Dr. Têtu is professor emeritus at the Faculty of Medicine of Laval University and a regular researcher in the Oncology axis of the CHU Research Centre of Quebec since 1986. Since the beginning of his career, in addition to his clinical practice and research activities, particularly as a FRSQ senior clinical researcher grant holder, he held various executive positions such as head of the Division of Pathology in the Department of Molecular Biology, Medical Biochemistry and Pathology, Director of the Clinician-Scientist Residency Program and Graduate Program in Clinical Epidemiology, Medical Director of RUIS Telepathology Project at Laval University, Chief of Pathology Services at CHUQ and CHA, Assistant Director of Clinical Research at CHUQ Research Centre, Chair of the Advisory Committee on Anatomical Pathology at the Quebec Cancer Board (Ministry of Health) and Chair of the membership committee of the Canadian Association of Pathologists.

His research themes are:

Clinical validation of new tumor markers

His studies aim to validate tumor markers identified as potentially interesting for predicting the evolution of cancers. These studies are applied to cohorts of patients using histopathological approaches, and therefore involve expertise in cellular and molecular biology, pathology and epidemiology. Several studies use samples from a tumor bank that he has been developing for over 20 years.

Studying the benefits and challenges of using telepathology

Telepathology is a technology that Dr. Têtu has helped to introduce in eastern Quebec, and allows the pathologist to establish remote diagnostics, mainly in oncology. Collaborations with experts in information technology assessment, applied in telemedicine, help identify the socio-political, organizational, clinical, professional, legal and technological benefits and challenges related to the introduction of telepathology.

Hôpital Saint-Sacrement
1050, chemin Sainte-Foy
Service d'anatomopathologie et de cytologie
Québec, Québec
Canada G1S 4L8
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Emond JP, Labriet A, Desjardins S, Rouleau M, Villeneuve L, Hovington H, Brisson H, Lacombe L, Simonyan D, Caron P, Perigny M, Tetu B, Fallon JK, Klein K, Smith PC, Zanger U, Guillemette C, Levesque E

Factors Affecting Interindividual Variability of Hepatic UGT2B17 Protein Expression Examined Using a Novel Specific Monoclonal Antibody.

Journal Article

Drug Metab Dispos, 47 (5), pp. 444-452, 2019, ISSN: 0090-9556.

Abstract | Links:

Wissing M, Brimo F, Chevalier S, Scarlata E, McKercher G, O'Flaherty A, Aprikian S, Thibodeau V, Saad F, Carmel M, Lacombe L, Tetu B, Ekindi-Ndongo N, Latour M, Trudel D, Aprikian A

Optimization of the 2014 Gleason grade grouping in a Canadian cohort of patients with localized prostate cancer.

Journal Article

BJU Int, 123 (4), pp. 624-631, 2019, ISSN: 1464-4096.

Abstract | Links:

Sinha A, Huang V, Livingstone J, Wang J, Fox NS, Kurganovs N, Ignatchenko V, Fritsch K, Donmez N, Heisler LE, Shiah YJ, Yao CQ, Alfaro JA, Volik S, Lapuk A, Fraser M, Kron K, Murison A, Lupien M, Sahinalp C, Collins CC, Tetu B, Masoomian M, Berman DM, van der Kwast T, Bristow RG, Kislinger T, Boutros PC

The Proteogenomic Landscape of Curable Prostate Cancer.

Journal Article

Cancer Cell, 35 (3), pp. 414-427.e6, 2019, ISSN: 1535-6108.

Abstract | Links:

Trudel D, Avarvarei LM, Orain M, Turcotte S, Plante M, Gregoire J, Kappelhoff R, Labbe DP, Bachvarov D, Tetu B, Overall CM, Bairati I

Proteases and their inhibitors as prognostic factors for high-grade serous ovarian cancer.

Journal Article

Pathol Res Pract, 2019, ISSN: 0344-0338.

Abstract | Links:

Chen S, Huang V, Xu X, Livingstone J, Soares F, Jeon J, Zeng Y, Hua JT, Petricca J, Guo H, Wang M, Yousif F, Zhang Y, Donmez N, Ahmed M, Volik S, Lapuk A, Chua MLK, Heisler LE, Foucal A, Fox NS, Fraser M, Bhandari V, Shiah YJ, Guan J, Li J, Orain M, Picard V, Hovington H, Bergeron A, Lacombe L, Fradet Y, Tetu B, Liu S, Feng F, Wu X, Shao YW, Komor MA, Sahinalp C, Collins C, Hoogstrate Y, de Jong M, Fijneman RJA, Fei T, Jenster G, van der Kwast T, Bristow RG, Boutros PC, He HH

Widespread and Functional RNA Circularization in Localized Prostate Cancer.

