Dr. Eric Biron, PhD, is a Regular Researcher at the CHU de Québec Research Center and Full Professor at the Faculty of Pharmacy of Laval University. Recognized for his contributions in peptide chemistry, combinatorial chemistry and antimicrobial peptides, Dr. Biron is particularly interested in the use of peptidomimetic macrocycles and heterocycles in medicinal chemistry. His research focuses on the discovery and development of novel therapeutic agents for the treatment of infectious diseases and cancers.

Discovery and development of new antibacterial agents

The alarming spread of antibiotic resistance has become a major problem in the treatment of bacterial infections. In this context, Dr. Biron is particularly interested in bacteriocins, a family of low molecular weight proteins produced by several bacteria, with strong antimicrobial activity. As they exhibit inhibitory activities against a large number of clinically important pathogenic bacteria, bacteriocins are increasingly considered as a promising substitute to antibiotics.

Based on their enormous potential in the pharmaceutical and medical areas, Dr. Biron’s laboratory is developing novel synthetic approaches to produce bacteriocins, and uses peptidomimetic strategies to optimize their pharmacological properties, improve their pharmacokinetic profile, and modify their spectrum of activity.

Development of new anti-cancer agents

Despite the progress made in various therapeutic approaches, the effectiveness of main anti-cancer therapies has reached a critical plateau in the treatment of several cancers. As a result, the demand for innovative and effective compounds with new modes of action is growing rapidly. In this context, Dr. Biron’s laboratory uses combinatorial chemistry to prepare libraries with high molecular diversity and perform target-based or phenotypic screenings to discover promising anti-cancer molecules.

In another approach, Dr. Biron is interested in the addiction of cancer cells to some multifunctional proteins that also play an important role in the resistance to treatment. In this case, Dr. Biron’s laboratory aims to develop functional inhibitors of these proteins through rational design, and peptidomimetic approaches.

CHUL
2705, boulevard Laurier
T4-50
Québec, Québec
Canada G1V 4G2
43 entries « 1 of 5 »

Vézina-Dawod S, Perreault M, Guay LD, Gerber N, Gobeil S, Biron E

Synthesis and biological evaluation of novel 1,4-benzodiazepin-3-one derivatives as potential antitumor agents against prostate cancer.

Journal Article

Bioorg Med Chem, 45 , 2021.

Abstract | Links:

Soltani S, Couture F, Boutin Y, Ben Said L, Cashman-Kadri S, Subirade M, Biron E, Fliss I

investigation of gastrointestinal stability and toxicity of 3-hyrdoxypropionaldehyde (reuterin) produced by .

Journal Article

Toxicol Rep, 8 , 2021.

Abstract | Links:

Soltani S, Hammami R, Cotter PD, Rebuffat S, Said LB, Gaudreau H, Bedard F, Biron E, Drider D, Fliss I

Bacteriocins as a new generation of antimicrobials: toxicity aspects and regulations.

Journal Article

FEMS Microbiol Rev, 45 (1), 2021.

Abstract | Links:

Jobin S, Beaumont C, Biron E

Development of a solid-phase traceless-Ugi multicomponent reaction for backbone anchoring and cyclic peptide synthesis

Journal Article

Pept Sci (Hoboken), 111 (1 (Special issue)), 2019.

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Bedard F, Fliss I, Biron E

Structure-Activity Relationships of the Bacteriocin Bactofencin A and Its Interaction with the Bacterial Membrane.

Journal Article

ACS Infect Dis, 5 (2), 2019.

Abstract | Links:

Picard M, Robitaille G, Karam F, Daigle JM, Bedard F, Biron E, Tardif MR, Lacombe-Barrios J, Begin P

Cross-Reactivity to Cephalosporins and Carbapenems in Penicillin-Allergic Patients: Two Systematic Reviews and Meta-Analyses.

Journal Article

J Allergy Clin Immunol Pract, 7 (8), 2019.

Abstract | Links:

Bouyakdan K, Martin H, Lienard F, Budry L, Taib B, Rodaros D, Chretien C, Biron E, Husson Z, Cota D, Penicaud L, Fulton S, Fioramonti X, Alquier T

The gliotransmitter ACBP controls feeding and energy homeostasis via the melanocortin system.

Journal Article

J Clin Invest, 129 (6), 2019.

Abstract | Links:

Bedard F, Biron E

Recent Progress in the Chemical Synthesis of Class II and S-Glycosylated Bacteriocins.

Journal Article

Front Microbiol, 9 , 2018.

Abstract | Links:

Bedard F, Hammami R, Zirah S, Rebuffat S, Fliss I, Biron E

Synthesis, antimicrobial activity and conformational analysis of the class IIa bacteriocin pediocin PA-1 and analogs thereof.

Journal Article

Sci Rep, 8 (1), 2018.

Abstract | Links:

Biron É, Vézina-Dawod S, Bédard F

Synthetic Strategies for Macrocyclic Peptides (Chapter 9)

Book Chapter

E, Marsault; ML, Peterson (Ed.): Practical medicinal chemistry with macrocycles : design, synthesis, and case studies, pp. 207-241, Hoboken, NJ, Wiley, 2017, ISBN: 9781119092568.

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43 entries « 1 of 5 »
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Active projects

  • Design et synthèse d'acides aminés biosourcés pour la préparation de nouveaux triterpènes fonctionnalisés et de peptides conjugés, from 2020-01-13 to 2022-03-12
  • Exploiter l'addiction des bactéries au fer: Conception de nouvelles molécules hybrides bactériocine-sidérophore et évaluation de leur potentiel comme alternative aux antibiotiques, from 2021-04-01 to 2024-03-31
  • Institut sur la nutrition et les aliments fonctionnels (INAF), from 2017-04-01 to 2024-03-31
  • New approaches for the design and synthesis of heterocyclic and macrocyclic bioactive peptidomimetics, from 2020-04-01 to 2025-03-31

Recently finished projects

  • Design and development of inhibitory peptides as tools to resolve the daratumumab interference in blood compatibility testing, from 2019-05-01 to 2021-06-30
  • Development and synthesis of molecular scaffolds for the manipulation of protein interactions and function, from 2015-04-01 to 2020-03-31
  • Essais d’activité et de stabilité des bactériocines de synthèses pour prévenir les infections alimentaires et vétérinaires, from 2018-04-01 to 2020-06-30
  • Utilisation de bactériocines de synthèse pour prévenir les infections alimentaires et vétérinaires, from 2019-05-31 to 2020-05-30
Data provided by the Université Laval research projects registery