Caroline Sirois is a professor in the Department of Social and Preventive Medicine at Laval University. She is a researcher at the CHU de Québec Research Center, the Center of Excellence on Aging in Quebec, the Center for Research in Primary Care and Services at Laval University, and a research associate at the Institut national de santé publique du Québec (INSPQ). Since July 2016, she holds the Chair of Research on Aging at Laval University. As a pharmacist with a master’s degree in hospital pharmacy, Ms. Sirois practiced in community pharmacies and hospital settings before completing a master’s degree and a doctorate in pharmacoepidemiology at Laval University. She then completed postdoctoral training in epidemiology at McGill University.

Her research interests focus on the appropriate use of drugs in older adults, polypharmacy, and deprescribing. Her interests include the study of potentially inappropriate drugs for older individuals and the conceptualization of appropriate polypharmacy. By using multicriteria analysis methods, she tries to determine which drug combinations generate more benefits than adverse effects on the health and quality of life of patients. She is also interested in deprescribing, both from the perspective of older adults, and clinicians.

Ms. Sirois works closely with the INSPQ on the development of polypharmacy surveillance for people aged 65 and over in Quebec. This project involves the development of polypharmacy indicators on which she collaborates with several international teams.

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Gosselin E, Simard M, Lunghi C, Sirois C

Trends in benzodiazepine and alternative hypnotic use in relation with multimorbidity among older adults in Quebec, Canada.

Journal Article

Pharmacoepidemiol Drug Saf, 2021.

Abstract | Links:

Breuker C, Teasdale J, Mallet L, Ricard G, Turcotte JP, Gosselin S, Langlois MF, Imbeault P, Breton M, Couturier Y, Sirois C, Cossette B

Communication between hospitals, Family Medicine Groups and community pharmacists during transitions of care interventions.

Journal Article

Res Social Adm Pharm, 2021.

Abstract | Links:

Simard M, Rahme E, Calfat AC, Sirois C

Multimorbidity measures from health administrative data using ICD system codes: A systematic review.

Journal Article

Pharmacoepidemiol Drug Saf, 2021.

Abstract | Links:

Sirois C, Khoury R, Durand A, Deziel PL, Bukhtiyarova O, Chiu Y, Talbot D, Bureau A, Després P, Gagné C, Laviolette F, Savard AM, Corbeil J, Badard T, Jean S, Simard M

Exploring polypharmacy with artificial intelligence: data analysis protocol.

Journal Article

BMC Med Inform Decis Mak, 21 (1), 2021.

Abstract | Links:

Laroche ML, Van Ngo TH, Sirois C, Daveluy A, Guillaumin M, Valnet-Rabier MB, Grau M, Roux B, Merle L

Mapping of drug-related problems among older adults conciliating medical and pharmaceutical approaches.

Journal Article

Eur Geriatr Med, 12 (3), 2021.

Abstract | Links:

Campeau Calfat A, Duval C, Laberge M, Savard AM, Sirois C

Clinical services in community pharmacies: a scoping review of policy and social implications.

Journal Article

Int J Pharm Pract, 29 (2), 2021.

Abstract | Links:

Sirois C, Turner JP, Hebert J

Health professionals' perspectives regarding polypharmacy in older patients with cancer: A mixed-design exploratory study.

Journal Article

J Geriatr Oncol, 12 (6), 2021.

Abstract | Links:

Laberge M, Sirois C, Lunghi C, Gaudreault M, Nakamura Y, Bolduc C, Laroche ML

Economic Evaluations of Interventions to Optimize Medication Use in Older Adults with Polypharmacy and Multimorbidity: A Systematic Review.

Journal Article

Clin Interv Aging, 16 , 2021.

Abstract | Links:

Garland CT, Guenette L, Kroger E, Carmichael PH, Rouleau R, Sirois C

A New Care Model Reduces Polypharmacy and Potentially Inappropriate Medications in Long-Term Care.

Journal Article

J Am Med Dir Assoc, 22 (1), 2021.

Abstract | Links:

Mbuya-Bienge C, Simard M, Gaulin M, Candas B, Sirois C

Does socio-economic status influence the effect of multimorbidity on the frequent use of ambulatory care services in a universal healthcare system? A population-based cohort study.

Journal Article

BMC Health Serv Res, 21 (1), 2021.

Abstract | Links:

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Active projects

  • Chaire de recherche sur le vieillissement, from 2016-07-01 to 2021-12-14
  • Démarrage d'un nouveau professeur, from 2020-01-01 to 2023-12-31
  • Déterminer la qualité de la polypharmacie chez les aînés : une approche basée sur l’intelligence artificielle, from 2020-04-01 to 2023-03-31
  • La polypharmacie est-elle un risque pour la santé des aînés?, from 2020-03-17 to 2022-03-31
  • Maison des aînés : étude d'un modèle d'habitation innovant dans une perspective de relance de l'économie et de progrès de notre société suite à la pandémie de COVID-19., from 2021-04-01 to 2021-11-30
  • Pharmacie sans médicaments: exploration des impacts des services cliniques offerts aux aînés québécois polymédicamentés, from 2021-02-19 to 2023-03-31
  • Phase Two of the Canadian Consortium on Neurodegeneration in Aging, from 2019-04-01 to 2024-03-31
  • Polymédication et usage approprié des médicaments chez les aînés québécois, from 2021-07-01 to 2024-06-30
  • Predicting population risk of suicide using health administrative data, from 2020-03-31 to 2022-03-30
  • Primary care reform and medication appropriateness for seniors: A comparative study of two provinces, from 2018-04-01 to 2022-09-01
  • Projet GPS: Évaluation de l'impact de la réorganisation du travail en Groupe de médecine de famille (GMF) sur la Pharmacothérapie et le Soutien à l'autonomie des personnes âgées ayant un trouble neuro-cognitif majeur, from 2019-04-01 to 2022-06-30
  • Real-World Evaluation of the Efficacy, Safety and Cost-Effectiveness of Statins for Primary Prevention of Cardiovascular Disease Among the Elderly – A Causal Perspective to Treatment Trajectory Analysis, from 2019-10-01 to 2023-03-31
  • Suivi de la qualité de la pratique de l'électroconvulsivothérapie au Québec basé sur le recueil de données médico-administratives, cliniques et socio-démographiques en contexte réel, from 2020-01-01 to 2021-12-31

Recently finished projects

  • Développement d’outils pour le dépistage et la gestion de la polypharmacie chez les aînés atteints de cancer, from 2018-11-16 to 2019-12-31
  • Étude de la polymédication chez les aînés québécois, from 2016-07-01 to 2020-06-30
  • Fonds de soutien du CERSSPL-UL pour chercheure-boursière, from 2016-11-18 to 2020-11-17
  • Portrait de la polypharmarcie et de la qualité des traitements des personnes âgées atteintes de schizophrénie au Québec: étude populationnelle de 2000 à 2018, from 2020-04-01 to 2021-03-31
  • Prescription et déprescription chez les personnes de grand âge au Québec : portrait, conditions et questions éthiques, from 2018-04-01 to 2019-12-31
  • The Multimorbidity Treatment Burden Questionnaire (MTBQ): translation and validation in French, from 2019-04-01 to 2020-09-30
  • Valorisation des résultats d'un projet décrivant l'usage des antibiotiques dans la population, selon la présence de maladies chroniques, from 2020-01-01 to 2020-03-31
Data provided by the Université Laval research projects registery