I completed my doctorate in physiology-endocrinology at Laval University in May 2012. My studies, conducted under the supervision of Dr. Serge Rivest, focused on understanding the role of pro-inflammatory cytokine interleukin-1 beta in regulating neuronal activity in various brain-related pathologies. I then completed, from July 2012 to March 2017, a postdoctoral fellowship in epigenomics under the direction of Dr. Christopher Glass at the University of California, San Diego (UC San Diego). My studies helped me gain a better understanding of the molecular mechanisms that regulate transcription in human and murine microglia (see Gosselin et al., Cell, 2014, Gosselin et al., Science, 2017). Finally, since April 2017, I am assistant professor under grant at Laval University. My laboratory, located at the CHU of Quebec-Laval University Research Centre, aims to better understand the role of microglia in brain physiology.

Understanding the microglial cell

 Microglia are the immune cells of the brain. More and more evidence suggests that they are actually involved in various physiological aspects of brain tissue, including its development, or diseases such as Alzheimer’s and autism spectrum deficits. On the other hand, the way microglia activity is regulated at the molecular level remains poorly known as of today.

To address this problem, we are using state-of-the-art next-generation sequencing techniques to better understand how microglia integrate the various signals that regulate it at the genome level, and how this integration modulates gene expression and cellular functions in microglia. Our studies are conducted in mice and we improve our sequencing technologies using microscopy and animal behavior tests. Our multidisciplinary research program, unique in Canada, allows us to define with unmatched precision how microglia contribute to brain function.

CHUL
2705 Boulevard Laurier
T-2-50
Ville de Québec, QC
Canada G1V 4G2
28 entries « 2 of 3 »

Eichenfield DZ, Troutman TD, Link VM, Lam MT, Cho H, Gosselin D, Spann NJ, Lesch HP, Tao J, Muto J, Gallo RL, Evans RM, Glass CK

Tissue damage drives co-localization of NF-κB, Smad3, and Nrf2 to direct Rev-erb sensitive wound repair in mouse macrophages.

Journal Article

Elife, 5 , 2016, ISSN: 2050-084X.

Abstract | Links:

Allison KA, Sajti E, Collier JG, Gosselin D, Troutman TD, Stone EL, Hedrick SM, Glass CK

Affinity and dose of TCR engagement yield proportional enhancer and gene activity in CD4+ T cells.

Journal Article

Elife, 5 , 2016, ISSN: 2050-084X.

Abstract | Links:

Bellavance MA, Gosselin D, Yong VW, Stys PK, Rivest S

Patrolling monocytes play a critical role in CX3CR1-mediated neuroprotection during excitotoxicity.

Journal Article

Brain Struct Funct, 220 (3), pp. 1759-76, 2015, ISSN: 1863-2653.

Abstract | Links:

Link VM, Gosselin D, Glass CK

Mechanisms Underlying the Selection and Function of Macrophage-Specific Enhancers.

Journal Article

Cold Spring Harb Symp Quant Biol, 80 , pp. 213-21, 2015, ISSN: 0091-7451.

Abstract | Links:

Gosselin D, Link VM, Romanoski CE, Fonseca GJ, Eichenfield DZ, Spann NJ, Stender JD, Chun HB, Garner H, Geissmann F, Glass CK

Environment drives selection and function of enhancers controlling tissue-specific macrophage identities.

Journal Article

Cell, 159 (6), pp. 1327-40, 2014, ISSN: 0092-8674.

Abstract | Links:

Gosselin D, Glass CK

Epigenomics of macrophages.

Journal Article

Immunol Rev, 262 (1), pp. 96-112, 2014, ISSN: 0105-2896.

Abstract | Links:

Norris PC, Gosselin D, Reichart D, Glass CK, Dennis EA

Phospholipase A2 regulates eicosanoid class switching during inflammasome activation.

Journal Article

Proc Natl Acad Sci U S A, 111 (35), pp. 12746-51, 2014, ISSN: 0027-8424.

Abstract | Links:

Crotti A, Benner C, Kerman BE, Gosselin D, Lagier-Tourenne C, Zuccato C, Cattaneo E, Gage FH, Cleveland DW, Glass CK

Mutant Huntingtin promotes autonomous microglia activation via myeloid lineage-determining factors.

Journal Article

Nat Neurosci, 17 (4), pp. 513-21, 2014, ISSN: 1097-6256.

Abstract | Links:

Lam MT, Cho H, Lesch HP, Gosselin D, Heinz S, Tanaka-Oishi Y, Benner C, Kaikkonen MU, Kim AS, Kosaka M, Lee CY, Watt A, Grossman TR, Rosenfeld MG, Evans RM, Glass CK

Rev-Erbs repress macrophage gene expression by inhibiting enhancer-directed transcription.

Journal Article

Nature, 498 (7455), pp. 511-5, 2013, ISSN: 0028-0836.

Abstract | Links:

Gosselin D, Bellavance MA, Rivest S

IL-1RAcPb signaling regulates adaptive mechanisms in neurons that promote their long-term survival following excitotoxic insults.

Journal Article

Front Cell Neurosci, 7 , pp. 9, 2013.

Abstract | Links:

28 entries « 2 of 3 »
Signaler des ajouts ou des modifications

Active projects

  • Aberrant microglial transcriptional regulation as an underlying core mechanism of disrupted brain development in ASD, Subvention, Scottish Rite Charitable Foundation of Canada, Subvention de recherche, from 2019-05-01 to 2022-04-30
  • Centre de recherche du CHU de Québec - Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
  • Centre thématique de recherche en neurosciences, Subvention, Institutionnel - BDR, BDR - Centres de recherche reconnus, from 1999-06-01 to 2023-05-01
  • Delineating the role of schizophrenia risk gene Mef2C in regulating microglial functions during brain development, Subvention, Brain & Behavior Research Foundation, NARSAD Young Investigator Grant, from 2019-01-15 to 2021-01-14
  • Delineation of the epigenomic principles underlying microglial transcriptional and cellular activity in chronic neurodegenerative diseases, Subvention, Instituts de recherche en santé du Canada, Subvention Projet, from 2020-03-01 to 2021-02-28
  • Étude des mécanismes épigénétiques responsables de l’identité cellulaire et des fonctions des microglies, Subvention, Fonds de recherche du Québec - Santé, Chercheur-boursier Juniors 1 et 2, Seniors, from 2017-07-01 to 2021-06-30

Recently finished projects

  • Étude des mécanismes épigénétiques responsables de l’identité cellulaire et des fonctions des microglies, Subvention, Fonds de recherche du Québec - Santé, Établissement de jeunes chercheurs - Juniors 1, from 2017-07-01 to 2020-06-30
  • Programme de soutien aux nouveaux professeurs de la Faculté de médecine, Subvention, Université Laval - démarrage nouveau chercheur, Soutien facultaire aux jeunes chercheurs de la Faculté de médecine, from 2017-05-01 to 2020-04-30
Data provided by the Université Laval research projects registery