Dr. Dimcho Bachvarov received his B.Sc. and M.Sc. degrees from the University of Sofia in 1975-1978. He obtained his Ph.D. degree in 1986 from the Institute of Molecular Biology at the Bulgarian Academy of Science. In 1994, he was appointed as Adjunct Professor at Laval University’s department of Pharmacology. Consecutively, Dr. Bachvarov was promoted to Assistant Professor (1997), Associate Professor (2002), and since 2005 he has been a Full Professor at Laval University’s Department of Molecular Medicine. During his academic career, Dr. Bachvarov has received different Scholarship Awards, with the most representative being the Ernest J.B. Tomlinson Scholarship Award from the Kidney Foundation of Canada and other Scholarship Awards (Junior and Senior) from Fonds de recherche du Québec – Santé (FRQ-S).

His research interests are focused on studying the initiation and progression mechanisms of epithelial ovarian cancer (EOC) and improving treatment for this deadly disease, including the identification of early diagnostic or prognostic EOC markers. Dr. Bachvarov has published over 80 papers, predominantly in the EOC research field, and has received funding from CIHR, NSERC, CFI, FRQ-S, CRS and the Terry-Fox Research Institute (TFRI). He has been a co-founder and an active member of the provincial Réseau de Recherche en Cancer (RRCancer, established in 2000; see http://www.rrcancer.ca/), and since then, he has been a co-Chair of the Research Committee of the RRCancer axis entitled “Research and Solid State Tumour Biobank”. Following the establishment of RRCancer, Dr. Bachvarov was also in charge of the organization for the RRCancer-supported ovarian tumor bank in the Centre de recherche sur le cancer de l’Université Laval and the Hôtel-Dieu de Québec Hospital (the bank currently contains EOC specimens from about 3,000 patients). He is also the Head of the RRCancer Core Genomic Facility in Québec city. This facility is based on the Agilent dual channel detection microarray platform and has all the necessary equipment, complementary software and expertise required to perform different microarray experiments, including global gene expression and microRNA expression analyses, methylation DNA microarray-based analyses, array-CGH/CNV and Chip-on-CHIP analyses. The Core Genomic Facility in Québec city is providing a genomics and bioinformatics service to Canadian and foreign scientists who implement genomics approaches in their research (see: https://www.crc.ulaval.ca/la-recherche/plateformes/).

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87 entries « 1 of 9 »

Trudel D, Avarvarei LM, Orain M, Turcotte S, Plante M, Gregoire J, Kappelhoff R, Labbe DP, Bachvarov D, Tetu B, Overall CM, Bairati I

Proteases and their inhibitors as prognostic factors for high-grade serous ovarian cancer.

Journal Article

Pathol Res Pract, 215 (6), pp. 152369, 2019, ISSN: 0344-0338.

Abstract | Links:

Sheta R, Bachvarova M, Macdonald E, Gobeil S, Vanderhyden B, Bachvarov D

The polypeptide GALNT6 Displays Redundant Functions upon Suppression of its Closest Homolog GALNT3 in Mediating Aberrant O-Glycosylation, Associated with Ovarian Cancer Progression.

Journal Article

Int J Mol Sci, 20 (9), 2019.

Abstract | Links:

Furrer D, Gregoire J, Turcotte S, Plante M, Bachvarov D, Trudel D, Tetu B, Douville P, Bairati I

Performance of preoperative plasma tumor markers HE4 and CA125 in predicting ovarian cancer mortality in women with epithelial ovarian cancer.

Journal Article

PLoS ONE, 14 (6), pp. e0218621, 2019.

Abstract | Links:

Le Page C, Rahimi K, Kobel M, Tonin PN, Meunier L, Portelance L, Bernard M, Nelson BH, Bernardini MQ, Bartlett JMS, Bachvarov D, Gotlieb WH, Gilks B, McAlpine JN, Nachtigal MW, Piche A, Watson PH, Vanderhyden B, Huntsman DG, Provencher DM, Mes-Masson AM

Characteristics and outcome of the COEUR Canadian validation cohort for ovarian cancer biomarkers.

Journal Article

BMC Cancer, 18 (1), pp. 347, 2018.

Abstract | Links:

Sheta R, Bachvarova M, Plante M, Gregoire J, Renaud MC, Sebastianelli A, Popa I, Bachvarov D

Altered expression of different GalNAc‑transferases is associated with disease progression and poor prognosis in women with high-grade serous ovarian cancer.

Journal Article

Int J Oncol, 51 (6), pp. 1887-1897, 2017, ISSN: 1019-6439.

Abstract | Links:

Sheta R, Wang ZQ, Bachvarova M, Plante M, Gregoire J, Renaud MC, Sebastianelli A, Gobeil S, Morin C, Macdonald E, Vanderhyden B, Bachvarov D

Hic-5 regulates epithelial to mesenchymal transition in ovarian cancer cells in a TGFβ1-independent manner.

Journal Article

Oncotarget, 8 (47), pp. 82506-82530, 2017, ISSN: 1949-2553.

Abstract | Links:

Faddaoui A, Sheta R, Bachvarova M, Plante M, Gregoire J, Renaud MC, Sebastianelli A, Gobeil S, Morin C, Ghani K, Bachvarov D

Suppression of the grainyhead transcription factor 2 gene (GRHL2) inhibits the proliferation, migration, invasion and mediates cell cycle arrest of ovarian cancer cells.

Journal Article

Cell Cycle, 16 (7), pp. 693-706, 2017, ISSN: 1538-4101.

Abstract | Links:

Papadopoulos T, Casemayou A, Neau E, Breuil B, Caubet C, Calise D, Thornhill BA, Bachvarova M, Belliere J, Chevalier RL, Moulos P, Bachvarov D, Buffin-Meyer B, Decramer S, Auriol FC, Bascands JL, Schanstra JP, Klein J

Systems biology combining human- and animal-data miRNA and mRNA data identifies new targets in ureteropelvic junction obstruction.

Journal Article

BMC Syst Biol, 11 (1), pp. 31, 2017.

Abstract | Links:

Bondi ML, Emma MR, Botto C, Augello G, Azzolina A, DI Gaudio F, Craparo EF, Cavallaro G, Bachvarov D, Cervello M

Biocompatible Lipid Nanoparticles as Carriers To Improve Curcumin Efficacy in Ovarian Cancer Treatment.

Journal Article

J Agric Food Chem, 65 (7), pp. 1342-1352, 2017, ISSN: 0021-8561.

Abstract | Links:

Sheta R, Roux-Dalvai F, Woo CM, Fournier F, Bourassa S, Bertozzi CR, Droit A, Bachvarov D

Proteomic dataset for altered glycoprotein expression upon GALNT3 knockdown in ovarian cancer cells.

Journal Article

Data Brief, 8 , pp. 342-9, 2016, ISSN: 2352-3409.

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Active projects

  • Centre de recherche sur le cancer, Subvention, Institutionnel - BDR, BDR - Centres de recherche reconnus, from 1996-05-01 to 2023-04-30
  • Centres hospitaliers universitaires de Québec - Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31

Recently finished projects

  • Investigating in vivo the role of EMT in epithelial ovarian cancer dissemination by modulating LY75 expression and analyzing the molecular mechanisms of LY75-mediated control of EOC phenotype, Subvention, Société de recherche sur le cancer, Subvention de fonctionnement, from 2016-09-01 to 2018-08-31
Data provided by the Université Laval research projects registery