Caroline Diorio has a PhD in epidemiology (2005). Following her studies in bioinformatics and molecular oncology (2005-2008), she set up her research laboratory at Saint-Sacrement Hospital, which is part of the CHU de Québec-Laval University network, where she oversees the storage of breast cancer samples for the Tissue and Data Bank Axis of the Cancer Research Network. She holds a senior research grant and is also an associate professor and the director of epidemiology programs in Laval University’s Department of Social and Preventive Medicine. Dr Diorio is also part of the research group from the Centre des maladies du sein du CHU de Québec-Université Laval. She is the author or co-author of over 80 peer-reviewed publications in scientific journals, one third of these publications focusing on breast tissue density:  a well-established and intermediary risk factor for breast cancer.

Her most recent research projects aim at a more personalized approach to the prevention and treatment of breast cancer. On one hand, her work aims at understanding how our lifestyle can influence the onset, evolution and treatment of breast cancer, to develop personalized prevention and treatment strategies for this type of cancer. Among the different life habits studied, she is mainly interested in obesity, physical activity, and nutrition. On the other hand, the heart of her work focuses on the identification of molecular risk and prognosis markers for breast cancer that can be modulated through changes in our lifestyle habits or can be targeted by preventive and therapeutic agents. Among others, she studies inflammatory, hormonal, metabolic, genetic and epigenetic markers in the blood, and the various components of breast tissue, as well as breast lesions of varying degrees of severity. Her laboratory is funded by the Canadian Institutes of Health Research, theFondation du cancer du sein du Québec, and the Fonds de recherche du Québec-santé.

Hôpital Saint-Sacrement
1050, chemin Sainte-Foy
J0-16
Québec, Québec
Canada G1S 4L8
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Kothari C, Diorio C, Durocher F

The Importance of Breast Adipose Tissue in Breast Cancer.

Journal Article

Int J Mol Sci, 21 (16), 2020.

Abstract | Links:

Dofara SG, Chang SL, Diorio C

Association between the polymorphisms in MMP-2 and MMP-9 with adiposity and mammographic features.

Journal Article

Breast Cancer Res Treat, 182 (1), pp. 169-179, 2020, ISSN: 0167-6806.

Abstract | Links:

Dofara SG, Chang SL, Diorio C

Gene Polymorphisms and Circulating Levels of MMP-2 and MMP-9: A Review of Their Role in Breast Cancer Risk.

Journal Article

Anticancer Res, 40 (7), pp. 3619-3631, 2020, ISSN: 0250-7005.

Abstract | Links:

Kothari C, Osseni MA, Agbo L, Ouellette G, Deraspe M, Laviolette F, Corbeil J, Lambert JP, Diorio C, Durocher F

Machine learning analysis identifies genes differentiating triple negative breast cancers.

Journal Article

Sci Rep, 10 (1), pp. 10464, 2020, ISSN: 2045-2322.

Abstract | Links:

Oudanonh T, Nabi H, Ennour-Idrissi K, Lemieux J, Diorio C

Progesterone receptor status modifies the association between body mass index and prognosis in women diagnosed with estrogen receptor positive breast cancer.

Journal Article

Int J Cancer, 146 (10), pp. 2736-2745, 2020, ISSN: 0020-7136.

Abstract | Links:

Laforest S, Pelletier M, Denver N, Poirier B, Nguyen S, Walker BR, Durocher F, Homer NZM, Diorio C, Andrew R, Tchernof A

Estrogens and Glucocorticoids in Mammary Adipose Tissue: Relationships with Body Mass Index and Breast Cancer Features.

Journal Article

J Clin Endocrinol Metab, 105 (4), 2020, ISSN: 0021-972X.

Abstract | Links:

Dragic D, Ennour-Idrissi K, Michaud A, Chang SL, Durocher F, Diorio C

Association Between BMI and DNA Methylation in Blood or Normal Adult Breast Tissue: A Systematic Review.

Journal Article

Anticancer Res, 40 (4), pp. 1797-1808, 2020, ISSN: 0250-7005.

Abstract | Links:

Clemenceau A, Diorio C, Durocher F

Role of Secreted Frizzled-Related Protein 1 in Early Mammary Gland Tumorigenesis and Its Regulation in Breast Microenvironment.

Journal Article

Cells, 9 (1), 2020, ISSN: 2073-4409.

Abstract | Links:

Kothari C, Diorio C, Durocher F

Gene signatures of breast cancer development and the potential for novel targeted treatments.

Journal Article

Pharmacogenomics, 21 (3), pp. 157-161, 2020, ISSN: 1462-2416.

| Links:

Burguin A, Furrer D, Ouellette G, Jacob S, Diorio C, Durocher F

Trastuzumab effects depend on HER2 phosphorylation in HER2-negative breast cancer cell lines.

Journal Article

PLoS ONE, 15 (6), pp. e0234991, 2020.

Abstract | Links:

76 entries « 1 of 8 »
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Active projects

  • Centre de recherche du CHU de Québec - Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
  • Centre de recherche sur le cancer, Subvention, Institutionnel - BDR, BDR - Centres de recherche reconnus, from 1996-05-01 to 2022-06-13
  • Deciphering breast cancer HER2-negativity with regard to HER2-targeted therapy, Subvention, Instituts de recherche en santé du Canada, Volet Projet: Concours pilotes, from 2016-07-01 to 2021-03-31
  • Design for Better Health: User-Centred Design and Evaluation of Interactive Media for Health Education, Communication and Decision-Making, Subvention, Instituts de recherche en santé du Canada, Subventions Fondation, from 2016-07-01 to 2021-06-30
  • Omega-3 fatty acids in the prevention of breast cancer: role of obesity-related markers in breast tissues, Subvention, Instituts de recherche en santé du Canada, Subvention Projet, from 2018-10-01 to 2022-09-30

Recently finished projects

  • Banque de tissu Sein-Ovaire, Subvention, Fonds de recherche du Québec - Santé, Réseaux thématiques de recherche, from 2000-01-01 to 2019-06-30
  • Effect of environmental contaminants and methylome of breast adipose tissue on aromatase inhibitor efficacy in breast cancer, Subvention, Instituts de recherche en santé du Canada, Volet Projet: Concours pilotes, from 2016-07-01 to 2020-06-30
  • Exposition cumulée aux stresseurs psychosociaux, marqueurs inflammatoires, télomères et fonction cognitive : une étude prospective de 20 ans, Subvention, Instituts de recherche en santé du Canada, Subvention de fonctionnement, from 2014-07-01 to 2019-06-30
  • Une approche personnalisée pour la prévention et le traitement du cancer du sein, Subvention, Fonds de recherche du Québec - Santé, Chercheur-boursier Juniors 1 et 2, Seniors, from 2017-08-01 to 2020-07-31
Data provided by the Université Laval research projects registery