Dr. Gagnon is an adult endocrinologist. She has completed a 3-year research fellowship in metabolic bone diseases and phosphocalcic metabolism disorders. She is a clinician researcher at the CHU de Québec-Laval University Research Centre and a Professor at Laval University’s School of Medicine. She is also an associate researcher at Laval University’s Institute of Nutrition and Functional Foods. Her research focusses on the impact of obesity and type 2 diabetes treatments on bone health (including bariatric surgery and medical treatments). She also works on the effects of vitamin D and other nutrients on the prevention of type 2 diabetes and, finally, on phosphocalcic metabolism disorders. Her research is financed by Diabète Québec, Diabetes Canada, and the Canadian Institutes of Health Research.

Dr. Gagnon has received several prizes and honours, including the 2017 research prize from the Fédération des médecins spécialistes du Québec, a 2015 young investigator award from the American Society for Bone and Mineral Research, an award at the 2015 International Symposium on the Nutritional Aspects of Osteoporosis, and a 2019 Jean-Davignon young investigator award from the FRQ-S cardiometabolic, diabetes and obesity network.

To evaluate the impact of bariatric surgery and other obesity treatments on bone health

Bariatric surgery is associated with clear benefits on reducing obesity-related diseases. However, data cumulated over the last few years suggest that certain types of bariatric procedures have adverse effects on bone health. Moreover, the effect of medical weight loss on bone health is not well studied. Dr. Gagnon’s research aims at evaluating the impact of different types of bariatric procedures and obesity treatments on bone markers, and to determine the mechanisms by which they influence bone health.

To evaluate the effects of vitamin D and other nutrients on the risk of developing type 2 diabetes

Certain nutrients hold promise to decrease the risk of diabetes in people at high risk. Dr. Gagnon’s expertise is to perform clinical trials to evaluate whether these nutrients are effective.

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Valle M, Mitchell PL, Pilon G, Varin T, Hénault L, Rolin J, McLeod R, Gill T, Richard D, Vohl MC, Jacques H, Gagnon C, Bazinet L, Marette A

Salmon peptides limit obesity-associated metabolic disorders by modulating a gut-liver axis in vitamin D-deficient mice.

Journal Article

Obesity (Silver Spring), 29 (10), 2021.

Abstract | Links:

Gagnon M, Trottier J, Weisnagel SJ, Gagnon C, Carreau AM, Barbier O, Morisset AS

Bile acids during pregnancy: Trimester variations and associations with glucose homeostasis.

Journal Article

Health Sci Rep, 4 (1), 2021.

Abstract | Links:

Khorraminezhad L, Leclercq M, O'Connor S, Julien P, Weisnagel SJ, Gagnon C, Droit A, Rudkowska I

Dairy product intake modifies gut microbiota composition among hyperinsulinemic individuals.

Journal Article

Eur J Nutr, 60 (1), 2021.

Abstract | Links:

Valle M, Mitchell PL, Pilon G, St-Pierre P, Varin T, Richard D, Vohl MC, Jacques H, Delvin E, Levy E, Bazinet L, Marette A, Gagnon C

Cholecalciferol Supplementation Does Not Prevent the Development of Metabolic Syndrome or Enhance the Beneficial Effects of Omega-3 Fatty Acids in Obese Mice.

Journal Article

J Nutr, 151 (5), 2021.

Abstract | Links:

Savard C, Bielecki A, Plante AS, Lemieux S, Gagnon C, Weiler HA, Morisset AS

Longitudinal Assessment of Vitamin D Status across Trimesters of Pregnancy.

Journal Article

J Nutr, 151 (7), 2021.

Abstract | Links:

Savard C, Plante AS, Carbonneau E, Gagnon C, Robitaille J, Lamarche B, Lemieux S, Morisset AS

Do pregnant women eat healthier than non-pregnant women of childbearing age?

Journal Article

Int J Food Sci Nutr, 71 (6), 2020.

Abstract | Links:

Turcotte AF, Grenier-Larouche T, Lacombe J, Carreau AM, Carpentier AC, Mac-Way F, Tchernof A, Richard D, Biertho L, Lebel S, Marceau S, Ferron M, Gagnon C

Association between changes in bioactive osteocalcin and glucose homeostasis after biliopancreatic diversion.

Journal Article

Endocrine, 69 (3), 2020.

Abstract | Links:

Lacombe J, Al Rifai O, Loter L, Moran T, Turcotte AF, Grenier-Larouche T, Tchernof A, Biertho L, Carpentier AC, Prud'homme D, Rabasa-Lhoret R, Karsenty G, Gagnon C, Jiang W, Ferron M

Measurement of bioactive osteocalcin in humans using a novel immunoassay reveals association with glucose metabolism and β-cell function.

Journal Article

Am J Physiol Endocrinol Metab, 318 (3), 2020.

Abstract | Links:

Turcotte AF, Kukuljan S, Dalla Via J, Gagnon C, Abbott G, Daly RM

Changes in spinal bone density, back muscle size, and visceral adipose tissue and their interaction following a multi-component exercise program in older men: secondary analysis of an 18-month randomized controlled trial.

Journal Article

Osteoporos Int, 31 (10), 2020.

Abstract | Links:

O'Connor S, Julien P, Weisnagel SJ, Gagnon C, Rudkowska I

Impact of a High Intake of Dairy Product on Insulin Sensitivity in Hyperinsulinemic Adults: A Crossover Randomized Controlled Trial.

Journal Article

Curr Dev Nutr, 3 (8), 2019.

Abstract | Links:

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Active projects

  • BEhaviors, Therapies, TEchnologies and hypoglycemic Risk in Type 1 diabetes: The BETTER study, from 2018-04-01 to 2022-03-31
  • Bone health after bariatric surgery in patient with type 2 diabetes, from 2017-07-01 to 2022-12-31
  • Covid-19 effects on ARTErial StIffness and vascular AgiNg (CARTESIAN) study- Canada, from 2021-06-01 to 2022-05-31
  • Demonstration of the prebiotic-like effects of camu-camu consumption against obesity-related disorders in humans, from 2019-07-01 to 2022-06-30
  • Dissecting host-microbiome modifiers of type 2 diabetes risk - Objective 1.3, from 2019-11-01 to 2024-10-31
  • Identifying low bone turnover disease in chronic kidney disease in order to guide anti-fracture therapy, from 2020-10-01 to 2025-09-30
  • Institut sur la nutrition et les aliments fonctionnels (INAF), from 2017-04-01 to 2024-03-31
  • Perinatal research unit for a sustainable health of mother and child, from 2018-03-01 to 2021-12-31
  • Traiter l’os pour prévenir l’hypertension et les maladies cardiovasculaires chez les femmes ménopausées., from 2021-05-01 to 2022-04-30

Recently finished projects

  • Determinants of bone and muscle quality and function in obesity with and without diabetes - BODI 2, from 2019-12-18 to 2021-09-30
  • Facteurs de risque et impacts de la carence en vitamine D chez les victimes de traumatisme craniocérébral modéré et grave: une étude rétrospective multicentrique., from 2018-04-01 to 2020-03-31
  • Insulinorésistance et santé osseuse chez l’obèse : rôle des nutriments et des facteurs hormonaux, from 2017-10-01 to 2021-09-30
  • Translational approach to establish the cardiometabolic health effects and mechanisms of action of fish nutrients: from animal models to obese insulin-resistant subjects, from 2013-06-01 to 2021-03-31
Data provided by the Université Laval research projects registery