Dr. Denis Talbot, Ph.D., is a regular investigator at the CHU de Québec – Laval University Research Center and professor in biostatistics at the Department of Social and Preventive Medicine of Laval University’s School of Medicine. His research interests focus on the development of statistical methods to perform causal inference and the application of such methods in health research, particularly in cardiovascular health research. Causal inference seeks to predict the effect that a potential intervention would have, for instance the effect of a public health policy or a medical treatment.

Model selection for causal inference

When observational data are utilized to investigate the relationship between an exposure and a disease, there can be variables that are both associated with the exposure and the disease. Such variables, called confounders, may distort the observed relationship between the exposure and the disease, unless adequate control is performed. Unfortunately, identifying confounders solely based on substantive knowledge can be difficult. Moreover, once confounders are identified, an appropriate statistical modeling approach must be employed to eliminate the bias that confounders produce.

One strategy to circumvent these problems would be to use statistical methods to supplement scientific knowledge with the information available in the data. Such methods would facilitate the identification and the control for confounders, and thus facilitate the identification of the causal relationship between the exposure and the disease. An important part of Dr. Talbot’s research program, funded by the Natural Sciences and Engineering Research Council of Canada, targets the development of such statistical methods.

Other interests in causal inference

Dr. Talbot is also interested in many other aspects of causal inference, notably in causal mediation methods and treatment regime effects (for example, cumulative exposure, and marginal structural models). He is involved in various collaborative research projects, for instance on health at work, nutrition or physical activity.

Hôpital Saint-Sacrement
1050, chemin Sainte-Foy
J0-09
Québec, Québec
Canada G1S 4L8

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Sall A, Aube K, Trudel X, Brisson C, Talbot D

A test for the correct specification of marginal structural models.

Journal Article

Stat Med, 2019, ISSN: 0277-6715.

Abstract | Links:

Valois P, Caron M, Gousse-Lessard AS, Talbot D, Renaud JS

Development and validation of five behavioral indices of flood adaptation.

Journal Article

BMC Public Health, 19 (1), pp. 245, 2019.

Abstract | Links:

Trudel X, Brisson C, Gilbert-Ouimet M, Duchaine CS, Dalens V, Talbot D, Milot A

Masked hypertension incidence and risk factors in a prospective cohort study.

Journal Article

Eur J Prev Cardiol, 26 (3), pp. 231-237, 2019, ISSN: 2047-4873.

Abstract | Links:

Ni J, Dasgupta K, Kahn SR, Talbot D, Lefebvre G, Lix LM, Berry G, Burman M, Dimentberg R, Laflamme Y, Cirkovic A, Rahme E

Comparing external and internal validation methods in correcting outcome misclassification bias in logistic regression: A simulation study and application to the case of postsurgical venous thromboembolism following total hip and knee arthroplasty.

Journal Article

Pharmacoepidemiol Drug Saf, 28 (2), pp. 217-226, 2019, ISSN: 1053-8569.

Abstract | Links:

Kiely M, Boulianne N, Talbot D, Ouakki M, Guay M, Landry M, Sauvageau C, De Serres G

Impact of vaccine delays at the 2, 4, 6 and 12 month visits on incomplete vaccination status by 24 months of age in Quebec, Canada.

Journal Article

BMC Public Health, 18 (1), pp. 1364, 2018.

Abstract | Links:

Harrison S, Carbonneau E, Talbot D, Lemieux S, Lamarche B

Development and validation of a dietary screener for carbohydrate intake in endurance athletes.

Journal Article

J Int Soc Sports Nutr, 15 (1), pp. 44, 2018.

Abstract | Links:

Talbot D, Rossi AM, Bacon SL, Atherton J, Lefebvre G

A graphical perspective of marginal structural models: An application for the estimation of the effect of physical activity on blood pressure.

Journal Article

Stat Methods Med Res, 27 (8), pp. 2428-2436, 2018, ISSN: 0962-2802.

Abstract | Links:

Allaire J, Talbot D, Couture P, Tchernof A, Jones PJH, Kris-Etherton P, West SG, Connelly PW, Jenkins DJA, Lamarche B

Assessing the impact of the diet on cardiometabolic outcomes: are multiple measurements post-intervention necessary?

Journal Article

Eur J Clin Nutr, 2018, ISSN: 0954-3007.

Abstract | Links:

Kiely M, Boulianne N, Talbot D, Ouakki M, Guay M, Landry M, Zafack J, Sauvageau C, De Serres G

Impact of the addition of new vaccines in the early childhood schedule on vaccine coverage by 24 months of age from 2006 to 2016 in Quebec, Canada.

Journal Article

Vaccine, 36 (29), pp. 4383-4391, 2018, ISSN: 0264-410X.

Abstract | Links:

Talbot D, Delaney JAC, Sandfort V, Herrington DM, McClelland RL

Importance of the lipid-related pathways in the association between statins, mortality, and cardiovascular disease risk: The Multi-Ethnic Study of Atherosclerosis.

Journal Article

Pharmacoepidemiol Drug Saf, 27 (4), pp. 365-372, 2018, ISSN: 1053-8569.

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Active projects

  • Centre de recherche sur les soins et les services de première ligne de l'Université Laval (CERSSPL-UL), Subvention, CIUSSS - CN - Centre de recherche sur les soins et les services de première ligne de l'ULaval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
  • Centre de recherches mathématiques (CRM), Subvention, Fonds de recherche du Québec - Nature et technologies, Regroupements stratégiques NT, from 2015-04-01 to 2022-03-31
  • Centre hospitalier universitaire de Québec - Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
  • DecreAsing sedentary behaviour and inCreasing physical acTIvity fOr healthy ageing (ACTION) study, Subvention, Instituts de recherche en santé du Canada, Subvention Projet, from 2017-04-01 to 2021-08-31
  • Inégalités sociales dans les trajectoires d'usage des traitements oraux pour le cancer du sein : Une comparaison France - Québec, Subvention, Instituts de recherche en santé du Canada, Subvention de fonctionnement, from 2017-04-01 to 2019-03-31
  • Méthodes d'inférence causale et la prise de décision dans un cadre bayésien, Subvention, Fonds de recherche du Québec - Nature et technologies, Projet de recherche en équipe, from 2018-04-01 to 2021-03-31
  • Model and variable selection for causal inference., Subvention, Conseil de recherches en sciences naturelles et génie Canada, Subventions à la découverte SD (individuelles et d'équipe), from 2016-04-01 to 2021-03-31
  • Real-World Cost-Effectiveness of Direct Oral Anticoagulants in Atrial Fibrillation: A Canadian Health Technology Reassessment Study, Subvention, Instituts de recherche en santé du Canada, Subvention Projet, from 2018-04-01 to 2020-09-30
  • Sélection de modèles statistiques pour effectuer de l'inférence causale à l'aide de données épidémiologiques, Subvention, Fonds de recherche du Québec - Santé, Chercheur-boursier Juniors 1 et 2, Seniors, from 2018-07-01 to 2022-06-30
  • Subvention d'établissement de jeune chercheur, Subvention, Fonds de recherche du Québec - Santé, Établissement de jeunes chercheurs - Juniors 1, from 2018-07-01 to 2022-06-30
Data provided by the Université Laval research projects registery