Dr. Denis Talbot, Ph.D., is a regular investigator at the CHU de Québec – Laval University Research Center and professor in biostatistics at the Department of Social and Preventive Medicine of Laval University’s School of Medicine. His research interests focus on the development of statistical methods to perform causal inference and the application of such methods in health research, particularly in cardiovascular health research. Causal inference seeks to predict the effect that a potential intervention would have, for instance the effect of a public health policy or a medical treatment.

Model selection for causal inference

When observational data are utilized to investigate the relationship between an exposure and a disease, there can be variables that are both associated with the exposure and the disease. Such variables, called confounders, may distort the observed relationship between the exposure and the disease, unless adequate control is performed. Unfortunately, identifying confounders solely based on substantive knowledge can be difficult. Moreover, once confounders are identified, an appropriate statistical modeling approach must be employed to eliminate the bias that confounders produce.

One strategy to circumvent these problems would be to use statistical methods to supplement scientific knowledge with the information available in the data. Such methods would facilitate the identification and the control for confounders, and thus facilitate the identification of the causal relationship between the exposure and the disease. An important part of Dr. Talbot’s research program, funded by the Natural Sciences and Engineering Research Council of Canada, targets the development of such statistical methods.

Other interests in causal inference

Dr. Talbot is also interested in many other aspects of causal inference, notably in causal mediation methods and treatment regime effects (for example, cumulative exposure, and marginal structural models). He is involved in various collaborative research projects, for instance on health at work, nutrition or physical activity.

Hôpital Saint-Sacrement
1050, chemin Sainte-Foy
J0-03
Québec, Québec
Canada G1S 4L8
37 entries « 1 of 4 »

Lavigne-Robichaud M, Trudel X, Duchaine CS, Milot A, Gilbert-Ouimet M, Vezina M, Talbot D, Dalens V, Aube K, Brisson C

Job strain and the prevalence of uncontrolled hypertension among white-collar workers.

Journal Article

Hypertens Res, 42 (10), pp. 1616-1623, 2019, ISSN: 0916-9636.

Abstract | Links:

Lafreniere J, Harrison S, Laurin D, Brisson C, Talbot D, Couture P, Lemieux S, Lamarche B

Development and validation of a Brief Diet Quality Assessment Tool in the French-speaking adults from Quebec.

Journal Article

Int J Behav Nutr Phys Act, 16 (1), pp. 61, 2019.

Abstract | Links:

Talbot D, Massamba VK

A descriptive review of variable selection methods in four epidemiologic journals: there is still room for improvement.

Journal Article

Eur J Epidemiol, 34 (8), pp. 725-730, 2019, ISSN: 0393-2990.

Abstract | Links:

Sall A, Aube K, Trudel X, Brisson C, Talbot D

A test for the correct specification of marginal structural models.

Journal Article

Stat Med, 38 (17), pp. 3168-3183, 2019, ISSN: 0277-6715.

Abstract | Links:

Giguere K, Behanzin L, Guedou FA, Talbot D, Leblond FA, Goma-Matsetse E, Zannou DM, Affolabi D, Keke RK, Gangbo F, Bachabi M, Alary M

PrEP Use Among Female Sex Workers: No Evidence for Risk Compensation.

Journal Article

J Acquir Immune Defic Syndr, 2019, ISSN: 1525-4135.

Abstract | Links:

Massamba VK, Talbot D, Milot A, Pearce N, Trudel X, Brisson C

Assessment of the healthy worker survivor effect in the relationship between psychosocial work-related factors and hypertension.

Journal Article

Occup Environ Med, 76 (6), pp. 414-421, 2019, ISSN: 1351-0711.

Abstract | Links:

Jacob J, Valois P, Aenishaenslin C, Bouchard C, Briand S, Talbot D, Tessier M

Factors Leading Municipal Authorities to Implement Preventive Interventions for Lyme Disease.

Journal Article

Int J Environ Res Public Health, 16 (9), 2019, ISSN: 1661-7827.

Abstract | Links:

Valois P, Caron M, Gousse-Lessard AS, Talbot D, Renaud JS

Development and validation of five behavioral indices of flood adaptation.

