Senior investigator at the CHU de Québec-Laval University Research Center, Dr. Côté is also full professor at the department of Réadaptation/Rehabiliatiton and has been a member of the School of medicine’s executive committee as associate dean for the rehabilitation programs since 2010.
For over 20 years, he has been conducting research work focussing on the pathophysiology of musculoskeletal trauma and injuries. More specifically, he is interested in elucidating the cellular and molecular mechanisms involved in the cascades behind the coordinated actions leading to the degeneration and regeneration of muscle tissue following acute trauma or injury, mainly using animal and cellular models.
His most recent work aims at understanding the importance of the inflammatory reaction for the healing and regenerative processes in skeletal muscle; one goal is to identify the specific roles assumed by the various cells implicated during an innate inflammatory reaction like the one triggered in injured skeletal muscle; specifically, one objective is to determine how mast cells can modulate such a process and the prostaglandins involved. Lastly, we also conduct work whose goal is to determine how pharmacological anti-inflammatory strategies can interfere with degenerative and regenerative processes.
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Identification of New Targets Used by 15-deoxy-delta-12,14-Prostaglandin J2 to Stimulate SkeletalJournal Article
Ann Sports Med Res, 2 (4), pp. 1027, 2015.
Monocyte depletion increases local proliferation of macrophage subsets after skeletal muscle injury.Journal Article
BMC Musculoskelet Disord, 14 , pp. 359, 2013.
Mast cells can regulate skeletal muscle cell proliferation by multiple mechanisms.Journal Article
Muscle Nerve, 48 (3), pp. 403-14, 2013, ISSN: 0148-639X.
Beneficial effects of cod protein on inflammatory cell accumulation in rat skeletal muscle after injury are driven by its high levels of arginine, glycine, taurine and lysine.Journal Article
PLoS ONE, 8 (10), pp. e77274, 2013.
MAPK signaling in the quadriceps of patients with chronic obstructive pulmonary disease.Journal Article
J Appl Physiol, 113 (1), pp. 159-66, 2012, ISSN: 8750-7587.
Beneficial effects of cod protein on skeletal muscle repair following injury.Journal Article
Appl Physiol Nutr Metab, 37 (3), pp. 489-98, 2012, ISSN: 1715-5312.
Mast cell tryptase stimulates myoblast proliferation; a mechanism relying on protease-activated receptor-2 and cyclooxygenase-2.Journal Article
BMC Musculoskelet Disord, 12 , pp. 235, 2011.
Quadriceps metabolism during constant workrate cycling exercise in chronic obstructive pulmonary disease.Journal Article
J Appl Physiol, 110 (1), pp. 116-24, 2011, ISSN: 8750-7587.
Peanut protein reduces body protein mass and alters skeletal muscle contractile properties and lipid metabolism in rats.Journal Article
Br J Nutr, 103 (9), pp. 1331-9, 2010, ISSN: 0007-1145.
Ubiquitination and proteolysis in limb and respiratory muscles of patients with chronic obstructive pulmonary disease.Journal Article
Proc Am Thorac Soc, 7 (1), pp. 84-90, 2010, ISSN: 1546-3222.
- Centre de recherche du CHU de Québec - Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31