I completed my doctorate in physiology-endocrinology at Laval University in May 2012. My studies, conducted under the supervision of Dr. Serge Rivest, focused on understanding the role of pro-inflammatory cytokine interleukin-1 beta in regulating neuronal activity in various brain-related pathologies. I then completed, from July 2012 to March 2017, a postdoctoral fellowship in epigenomics under the direction of Dr. Christopher Glass at the University of California, San Diego (UC San Diego). My studies helped me gain a better understanding of the molecular mechanisms that regulate transcription in human and murine microglia (see Gosselin et al., Cell, 2014, Gosselin et al., Science, 2017). Finally, since April 2017, I am assistant professor under grant at Laval University. My laboratory, located at the CHU of Quebec-Laval University Research Centre, aims to better understand the role of microglia in brain physiology.
Understanding the microglial cell
Microglia are the immune cells of the brain. More and more evidence suggests that they are actually involved in various physiological aspects of brain tissue, including its development, or diseases such as Alzheimer’s and autism spectrum deficits. On the other hand, the way microglia activity is regulated at the molecular level remains poorly known as of today.
To address this problem, we are using state-of-the-art next-generation sequencing techniques to better understand how microglia integrate the various signals that regulate it at the genome level, and how this integration modulates gene expression and cellular functions in microglia. Our studies are conducted in mice and we improve our sequencing technologies using microscopy and animal behavior tests. Our multidisciplinary research program, unique in Canada, allows us to define with unmatched precision how microglia contribute to brain function.
2705 Boulevard Laurier
Ville de Québec, QC
Canada G1V 4G2
An environment-dependent transcriptional network specifies human microglia identity.Journal Article
Science, 356 (6344), 2017, ISSN: 0036-8075.
Tissue damage drives co-localization of NF-κB, Smad3, and Nrf2 to direct Rev-erb sensitive wound repair in mouse macrophages.Journal Article
Elife, 5 , 2016, ISSN: 2050-084X.
Affinity and dose of TCR engagement yield proportional enhancer and gene activity in CD4+ T cells.Journal Article
Elife, 5 , 2016, ISSN: 2050-084X.
Patrolling monocytes play a critical role in CX3CR1-mediated neuroprotection during excitotoxicity.Journal Article
Brain Struct Funct, 220 (3), pp. 1759-76, 2015, ISSN: 1863-2653.
Mechanisms Underlying the Selection and Function of Macrophage-Specific Enhancers.Journal Article
Cold Spring Harb Symp Quant Biol, 80 , pp. 213-21, 2015, ISSN: 0091-7451.
- Étude des mécanismes épigénétiques responsables de l’identité cellulaire et des fonctions des microglies, Subvention, Fonds de recherche du Québec - Santé, Chercheur-boursier Juniors 1 et 2, Seniors, from 2017-07-01 to 2021-06-30
- Étude des mécanismes épigénétiques responsables de l’identité cellulaire et des fonctions des microglies, Subvention, Fonds de recherche du Québec - Santé, Établissement de jeunes chercheurs - Juniors 1, from 2017-07-01 to 2020-06-30
- Programme de soutien aux nouveaux professeurs de la Faculté de médecine, Subvention, Université Laval - démarrage nouveau chercheur, Soutien facultaire aux jeunes chercheurs de la Faculté de médecine, from 2017-05-01 to 2020-04-30
Recently finished projects
- Étude des mécanismes épigénétiques responsables de l’identité cellulaire et des fonctions des microglies, Subvention, Fondation de l'Université Laval, from 2017-05-01 to 2018-04-30