Journal Article

BMC Public Health, 19 (1), pp. 245, 2019.

Abstract | Links:

Trudel X, Brisson C, Gilbert-Ouimet M, Duchaine CS, Dalens V, Talbot D, Milot A

Masked hypertension incidence and risk factors in a prospective cohort study.

Journal Article

Eur J Prev Cardiol, 26 (3), pp. 231-237, 2019, ISSN: 2047-4873.

Abstract | Links:

Ni J, Dasgupta K, Kahn SR, Talbot D, Lefebvre G, Lix LM, Berry G, Burman M, Dimentberg R, Laflamme Y, Cirkovic A, Rahme E

Comparing external and internal validation methods in correcting outcome misclassification bias in logistic regression: A simulation study and application to the case of postsurgical venous thromboembolism following total hip and knee arthroplasty.

Journal Article

Pharmacoepidemiol Drug Saf, 28 (2), pp. 217-226, 2019, ISSN: 1053-8569.

Abstract | Links:

37 entries « 1 of 4 »
Signaler des ajouts ou des modifications

Active projects

  • Centre de recherche du CHU de Québec - Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
  • Centre de recherche sur les soins et les services de première ligne de l'Université Laval (CERSSPL-UL), Subvention, CIUSSS - CN - Centre de recherche sur les soins et les services de première ligne de l'ULaval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
  • Centre de recherches mathématiques (CRM), Subvention, Fonds de recherche du Québec - Nature et technologies, Regroupements stratégiques NT, from 2015-04-01 to 2022-03-31
  • DecreAsing sedentary behaviour and inCreasing physical acTIvity fOr healthy ageing (ACTION) study, Subvention, Instituts de recherche en santé du Canada, Subvention Projet, from 2017-04-01 to 2021-08-31
  • Méthodes d'inférence causale et la prise de décision dans un cadre bayésien, Subvention, Fonds de recherche du Québec - Nature et technologies, Projet de recherche en équipe, from 2018-04-01 to 2021-03-31
  • Model and variable selection for causal inference., Subvention, Conseil de recherches en sciences naturelles et génie Canada, Subventions à la découverte SD (individuelles et d'équipe), from 2016-04-01 to 2021-03-31
  • Programme de soutien aux nouveaux chercheurs, Subvention, Université Laval - démarrage nouveau chercheur, Soutien facultaire aux jeunes chercheurs de la Faculté de médecine, from 2019-07-01 to 2021-06-30
  • Real-World Cost-Effectiveness of Direct Oral Anticoagulants in Atrial Fibrillation: A Canadian Health Technology Reassessment Study, Subvention, Instituts de recherche en santé du Canada, Subvention Projet, from 2018-04-01 to 2020-09-30
  • Real-World Evaluation of the Efficacy, Safety and Cost-Effectiveness of Statins for Primary Prevention of Cardiovascular Disease Among the Elderly – A Causal Perspective to Treatment Trajectory Analysis, Subvention, Instituts de recherche en santé du Canada, Subvention Projet, from 2019-10-01 to 2023-03-31
  • Sélection de modèles statistiques pour effectuer de l'inférence causale à l'aide de données épidémiologiques, Subvention, Fonds de recherche du Québec - Santé, Chercheur-boursier Juniors 1 et 2, Seniors, from 2018-07-01 to 2022-06-30
  • Subvention d'établissement de jeune chercheur, Subvention, Fonds de recherche du Québec - Santé, Établissement de jeunes chercheurs - Juniors 1, from 2018-07-01 to 2022-06-30

Recently finished projects

  • Inégalités sociales dans les trajectoires d'usage des traitements oraux pour le cancer du sein : Une comparaison France - Québec, Subvention, Instituts de recherche en santé du Canada, Subvention de fonctionnement, from 2017-04-01 to 2019-03-31
  • Observatoire québécois de l'adaptation aux changements climatiques, Subvention, Institut national de santé publique du Québec, from 2015-01-01 to 2019-03-31
Data provided by the Université Laval research projects registery