Christian Salesse is a full-time researcher at the Centre de recherche du CHU de Québec – Laval University, and full professor in Laval University’s Department of Ophthalmology. He graduated in biophysics from Université du Québec à Trois-Rivières (UQTR). He was then a postdoctoral fellow at the Johannes-Gutenberg Universität in Mainz, Germany. He then became professor at the UQTR for 14 years until he moved on to work at Laval University, in 2002. He has been a fellow from Fonds de Recherche – Québec Santé (FRQS) from the Junior 1 to the National level. He has also been Adjunct Professor at Jilin University in Changchun, China since 1995. He was an invited professor at several universities in France and Portugal.

His expertise is in the field of visual phototransduction and visual cycle, and the proteins involved in these processes. These processes require the binding of most of these proteins to membranes. We therefore perform membrane binding measurements of proteins. We are using simple model membranes such as lipid monolayers and bilayers to characterize their membrane binding. Protein binding to monolayers of saturated and highly polyunsaturated neutral or negatively charged lipids, that are typical of photoreceptors, is characterized by performing measurements of maximum insertion pressure, fluorescence microscopy, ellipsometry, as well as infrared spectroscopy (PM-IRRAS which also allows to determine protein orientation). Steady state fluorescence spectroscopy and fluorescence lifetime are used to characterize protein binding to lipid bilayers. The proteins we are studying also often have enzymatic activities; we have thus developed methods to characterize the activity of some of these enzymes. Moreover, we use nuclear magnetic resonance to determine the structure of a protein involved in the visual cycle.

Hôpital Saint-Sacrement
1050, chemin Sainte-Foy
CUO-Recherche
K2-02
Québec, Québec
Canada G1S 4L8
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Salesse C

Physiologie du signal visuel rétinien : de la phototransduction jusqu’au cycle visuel

Book Chapter

EM| consulte. Ophtalmologie, 13 , pp. [Article 21-026-K-10], Issy les Moulineaux, Elsevier Masson SAS, 2016.

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Lake J, Zaniolo K, Gingras ME, Couture C, Salesse C, Guerin SL

Functional Impact of Collagens on the Activity Directed by the Promoter of the α5 Integrin Subunit Gene in Corneal Epithelial Cells.

Journal Article

Invest Ophthalmol Vis Sci, 56 (11), pp. 6217-32, 2015, ISSN: 0146-0404.

Abstract | Links:

Duval C, Zaniolo K, Leclerc S, Salesse C, Guerin SL

Characterization of the human α9 integrin subunit gene: Promoter analysis and transcriptional regulation in ocular cells.

Journal Article

Exp Eye Res, 135 , pp. 146-63, 2015, ISSN: 0014-4835.

Abstract | Links:

Demers E, Boisselier E, Horchani H, Blaudez D, Calvez P, Cantin L, Belley N, Champagne S, Desbat B, Salesse C

Lipid Selectivity, Orientation, and Extent of Membrane Binding of Nonacylated RP2.

Journal Article

Biochemistry, 54 (16), pp. 2560-70, 2015, ISSN: 0006-2960.

Abstract | Links:

Lhor M, Methot M, Horchani H, Salesse C

Structure of the N-terminal segment of human retinol dehydrogenase 11 and its preferential lipid binding using model membranes.

Journal Article

Biochim Biophys Acta, 1848 (3), pp. 878-85, 2015, ISSN: 0006-3002.

Abstract | Links:

Bernier S, Horchani H, Salesse C

Structure and binding of the C-terminal segment of R9AP to lipid monolayers.

Journal Article

Langmuir, 31 (6), pp. 1967-79, 2015, ISSN: 0743-7463.

Abstract | Links:

Bernier SC, Demers É, Cantin L, Bussières S, Salesse C

How To Decipher Protein and Peptide Selectivity for Lipids in Monolayers (Chapter 6)

Book Chapter

C, Wang; RM, Leblanc (Ed.): Recent Progress in Colloid and Surface Chemistry with Biological Applications, 1215 , pp. 109-128, American Chemical Society, 2015, ISBN: 9780841231207 / 9780841231191 (eISBN).

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Zhang C, Pan T, Salesse C, Zhang D, Miao L, Wang L, Gao Y, Xu J, Dong Z, Luo Q, Liu J

Reversible Ca(2+) switch of an engineered allosteric antioxidant selenoenzyme.

Journal Article

Angew Chem Int Ed Engl, 53 (49), pp. 13536-9, 2014, ISSN: 0570-0833.

Abstract | Links:

Lhor M, Salesse C

Retinol dehydrogenases: membrane-bound enzymes for the visual function.

Journal Article

Biochem Cell Biol, 92 (6), pp. 510-23, 2014, ISSN: 0829-8211.

Abstract | Links:

Horchani H, Bussieres S, Cantin L, Lhor M, Laliberte-Gemme JS, Breton R, Salesse C

Enzymatic activity of Lecithin:retinol acyltransferase: a thermostable and highly active enzyme with a likely mode of interfacial activation.

Journal Article

Biochim Biophys Acta, 1844 (6), pp. 1128-36, 2014, ISSN: 0006-3002.

Abstract | Links:

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Active projects

  • Centre de recherche du CHU de Québec - Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
  • Déterminants moléculaires de la lécithine rétinol acyltransférase responsables de la dégénérescence des photorécepteurs, Subvention, Instituts de recherche en santé du Canada, Volet Projet: Concours pilotes, from 2016-07-01 to 2021-06-30
  • Implication de diverses protéines dans la fonction des photorécepteurs visuels, Subvention, Conseil de recherches en sciences naturelles et génie Canada, Subventions à la découverte SD (individuelles et d'équipe), from 2017-04-01 to 2022-03-31
  • PROTEO, le regroupement québécois de recherche sur la fonction, l'ingénierie et les applications des protéines (PROTEO), Subvention, Fonds de recherche du Québec - Nature et technologies, Regroupements stratégiques NT, from 2015-04-01 to 2022-03-31
  • Regroupement québécois de recherche sur la fonction, la structure et l'ingénierie des protéines, Subvention, Institutionnel - BDR, BDR - Centres de recherche reconnus, from 2014-05-01 to 2023-04-03

Recently finished projects

  • Système FPLC pour la purification des protéines, Subvention, Conseil de recherches en sciences naturelles et génie Canada, Subventions d'outils et d'instruments de recherche (OIR), from 2019-03-28 to 2020-03-31
Data provided by the Université Laval research projects registery