Dr. Élodie Boisselier obtained her PhD from the University of Bordeaux (France) in 2009, during which she synthesized and functionalized gold nanoparticles and dendrimers for biomedical applications. She then completed a postdoctoral training at Laval University (Quebec, Canada) where she studied the biophysical behavior of membrane proteins involved in ocular diseases. She has received several awards and scholarships, including the prestigious Banting Fellowship, for her postdoctoral training. She joined the Ophthalmology Department as an Assistant Professor in 2014. Dr. Boisselier holds three patents and has over 20 publications to her credit, which have been cited more than 2,600 times. Her team pursues several research topics related to the field of ophthalmology.

One of their projects aims to study the membrane interaction of proteins found in the eye to better understand their physiological and pathological roles. For example, a project on S100 proteins and annexins is currently underway and aims to determine their mode of action in membrane repair, which is essential to cell survival.

In parallel, a membrane study of a pigment that accumulates in the eye, the A2E, is conducted to understand its involvement in the development of age-related macular degeneration (AMD).

Her team also aims to understand the interaction between proteins on the surface of the cornea, mucins, and gold nanoparticles, to optimize ophthalmic medication. Indeed, gold nanoparticles can be used as drug vectors to modulate their properties, and thus improve their retention on the ocular surface, and therefore their effectiveness.

Finally, another collaborative project uses gold nanoparticles to design probes that detect neurotransmitters, particularly those that are unbalanced in ocular pathologies.

Hôpital Saint-Sacrement
1050, chemin Sainte-Foy
JS2-06
Québec, Québec
Canada G1S 4L8
31 entries « 2 of 4 »

Niyonambaza SD, Boisselier E, Boukadoum M, Miled A

Microfluidic Spectrophotometer for Neurotransmitter Detection Based on Gold Nanoparticles: Preliminary Results.

Journal Article

Conf Proc IEEE Eng Med Biol Soc, 2018 , pp. 3854-3857, 2018, ISSN: 1557-170X.

Abstract | Links:

Niyonambaza SD, Boisselier E, Boukadoum M, Miled A

Microfluidic H-filter Cell Modeling for Robust Purification of Gold Nanoparticles

Book Chapter

2018 16th IEEE International New Circuits and Systems Conference (NEWCAS) : 24-27 June 2018, Montreal, Canada, pp. 370-373, Piscataway, NJ, IEEE, 2018, ISBN: 978-1-5386-4859-9.

Boisselier E, Demers E, Cantin L, Salesse C

How to gather useful and valuable information from protein binding measurements using Langmuir lipid monolayers.

Journal Article

Adv Colloid Interface Sci, 243 , pp. 60-76, 2017, ISSN: 0001-8686.

Abstract | Links:

Ghodsevali E, Morneau-Gamache S, Mathault J, Landari H, Boisselier E, Boukadoum M, Gosselin B, Miled A

Miniaturized FDDA and CMOS Based Potentiostat for Bio-Applications.

Journal Article

Sensors (Basel), 17 (4), 2017, ISSN: 1424-8220.

Abstract | Links:

Kara A, Rouillard C, Mathault J, Boisvert M, Tessier F, Landari H, Melki I, Laprise-Pelletier M, Boisselier E, Fortin MA, Boilard E, Greener J, Miled A

Towards a Multifunctional Electrochemical Sensing and Niosome Generation Lab-on-Chip Platform Based on a Plug-and-Play Concept.

Journal Article

Sensors (Basel), 16 (6), 2016, ISSN: 1424-8220.

Abstract | Links:

Lemire S, Jeromin A, Boisselier E

Membrane binding of Neuronal Calcium Sensor-1 (NCS1).

Journal Article

Colloids Surf B Biointerfaces, 139 , pp. 138-47, 2016, ISSN: 0927-7765.

Abstract | Links:

Lemire S, Boisselier E

Upregulation of a protein in the brains of patients with neurodegenerative diseases due to its altered membrane binding

Journal Article

Atlas of science : another view on science, 2016.

Demers E, Boisselier E, Horchani H, Blaudez D, Calvez P, Cantin L, Belley N, Champagne S, Desbat B, Salesse C

Lipid Selectivity, Orientation, and Extent of Membrane Binding of Nonacylated RP2.

Journal Article

Biochemistry, 54 (16), pp. 2560-70, 2015, ISSN: 0006-2960.

Abstract | Links:

Boisselier E, Calvez P, Demers E, Cantin L, Salesse C

Effect of oxidation of polyunsaturated phospholipids on the binding of proteins in monolayers.

Journal Article

Colloids Surf B Biointerfaces, 109 , pp. 109-14, 2013, ISSN: 0927-7765.

Abstract | Links:

Boisselier E, Calvez P, Demers E, Cantin L, Salesse C

Influence of the physical state of phospholipid monolayers on protein binding.

Journal Article

Langmuir, 28 (25), pp. 9680-8, 2012, ISSN: 0743-7463.

Abstract | Links:

31 entries « 2 of 4 »
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Active projects

  • Centre de recherche du CHU de Québec - Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
  • Centre de recherche sur les matériaux avancés, Subvention, Institutionnel - BDR, BDR - Centres de recherche reconnus, from 1996-06-01 to 2025-04-30
  • Centre Québécois sur les Matériaux Fonctionnels (CQMF), Subvention, Fonds de recherche du Québec - Nature et technologies, Regroupements stratégiques NT, from 2017-04-01 to 2023-03-31
  • Développement d'une plateforme moléculaire de dosage des mucines oculaires pour l'amélioration de la médication en ophtalmologie, Subvention, Fonds de recherche du Québec - Nature et technologies, Programme Samuel-De Champlain, from 2019-04-01 to 2021-03-31
  • Implication des protéines de la famille S100, des annexines et de leur complexe dans les processus membranaires., Subvention, Conseil de recherches en sciences naturelles et génie Canada, Subventions à la découverte SD (individuelles et d'équipe), from 2015-04-01 to 2021-03-31
  • PROTEO, le regroupement québécois de recherche sur la fonction, l'ingénierie et les applications des protéines (PROTEO), Subvention, Fonds de recherche du Québec - Nature et technologies, Regroupements stratégiques NT, from 2015-04-01 to 2022-03-31
  • Regroupement québécois de recherche sur la fonction, la structure et l'ingénierie des protéines, Subvention, Institutionnel - BDR, BDR - Centres de recherche reconnus, from 2014-05-01 to 2023-04-03

Recently finished projects

  • Interactions nanoparticulaires et membranaires des protéines de l'oeil pour l'optimisation des thérapies en ophtalmologie., Subvention, Fonds de recherche du Québec - Santé, Chercheur-boursier Juniors 1 et 2, Seniors, from 2016-07-01 to 2020-06-30
  • Interactions nanoparticulaires et membranaires des protéines de l'oeil pour l'optimisation des thérapies en ophtalmologie., Subvention, Fonds de recherche du Québec - Santé, Établissement de jeunes chercheurs - Juniors 1, from 2016-07-01 to 2019-06-30
  • Système FPLC pour la purification des protéines, Subvention, Conseil de recherches en sciences naturelles et génie Canada, Subventions d'outils et d'instruments de recherche (OIR), from 2019-03-28 to 2020-03-31
Data provided by the Université Laval research projects registery