategies to optimize their pharmacological properties, improve their pharmacokinetic profile, and modify their spectrum of activity.

Development of new anti-cancer agents

Despite the progress made in various therapeutic approaches, the effectiveness of main anti-cancer therapies has reached a critical plateau in the treatment of several cancers. As a result, the demand for innovative and effective compounds with new modes of action is growing rapidly. In this context, Dr. Biron’s laboratory uses combinatorial chemistry to prepare libraries with high molecular diversity and perform target-based or phenotypic screenings to discover promising anti-cancer molecules.

In another approach, Dr. Biron is interested in the addiction of cancer cells to some multifunctional proteins that also play an important role in the resistance to treatment. In this case, Dr. Biron’s laboratory aims to develop functional inhibitors of these proteins through rational design, and peptidomimetic approaches.

CHUL
2705, boulevard Laurier
T-4-50
Québec, Québec
Canada G1V 4G2
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Picard M, Robitaille G, Karam F, Daigle JM, Bedard F, Biron E, Tardif MR, Lacombe-Barrios J, Begin P

Cross-Reactivity to Cephalosporins and Carbapenems in Penicillin-Allergic Patients: Two Systematic Reviews and Meta-Analyses.

Journal Article

J Allergy Clin Immunol Pract, 2019.

Abstract | Links:

Bouyakdan K, Martin H, Lienard F, Budry L, Taib B, Rodaros D, Chretien C, Biron E, Husson Z, Cota D, Penicaud L, Fulton S, Fioramonti X, Alquier T

The gliotransmitter ACBP controls feeding and energy homeostasis via the melanocortin system.

Journal Article

J Clin Invest, 129 (6), pp. 2417-2430, 2019, ISSN: 0021-9738.

Abstract | Links:

Bedard F, Fliss I, Biron E

Structure-Activity Relationships of the Bacteriocin Bactofencin A and Its Interaction with the Bacterial Membrane.

Journal Article

ACS Infect Dis, 5 (2), pp. 199-207, 2019, ISSN: 2373-8227.

Abstract | Links:

Jobin S, Beaumont C, Biron E

Development of a solid-phase traceless-Ugi multicomponent reaction for backbone anchoring and cyclic peptide synthesis

Journal Article

Pept Sci (Hoboken), 111 (1 (Special issue)), pp. e24044, 2019, ISSN: 2475-8817.

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Bedard F, Hammami R, Zirah S, Rebuffat S, Fliss I, Biron E

Synthesis, antimicrobial activity and conformational analysis of the class IIa bacteriocin pediocin PA-1 and analogs thereof.

Journal Article

Sci Rep, 8 (1), pp. 9029, 2018, ISSN: 2045-2322.

Abstract | Links:

Bedard F, Biron E

Recent Progress in the Chemical Synthesis of Class II and S-Glycosylated Bacteriocins.

Journal Article

Front Microbiol, 9 , pp. 1048, 2018, ISSN: 1664-302X.

Abstract | Links:

Vézina-Dawod S, Gerber N, Liang X, Biron E

Convenient two-step synthesis of highly functionalized benzo-fused 1,4-diazepin-3-ones and 1,5-diazocin-4-ones by sequential Ugi and intramolecular SNAr reactions

Journal Article

Tetrahedron, 44 , pp. 6347-6355, 2017, ISSN: 0040-4020.

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Biron É, Vézina-Dawod S, Bédard F

Synthetic Strategies for Macrocyclic Peptides (Chapter 9)

Book Chapter

E, Marsault; ML, Peterson (Ed.): Practical medicinal chemistry with macrocycles : design, synthesis, and case studies, pp. 207-241, Hoboken, NJ, Wiley, 2017, ISBN: 9781119092568 (Print) / 9781119092582 (eBook).

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Jobin S, Mejean A, Galindo SM, Liang X, Vezina-Dawod S, Biron E

Toward solid-phase peptide fragment ligation by a traceless-Ugi multicomponent reaction approach.

Journal Article

Org Biomol Chem, 14 (47), pp. 11230-11237, 2016, ISSN: 1477-0520.

Abstract | Links:

Ennaas N, Hammami R, Gomaa A, Bedard F, Biron E, Subirade M, Beaulieu L, Fliss I

Collagencin, an antibacterial peptide from fish collagen: Activity, structure and interaction dynamics with membrane.

Journal Article

Biochem Biophys Res Commun, 473 (2), pp. 642-7, 2016, ISSN: 0006-291X.

Abstract | Links:

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Active projects

  • Centres hospitaliers universitaires de Québec - Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
  • Development and synthesis of molecular scaffolds for the manipulation of protein interactions and function, Subvention, Conseil de recherches en sciences naturelles et génie Canada, Subventions à la découverte SD (individuelles et d'équipe), from 2015-04-01 to 2020-03-31
  • Essais d’activité et de stabilité des bactériocines de synthèses pour prévenir les infections alimentaires et vétérinaires, Partenariat, Ministère de l'Économie et de l'Innovation, Programme de soutien aux organismes de recherche et d’innovation (PSO) - Volet 1 : Soutien au fonctionnement d'organisme (Ancien PSVT), from 2018-04-01 to 2020-02-28
  • Institut sur la nutrition et les aliments fonctionnels (INAF), Subvention, Fonds de recherche du Québec - Nature et technologies, Regroupements stratégiques NT, from 2017-04-01 to 2023-03-31
  • Utilisation de bactériocines de synthèse pour prévenir les infections alimentaires et vétérinaires, Subvention, Conseil de recherches en sciences naturelles et génie Canada, De l'idée à l'innovation (INNOV), from 2019-05-31 to 2020-05-30

Recently finished projects

  • Centre de recherche en endocrinologie, métabolisme et inflammation, Subvention, Institutionnel - BDR, BDR - Centres de recherche reconnus, from 1996-06-01 to 2018-04-30
Data provided by the Université Laval research projects registery