Dr. Élodie Boisselier obtained her PhD from the University of Bordeaux (France) in 2009, during which she synthesized and functionalized gold nanoparticles and dendrimers for biomedical applications. She then completed a postdoctoral training at Laval University (Quebec, Canada) where she studied the biophysical behavior of membrane proteins involved in ocular diseases. She has received several awards and scholarships, including the prestigious Banting Fellowship, for her postdoctoral training. She joined the Ophthalmology Department as an Assistant Professor in 2014. Dr. Boisselier holds three patents and has over 20 publications to her credit, which have been cited more than 2,600 times. Her team pursues several research topics related to the field of ophthalmology.

One of their projects aims to study the membrane interaction of proteins found in the eye to better understand their physiological and pathological roles. For example, a project on S100 proteins and annexins is currently underway and aims to determine their mode of action in membrane repair, which is essential to cell survival.

In parallel, a membrane study of a pigment that accumulates in the eye, the A2E, is conducted to understand its involvement in the development of age-related macular degeneration (AMD).

Her team also aims to understand the interaction between proteins on the surface of the cornea, mucins, and gold nanoparticles, to optimize ophthalmic medication. Indeed, gold nanoparticles can be used as drug vectors to modulate their properties, and thus improve their retention on the ocular surface, and therefore their effectiveness.

Finally, another collaborative project uses gold nanoparticles to design probes that detect neurotransmitters, particularly those that are unbalanced in ocular pathologies.

Hôpital Saint-Sacrement
1050, chemin Sainte-Foy
JS2-06
Québec, Québec
Canada G1S 4L8
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Niyonambaza SD, Koudrina A, DeRosa MC, Boukadoum M, Miled A, Boisselier E

Aptamer-Modified Ultrastable Gold Nanoparticles for Dopamine Detection

Journal Article

IEEE Sens J, 21 (3), 2021.

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Yan X, Kumar K, Miclette Lamarche R, Youssef H, Shaw GS, Marcotte I, DeWolf CE, Warschawski DE, Boisselier E

Interactions between the Cell Membrane Repair Protein S100A10 and Phospholipid Monolayers and Bilayers.

Journal Article

Langmuir, 2021.

Abstract | Links:

Hacene YC, Loiseau A, Maio VDP, Grenier P, Boisselier E, Bertrand N

Isolating Nanoparticles from Complex Biological Media by Immunoprecipitation.

Journal Article

Nano Lett, 21 (11), 2021.

Abstract | Links:

Lachance GP, Niyonambaza SD, Boisselier É, Boukadoum M, Miled A

Critical Comparison of Sequential and Non-sequential Modes Usage for the Design of a Czerny-Turner Spectrometer

Book Chapter

2020 18th IEEE International New Circuits and Systems Conference (NEWCAS) : Montréal, QC, Canada, June 16-19, pp. 162-165, IEEE, 2020, ISBN: 9781728170442.

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Lachance GP, Niyonambaza SD, Boisselier É, Boukadoum M, Miled A

Critical Comparison of Sequential and Non-sequential Modes Usage for the Design of a Czerny-Turner Spectrometer

Book Chapter

2020 18th IEEE International New Circuits and Systems Conference (NEWCAS) : Montréal, QC, Canada, June 16-19, pp. 162-165, IEEE, 2020, ISBN: 9781728170442.

| Links:

Bellemare-Rousseau S, Lachance G, Niyonambaza SD, Boisselier É, Bouakadoum M, Miled A

FPGA-based Prediction System for Neurotransmitter Concentration Measurement from Spectrophotometry Data

Book Chapter

2020 18th IEEE International New Circuits and Systems Conference (NEWCAS) : Montréal, QC, Canada, June 16-19, pp. 267-270, IEEE, 2020, ISBN: 9781728170442.

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Yan X, Noel F, Marcotte I, DeWolf CE, Warschawski D, Boisselier E

AHNAK C-Terminal Peptide Membrane Binding-Interactions between the Residues 5654-5673 of AHNAK and Phospholipid Monolayers and Bilayers.

Journal Article

Langmuir, 36 (1), 2020.

Abstract | Links:

Niyonambaza SD, Kumar P, Xing P, Mathault J, De Koninck P, Boisselier E, Boukadoum M, Miled A

A review of neurotransmitters sensing methods for neuro-engineering research

Journal Article

Appl Sci (Basel), 9 (21), 2019.

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Ouellette M, Mathault J, Niyonambaza SD, Miled A, Boisselier E

Electrochemical Detection of Dopamine Based on Functionalized Electrodes

Journal Article

9 , 2019.

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Niyonambaza SD, Boisselier E, Boukadoum M, Miled A

A Compact Visible Light Spectrometer for Molecular Detection with Spherical Gold Nanoparticles.

Journal Article

Annu Int Conf IEEE Eng Med Biol Soc, 2019 , 2019.

Abstract | Links:

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Active projects

  • Centre Québécois sur les Matériaux Fonctionnels (CQMF), from 2017-04-01 to 2024-03-31
  • Développement d'une plateforme moléculaire de dosage des mucines oculaires pour l'amélioration de la médication en ophtalmologie, from 2019-04-01 to 2022-05-31
  • Implication des protéines de la famille S100, des annexines et de leur complexe dans les processus membranaires., from 2015-04-01 to 2022-03-31
  • Metal-Organic Frameworks for Applications in Ophthalmic Drug Delivery - Boisselier, from 2020-04-01 to 2022-03-31
  • Nouvelles nanotechnologies et plateformes pour le développement d’outils de thérapie et de diagnostic en ophtalmologie, from 2020-07-01 to 2024-06-30
  • PROTEO, le regroupement québécois de recherche sur la fonction, l'ingénierie et les applications des protéines (PROTEO), from 2015-04-01 to 2022-03-31
  • Un nouveau vecteur de médicaments ophtalmiques à base de nanoparticules d'or, from 2020-10-01 to 2025-09-30
  • Vectorisation de médicaments anti-inflammatoires ophtalmiques, from 2020-04-01 to 2022-03-31

Recently finished projects

  • Évaluation de la biodistribution in vivo de nanoparticules d'or mucoadhésives et de leur capacité à vectoriser la combinaison synergique C646-SC79, pour accélérer la cicatrisation de plaies cornéennes, from 2020-08-01 to 2021-04-30
  • Interactions nanoparticulaires et membranaires des protéines de l'oeil pour l'optimisation des thérapies en ophtalmologie., from 2016-07-01 to 2020-06-30
  • Système FPLC pour la purification des protéines, from 2019-03-28 to 2020-03-31
Data provided by the Université Laval research projects registery