I completed my doctorate in physiology-endocrinology at Laval University in May 2012. My studies, conducted under the supervision of Dr. Serge Rivest, focused on understanding the role of pro-inflammatory cytokine interleukin-1 beta in regulating neuronal activity in various brain-related pathologies. I then completed, from July 2012 to March 2017, a postdoctoral fellowship in epigenomics under the direction of Dr. Christopher Glass at the University of California, San Diego (UC San Diego). My studies helped me gain a better understanding of the molecular mechanisms that regulate transcription in human and murine microglia (see Gosselin et al., Cell, 2014, Gosselin et al., Science, 2017). Finally, since April 2017, I am assistant professor under grant at Laval University. My laboratory, located at the CHU of Quebec-Laval University Research Centre, aims to better understand the role of microglia in brain physiology.

Understanding the microglial cell

 Microglia are the immune cells of the brain. More and more evidence suggests that they are actually involved in various physiological aspects of brain tissue, including its development, or diseases such as Alzheimer’s and autism spectrum deficits. On the other hand, the way microglia activity is regulated at the molecular level remains poorly known as of today.

To address this problem, we are using state-of-the-art next-generation sequencing techniques to better understand how microglia integrate the various signals that regulate it at the genome level, and how this integration modulates gene expression and cellular functions in microglia. Our studies are conducted in mice and we improve our sequencing technologies using microscopy and animal behavior tests. Our multidisciplinary research program, unique in Canada, allows us to define with unmatched precision how microglia contribute to brain function.

CHUL
2705 Boulevard Laurier
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Ville de Québec, QC
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32 entries « 1 of 4 »

Chignon A, Rosa M, Boulanger MC, Argaud D, Devillers R, Bon-Baret V, Mkannez G, Li Z, Rufiange A, Gaudreault N, Gosselin D, Theriault S, Bosse Y, Mathieu P

Enhancer-associated aortic valve stenosis risk locus 1p21.2 alters NFATC2 binding site and promotes fibrogenesis.

Journal Article

iScience, 24 (3), 2021.

Abstract | Links:

Senecal V, Barat C, Gagnon MT, Vanasse F, Leboeuf M, Gosselin D, Tremblay MJ

Altered expression of fractalkine in HIV-1-infected astrocytes and consequences for the virus-related neurotoxicity.

Journal Article

J Neurovirol, 27 (2), 2021.

Abstract | Links:

Mishra MK, Rawji KS, Keough MB, Kappen J, Dowlatabadi R, Vogel HJ, Chopra S, Distefano-Gagne F, Dufour A, Gosselin D, Yong VW

Harnessing the Benefits of Neuroinflammation: Generation of Macrophages/Microglia with Prominent Remyelinating Properties.

Journal Article

J Neurosci, 41 (15), 2021.

Abstract | Links:

Lee J, Villarreal OD, Chen X, Zandee S, Young YK, Torok C, Lamarche-Vane N, Prat A, Rivest S, Gosselin D, Richard S

QUAKING Regulates Microexon Alternative Splicing of the Rho GTPase Pathway and Controls Microglia Homeostasis.

Journal Article

Cell Rep, 33 (13), 2020.

Abstract | Links:

Schlachetzki JCM, Prots I, Tao J, Chun HB, Saijo K, Gosselin D, Winner B, Glass CK, Winkler J

Author Correction: A monocyte gene expression signature in the early clinical course of Parkinson's disease.

Journal Article

Sci Rep, 10 (1), 2020.

Abstract | Links:

Seidman JS, Troutman TD, Sakai M, Gola A, Spann NJ, Bennett H, Bruni CM, Ouyang Z, Li RZ, Sun X, Vu BT, Pasillas MP, Ego KM, Gosselin D, Link VM, Chong LW, Evans RM, Thompson BM, McDonald JG, Hosseini M, Witztum JL, Germain RN, Glass CK

Niche-Specific Reprogramming of Epigenetic Landscapes Drives Myeloid Cell Diversity in Nonalcoholic Steatohepatitis.

Journal Article

Immunity, 52 (6), 2020.

Abstract | Links:

Gosselin D

Epigenomic and transcriptional determinants of microglial cell identity.

Journal Article

Glia, 68 (8), 2020.

Abstract | Links:

Gyoneva S, Hosur R, Gosselin D, Zhang B, Ouyang Z, Cotleur AC, Peterson M, Allaire N, Challa R, Cullen P, Roberts C, Miao K, Reynolds TL, Glass CK, Burkly L, Ransohoff RM

deficient microglia exhibit a premature aging transcriptome.

Journal Article

Life Sci Alliance, 2 (6), 2019.

Abstract | Links:

Machado Xavier A, Belhocine S, Gosselin D

Essential contributions of enhancer genomic regulatory elements to microglial cell identity and functions.

Journal Article

Wiley Interdiscip Rev Syst Biol Med, 11 (5), 2019.

Abstract | Links:

Schafer ST, Paquola ACM, Stern S, Gosselin D, Ku M, Pena M, Kuret TJM, Liyanage M, Mansour AA, Jaeger BN, Marchetto MC, Glass CK, Mertens J, Gage FH

Pathological priming causes developmental gene network heterochronicity in autistic subject-derived neurons.

Journal Article

Nat Neurosci, 22 (2), 2019.

Abstract | Links:

32 entries « 1 of 4 »
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Active projects

  • Aberrant microglial transcriptional regulation as an underlying core mechanism of disrupted brain development in ASD, from 2019-05-01 to 2022-04-30
  • Delineating the role of schizophrenia risk gene Mef2C in regulating microglial functions during brain development, from 2019-01-15 to 2022-01-14
  • Delineation of the epigenomic principles underlying microglial transcriptional and cellular activity in chronic neurodegenerative diseases, from 2020-03-01 to 2025-03-31
  • Delineation of the epigenomic principles underlying microglial transcriptional and cellular activity in demyelinating brain disorders, from 2021-04-01 to 2026-03-31
  • Enhancing microglial myelin repair mechanisms through stimulation of the Ppar-delta nuclear receptor as a novel therapeutic approach for multiple sclerosis, from 2020-09-01 to 2023-08-31
  • Étude de criblage sur la reprogrammation du métabolisme, du micro-environnement tumoral et des cellules souches cancéreuses dans le médulloblastome, from 2021-05-01 to 2022-04-30
  • Understanding and rejuvenating microglial phagocytosis as mean to inhibit progression of tauopathies in a mouse model of Alzheimer’s Disease, from 2020-10-01 to 2024-09-30

Recently finished projects

  • Étude des mécanismes épigénétiques responsables de l’identité cellulaire et des fonctions des microglies, from 2017-07-01 to 2020-06-30
  • Étude des mécanismes épigénétiques responsables de l’identité cellulaire et des fonctions des microglies, from 2017-07-01 to 2021-06-30
  • Programme de soutien aux nouveaux professeurs de la Faculté de médecine, from 2017-05-01 to 2020-04-30
Data provided by the Université Laval research projects registery