I completed my doctorate in physiology-endocrinology at Laval University in May 2012. My studies, conducted under the supervision of Dr. Serge Rivest, focused on understanding the role of pro-inflammatory cytokine interleukin-1 beta in regulating neuronal activity in various brain-related pathologies. I then completed, from July 2012 to March 2017, a postdoctoral fellowship in epigenomics under the direction of Dr. Christopher Glass at the University of California, San Diego (UC San Diego). My studies helped me gain a better understanding of the molecular mechanisms that regulate transcription in human and murine microglia (see Gosselin et al., Cell, 2014, Gosselin et al., Science, 2017). Finally, since April 2017, I am assistant professor under grant at Laval University. My laboratory, located at the CHU of Quebec-Laval University Research Centre, aims to better understand the role of microglia in brain physiology.

Understanding the microglial cell

 Microglia are the immune cells of the brain. More and more evidence suggests that they are actually involved in various physiological aspects of brain tissue, including its development, or diseases such as Alzheimer’s and autism spectrum deficits. On the other hand, the way microglia activity is regulated at the molecular level remains poorly known as of today.

To address this problem, we are using state-of-the-art next-generation sequencing techniques to better understand how microglia integrate the various signals that regulate it at the genome level, and how this integration modulates gene expression and cellular functions in microglia. Our studies are conducted in mice and we improve our sequencing technologies using microscopy and animal behavior tests. Our multidisciplinary research program, unique in Canada, allows us to define with unmatched precision how microglia contribute to brain function.

CHUL
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T-2-50
Ville de Québec, QC
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28 entries « 1 of 3 »

Gosselin D

Epigenomic and transcriptional determinants of microglial cell identity.

Journal Article

Glia, 68 (8), pp. 1643-1654, 2020, ISSN: 0894-1491.

Abstract | Links:

Seidman JS, Troutman TD, Sakai M, Gola A, Spann NJ, Bennett H, Bruni CM, Ouyang Z, Li RZ, Sun X, Vu BT, Pasillas MP, Ego KM, Gosselin D, Link VM, Chong LW, Evans RM, Thompson BM, McDonald JG, Hosseini M, Witztum JL, Germain RN, Glass CK

Niche-Specific Reprogramming of Epigenetic Landscapes Drives Myeloid Cell Diversity in Nonalcoholic Steatohepatitis.

Journal Article

Immunity, 52 (6), pp. 1057-1074.e7, 2020, ISSN: 1074-7613.

Abstract | Links:

Schlachetzki JCM, Prots I, Tao J, Chun HB, Saijo K, Gosselin D, Winner B, Glass CK, Winkler J

Author Correction: A monocyte gene expression signature in the early clinical course of Parkinson's disease.

Journal Article

Sci Rep, 10 (1), pp. 6261, 2020, ISSN: 2045-2322.

Abstract | Links:

Nott A, Holtman IR, Coufal NG, Schlachetzki JCM, Yu M, Hu R, Han CZ, Pena M, Xiao J, Wu Y, Keulen Z, Pasillas MP, O'Connor C, Nickl CK, Schafer ST, Shen Z, Rissman RA, Brewer JB, Gosselin D, Gonda DD, Levy ML, Rosenfeld MG, McVicker G, Gage FH, Ren B, Glass CK

Brain cell type-specific enhancer-promoter interactome maps and disease-risk association.

Journal Article

Science, 366 (6469), pp. 1134-1139, 2019, ISSN: 0036-8075.

Abstract | Links:

Schafer ST, Paquola ACM, Stern S, Gosselin D, Ku M, Pena M, Kuret TJM, Liyanage M, Mansour AA, Jaeger BN, Marchetto MC, Glass CK, Mertens J, Gage FH

Pathological priming causes developmental gene network heterochronicity in autistic subject-derived neurons.

Journal Article

Nat Neurosci, 22 (2), pp. 243-255, 2019, ISSN: 1097-6256.

Abstract | Links:

Machado Xavier A, Belhocine S, Gosselin D

Essential contributions of enhancer genomic regulatory elements to microglial cell identity and functions.

Journal Article

Wiley Interdiscip Rev Syst Biol Med, 11 (5), pp. e1449, 2019, ISSN: 1939-005X.

Abstract | Links:

Gyoneva S, Hosur R, Gosselin D, Zhang B, Ouyang Z, Cotleur AC, Peterson M, Allaire N, Challa R, Cullen P, Roberts C, Miao K, Reynolds TL, Glass CK, Burkly L, Ransohoff RM

Cx3cr1-deficient microglia exhibit a premature aging transcriptome.

Journal Article

Life Sci Alliance, 2 (6), 2019, ISSN: 2575-1077.

Abstract | Links:

Gosselin D, Rivest S

Getting Too Old Too Quickly for Their Job: Senescent Glial Cells Promote Neurodegeneration.

Journal Article

Neuron, 100 (4), pp. 777-779, 2018, ISSN: 0896-6273.

Abstract | Links:

Schlachetzki JCM, Prots I, Tao J, Chun HB, Saijo K, Gosselin D, Winner B, Glass CK, Winkler J

A monocyte gene expression signature in the early clinical course of Parkinson's disease.

Journal Article

Sci Rep, 8 (1), pp. 10757, 2018, ISSN: 2045-2322.

Abstract | Links:

Gosselin D, Skola D, Coufal NG, Holtman IR, Schlachetzki JCM, Sajti E, Jaeger BN, O'Connor C, Fitzpatrick C, Pasillas MP, Pena M, Adair A, Gonda DD, Levy ML, Ransohoff RM, Gage FH, Glass CK

An environment-dependent transcriptional network specifies human microglia identity.

Journal Article

Science, 356 (6344), 2017, ISSN: 0036-8075.

Abstract | Links:

28 entries « 1 of 3 »
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Active projects

  • Aberrant microglial transcriptional regulation as an underlying core mechanism of disrupted brain development in ASD, Subvention, Scottish Rite Charitable Foundation of Canada, Subvention de recherche, from 2019-05-01 to 2022-04-30
  • Centre de recherche du CHU de Québec - Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
  • Centre thématique de recherche en neurosciences, Subvention, Institutionnel - BDR, BDR - Centres de recherche reconnus, from 1999-06-01 to 2023-05-01
  • Delineating the role of schizophrenia risk gene Mef2C in regulating microglial functions during brain development, Subvention, Brain & Behavior Research Foundation, NARSAD Young Investigator Grant, from 2019-01-15 to 2021-01-14
  • Delineation of the epigenomic principles underlying microglial transcriptional and cellular activity in chronic neurodegenerative diseases, Subvention, Instituts de recherche en santé du Canada, Subvention Projet, from 2020-03-01 to 2021-02-28
  • Étude des mécanismes épigénétiques responsables de l’identité cellulaire et des fonctions des microglies, Subvention, Fonds de recherche du Québec - Santé, Chercheur-boursier Juniors 1 et 2, Seniors, from 2017-07-01 to 2021-06-30

Recently finished projects

  • Étude des mécanismes épigénétiques responsables de l’identité cellulaire et des fonctions des microglies, Subvention, Fonds de recherche du Québec - Santé, Établissement de jeunes chercheurs - Juniors 1, from 2017-07-01 to 2020-06-30
  • Programme de soutien aux nouveaux professeurs de la Faculté de médecine, Subvention, Université Laval - démarrage nouveau chercheur, Soutien facultaire aux jeunes chercheurs de la Faculté de médecine, from 2017-05-01 to 2020-04-30
Data provided by the Université Laval research projects registery