Dr. Denis Talbot, Ph.D., is a regular investigator at the CHU de Québec – Laval University Research Center and professor in biostatistics at the Department of Social and Preventive Medicine of Laval University’s School of Medicine. His research interests focus on the development of statistical methods to perform causal inference and the application of such methods in health research, particularly in cardiovascular health research. Causal inference seeks to predict the effect that a potential intervention would have, for instance the effect of a public health policy or a medical treatment.

Model selection for causal inference

When observational data are utilized to investigate the relationship between an exposure and a disease, there can be variables that are both associated with the exposure and the disease. Such variables, called confounders, may distort the observed relationship between the exposure and the disease, unless adequate control is performed. Unfortunately, identifying confounders solely based on substantive knowledge can be difficult. Moreover, once confounders are identified, an appropriate statistical modeling approach must be employed to eliminate the bias that confounders produce.

One strategy to circumvent these problems would be to use statistical methods to supplement scientific knowledge with the information available in the data. Such methods would facilitate the identification and the control for confounders, and thus facilitate the identification of the causal relationship between the exposure and the disease. An important part of Dr. Talbot’s research program, funded by the Natural Sciences and Engineering Research Council of Canada, targets the development of such statistical methods.

Other interests in causal inference

Dr. Talbot is also interested in many other aspects of causal inference, notably in causal mediation methods and treatment regime effects (for example, cumulative exposure, and marginal structural models). He is involved in various collaborative research projects, for instance on health at work, nutrition or physical activity.

Hôpital Saint-Sacrement
1050, chemin Sainte-Foy
J0-03
Québec, Québec
Canada G1S 4L8
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Diop SA, Cumming SG, Diop A, Talbot D, Duchesne T

Confounding adjustment methods for multi-level treatment comparisons under lack of positivity and unknown model specification

Journal Article

J Appl Stat, 2021.

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Pena-Gralle APB, Talbot D, Trudel X, Aubé K, Lesage A, Lauzier S, Milot A, Brisson C

Validation of case definitions of depression derived from administrative data against the CIDI-SF as reference standard: results from the PROspective Québec (PROQ) study.

Journal Article

BMC Psychiatry, 21 (1), 2021.

Abstract | Links:

Pena-Gralle APB, Talbot D, Duchaine CS, Lavigne-Robichaud M, Trudel X, Aubé K, Gralle M, Gilbert-Ouimet M, Milot A, Brisson C

Job strain and effort-reward imbalance as risk factors for type 2 diabetes mellitus: A systematic review and meta-analysis of prospective studies.

Journal Article

Scand J Work Environ Health, 2021.

Abstract | Links:

Duchaine CS, Brisson C, Talbot D, Gilbert-Ouimet M, Trudel X, Vézina M, Milot A, Diorio C, Ndjaboué R, Giguère Y, Mâsse B, Dionne CE, Maunsell E, Laurin D

Psychosocial stressors at work and inflammatory biomarkers: PROspective Quebec Study on Work and Health.

Journal Article

Psychoneuroendocrinology, 133 , 2021.

Abstract | Links:

Duchaine CS, Brisson C, Talbot D, Gilbert-Ouimet M, Trudel X, Vézina M, Milot A, Diorio C, Ndjaboué R, Giguère Y, Mâsse B, Dionne CE, Maunsell E, Laurin D

Cumulative exposure to psychosocial stressors at work and global cognitive function: the PROspective Quebec Study on Work and Health.

Journal Article

Occup Environ Med, 2021.

Abstract | Links:

Ducrocq J, Ndao M, Yansouni CP, Proulx JF, Mondor M, Hamel D, Lévesque B, De Serres G, Talbot D

Epidemiology associated with the exposure to Toxoplasma gondii in Nunavik's Inuit population using the 2017 Qanuilirpitaa cross-sectional health survey.

Journal Article

Zoonoses Public Health, 68 (7), 2021.

Abstract | Links:

Sirois C, Khoury R, Durand A, Deziel PL, Bukhtiyarova O, Chiu Y, Talbot D, Bureau A, Després P, Gagné C, Laviolette F, Savard AM, Corbeil J, Badard T, Jean S, Simard M

Exploring polypharmacy with artificial intelligence: data analysis protocol.

Journal Article

BMC Med Inform Decis Mak, 21 (1), 2021.

Abstract | Links:

Trudel X, Brisson C, Talbot D, Gilbert-Ouimet M, Milot A

Reply: Job Strain and Recurrent Coronary Events.

Journal Article

J Am Coll Cardiol, 78 (4), 2021.

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Talbot D, Diop A, Lavigne-Robichaud M, Brisson C

The change in estimate method for selecting confounders: A simulation study.

Journal Article

Stat Methods Med Res, 30 (9), 2021.

Abstract | Links:

Carazo S, Talbot D, Boulianne N, Brisson M, Gilca R, Deceuninck G, Brousseau N, Drolet M, Ouakki M, Sauvageau C, Barkati S, Fortin É, Carignan A, De Wals P, Skowronski DM, De Serres G

Single-dose mRNA vaccine effectiveness against SARS-CoV-2 in healthcare workers extending 16 weeks post-vaccination: a test-negative design from Quebec, Canada.

Journal Article

Clin Infect Dis, 2021.

Abstract | Links:

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Active projects

  • Centre de recherches mathématiques (CRM), from 2015-04-01 to 2022-03-31
  • Déterminer la qualité de la polypharmacie chez les aînés : une approche basée sur l’intelligence artificielle, from 2020-04-01 to 2023-03-31
  • Méthodes d'inférence causale et la prise de décision dans un cadre bayésien, from 2018-04-01 to 2022-03-31
  • Model and variable selection for causal inference., from 2016-04-01 to 2022-03-31
  • Real-World Evaluation of the Efficacy, Safety and Cost-Effectiveness of Statins for Primary Prevention of Cardiovascular Disease Among the Elderly – A Causal Perspective to Treatment Trajectory Analysis, from 2019-10-01 to 2023-03-31
  • Sélection de modèles statistiques pour effectuer de l'inférence causale à l'aide de données épidémiologiques, from 2018-07-01 to 2022-06-30
  • Subvention d'établissement de jeune chercheur, from 2018-07-01 to 2022-06-30
  • The right care, for the right patient, at the right time, by the right provider: A value-based comparison of the management of ambulatory respiratory diseases in walk-in clinics, primary care physician practices and emergency departments, from 2021-03-01 to 2022-02-28
  • The right care, for the right patient, at the right time, by the right provider: A value-based comparison of the management of ambulatory respiratory diseases in walk-in clinics, primary care physician practices and emergency departments, from 2020-04-01 to 2024-03-31

Recently finished projects

  • Adoption de comportements préventifs chez les ainés vulnérables en situation d'épidémie /pandémie : vers une participation sociale sécuritaire (sans sortir de la maison) et une réduction des risques accrues , from 2020-04-01 to 2021-03-31
  • DecreAsing sedentary behaviour and inCreasing physical acTIvity fOr healthy ageing (ACTION) study, from 2017-04-01 to 2021-08-31
  • Programme de soutien aux nouveaux chercheurs, from 2019-07-01 to 2021-06-30
  • Real-World Cost-Effectiveness of Direct Oral Anticoagulants in Atrial Fibrillation: A Canadian Health Technology Reassessment Study, from 2018-04-01 to 2020-09-30
Data provided by the Université Laval research projects registery