I completed my doctorate in physiology-endocrinology at Laval University in May 2012. My studies, conducted under the supervision of Dr. Serge Rivest, focused on understanding the role of pro-inflammatory cytokine interleukin-1 beta in regulating neuronal activity in various brain-related pathologies. I then completed, from July 2012 to March 2017, a postdoctoral fellowship in epigenomics under the direction of Dr. Christopher Glass at the University of California, San Diego (UC San Diego). My studies helped me gain a better understanding of the molecular mechanisms that regulate transcription in human and murine microglia (see Gosselin et al., Cell, 2014, Gosselin et al., Science, 2017). Finally, since April 2017, I am assistant professor under grant at Laval University. My laboratory, located at the CHU of Quebec-Laval University Research Centre, aims to better understand the role of microglia in brain physiology.

Understanding the microglial cell

 Microglia are the immune cells of the brain. More and more evidence suggests that they are actually involved in various physiological aspects of brain tissue, including its development, or diseases such as Alzheimer’s and autism spectrum deficits. On the other hand, the way microglia activity is regulated at the molecular level remains poorly known as of today.

To address this problem, we are using state-of-the-art next-generation sequencing techniques to better understand how microglia integrate the various signals that regulate it at the genome level, and how this integration modulates gene expression and cellular functions in microglia. Our studies are conducted in mice and we improve our sequencing technologies using microscopy and animal behavior tests. Our multidisciplinary research program, unique in Canada, allows us to define with unmatched precision how microglia contribute to brain function.

CHUL
2705 Boulevard Laurier
T-2-50
Ville de Québec, QC
Canada G1V 4G2

Bellavance MA, Gosselin D, Yong VW, Stys PK, Rivest S

Patrolling monocytes play a critical role in CX3CR1-mediated neuroprotection during excitotoxicity.

Journal Article

Brain Struct Funct, 220 (3), pp. 1759-76, 2015, ISSN: 1863-2653.

Abstract | Links:

Gosselin D, Bellavance MA, Rivest S

IL-1RAcPb signaling regulates adaptive mechanisms in neurons that promote their long-term survival following excitotoxic insults.

Journal Article

Front Cell Neurosci, 7 , pp. 9, 2013.

Abstract | Links:

Boivin N, Menasria R, Gosselin D, Rivest S, Boivin G

Impact of deficiency in CCR2 and CX3CR1 receptors on monocytes trafficking in herpes simplex virus encephalitis.

Journal Article

J Gen Virol, 93 (Pt 6), pp. 1294-304, 2012, ISSN: 0022-1317.

Abstract | Links:

Gosselin D, Rivest S

Immune mechanisms underlying the beneficial effects of autologous hematopoietic stem cell transplantation in multiple sclerosis.

Journal Article

Neurotherapeutics, 8 (4), pp. 643-9, 2011, ISSN: 1933-7213.

Abstract | Links:

Lampron A, Gosselin D, Rivest S

Targeting the hematopoietic system for the treatment of Alzheimer's disease.

Journal Article

Brain Behav Immun, 25 Suppl 1 , pp. S71-9, 2011, ISSN: 0889-1591.

Abstract | Links:

Gosselin D, Rivest S

Estrogen receptor transrepresses brain inflammation.

Journal Article

Cell, 145 (4), pp. 495-7, 2011, ISSN: 0092-8674.

Abstract | Links:

Fiola S, Gosselin D, Takada K, Gosselin J

TLR9 contributes to the recognition of EBV by primary monocytes and plasmacytoid dendritic cells.

Journal Article

J Immunol, 185 (6), pp. 3620-31, 2010, ISSN: 0022-1767.

Abstract | Links:

Gosselin D, Rivest S

MyD88 signaling in brain endothelial cells is essential for the neuronal activity and glucocorticoid release during systemic inflammation.

Journal Article

Mol Psychiatry, 13 (5), pp. 480-97, 2008, ISSN: 1359-4184.

Abstract | Links:

Sergerie Y, Boivin G, Gosselin D, Rivest S

Delayed but Not Early Glucocorticoid Treatment Protects the Host during Experimental Herpes Simplex Virus Encephalitis in Mice.

Journal Article

J Infect Dis, 195 (6), pp. 817-25, 2007, ISSN: 0022-1899.

Abstract | Links:

Gosselin D, Rivest S

Role of IL-1 and TNF in the brain: Twenty years of progress on a Dr. Jekyll/Mr. Hyde duality of the innate immune system.

Journal Article

Brain Behav Immun, 21 (3), pp. 281-9, 2007, ISSN: 0889-1591.

Abstract | Links:

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Active projects

  • Centre thématique de recherche en neurosciences, Subvention, Institutionnel - BDR, BDR - Centres de recherche reconnus, from 1999-06-01 to 2020-10-18
  • Centres hospitaliers universitaires de Québec - Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
  • Delineating the role of schizophrenia risk gene Mef2C in regulating microglial functions during brain development, Subvention, Brain & Behavior Research Foundation, NARSAD Young Investigator Grant, from 2019-01-15 to 2021-01-14
  • Étude des mécanismes épigénétiques responsables de l’identité cellulaire et des fonctions des microglies, Subvention, Fonds de recherche du Québec - Santé, Chercheur-boursier Juniors 1 et 2, Seniors, from 2017-07-01 to 2021-06-30
  • Étude des mécanismes épigénétiques responsables de l’identité cellulaire et des fonctions des microglies, Subvention, Fonds de recherche du Québec - Santé, Établissement de jeunes chercheurs - Juniors 1, from 2017-07-01 to 2020-06-30
  • Programme de soutien aux nouveaux professeurs de la Faculté de médecine, Subvention, Université Laval - démarrage nouveau chercheur, Soutien facultaire aux jeunes chercheurs de la Faculté de médecine, from 2017-05-01 to 2020-04-30

Recently finished projects

  • Chercheur boursier - Complément de salaire, Subvention, Université Laval - budget de fonctionnement, Compléments de salaire des professeurs sous octroi, from 2017-05-01 to 2018-04-30
  • Étude des mécanismes épigénétiques responsables de l'identité cellulaire et des fonctions des microglies, Subvention, Fondation du CHU de Québec, from 2017-04-20 to 2019-03-31
  • Étude des mécanismes épigénétiques responsables de l’identité cellulaire et des fonctions des microglies, Subvention, Fondation de l'Université Laval, from 2017-05-01 to 2018-04-30
Data provided by the Université Laval research projects registery