Dr. Barbara Papadopoulou, B.Pharm., M.Sc., Ph.D., is a Professor in the Department of Microbiology-Infectious Disease and Immunology of the Laval University School of Medicine and the Director of the Axis of Infectious Diseases and Immunity of the CHU de Quebec Research Center-Laval University, since 2010. Her areas of expertise are parasitic diseases, regulation of gene expression, microbial pathogenesis, genomics, and vaccinology. Over the years, her laboratory has made remarkable discoveries on the molecular mechanisms controlling the intracellular development of the protozoan parasite Leishmania and on post-transcriptional regulation by novel classes of 3’UTR elements and RNA binding factors that have significantly advanced knowledge in this area. The fascinating concept of coordinated gene regulation by retroposons has revolutionized the landscape of gene expression control in this parasite. Her laboratory has also been a pioneer in the use of reverse genetics and genomics in Leishmania. She has also contributed to original work on the development of promising vaccine strategies against Leishmania infections. Her sustained efforts on vaccine development have led to patents and innovative live vaccine-based strategies that are currently being evaluated in relevant disease models in endemic countries. Dr. Papadopoulou is an internationally recognized leader in the field of Leishmania. She currently holds some very influential roles in international research networks (Leishmania Genome Network, TriTrypDB, The European Cooperation in the Field of Scientific and Technical Research COST B22) and in advisory expert committees (WorldLeish, World Health Organization) and she has established numerous collaborations, internationally. She has been actively involved, as member of the organizing scientific or local committees, in the organization of more than 8 international congresses on leishmaniasis and other parasitic diseases, and has also organized more than 15 symposia in this field.

Dr. Papadopoulou is the author of over 135 scientific publications and of several reviews and book chapters. She has received several prestigious national and international awards and distinctions for excellence in research, including the Burroughs Wellcome Fund Award in Molecular Parasitology for her outstanding contributions to the field of Leishmania research, and the nomination as Fellow of the Canadian Academy of Health Sciences, in 2013. Her leadership role as a woman in biomedical sciences has also been highlighted on several occasions (YWCA Women of Distinction Award Winner 2012, Science and Technology, 50 Successful Women from the Quebec City Region of Chaudière-Appalaches, ’22 Quebecers to watch’ by L’Actualité magazine, etc.). Dr. Papadopoulou is a member of several international consortia, as well as national (CIHR) and international (Burroughs Wellcome Fund Pathogenesis of Infectious Disease Program, Faculty of 1000 Biology, National Council for Scientific and Technological Development/Brazil, Hellenic Quality Assurance Agency for higher education, etc.) peer review and advisory committees. She is also an elected Faculty member of Greek Universities (APELLA). Until recently, she was until a member and Vice-Chairman of the Board of Directors of the Fonds de Recherche du Québec-Santé (FRQS) and the Board of Directors of the Canadian Academy of Health Sciences.

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Gazanion E, Fernandez-Prada C, Papadopoulou B, Leprohon P, Ouellette M

Cos-Seq for high-throughput identification of drug target and resistance mechanisms in the protozoan parasite Leishmania.

Journal Article

Proc Natl Acad Sci U S A, 113 (21), pp. E3012-21, 2016, ISSN: 0027-8424.

Abstract | Links:

Laffitte MN, Leprohon P, Papadopoulou B, Ouellette M

Plasticity of the Leishmania genome leading to gene copy number variations and drug resistance.

Journal Article

F1000Res, 5 , pp. 2350, 2016, ISSN: 2046-1402.

Abstract | Links:

Katebi A, Gholami E, Taheri T, Zahedifard F, Habibzadeh S, Taslimi Y, Shokri F, Papadopoulou B, Kamhawi S, Valenzuela JG, Rafati S

Leishmania tarentolae secreting the sand fly salivary antigen PpSP15 confers protection against Leishmania major infection in a susceptible BALB/c mice model.

Journal Article

Mol Immunol, 67 (2 Pt B), pp. 501-11, 2015, ISSN: 0161-5890.

Abstract | Links:

Shahbazi M, Zahedifard F, Saljoughian N, Doroud D, Jamshidi S, Mahdavi N, Shirian S, Daneshbod Y, Hamid Zarkesh-Esfahani S, Papadopoulou B, Rafati S

Immunological comparison of DNA vaccination using two delivery systems against canine leishmaniasis.

Journal Article

Vet Parasitol, 212 (3-4), pp. 130-9, 2015, ISSN: 0304-4017.

Abstract | Links:

Mandal G, Mandal S, Sharma M, Charret KS, Papadopoulou B, Bhattacharjee H, Mukhopadhyay R

Species-specific antimonial sensitivity in Leishmania is driven by post-transcriptional regulation of AQP1.

Journal Article

PLoS Negl Trop Dis, 9 (2), pp. e0003500, 2015, ISSN: 1935-2727.

Abstract | Links:

Shahbazi M, Zahedifard F, Taheri T, Taslimi Y, Jamshidi S, Shirian S, Mahdavi N, Hassankhani M, Daneshbod Y, Zarkesh-Esfahani SH, Papadopoulou B, Rafati S

Evaluation of Live Recombinant Nonpathogenic Leishmania tarentolae Expressing Cysteine Proteinase and A2 Genes as a Candidate Vaccine against Experimental Canine Visceral Leishmaniasis.

Journal Article

PLoS ONE, 10 (7), pp. e0132794, 2015.

Abstract | Links:

Papadopoulou B, Muller-McNicoll M, Padmanabhan PK

Approaches for studying mRNA decay mediated by SIDER2 retroposons in Leishmania.

Journal Article

Methods Mol Biol, 1201 , pp. 123-42, 2015, ISSN: 1064-3745.

Abstract | Links:

Dupe A, Dumas C, Papadopoulou B

Differential Subcellular Localization of Leishmania Alba-Domain Proteins throughout the Parasite Development.

Journal Article

PLoS ONE, 10 (9), pp. e0137243, 2015.

Abstract | Links:

de Melo Neto OP, da Costa Lima TD, Xavier CC, Nascimento LM, Romao TP, Assis LA, Pereira MM, Reis CR, Papadopoulou B

The unique Leishmania EIF4E4 N-terminus is a target for multiple phosphorylation events and participates in critical interactions required for translation initiation.

Journal Article

RNA Biol, 12 (11), pp. 1209-21, 2015, ISSN: 1547-6286.

Abstract | Links:

Ferreira TR, Alves-Ferreira EV, Defina TP, Walrad P, Papadopoulou B, Cruz AK

Altered expression of an RBP-associated arginine methyltransferase 7 in Leishmania major affects parasite infection.

Journal Article

Mol Microbiol, 2014, ISSN: 0950-382X.

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Active projects

  • Centre de recherche du CHU de Québec - Université Laval, Subvention, Centre hospitalier universitaire de Québec - Université Laval, Centres de recherche affiliés, from 2017-01-01 to 2099-12-31
  • Centre de recherche en infectiologie, Subvention, Institutionnel - BDR, BDR - Centres de recherche reconnus, from 1996-06-01 to 2024-11-06
  • Post-transcriptional regulatory networks coordinating developmental gene expression in the human pathogen Leishmania, Subvention, Instituts de recherche en santé du Canada, Volet Projet: Concours pilotes, from 2016-07-01 to 2021-06-30

Recently finished projects

  • 3.5 Impact of environmental conditions on airway microbiota and resratory health in the North, Subvention, Secrétariat des programmes interorganismes à l’intention des établissements, Fonds d'excellence en recherche Apogée Canada, from 2017-04-01 to 2020-03-31
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