Journal Article

Cell, 176 (4), pp. 831-843.e22, 2019, ISSN: 0092-8674.

Abstract | Links:

Gagne A, Tetu B, Orain M, Turcotte S, Plante M, Gregoire J, Renaud MC, Bairati I, Trudel D

Correction to: HtrA1 expression and the prognosis of high-grade serous ovarian carcinoma: a cohort study using digital analysis.

Journal Article

Diagn Pathol, 13 (1), pp. 75, 2018.

Abstract | Links:

Wissing M, Chevalier S, McKercher G, Laprise C, Aprikian S, O'Flaherty A, Scarlata E, Saad F, Carmel M, Lacombe L, Brimo F, Latour M, Ekindi-Ndongo N, Tetu B, Aprikian A

The relationship between body-mass index, physical activity, and pathologic and clinical outcomes after radical prostatectomy for prostate cancer.

Journal Article

World J Urol, 2018, ISSN: 0724-4983.

Abstract | Links:

Gagne A, Tetu B, Orain M, Turcotte S, Plante M, Gregoire J, Renaud MC, Bairati I, Trueel D

HtrA1 expression and the prognosis of high-grade serous ovarian carcinoma: a cohort study using digital analysis.

Journal Article

Diagn Pathol, 13 (1), pp. 57, 2018.

Abstract | Links:

Ricketts CJ, De Cubas AA, Fan H, Smith CC, Lang M, Reznik E, Bowlby R, Gibb EA, Akbani R, Beroukhim R, Bottaro DP, Choueiri TK, Gibbs RA, Godwin AK, Haake S, Hakimi AA, Henske EP, Hsieh JJ, Ho TH, Kanchi RS, Krishnan B, Kwiatkowski DJ, Lui W, Merino MJ, Mills GB, Myers J, Nickerson ML, Reuter VE, Schmidt LS, Shelley CS, Shen H, Shuch B, Signoretti S, Srinivasan R, Tamboli P, Thomas G, Vincent BG, Vocke CD, Wheeler DA, Yang L, Kim WY, Robertson AG, Cancer Genome Atlas Research Network, Spellman PT, Rathmell WK, Linehan WM

The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma.

Journal Article

Cell Rep, 23 (12), pp. 3698, 2018.

| Links:

Thorsson V, Gibbs DL, Brown SD, Wolf D, Bortone DS, Ou Yang TH, Porta-Pardo E, Gao GF, Plaisier CL, Eddy JA, Ziv E, Culhane AC, Paull EO, Sivakumar IKA, Gentles AJ, Malhotra R, Farshidfar F, Colaprico A, Parker JS, Mose LE, Vo NS, Liu J, Liu Y, Rader J, Dhankani V, Reynolds SM, Bowlby R, Califano A, Cherniack AD, Anastassiou D, Bedognetti D, Rao A, Chen K, Krasnitz A, Hu H, Malta TM, Noushmehr H, Pedamallu CS, Bullman S, Ojesina AI, Lamb A, Zhou W, Shen H, Choueiri TK, Weinstein JN, Guinney J, Saltz J, Holt RA, Rabkin CE, Cancer Genome Atlas Research Network, Lazar AJ, Serody JS, Demicco EG, Disis ML, Vincent BG, Shmulevich L

The Immune Landscape of Cancer.

Journal Article

Immunity, 48 (4), pp. 812-830.e14, 2018, ISSN: 1074-7613.

Abstract | Links:

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Recently finished projects

  • (FRSQ 67140-CHUM) Axe banque de tissus et de données BTD / Réseau de recherche sur le cancer / projet "Tumeurs sein / ovaire 26380 , Subvention, Fonds de recherche du Québec - Santé, Réseaux thématiques de recherche, from 2007-04-01 to 2018-03-31
  • DNA methylation in normal breast tissue associated to risk of second contralateral breast cancer., Subvention, L'Institut de recherche de la Société canadienne du cancer, Subventions pour l'innovation, from 2014-02-01 to 2018-01-30
Data provided by the Université Laval research projects registery